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Article: Potential anti-carcinogenic effect of probiotic and lactic acid bacteria in detoxification of benzo[a]pyrene: A review

Shoukat, Sana

Trends in food science & technology. 2020 May, v. 99

2020

Abstract: Contaminations of benzo[a]pyrene (B[a]p) in food is the main source of B[a]p exposure to humans. B[a]p as one of the most studied polycyclic aromatic hydrocarbon (PAH) omnipresent in the environment and food. Bifidobacteria and lactic acid bacteria (LAB) ...

Abstract	Contaminations of benzo[a]pyrene (B[a]p) in food is the main source of B[a]p exposure to humans. B[a]p as one of the most studied polycyclic aromatic hydrocarbon (PAH) omnipresent in the environment and food. Bifidobacteria and lactic acid bacteria (LAB) now have been used to study the elimination of carcinogenic contaminants of food via stable physical binding.The current theoretical study revealed that biological detoxification of B[a]p is an environmentally friendly and cost-effective method. Data was collected by “web of science”, “research gate”, “google scholar”, BJFU online library etc. The aim of this study was to discuss the efficiency of probiotic and LAB cells in in-vitro binding with B[a]p and in in-vivo anti-carcinogenicity and anti-mutagenicity against B[a]p and the whole overview of detoxification mechanism in the food system. To the best we know, this is the first review that focuses on the approaches of probiotics and LABs in the removal of B[a]p. This research will be utilized in the food industrial processing and in the industries that use the “probiotic cell technology” such as pharmaceutical, food, feed etc.This study established that B[a]p binding percentage of probiotic and LAB cells were double comparatively non-LAB cells after a critical comparison. It was found that probiotic and LAB cells were effective in in-vivo removal of B[a]p on oral administration and also effective in removal of B[a]p from the food systems. It was concluded that probiotic strains were highly efficient in the removal of B[a]p also having no toxic effects and potential adverse health effects.
Keywords	Bifidobacterium ; adverse effects ; anticarcinogenic activity ; benzo(a)pyrene ; carcinogenicity ; cost effectiveness ; humans ; industry ; lactic acid bacteria ; oral administration ; polycyclic aromatic hydrocarbons ; probiotics ; processing technology
Language	English
Dates of publication	2020-05
Size	p. 450-459.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1049246-x
ISSN	1879-3053 ; 0924-2244
ISSN (online)	1879-3053
ISSN	0924-2244
DOI	10.1016/j.tifs.2020.02.029
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Article ; Online: SURVEY ON PREVALENCE OF TEMPOROMANDIBULAR JOINT DYSFUNCTION AND ITS ASSOCIATION WITH NECK PAIN AMONG UNIVERSITY STUDENTS

Muhammad Kashif / Sana Bashir / Ayesha Shoukat / Khurram Shehzad / Sidra Ashraf

Rehman Journal of Health Sciences, Vol 4, Iss 2, Pp 82-

2023 Volume 89

Abstract: Introduction: Temporomandibular Joint (TMJ) dysfunction is second most frequent cause of orofacial pain after dental pain. TMJ dysfunction and disorders of cervical region greatly affect the routine activities and lifestyle and lower the person’s ability ...

Abstract	Introduction: Temporomandibular Joint (TMJ) dysfunction is second most frequent cause of orofacial pain after dental pain. TMJ dysfunction and disorders of cervical region greatly affect the routine activities and lifestyle and lower the person’s ability to interact socially and work independently. The objective of current study was to determine the prevalence of TMJ dysfunction and its association with neck pain among university students. Material & Methods: Participants from different universities in Faisalabad were selected using convenient sampling. Out of 1513 students, 1338 who met inclusion criteria were included in this study. The participants were asked to respond to a self-structured questionnaire that contained the Fonseca's Anamnestic Index (FAI) and Neck Disability Index (NDI). SPSS version 21 was used for data analysis. Results: A total of 58% of the subjects were having mild to moderate level of temporomandibular dysfunction while 41% of the student’s reported absence of neck pain. Study revealed that the headache was most common problem (61.5%) among university students and least common problem (16.5%) was moving jaw to the sides. Moderate and severe TMJ dysfunction were associated with severe and complete levels of NDI with p<0.001. Conclusion: The results of this study showed that most of the students had mild to moderate TMJ dysfunction, and there was a significant association between TMJ dysfunction and neck pain.
Keywords	neck pain ; students ; temporomandibular joint ; Medicine ; R
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Rehman Medical Institute
Document type	Article ; Online
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Article ; Online: Optimizing E

Zhou, Zhaorui / Zhao, Lanling / Wang, Jun / Zhang, Yiming / Li, Yebing / Shoukat, Sana / Han, Xue / Long, Yuxin / Liu, Yao

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 41, Page(s) e2302598

Abstract: ... Li- ... ...

Abstract	Li-O
Language	English
Publishing date	2023-06-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202302598
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Article ; Online: Cardiotoxicity Related to Radiation Therapy.

Shoukat, Sana / Zheng, Danyi / Yusuf, Syed Wamique

Cardiology clinics

2019 Volume 37, Issue 4, Page(s) 449–458

Abstract: With increasing survival from cancer, the incidence of cardiovascular diseases is increasing as a chronic side effect of radiation therapy. Prevention, early recognition, and prompt intervention should be the major focus in the care of these patients. ...

Abstract	With increasing survival from cancer, the incidence of cardiovascular diseases is increasing as a chronic side effect of radiation therapy. Prevention, early recognition, and prompt intervention should be the major focus in the care of these patients.
MeSH term(s)	Cardiotoxicity ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Dose-Response Relationship, Radiation ; Global Health ; Humans ; Incidence ; Neoplasms/radiotherapy ; Radiotherapy/adverse effects
Language	English
Publishing date	2019-08-31
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1196385-2
ISSN	1558-2264 ; 0733-8651
ISSN (online)	1558-2264
ISSN	0733-8651
DOI	10.1016/j.ccl.2019.07.010
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Article ; Online: Synergistic neuroprotection by phytocompounds of Bacopa monnieri in scopolamine-induced Alzheimer's disease mice model.

Shoukat, Shehla / Zia, Muhammad Amir / Uzair, Muhammad / Alsubki, Roua A / Sajid, Kaynat / Shoukat, Sana / Attia, Kotb A / Fiaz, Sajid / Ali, Shaukat / Kimiko, Itoh / Ali, Ghulam Muhammad

Molecular biology reports

2023 Volume 50, Issue 10, Page(s) 7967–7979

Abstract: Background: Millions of people around the globe are affected by Alzheimer's disease (AD). This crippling condition has no treatment despite intensive studies. Some phytocompounds have been shown to protect against Alzheimer's in recent studies.: ... ...

Abstract	Background: Millions of people around the globe are affected by Alzheimer's disease (AD). This crippling condition has no treatment despite intensive studies. Some phytocompounds have been shown to protect against Alzheimer's in recent studies. Methods: Thus, this work aimed to examine Bacopa monnieri phytocompounds' synergistic effects on neurodegeneration, antioxidant activity, and cognition in the scopolamine-induced AD mice model. The toxicity study of two phytocompounds: quercetin and bacopaside X revealed an LD Results: The neuroprotection experiment consists of 6 groups i.e., control (saline), scopolamine (1 mg/kg), donepezil (5 mg/kg), Q (25 mg/kg), BX (20 mg/kg), and Q + BX (25 mg/kg + 20 mg/kg). Visual behavioral assessment using the Morris water maze showed that animals in the diseased model group (scopolamine) moved more slowly toward the platform and exhibited greater thigmotaxis behavior than the treatment and control groups. Likewise, the concentration of biochemical NO, GSH, and MDA improved in treatment groups concerning the diseased group. mRNA levels of different marker genes including ChAT, IL-1α, IL-1 β, TNF α, tau, and β secretase (BACE1) improved in treatment groups with respect to the disease group. Conclusion: Both bacopaside X and quercetin synergistically have shown promising results in neuroprotection. Therefore, it is suggested that Q and BX may work synergistically due to their antioxidant and neuroprotective property.
MeSH term(s)	Humans ; Mice ; Animals ; Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Scopolamine/pharmacology ; Scopolamine/therapeutic use ; Bacopa/chemistry ; Amyloid Precursor Protein Secretases ; Quercetin/pharmacology ; Quercetin/therapeutic use ; Neuroprotection ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Aspartic Acid Endopeptidases ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Maze Learning
Chemical Substances	bacopaside X (P1040545PX) ; Scopolamine (DL48G20X8X) ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; Quercetin (9IKM0I5T1E) ; Neuroprotective Agents ; Aspartic Acid Endopeptidases (EC 3.4.23.-) ; Antioxidants
Language	English
Publishing date	2023-08-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08674-0
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Article ; Online: Screening of Bifidobacterium strains with assignment of functional groups to bind with benzo[a]pyrene under food stress factors.

Shoukat, Sana / Liu, Yue / Rehman, Abdul / Zhang, Bolin

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

2019 Volume 1114-1115, Page(s) 100–109

Abstract: The purpose of this study was to find the component of the Bifidobacterium cell wall more particularly the functional groups from peptidoglycan involved in the mechanism of binding with Benzo[a]pyrene. Additionally, the effect of different stress factors ...

Abstract	The purpose of this study was to find the component of the Bifidobacterium cell wall more particularly the functional groups from peptidoglycan involved in the mechanism of binding with Benzo[a]pyrene. Additionally, the effect of different stress factors (acid, heat, alkaline, oxidative, osmotic, enzymatic, and detergent factors) on the functional group and the overall binding mechanism of Bifidobacterium with B[a]p were also evaluated. Scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) were used to explain the binding mechanism of Bifidobacterium with B[a]p along with HPLC (high-performance liquid chromatography). The peptidoglycan-B[a]p complexes were highly stable after benzene washing. Peptidoglycan from Bifidobacterium infantis BY12 showed highest binding rate with B[a]p out of nine selected strains. FTIR spectra showed that the main functional groups involved in B[a]p binding were CO, OH and/or NH. FTIR spectrums along with SEM electrographs as a function of stress factors reveal that peptidoglycan structural integrity is important in B[a]p binding. Bifidobacterium longum subsp. infantis BY12 may be employed as a biological detoxification agent for the elimination of B[a]p from human diet and animal feed in the future.
MeSH term(s)	Benzo(a)pyrene/analysis ; Benzo(a)pyrene/metabolism ; Bifidobacterium/chemistry ; Bifidobacterium/cytology ; Bifidobacterium/metabolism ; Bifidobacterium/physiology ; Peptidoglycan/chemistry ; Peptidoglycan/metabolism ; Probiotics ; Spectroscopy, Fourier Transform Infrared ; Stress, Physiological
Chemical Substances	Peptidoglycan ; Benzo(a)pyrene (3417WMA06D)
Language	English
Publishing date	2019-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1180823-8
ISSN	1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
ISSN (online)	1873-376X
ISSN	0378-4347 ; 1570-0232 ; 1387-2273
DOI	10.1016/j.jchromb.2019.03.024
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Article: Screening of Bifidobacterium strains to bind with Benzo[a]pyrene under food stress factors and the mechanism of the process

Shoukat, Sana / Aslam, Muhammad Zohaib / Rehman, Abdul / Zhang, Bolin

Journal of food processing and preservation. 2019 July, v. 43, no. 7

2019

Abstract: The ability of Bifidobacterium strains to bind with Benzo[a]pyrene in foods, feeds, digestive tract, and environment can decrease the toxic effects of B[a]p on humans and farm animals. In this study, nine Bifidobacterium strains were tested for their ... ...

Abstract	The ability of Bifidobacterium strains to bind with Benzo[a]pyrene in foods, feeds, digestive tract, and environment can decrease the toxic effects of B[a]p on humans and farm animals. In this study, nine Bifidobacterium strains were tested for their ability to binding with B[a]p. Bifidobacterium lactisBI‐04, HN019, and Bifidobacterium infantisBY12 showed highest binding rate with B[a]p. Moreover, the effect of different food stress factors (acid, detergent, oxidative, alkaline, enzymatic, osmotic, and heat) was also evaluated on the binding rate of B[a]p. Positive correlations were observed for acid, and TCA (Trichloracetic acid) stress, while heat stress showed that the viability of bacteria cells was not significant for binding. The mechanisms behind the effect of each stress factor on binding ability were also discussed. These results revealed the importance of cell technological resistance as different factors could significantly affect the performance of the probiotic strains. PRACTICAL APPLICATIONS: Benzo[a]pyrene is recognized as one of the most potent carcinogens and found in a wide variety of foods, especially smoked, fried, and roasted foods. Therefore, it is crucial to find a safe method in order to remove B[a]p. Bifidobacterium is the most important lactic acid bacteria found in the human intestine and are well known to have many important nutritional and therapeutic benefits. Bifidobacterium, due to their Generally Recognized as Safe status and use as probiotics, is nonpathogenic and without generating toxic residues, making Bifidobacterium strains feasible to use in detoxification method. In this study, the selected Bifidobacterium strains were found highly efficient in the removal of B[a]p.
Keywords	benzo(a)pyrene ; Bifidobacterium ; binding capacity ; carcinogens ; detergents ; digestive tract ; farmed animal species ; feeds ; foods ; GRAS substances ; heat ; heat stress ; intestines ; lactic acid bacteria ; probiotics ; screening ; therapeutics ; toxicity ; viability
Language	English
Dates of publication	2019-07
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.13956
Database	NAL-Catalogue (AGRICOLA)

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Article: Dual Z-scheme core-shell PANI-CeO2-Fe2O3-NiO heterostructured nanocomposite for dyes remediation under sunlight and bacterial disinfection

Mukhtar, Faisal / Munawar, Tauseef / Nadeem, Muhammad Shahid / Naveed ur Rehman, Muhammad / Khan, Shoukat Alim / Koc, Muammer / Batool, Sana / Hasan, Murtaza / Iqbal, Faisal

Environmental research. 2022 Aug. 15,

2022

Abstract: Nowadays, environmental pollution due to discharge of organic pollutants from food, textile, and pharmaceutical industries into clean water and development of contagious diseases due to pathogenic organisms provide impetus to material researcher to ... ...

Abstract	Nowadays, environmental pollution due to discharge of organic pollutants from food, textile, and pharmaceutical industries into clean water and development of contagious diseases due to pathogenic organisms provide impetus to material researcher to fabricate novel design for efficient photocatalyst and antimicrobial agents. In this regard, designing a core-shell heterojunction catalyst based on metal oxides is considered an auspicious approach. In present study, combating the problems of singular oxides, core-shell PANI-CeO₂-Fe₂O₃–NiO nanocomposite (PCFN) and CeO₂–Fe₂O₃–NiO nanocomposite (CFN) was synthesized through sol-gel and oxidative polymerization route with cetyletrimethylammonium bromide (CTAB) as surfactant. The XRD, FTIR, and Raman confirmed the formation pof nanocomposites with core-shell morphology composed of PANI (shell) and oxides (Core) in PCFN with a particle size of 52 nm (TEM). Surprisingly, PCFN has lower band gap, e⁻/h⁺ recombination, and larger charge transfer character than CFN. The decomposition test using MB and MO dyes showed that PCFN degraded 99%, 98%, while CFN degraded only 73% and 54%, respectively, under 50 min sunlight illumination. The reusability was assessed up to 7th cycle for PCFN. The influence of operational parameters (catalyst dose, dye concentration, pH) was tested for PCFN. Further, the antimicrobial action against S. aureus (gram + ve), E. coli (gram -ve) were also tested. The supreme performance of PCFN has been credited to heterostructure dual Z-scheme formation and core-shell morphology supported with PANI, which suppresses the e⁻/h⁺ recombination process by promoting their separation. The present finding indicated that the PCFN is a promising modifier for bacterial disinfection and acts as a superb photocatalyst through core-shell formation with PANI support.
Keywords	Escherichia coli ; antimicrobial properties ; disinfection ; dyes ; fabrics ; lighting ; nanocomposites ; pH ; particle size ; photocatalysts ; pollution ; polymerization ; remediation ; research ; researchers ; solar radiation ; surfactants
Language	English
Dates of publication	2022-0815
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.114140
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Article: Knowledge, Attitude, and Practices Related to Cervical Cancer Among Adult Women in Azad Kashmir: A Hospital-based Cross-sectional Study.

Javaeed, Arslaan / Shoukat, Sana / Hina, Saddaf / Hameed, Zartasha / Ghauri, Sanniya Khan / Ahmed, Malik Mahmood

Cureus

2019 Volume 11, Issue 3, Page(s) e4234

Abstract: Objective To assess the knowledge, attitude, and practices (KAP) related to cervical cancer among the adult women of Azad Kashmir, Pakistan. Methods A cross-sectional study, involving 594 patients visiting the Gynecology and Obstetrics outpatient ... ...

Abstract	Objective To assess the knowledge, attitude, and practices (KAP) related to cervical cancer among the adult women of Azad Kashmir, Pakistan. Methods A cross-sectional study, involving 594 patients visiting the Gynecology and Obstetrics outpatient departments of Khalifa bin Zayed Hospital, Rawalakot, Azad Kashmir, Pakistan, was done. The study questionnaire (interviewer-administered) included 26 items to measure the knowledge, attitude, and practices related to cervical cancer and was formulated and validated with the help of gynecologists and epidemiologists. Descriptive statistics were used to present the knowledge, attitude, and practice level of respondents. The respondents' knowledge, attitude, and practice score was compared across gender and level of education. Data analysis was done using SPSS v 23.0 (IBM Corporation, Armonk, NY, US) at 95% CI. Results A total of 346 (58.2%) women heard about cervical cancer and 210 (35.4%) women heard about the pap smear test. Thirty-five women (5.9%) underwent a pap smear test in their lifetime. More than half (51.7%) thought that undergoing a pap smear test is embarrassing. But 382 respondents (64.3%) will undergo a pap smear test if the test is provided free of cost. Unmarried women had a better KAP score as compared to married women (13.58±5.14 vs 9.12±4.04, p<.001). The KAP score was significantly different in respondents with different levels of education (p<.001). Conclusion This study showed a better KAP score as compared to previous Pakistani studies but, still, there is plenty of room to improve. Women of developed countries have significantly better knowledge, attitude, and practices related to cervical cancer. Local authorities may run a free pap smear screening program in communities to detect cervical cancer early.
Language	English
Publishing date	2019-03-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.4234
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Article ; Online: Evaluation of Hepatoprotective and Gastroprotective Activities of Paspalidium flavidum Leaves Extract in Experimental Animal Models.

Ismail, Sana / Naveed Mushtaq, Muhammad / Shabbir, Ushna / Saima / Razzaq, Asma / Ramzan, Hafiz Muhammad / Shoukat, Alina / Ahsan, Haseeb / Movafagh, Abolfazl / Kahrizi, Danial / Anjum, Irfan

Cellular and molecular biology (Noisy-le-Grand, France)

2022 Volume 68, Issue 10, Page(s) 8–14

Abstract: Paspalidium flavidum (watercrown grass), a medicinal plant, is traditionally used in liver ailments and stomach problems. The hepatoprotective and gastroprotective activities of the aqueous methanol extract of Paspalidium flavidum (AMEPF) were studied in ...

Abstract	Paspalidium flavidum (watercrown grass), a medicinal plant, is traditionally used in liver ailments and stomach problems. The hepatoprotective and gastroprotective activities of the aqueous methanol extract of Paspalidium flavidum (AMEPF) were studied in experimental animal models. Paracetamol and aspirin were used to induce hepatotoxicity and gastric ulcer in rats, respectively. Biochemical hepatic parameters, gastric pH, total acidity, ulcer index, percentage protection, nitric oxide and TNF-α were measured in AMEPF-treated groups. Moreover, GC-MS analysis of AMEPF was performed. Pretreatment with AMEPF improved the blood lipid profile and restored liver function tests in paracetamol-induced hepatotoxicity. While in aspirin-induced gastric ulcer, oral administration of AMEPF significantly reduced (P<0.05) the gastric lesions, total acidity and ulcer scoring index, TNF-α with upregulation of nitric oxide when compared with the Diseased group. AMEPF exhibited anti-lipid peroxidation activity. Histopathological studies were in good agreement with the biochemical findings. GC-MS analysis revealed the presence of anti-oxidant phyto-constituents, including oleic acid and 1,2-benzenedicarboxylic acid, mono(2-ethylhexyl) in AMEPF. This study suggested that aqueous methanol extract from the leaves of P. flavidum has beneficial hepatoprotective and gastroprotective activities related to its anti-oxidant phytochemicals.
MeSH term(s)	Rats ; Animals ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Gastric Mucosa ; Methanol ; Anti-Ulcer Agents/adverse effects ; Ulcer/drug therapy ; Ulcer/pathology ; Acetaminophen/adverse effects ; Nitric Oxide ; Tumor Necrosis Factor-alpha ; Disease Models, Animal ; Aspirin/adverse effects ; Poaceae ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury/pathology ; Plant Leaves ; Phytotherapy
Chemical Substances	Antioxidants ; Plant Extracts ; Methanol (Y4S76JWI15) ; Anti-Ulcer Agents ; Acetaminophen (362O9ITL9D) ; Nitric Oxide (31C4KY9ESH) ; Tumor Necrosis Factor-alpha ; Aspirin (R16CO5Y76E)
Language	English
Publishing date	2022-09-30
Publishing country	France
Document type	Journal Article
ZDB-ID	1161779-2
ISSN	1165-158X ; 0145-5680
ISSN (online)	1165-158X
ISSN	0145-5680
DOI	10.14715/cmb/2022.68.10.2
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