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Article ; Online: Prevalence of oral human papillomavirus infection among university students in Valencia, Spain.

Sastre-Cantón, Macrina / Pérez-Vilar, Silvia / Vilata-Corell, Juan José / Díez-Domingo, Javier

2019 Volume 37, Issue 43, Page(s) 6276–6281

Abstract: Human papillomavirus (HPV) infection contributes to the pathogenesis of oropharyngeal squamous cell carcinomas. We estimated prevalence and six-month persistence of oral HPV infections among university students ages 18-25 years living in Valencia, Spain, ...

Abstract	Human papillomavirus (HPV) infection contributes to the pathogenesis of oropharyngeal squamous cell carcinomas. We estimated prevalence and six-month persistence of oral HPV infections among university students ages 18-25 years living in Valencia, Spain, during the 2012-2013 academic year. Participants provided oral rinse samples; HPV-positive subjects provided a follow-up sample. The study included 543 students; 70 (12.9%) women had received HPV vaccination. Prevalence among vaccinees and non-vaccinees were 10.0% (95% CI: 4.1-19.5%) and 6.8% (95% CI: 4.7-9.4%), respectively. All HPV infections among vaccinees were non-typeable genotypes; 59.4% of non-vaccinees had high-risk genotype infections. Follow-up samples were obtained from 36 participants; one vaccinee (whose specimen was non-typeable) and seven non-vaccinees were found to be HPV positive. Among non-vaccinees, six-month persistence was 10.3% (95% CI: 2.2-27.4%); all persistent infections were with high-risk genotypes. Our results, although subject to study limitations, may support the need to implement new public health strategies.
MeSH term(s)	Adolescent ; Adult ; DNA, Viral/genetics ; Female ; Genotype ; Human papillomavirus 16 ; Humans ; Male ; Mouth/virology ; Mouth Diseases/epidemiology ; Mouth Diseases/virology ; Oropharyngeal Neoplasms/epidemiology ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/virology ; Papillomavirus Vaccines/administration & dosage ; Prevalence ; Spain/epidemiology ; Students/statistics & numerical data ; Universities ; Vaccination/statistics & numerical data ; Young Adult
Chemical Substances	DNA, Viral ; Papillomavirus Vaccines
Language	English
Publishing date	2019-09-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2019.08.058
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article: Prevalence of oral human papillomavirus infection among university students in Valencia, Spain

Sastre-Cantón, Macrina / Pérez-Vilar, Silvia / Vilata-Corell, Juan José / Díez-Domingo, Javier

Vaccine. 2019 Oct. 08, v. 37, no. 43

2019

Abstract	Human papillomavirus (HPV) infection contributes to the pathogenesis of oropharyngeal squamous cell carcinomas. We estimated prevalence and six-month persistence of oral HPV infections among university students ages 18–25 years living in Valencia, Spain, during the 2012–2013 academic year. Participants provided oral rinse samples; HPV-positive subjects provided a follow-up sample. The study included 543 students; 70 (12.9%) women had received HPV vaccination. Prevalence among vaccinees and non-vaccinees were 10.0% (95% CI: 4.1–19.5%) and 6.8% (95% CI: 4.7–9.4%), respectively. All HPV infections among vaccinees were non-typeable genotypes; 59.4% of non-vaccinees had high-risk genotype infections. Follow-up samples were obtained from 36 participants; one vaccinee (whose specimen was non-typeable) and seven non-vaccinees were found to be HPV positive. Among non-vaccinees, six-month persistence was 10.3% (95% CI: 2.2–27.4%); all persistent infections were with high-risk genotypes. Our results, although subject to study limitations, may support the need to implement new public health strategies.
Keywords	Papillomaviridae ; carcinoma ; chronic diseases ; college students ; genotype ; pathogenesis ; public health ; vaccination ; vaccines ; women ; Spain
Language	English
Dates of publication	2019-1008
Size	p. 6276-6281.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2019.08.058
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Mucin granule intraluminal organization.

Perez-Vilar, Juan

American journal of respiratory cell and molecular biology

2007 Volume 36, Issue 2, Page(s) 183–190

Abstract: Mucus secretions have played a central role in the evolution of multicellular organisms, enabling adaptation to widely differing environments. In vertebrates, mucus covers and protects the epithelial cells in the respiratory, gastrointestinal, urogenital, ...

Abstract	Mucus secretions have played a central role in the evolution of multicellular organisms, enabling adaptation to widely differing environments. In vertebrates, mucus covers and protects the epithelial cells in the respiratory, gastrointestinal, urogenital, visual, and auditory systems, amphibian's epidermis, and the gills in fishes. Deregulation of mucus production and/or composition has important consequences for human health. For example, mucus obstruction of small airways is observed in chronic airway diseases, including chronic obstructive pulmonary disease, asthma, and cystic fibrosis. The major protein component in the mucus is a family of large, disulfide-bonded glycoproteins known as gel-forming mucins. These proteins are accumulated in large, regulated secretory granules (the mucin granules) that occupy most of the apical cytoplasm of specialized cells known as mucous/goblet cells. Since mucin oligomers have contour dimensions larger than the mucin granule average diameter, the question arises how these highly hydrophilic macromolecules are organized within these organelles. I review here the intraluminal organization of the mucin granule in view of our knowledge on the structure, biosynthesis, and biophysical properties of gel-forming mucins, and novel imaging studies in living mucous/goblet cells. The emerging concept is that the mucin granule lumen comprises a partially condensed matrix meshwork embedded in a fluid phase where proteins slowly diffuse.
MeSH term(s)	Animals ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Extracellular Matrix/metabolism ; Goblet Cells/cytology ; Humans ; Mucins/biosynthesis ; Mucins/chemistry ; Mucins/metabolism ; Protein Transport ; Secretory Vesicles/metabolism
Chemical Substances	Mucins ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2007-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1025960-0
ISSN	1535-4989 ; 1044-1549
ISSN (online)	1535-4989
ISSN	1044-1549
DOI	10.1165/rcmb.2006-0291TR
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Article ; Online: Afectación pulmonar extensa como presentación de un tumor del saco vitelino ovárico.

Expósito Marrero, Andrea / Hernández Pérez, José María / Vilar Chesa, Mónica / Díaz Llanos, Juan Manuel

Open respiratory archives

2022 Volume 4, Issue 2, Page(s) 100156

Title translation	Extensive Pulmonary Involvement as a Presentation of an Ovarian Yolk Sac Tumor.
Language	Spanish
Publishing date	2022-01-17
Publishing country	Spain
Document type	Case Reports
ISSN	2659-6636
ISSN (online)	2659-6636
DOI	10.1016/j.opresp.2022.100156
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Article: Medullary colorectal carcinoma. Do we really know it?

Puerta Vicente, Ana / Vilar Tabanera, Alberto / García Pérez, Juan Carlos

Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

2020 Volume 112, Issue 7, Page(s) 579–580

Abstract: Medullary carcinoma (MC) is a recently described subtype of mismatch repair deficient (MMRd) colorectal carcinoma (CRC) which, despite being poorly differentiated by traditional morphological criteria, has been reported to have a good prognosis. By the ... ...

Abstract	Medullary carcinoma (MC) is a recently described subtype of mismatch repair deficient (MMRd) colorectal carcinoma (CRC) which, despite being poorly differentiated by traditional morphological criteria, has been reported to have a good prognosis. By the moment, there is a handful reports about its clinical and pathological features, without agreement between results obtained.
MeSH term(s)	Carcinoma, Medullary ; Colonic Neoplasms ; Colorectal Neoplasms/diagnosis ; DNA Mismatch Repair ; Humans ; Thyroid Neoplasms
Language	English
Publishing date	2020-06-24
Publishing country	Spain
Document type	Journal Article
ZDB-ID	1070381-0
ISSN	1130-0108 ; 0212-7512
ISSN	1130-0108 ; 0212-7512
DOI	10.17235/reed.2020.6728/2019
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Article ; Online: Computational mechanisms underpinning greater exploratory behaviour in excess weight relative to healthy weight adolescents.

Halim, Jocelyn / Robinson, Alex H / Navas, Juan F / Martin-Perez, Cristina / Vilar-Lopez, Raquel / Chong, Trevor T-J / Verdejo-Garcia, Antonio

Appetite

2023 Volume 183, Page(s) 106484

Abstract: Obesity in adolescence is associated with cognitive changes that lead to difficulties in shifting unhealthy habits in favour of alternative healthy behaviours, similar to addictive behaviours. An outstanding question is whether this shift in goal- ... ...

Abstract	Obesity in adolescence is associated with cognitive changes that lead to difficulties in shifting unhealthy habits in favour of alternative healthy behaviours, similar to addictive behaviours. An outstanding question is whether this shift in goal-directed behaviour is driven by over-exploitation or over-exploration of rewarding outcomes. Here, we addressed this question by comparing explore/exploit behaviour on the Iowa Gambling Task in 43 adolescents with excess weight against 38 adolescents with healthy weight. We computationally modelled both exploitation behaviour (e.g., reinforcement sensitivity and inverse decay parameters), and explorative behaviour (e.g., maximum directed exploration value). We found that overall, adolescents with excess weight displayed more behavioural exploration than their healthy-weight counterparts - specifically, demonstrating greater overall switching behaviour. Computational models revealed that this behaviour was driven by a higher maximum directed exploration value in the excess-weight group (U = 520.00, p = .005, BF
MeSH term(s)	Humans ; Adolescent ; Exploratory Behavior ; Overweight/psychology ; Obesity ; Weight Gain ; Reinforcement, Psychology
Language	English
Publishing date	2023-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1461347-5
ISSN	1095-8304 ; 0195-6663
ISSN (online)	1095-8304
ISSN	0195-6663
DOI	10.1016/j.appet.2023.106484
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Article ; Online: Inferior epigastric artery pseudoaneurysm: Complication of surgical drain insertion.

Vilar Tabanera, Alberto / Bajawi, Mariam / Vidal Mondejar, Jaime / García Perez, Juan Carlos

Cirugia espanola

2021 Volume 99, Issue 6, Page(s) 467

MeSH term(s)	Aneurysm, False/etiology ; Drainage ; Epigastric Arteries ; Humans ; Surgical Instruments
Language	English
Publishing date	2021-05-19
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5077
ISSN (online)	2173-5077
DOI	10.1016/j.cireng.2021.05.001
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Article: Extrarenal fibrillary glomerulonephritis as an unknown etiology of advanced liver disease.

Alventosa Mateu, Carlos / Vilar Gimeno, Ana / Pérez Álvarez, Irene / Carbonell Zamorano, Javier / Castelló Miralles, Inmaculada / Latorre Sánchez, Mercedes / José Urquijo Ponce, Juan / Martínez Leandro, Encarnación / Terrádez Mas, Liria / Diago, Moisés

Gastroenterologia y hepatologia

2023 Volume 47, Issue 4, Page(s) 381–383

Title translation	Glomerulonefritis fibrilar extrarrenal como nueva etiología de enfermedad hepática avanzada.
MeSH term(s)	Humans ; Glomerulonephritis/etiology ; Liver Diseases/etiology ; Abdomen
Language	Spanish
Publishing date	2023-08-09
Publishing country	Spain
Document type	Case Reports
ZDB-ID	632502-6
ISSN	0210-5705
ISSN	0210-5705
DOI	10.1016/j.gastrohep.2023.08.002
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Article ; Online: Ascites-Derived Organoids to Depict Platinum Resistance in Gynaecological Serous Carcinomas.

Arias-Diaz, Andrea Estrella / Ferreiro-Pantin, Miriam / Barbazan, Jorge / Perez-Beliz, Edurne / Ruiz-Bañobre, Juan / Casas-Arozamena, Carlos / Muinelo-Romay, Laura / Lopez-Lopez, Rafael / Vilar, Ana / Curiel, Teresa / Abal, Miguel

International journal of molecular sciences

2023 Volume 24, Issue 17

Abstract: Gynaecological serous carcinomas (GSCs) constitute a distinctive entity among female tumours characterised by a very poor prognosis. In addition to late-stage diagnosis and a high rate of recurrent disease associated with massive peritoneal ... ...

Abstract	Gynaecological serous carcinomas (GSCs) constitute a distinctive entity among female tumours characterised by a very poor prognosis. In addition to late-stage diagnosis and a high rate of recurrent disease associated with massive peritoneal carcinomatosis, the systematic acquisition of resistance to first-line chemotherapy based on platinum determines the unfavourable outcome of GSC patients. To explore the molecular mechanisms associated with platinum resistance, we generated patient-derived organoids (PDOs) from liquid biopsies of GSC patients. PDOs are emerging as a relevant preclinical model system to assist in clinical decision making, mainly from tumoural tissue and particularly for personalised therapeutic options. To approach platinum resistance in a GSC context, proficient PDOs were generated from the ascitic fluid of ovarian, primary peritoneal and uterine serous carcinoma patients in platinum-sensitive and platinum-resistant clinical settings from the uterine aspirate of a uterine serous carcinoma patient, and we also induced platinum resistance in vitro in a representative platinum-sensitive PDO. Histological and immunofluorescent characterisation of these ascites-derived organoids showed resemblance to the corresponding original tumours, and assessment of platinum sensitivity in these preclinical models replicated the clinical setting of the corresponding GSC patients. Differential gene expression profiling of a panel of 770 genes representing major canonical cancer pathways, comparing platinum-sensitive and platinum-resistant PDOs, revealed cellular response to DNA damage stimulus as the principal biological process associated with the acquisition of resistance to the first-line therapy for GSC. Additionally, candidate genes involved in regulation of cell adhesion, cell cycles, and transcription emerged from this proof-of-concept study. In conclusion, we describe the generation of PDOs from liquid biopsies in the context of gynaecological serous carcinomas to explore the molecular determinants of platinum resistance.
MeSH term(s)	Humans ; Female ; Ascites ; Organoids ; Peritoneum ; Ascitic Fluid ; Cystadenocarcinoma, Serous/drug therapy ; Cystadenocarcinoma, Serous/genetics
Language	English
Publishing date	2023-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241713208
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Article ; Online: Stressing diets? Amygdala networks, cumulative cortisol, and weight loss in adolescents with excess weight.

Martín-Pérez, Cristina / Contreras-Rodríguez, Oren / Verdejo-Román, Juan / Vilar-López, Raquel / González-Pérez, Raquel / Verdejo-García, Antonio

International journal of obesity (2005)

2020 Volume 44, Issue 10, Page(s) 2001–2010

Abstract: Objective: The amygdala is importantly involved in stress and obesity, but its role on weight change and diet-related stress remains unexplored among adolescents with excess weight. We aimed to examine the functional connectivity of the Central and ... ...

Abstract	Objective: The amygdala is importantly involved in stress and obesity, but its role on weight change and diet-related stress remains unexplored among adolescents with excess weight. We aimed to examine the functional connectivity of the Central and Basolateral amygdala nuclei (CeA and BLA) among adolescents, and to explore the longitudinal association between brain connectivity measures and diet-related cortisol and weight loss in adolescents with excess weight. Methods: We compared resting-state functional connectivity between adolescents with excess (EW, N = 34; Age = 16.44 ± 1.66) and normal weight (NW, N = 36; Age = 16.50 ± 1.40) using a seed-based (CeA and BLA) whole-brain approach. Then, in a subset of 30 adolescents with EW, followed-up after 3-months of dietary/lifestyle intervention, we explored for interactions between connectivity in the CeA/BLA networks and weight loss. Regression analyses were performed to explore the relationship between accumulated cortisol and weight loss, and to test the potential effect of the amygdala networks on such association. Results: In EW compared with NW, the CeA regions showed higher functional connectivity with anterior portions, and lower connectivity with posterior portions of the cingulate cortex, while the left BLA regions showed lower connectivity with the dorsal caudate and angular gyrus. In addition, higher connectivity between the left CeA-midbrain network was negatively associated with weight loss. Hair cortisol significantly predicted weight change (p = 0.012). However, this association was no longer significant (p = 0.164) when considering the CeA-midbrain network in the model as an additional predictor. Conclusions: Adolescents with EW showed functional connectivity alterations within the BLA/CeA networks. The CeA-midbrain network might constitute an important brain pathway regulating weight change.
MeSH term(s)	Adolescent ; Amygdala/diagnostic imaging ; Amygdala/physiopathology ; Diet ; Female ; Hair/chemistry ; Humans ; Hydrocortisone/analysis ; Male ; Overweight/diet therapy ; Stress, Physiological ; Weight Loss
Chemical Substances	Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2020-06-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-020-0633-4
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