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Article ; Online: San Miguel Pérez, Enrique (Investigador Principal); Prado Higuera, Cristina del; Duque Silva, Guillermo Andrés; Pérez Bolaños, Diana Marcela (Coordinadores)

José Carlos Muñoz Castellanos

Cuadernos de Investigación Histórica, Iss

Informe del proyecto. integración. Derechos humanos y ciudadanía global. Madrid, Dykinson, 2023

2023 Volume 40

Abstract: ... Andrés; Pérez Bolaños, Diana Marcela (Coordinadoes) ...

Abstract	Reseña del libro Informe del proyecto. integración. Derechos humanos y ciudadanía global, de Enrique San Miguel Pérez, (Investigador Principal); Prado Higuera, Cristina del; Duque Silva, Guillermo Andrés; Pérez Bolaños, Diana Marcela (Coordinadoes)
Keywords	Migración ; Integración ; Derechos Humanos ; Ciudadanía Global ; History (General) and history of Europe ; D
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Fundación Universitaria Española
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Profiles of suicide attempted in children and adolescents.

Ortega-Narváez, Alicia / Muñoz-Manquillo, Diana Marcela / Guzmán-Lopez, Claudia Patricia / Cabra-Bautista, Ginna

Jornal de pediatria

2024

Abstract: Objective: Suicide attempt (SA) is the strongest predictive variable for completed suicide. The Department of Cauca in Colombia has an SA rate higher than the national average, but the factors are unknown. The objective was to identify the profiles of ... ...

Abstract	Objective: Suicide attempt (SA) is the strongest predictive variable for completed suicide. The Department of Cauca in Colombia has an SA rate higher than the national average, but the factors are unknown. The objective was to identify the profiles of SA in children and adolescents of Cauca. Methods: Cross-sectional study, which included all SA (Event-356) records from the SIVIGILA platform in children under 18 years of age between 2016 and 2019. The authors described the variables and multiple correspondence analysis (MCA) with the Burt method, according to the completeness of the data to establish the possible SA profiles using STATA 15.1, and R. The Ethics Committee at Universidad del Cauca approved it. Results: The study found 977 SA during this period, 72.4% female, 97.1% adolescent, 74.4% mestizo, 19.3% indigenous, 45.3% resided in municipalities exposed to the armed conflict, 32.3% expressed ideation and previous attempts, and 15.5% prior attempts. The MCA included 810 SA and identified three profiles: "Classic", which had mestizo adolescents with a history of prior SA, mental illness, or psychoactive substance use problems; "Related to the armed conflict", which included female adolescents with a first SA and residents in municipalities exposed to the armed conflict; "Ethnic" represented by male indigenous, with housing in a rural area. Conclusion: The SA profiles found in Cauca were "Classic", "Related to the armed conflict", and "Ethnic"; these can be considered to implement prevention strategies from a cross-cultural, mental health, and gender perspective, with the presence of the state in the territories.
Language	English
Publishing date	2024-04-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	731324-x
ISSN	1678-4782 ; 0021-7557
ISSN (online)	1678-4782
ISSN	0021-7557
DOI	10.1016/j.jped.2024.01.007
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Zs.B 1265: Show issues

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Article: Corrigendum to "The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study" <Heliyon 9(2) February 2023 e13634]>.

Muñoz Sarmiento, Diana Marcela / Rodríguez Montaño, Óscar Libardo / Alarcón Castiblanco, Juan David / Cortés Rodríguez, Carlos Julio

Heliyon

2023 Volume 9, Issue 3, Page(s) e14487

Abstract: This corrects the article DOI: 10.1016/j.heliyon.2023.e13634.]. ...

Abstract	[This corrects the article DOI: 10.1016/j.heliyon.2023.e13634.].
Language	English
Publishing date	2023-03-17
Publishing country	England
Document type	Published Erratum
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14487
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Article ; Online: Euthanasia in Colombia: Experience in a palliative care program and bioethical reflections.

Erazo-Munoz, Marcela / Borda-Restrepo, Diana / Benavides-Cruz, Johana

Developing world bioethics

2023

Abstract: The increased prevalence of advanced-stage chronic diseases has augmented the need for palliative care teams. In Colombia, although the legislation promotes palliative care development, people still die without receiving management from a palliative care ...

Abstract	The increased prevalence of advanced-stage chronic diseases has augmented the need for palliative care teams. In Colombia, although the legislation promotes palliative care development, people still die without receiving management from a palliative care team. In addition, judiciary regulations regarding euthanasia have generated public confusion and ethical conflicts among members of the palliative care teams. Therefore, this study aimed to perform a bioethical reflection on the relationship between palliative care and euthanasia supported by data on euthanasia requests in a palliative care program. This reflection is based on retrospective and descriptive observational data, collected in two highly complex hospitals in Bogotá, Colombia. A total of 50 euthanasia requests were identified, of which 62% met the defined criteria, 16% did not, and 22% were not considered by the interdisciplinary committee for the right to die with dignity due to early death. All patients were treated and followed up by a palliative care team until their death. This study considered that palliative care could be a complement management for patients requesting euthanasia based on their experience by supporting the decision-making, alleviating suffering, and providing emotional support in the last days of life.
Language	English
Publishing date	2023-10-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2049034-3
ISSN	1471-8847 ; 1471-8731
ISSN (online)	1471-8847
ISSN	1471-8731
DOI	10.1111/dewb.12430
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Zs.A 5461: Show issues

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Article ; Online: Lidocaine infusion for malignant visceral pain: case report.

Velilla Echeverri, Diana Catalina / Gómez Díaz, Mateo / Beltrán Pachón, Paloma / Lasso Valenzuela, David / Poveda Carreño, Sofía / Erazo-Muñoz, Marcela

BMJ supportive & palliative care

2024 Volume 13, Issue e3, Page(s) e974–e976

Abstract: Background: Visceral pain accounts for nearly 28% of cancer-related pain, and its effective management poses significant challenges. The diverse pathways of neurotransmission, neurotransmitters, channels, and receptors suggest the need for ... ...

Abstract	Background: Visceral pain accounts for nearly 28% of cancer-related pain, and its effective management poses significant challenges. The diverse pathways of neurotransmission, neurotransmitters, channels, and receptors suggest the need for individualized analgesic therapy. Our objective is to explore a therapeutic alternative for managing malignant visceral pain in advanced cancer. Cases: In this report, we present two patients with malignant bowel obstruction and severe visceral pain, despite receiving opioid treatment, necessitating an alternative approach. Surgical interventions were considered but promptly ruled out. Paracentesis was performed as necessary. Pain management was initiated using a combination of opioids and co-analgesics. However, both patients required opioid dose escalation without achieving adequate pain control or tolerating the associated side effects. Consequently, a lidocaine infusion was administered to alleviate pain. Outcome: Following 24-48 hours of lidocaine infusion, both patients achieved satisfactory symptom control, enabling a reduction in opioid doses and improvement in intestinal transit. No side effects were reported during the treatment. Discussion: Lidocaine infusions may be beneficial for pain management in patients with malignant bowel obstruction and visceral pain. The extent of pain control achieved in comparison to other therapeutics remains challenging to ascertain. We posit that lidocaine infusions, with their potential impact on visceral hypersensitivity, can enhance pain control and facilitate the recovery of bowel transit. Further studies are warranted to validate these findings.
MeSH term(s)	Humans ; Analgesics ; Analgesics, Opioid/therapeutic use ; Lidocaine/therapeutic use ; Pain Management ; Visceral Pain/drug therapy ; Visceral Pain/etiology
Chemical Substances	Analgesics ; Analgesics, Opioid ; Lidocaine (98PI200987)
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/spcare-2023-004350
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Article ; Online: In vitro activity of ceftazidime-avibactam against gram-negative bacteria in patients with bacteremia and skin and soft-tissue infections in Colombia 2019-2021.

Lemos-Luengas, Elkin Vladimir / Rentería-Valoyes, Sixta / Muñoz, Diana Marcela Almario / Gonzalez, Cinthya Katherine Galindo / Guerrón-Gómez, Gabriela / Ramos-Castaneda, Jorge Andres

Diagnostic microbiology and infectious disease

2024 Volume 109, Issue 2, Page(s) 116235

Abstract: Objectives: Ceftazidime-avibactam (CAZ-AVI) is an option for infections caused by MDR gram-negative bacilli. In this study, we aimed to analyze the in vitro antimicrobial activity of CAZ-AVI and other antimicrobial agents against gram-negative bacilli ... ...

Abstract	Objectives: Ceftazidime-avibactam (CAZ-AVI) is an option for infections caused by MDR gram-negative bacilli. In this study, we aimed to analyze the in vitro antimicrobial activity of CAZ-AVI and other antimicrobial agents against gram-negative bacilli that were collected in Colombia between 2019 and 2021 from patients with bacteremia and skin and soft-tissue infections (SSTIs). Methods: A total of 600 Enterobacterales and 259 P. aeruginosa strains were analyzed. The phenotypic resistance of isolates, particularly non-susceptibility to meropenem, multidrug-resistant (MDR) isolates, and difficult-to-treat (DTR) P. aeruginosa, was evaluated according to CLSI breakpoints. Results: Enterobacterales had the most susceptibility to CAZ-AVI (96.5 %) and tigecycline (95 %). Tigecycline and CAZ-AVI were the antimicrobial agents with the most in vitro activity against carbapenem-resistant Enterobacterales (CRE). CAZ-AVI was the antimicrobial treatment with the most activity against P. aeruginosa. Conclusions: Tigecycline and CAZ-AVI were the antimicrobial agents with the most activity against CRE and MDR Enterobacterales. For P. aeruginosa, CAZ-AVI was the antimicrobial treatment with the most in vitro activity.
Language	English
Publishing date	2024-02-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2024.116235
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Article ; Online: T cell metabolism and possible therapeutic targets in systemic lupus erythematosus: a narrative review.

Muñoz-Urbano, Marcela / Quintero-González, Diana C / Vasquez, Gloria

Immunopharmacology and immunotoxicology

2022 Volume 44, Issue 4, Page(s) 457–470

Abstract: In the immunopathogenesis of systemic lupus erythematosus (SLE), there is a dysregulation of specific immune cells, including T cells. The metabolic reprogramming in T cells causes different effects. Metabolic programs are critical checkpoints in immune ... ...

Abstract	In the immunopathogenesis of systemic lupus erythematosus (SLE), there is a dysregulation of specific immune cells, including T cells. The metabolic reprogramming in T cells causes different effects. Metabolic programs are critical checkpoints in immune responses and are involved in the etiology of autoimmune disease. For instance, resting lymphocytes generate energy through oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO), whereas activated lymphocytes rapidly shift to the glycolytic pathway. Specifically, mitochondrial dysfunction, oxidative stress, abnormal metabolism (including glucose, lipid, and amino acid metabolism), and mTOR signaling are hallmarks of T lymphocyte metabolic dysfunction in SLE. Herein it is summarized how metabolic defects contribute to T cell responses in SLE, and some epigenetic alterations involved in the disease. Finally, it is shown how metabolic defects could be modified therapeutically.
MeSH term(s)	Humans ; Lupus Erythematosus, Systemic/drug therapy ; Oxidative Stress ; Signal Transduction ; T-Lymphocytes
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	807033-7
ISSN	1532-2513 ; 0892-3973
ISSN (online)	1532-2513
ISSN	0892-3973
DOI	10.1080/08923973.2022.2055568
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Article: The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics: A tridimensional finite element analysis study.

Muñoz Sarmiento, Diana Marcela / Rodríguez Montaño, Óscar Libardo / Alarcón Castiblancoa, Juan David / Cortés Rodríguez, Carlos Julio

Heliyon

2023 Volume 9, Issue 2, Page(s) e13634

Abstract: It has been proposed that eye movements could be related to glaucoma development. This research aimed to compare the impact of intraocular pressure (IOP) versus horizontal duction on optic nerve head (ONH) strains. Thus, a tridimensional finite element ... ...

Abstract	It has been proposed that eye movements could be related to glaucoma development. This research aimed to compare the impact of intraocular pressure (IOP) versus horizontal duction on optic nerve head (ONH) strains. Thus, a tridimensional finite element model of the eye including the three tunics of the eye, all of the meninges, and the subarachnoid space (SAS) was developed using a series of medical tests and anatomical data. The ONH was divided into 22 subregions, and the model was subjected to 21 different eye pressures, as well as 24 different degrees of adduction and abduction ranging from 0.5° to 12°. Mean deformations were documented along anatomical axes and in principal directions. Additionally, the impact of tissue stiffness was assessed. The results show no statistically significant differences between the lamina cribrosa (LC) strains due to eye rotation and IOP variation. However, when assessing LC regions some experienced a reduction in principal strains following a 12° duction, while after the IOP reached 12 mmHg, all LC subzones showed an increase in strains. From an anatomical perspective, the effect on the ONH following 12° duction was opposite to that observed after a rise in IOP. Moreover, high strain dispersion inside the ONH subregions was obtained with lateral eye movements, which was not observed with increased IOP and variation. Finally, SAS and orbital fat stiffness strongly influenced ONH strains during eye movements, while SAS stiffness was also influential under ocular hypertension. Even if horizontal eye movements cause large ONH deformations, their biomechanical effect would be markedly distinct from that induced by IOP. It could be predicted that, at least in physiological conditions, their potential to cause axonal injury would not be so relevant. Thus, a causative role in glaucoma does not appear likely. By contrast, an important role of SAS would be expectable.
Language	English
Publishing date	2023-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13634
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Article ; Online: Mitochondria as a key player in systemic lupus erythematosus.

Quintero-González, Diana C / Muñoz-Urbano, Marcela / Vásquez, G

Autoimmunity

2022 Volume 55, Issue 8, Page(s) 497–505

Abstract: Systemic lupus erythematosus (SLE) is a heterogeneous, multisystemic autoimmune disease with a broad clinical spectrum. Loss of self-tolerance and chronic inflammation are critical markers of SLE pathogenesis. Although alterations in adaptive immunity ... ...

Abstract	Systemic lupus erythematosus (SLE) is a heterogeneous, multisystemic autoimmune disease with a broad clinical spectrum. Loss of self-tolerance and chronic inflammation are critical markers of SLE pathogenesis. Although alterations in adaptive immunity are widely recognized, increasing reports indicate the role of mitochondrial dysfunction in activating pathogenic pathways involving the innate immune system. Among these, disarrangements in mitochondrial DNA copy number and heteroplasmy percentage are related to SLE activity. Furthermore, increased oxidative stress contributes to post-translational changes in different molecules (proteins, nucleic acids, and lipids), release of oxidized mitochondrial DNA through a pore of voltage-dependent anion channel oligomers, and spontaneous mitochondrial antiviral signaling protein oligomerization. Finally, a reduction in mitophagy, apoptosis induction, and NETosis has been reported in SLE. Most of these pathways lead to persistent and inappropriate exposure to oxidized mitochondrial DNA, which can stimulate plasmacytoid dendritic cells, enhance autoreactive lymphocyte activation, and release increased amounts of interferons through stimulation of toll-like receptors and cytosolic DNA sensors. Likewise, abnormal T-cell receptor activation, decreased regulatory T cells, enhanced Th17 phenotypes, and increased monocyte maturation to dendritic cells have also been observed in SLE. Targeting the players involved in mitochondrial damage can ultimately help.
MeSH term(s)	Antiviral Agents/metabolism ; DNA, Mitochondrial/genetics ; DNA, Mitochondrial/metabolism ; Humans ; Interferons/metabolism ; Lipids ; Lupus Erythematosus, Systemic ; Mitochondria/genetics ; Mitochondria/metabolism ; Receptors, Antigen, T-Cell/metabolism ; Toll-Like Receptors/metabolism
Chemical Substances	Antiviral Agents ; DNA, Mitochondrial ; Lipids ; Receptors, Antigen, T-Cell ; Toll-Like Receptors ; Interferons (9008-11-1)
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1025450-x
ISSN	1607-842X ; 0891-6934
ISSN (online)	1607-842X
ISSN	0891-6934
DOI	10.1080/08916934.2022.2112181
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Zs.A 2777: Show issues

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Article ; Online: Corrigendum to “The impact of horizontal eye movements versus intraocular pressure on optic nerve head biomechanics

Diana Marcela Muñoz Sarmiento / Óscar Libardo Rodríguez Montaño / Juan David Alarcón Castiblanco / Carlos Julio Cortés Rodríguez

Heliyon, Vol 9, Iss 3, Pp e14487- (2023)

A tridimensional finite element analysis study”

2023

Keywords	Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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