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  1. Article ; Online: Halting the Vicious Cycle of Atopic Dermatitis: Empowered by Scientific Understanding.

    Brown, Sara J / Gudjonsson, Johann E

    The Journal of investigative dermatology

    2024  Volume 144, Issue 5, Page(s) 917–918

    MeSH term(s) Dermatitis, Atopic/immunology ; Humans
    Language English
    Publishing date 2024-04-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Editorial
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2024.03.003
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  2. Article ; Online: IL-33 antagonism does not improve chronic atopic dermatitis: What can we learn?

    Schuler, Charles F / Gudjonsson, Johann E

    The Journal of allergy and clinical immunology

    2022  Volume 150, Issue 6, Page(s) 1410–1411

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Interleukin-33 ; Eczema ; Protein Transport
    Chemical Substances Interleukin-33
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2022.10.009
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  3. Article ; Online: Hitting the Bullseye in Autoimmunity: Targeting Biologics through Tethering: Examining a Therapeutic Potential for Vitiligo and Beyond.

    Plazyo, Olesya / Gudjonsson, Johann E

    The Journal of investigative dermatology

    2022  Volume 142, Issue 12, Page(s) 3133–3135

    MeSH term(s) Humans ; Vitiligo/drug therapy ; Autoimmunity ; Biological Products/therapeutic use ; Hypopigmentation ; Melanocytes
    Chemical Substances Biological Products
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2022.07.005
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  4. Article ; Online: Targeting immune cell trafficking and vascular endothelial cells in psoriasis.

    Young, Kelly Z / Plazyo, Olesya / Gudjonsson, Johann E

    The Journal of clinical investigation

    2023  Volume 133, Issue 9

    Abstract: The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a ... ...

    Abstract The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting immune cells to specific areas of vascular damage, infection, or foreign material. However, mechanisms through which ECs participate in immune-mediated responses remain to be fully explored. In this issue of the JCI, Li, Shao, et al. report on vascular endothelial glycocalyx destruction and the mechanisms through which EC dysfunction contributes to the well-characterized immune-mediated features of psoriasis, a chronic inflammatory skin disease. Here, we discuss the implications of these findings and highlight some risks and benefits of existing therapies designed to target immune cell trafficking in a variety of inflammatory conditions.
    MeSH term(s) Humans ; Endothelial Cells ; Psoriasis ; Skin
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI169450
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  5. Article ; Online: Pathophysiology of generalized pustular psoriasis.

    Young, Kelly Z / Sarkar, Mrinal K / Gudjonsson, Johann E

    Experimental dermatology

    2023  Volume 32, Issue 8, Page(s) 1194–1203

    Abstract: Psoriasis is a chronic, immune-mediated skin disease that affects over 3% of adults in the United States. Psoriasis can present in several clinical forms. Of these, generalized pustular psoriasis is an acute, severe form, associated with increased ... ...

    Abstract Psoriasis is a chronic, immune-mediated skin disease that affects over 3% of adults in the United States. Psoriasis can present in several clinical forms. Of these, generalized pustular psoriasis is an acute, severe form, associated with increased morbidity and mortality. Unlike the more common plaque psoriasis, which is thought to feature dysregulation of the adaptive immune system, generalized pustular psoriasis reflects heightened autoinflammatory responses. Recent advances in genetic and immunological studies highlight a key role of the IL-36 immune axis in the pathogenesis of generalized pustular psoriasis. In this article, we review the psoriatic subtypes and discuss diagnostic criteria of generalized pustular psoriasis, discuss several newly identified genetic variants associated with pustular disease in the skin, and discuss how these mutations shed light on pustular disease mechanisms. Furthermore, we gather insights from recent transcriptomic studies that similarly implicate a pathogenic role of the IL-36 immune axis in generalized pustular psoriasis.
    MeSH term(s) Adult ; Humans ; Psoriasis ; Skin ; Chronic Disease ; Acute Disease ; Mutation
    Language English
    Publishing date 2023-02-20
    Publishing country Denmark
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14768
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  6. Article ; Online: Targeting immune cell trafficking and vascular endothelial cells in psoriasis

    Kelly Z. Young / Olesya Plazyo / Johann E. Gudjonsson

    The Journal of Clinical Investigation, Vol 133, Iss

    2023  Volume 9

    Abstract: The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a ... ...

    Abstract The role of the vasculature in inflammatory skin disorders is an exciting area of investigation. Vascular endothelial cells (ECs) play instrumental roles in maintaining the vascular barrier and control of blood flow. Furthermore, ECs contribute to a variety of immune responses, such as targeting immune cells to specific areas of vascular damage, infection, or foreign material. However, mechanisms through which ECs participate in immune-mediated responses remain to be fully explored. In this issue of the JCI, Li, Shao, et al. report on vascular endothelial glycocalyx destruction and the mechanisms through which EC dysfunction contributes to the well-characterized immune-mediated features of psoriasis, a chronic inflammatory skin disease. Here, we discuss the implications of these findings and highlight some risks and benefits of existing therapies designed to target immune cell trafficking in a variety of inflammatory conditions.
    Keywords Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Significance of stress keratin expression in normal and diseased epithelia.

    Cohen, Erez / Johnson, Craig N / Wasikowski, Rachael / Billi, Allison C / Tsoi, Lam C / Kahlenberg, J Michelle / Gudjonsson, Johann E / Coulombe, Pierre A

    iScience

    2024  Volume 27, Issue 2, Page(s) 108805

    Abstract: A group of keratin intermediate filament genes, the type ... ...

    Abstract A group of keratin intermediate filament genes, the type II
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108805
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  8. Article ; Online: An Assessment of Comparative Medication Durability in Inflammatory Bowel Disease Patients With and Without Co-morbid Psoriasis, Rheumatoid Arthritis, and/or Enteropathic Arthritis.

    Cushing, Kelly / Gudjonsson, Johann E / Speliotes, Elizabeth / Higgins, Peter D R

    Digestive diseases and sciences

    2023  Volume 68, Issue 10, Page(s) 4001–4008

    Abstract: Background: Patients with inflammatory bowel disease (IBD) are at increased risk for many co-morbid diseases. However, little is known about durability of IBD medications in patients with co-morbid diseases.: Aims: Determine medication durability in ... ...

    Abstract Background: Patients with inflammatory bowel disease (IBD) are at increased risk for many co-morbid diseases. However, little is known about durability of IBD medications in patients with co-morbid diseases.
    Aims: Determine medication durability in IBD patients with and without psoriasis, rheumatoid arthritis, and/or enteropathic arthropathy.
    Methods: All patients with at least three ICD-9 or 10 diagnoses for IBD were included in the cohort. The risk factors of interest were a co-morbid diagnosis of psoriasis (IBD-Ps), rheumatoid arthritis (IBD-RA), and/or enteropathic arthritis (IBD-EA). Medication durability was defined as days of medication use, calculated using order start and stop dates from the electronic medical record. Significant differences were tested using the Wilcoxon rank sum test for continuous variables and Fisher's exact test or Pearson's Chi-squared test, as appropriate, for categorical variables. Boxplots were constructed for graphical interpretation of results.
    Results: In the psoriasis group, there were 481 patients with 831 medication exposures [131 IBS-Ps (16%), 700 IBD only (84%)]. The median days of medication use were numerically higher in the IBD-Ps group for all therapies [anti-TNF: 1109 vs 861 (p = 0.17); anti-IL-12/23: 984 vs 834 (p = 0.33); JAKi: 682 vs 230 (p = 0.13)], anti-TNF/IM: 370 vs 202 (p = 0.57), except anti-integrin therapy [214 vs 470 (p = 0.08)]. When restricting to UC only, patients with co-morbid again Ps had a significantly shorter duration on anti-integrin therapy (84 vs 456 days, p = 0.02). While not reaching statistical significance, there was a distinctly longer medication duration on JAKi therapy (910 vs 317, p = 0.10). When restricting to patients with CD only, no results reached statistical significance though there was a trend towards longer anti-TNF durability in CD-Ps (1340 vs 1000 days, p = 0.098). There were no differences in medication durability in IBD-RA or IBD-EA patients.
    Discussion: Larger studies investigating medication durability of JAKi and anti-integrin therapy in IBD patients with psoriasis would be beneficial given noteworthy trends towards increased and decreased durability, respectively.
    MeSH term(s) Humans ; Tumor Necrosis Factor Inhibitors/therapeutic use ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/epidemiology ; Arthritis, Rheumatoid/complications ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/epidemiology ; Psoriasis/complications ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Comorbidity
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2023-08-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 304250-9
    ISSN 1573-2568 ; 0163-2116
    ISSN (online) 1573-2568
    ISSN 0163-2116
    DOI 10.1007/s10620-023-08062-5
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  9. Article ; Online: Meeting Report: 68

    Gudjonsson, Johann E / Elder, James T

    The Journal of investigative dermatology

    2020  Volume 140, Issue 11, Page(s) 2105–2110

    Abstract: ... The ... ...

    Abstract The 68
    MeSH term(s) Animals ; Cartoons as Topic ; Chromatin/chemistry ; Genome-Wide Association Study ; Genomics ; Humans ; Quantitative Trait Loci ; Skin Diseases/etiology ; Skin Diseases/genetics ; Skin Diseases/immunology ; Skin Physiological Phenomena ; Transcriptome
    Chemical Substances Chromatin
    Language English
    Publishing date 2020-06-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 80136-7
    ISSN 1523-1747 ; 0022-202X
    ISSN (online) 1523-1747
    ISSN 0022-202X
    DOI 10.1016/j.jid.2020.06.010
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  10. Article: Epigenetics of Psoriasis.

    Shao, Shuai / Gudjonsson, Johann E

    Advances in experimental medicine and biology

    2020  Volume 1253, Page(s) 209–221

    Abstract: Psoriasis is a chronic and recurrent inflammatory skin disease, involving the rapid proliferation and abnormal differentiation of keratinocytes and activation of T cells. It is generally accepted that the central pathogenesis of psoriasis is a T cell- ... ...

    Abstract Psoriasis is a chronic and recurrent inflammatory skin disease, involving the rapid proliferation and abnormal differentiation of keratinocytes and activation of T cells. It is generally accepted that the central pathogenesis of psoriasis is a T cell-dominant immune disorder affected by multiple factors including genetic susceptibility, environmental factors, innate and adaptive immune responses, etc. However, the exact etiology is largely unknown. In recent years, epigenetic involvements, such as the DNA methylation, chromatin modifications, and noncoding RNA regulation are reported to be critical for the pathogenesis of psoriasis. However, the interplay between these factors has only recently been started to be unraveled. Notably, inhibitors of enzymes that work in epigenetic modifications, such as DNA methyltransferases and histone deacetylases, are beginning to appear in the clinical setting to restore normal epigenetic patterns (Generali et al. in J Autoimmun 83:51-61, 2017), providing novel therapeutic potential as novel treatment targets for psoriasis. Indeed, medications previously used to treat autoimmune diseases have later been discovered to exert their action via epigenetic mechanisms. Herein, we review the findings on epigenetics associated with psoriasis, and discuss future perspectives in this field.
    MeSH term(s) DNA Methylation ; Epigenesis, Genetic ; Epigenomics ; Genetic Predisposition to Disease ; Humans ; Psoriasis/genetics
    Language English
    Publishing date 2020-05-14
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-15-3449-2_8
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