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Article: Editorial: Elevated Carbon Dioxide Sensing and Physiologic Effects.

Cummins, Eoin P / Bharat, Ankit / Sznajder, Jacob I / Vadász, István

2022 Volume 13, Page(s) 894222

Language	English
Publishing date	2022-04-27
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.894222
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Article: Kinematics and muscle activity of the lower limb during single-leg stance on the two sides of the Togu Jumper.

Mayer, Petra / Sebesi, Balázs / Vadász, Kitty / Laczkó, József / Zentai, Norbert / Balázs, Bence / Váczi, Márk

Frontiers in physiology

2023 Volume 14, Page(s) 1049035

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1049035
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Article ; Online: Predictive features associated with chronic spontaneous urticaria recurrence.

Toubi, Elias / Vadasz, Zahava

The Journal of dermatology

2021 Volume 48, Issue 11, Page(s) 1786–1788

Abstract: ... 180 (25%) in the general CSU population (p = 0.049). In addition, increased levels of total ... of the general CSU group (p = 0.04). Anti-thyroid peroxidase antibodies were also found in 11/25 (44 ... of the recurrence group as compared with 32/160 (20%) of the general group (p = 0.003). The prevalence of CSU ...

Abstract	When chronic spontaneous urticaria (CSU) is resolved, patients are often apprehensive about the likelihood of recurrence, and want to know if we can predict this using clinical or laboratory markers. This question is crucial because CSU is frequently accompanied by a high incidence of stressful comorbidities, and the fear of experiencing this again can be devastating to the patient. This study was designed with the aim of focusing on the prevalence and characteristics of the recurrence of CSU. We used our CSU patient registry that includes data on 180 patients who are followed periodically. In 23 (13%) patients, CSU was resolved during the first year. In 47 (26%) patients, CSU lasted more than 5 years. The recurrence of CSU was recorded in 21% of our patients after having experienced a full remission anywhere between 1 to 10 years (mean ± 2.9 years). While investigating predictive clinical or laboratory markers, we noticed that bronchial asthma existed in 10/25 (40%) of patients in whom CSU recurred as compared with 45/180 (25%) in the general CSU population (p = 0.049). In addition, increased levels of total immunoglobulin (Ig)E were found in 10/25 (40%) of the recurrence group as compared with 34/150 (23%) of the general CSU group (p = 0.04). Anti-thyroid peroxidase antibodies were also found in 11/25 (44%) of the recurrence group as compared with 32/160 (20%) of the general group (p = 0.003). The prevalence of CSU recurrence after a full remission is significantly higher among patients with existing bronchial asthma, increased levels of total IgE, and autoimmunity. Further studies are required in order to substantiate this important issue.
MeSH term(s)	Autoimmunity ; Chronic Disease ; Chronic Urticaria ; Comorbidity ; Humans ; Urticaria/diagnosis ; Urticaria/epidemiology
Language	English
Publishing date	2021-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	800103-0
ISSN	1346-8138 ; 0385-2407
ISSN (online)	1346-8138
ISSN	0385-2407
DOI	10.1111/1346-8138.16119
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Article ; Online: An Observational Study on the Pharmacokinetics of Oseltamivir in Lactating Influenza Patients.

Fodor, Eszter / Nagy, Regina N / Nógrádi, András / Toovey, Stephen / Kamal, Mohamed A / Vadász, Péter / Bencsik, Péter / Görbe, Anikó / Ferdinandy, Péter

Clinical pharmacology and therapeutics

2023 Volume 115, Issue 2, Page(s) 318–323

Abstract: Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating ... ...

Abstract	Influenza infection may lead to serious complications in the postpartum period, therefore, oseltamivir treatment in these patients and their breastfed infants is of great importance. However, the pharmacokinetics of oseltamivir in postpartum lactating women with acute influenza infection, and the consequent infant exposure to oseltamivir are still unknown, and these data would help in assessing risk and the need for dose adjustment in breastfed infants. Six lactating women with influenza-like symptoms, at a standard dose of 75 mg oral oseltamivir twice daily for 5 days, were recruited in this phase IV clinical study during the 2011/2012 H1N1 pandemic seasons. Breast milk/colostrum and venous blood samples were taken at multiple timepoints, maternal urine samples were obtained from total output within the 12-hour observational period following the seventh dose of oseltamivir. Oseltamivir phosphate (OP) reached a maximum 69.5 ± 29.4 ng/mL concentration in breast milk, higher than that found in the plasma, and showed elimination within ~ 8 hours. Oseltamivir carboxylate (active metabolite of OP) showed a lower, nearly steady-state concentration in breast milk during the observational period (maximum plasma concentration (C
MeSH term(s)	Infant ; Humans ; Female ; Oseltamivir ; Influenza, Human/drug therapy ; Antiviral Agents/pharmacokinetics ; Lactation ; Influenza A Virus, H1N1 Subtype
Chemical Substances	Oseltamivir (20O93L6F9H) ; Antiviral Agents
Language	English
Publishing date	2023-12-03
Publishing country	United States
Document type	Clinical Trial, Phase IV ; Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3107
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Article ; Online: A nyelés képességének helyreállítása lúgivás utáni nyelőcsőszűkületben.

Kotsis, Lajos / Kostic, Szilárd / Heiler, Zoltán / Vadász, Pál

Orvosi hetilap

2019 Volume 160, Issue 16, Page(s) 613–618

Abstract: The authors discuss their experience in the surgical treatment of caustic stenosis in the upper gastrointestinal tract. They present operative solutions using isoperistaltic transverse colonic segment in oesophageal stenosis caused by gastric outlet ... ...

Title translation	Physiologic type reconstruction in upper gastrointestinal caustic strictures.
Abstract	The authors discuss their experience in the surgical treatment of caustic stenosis in the upper gastrointestinal tract. They present operative solutions using isoperistaltic transverse colonic segment in oesophageal stenosis caused by gastric outlet obstruction, or when these two presented together. Further indications for the above were bronchial or tracheo-oesophageal fistulas and oesophageal perforation. Late adaptation of the colonic grafts were measured by radiokinematography and histochemistry. The overall morbidity was 4.9%. Postoperative salivary fistulas closed spontaneously. Late postoperative complications (13.5%) were treated successfully. The multihaustral motility of the graft prevented the reflux, while the altered mucopolysaccharides of the colonic mucosa prevented the ulcer formation. Orv Hetil. 2019; 160(16): 613-618.
MeSH term(s)	Caustics ; Colon ; Constriction, Pathologic ; Esophageal Stenosis/complications ; Esophageal Stenosis/etiology ; Esophageal Stenosis/surgery ; Gastric Outlet Obstruction/etiology ; Gastric Outlet Obstruction/surgery ; Humans ; Postoperative Complications ; Treatment Outcome ; Upper Gastrointestinal Tract/surgery
Chemical Substances	Caustics
Language	Hungarian
Publishing date	2019-05-17
Publishing country	Hungary
Document type	Journal Article ; Review
ZDB-ID	123879-6
ISSN	1788-6120 ; 0030-6002
ISSN (online)	1788-6120
ISSN	0030-6002
DOI	10.1556/650.2019.31358
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Article ; Online: Nagy időveszteséggel felismert nyelőcső-perforációk és -rupturák.

Kotsis, Lajos / Kostic, Szilárd / Heller, Zoltán / Vadász, Pál

Magyar sebeszet

2019 Volume 72, Issue 2, Page(s) 47–51

Abstract: The aim of this study is to present the treatment modalities of unusual late esophageal perforations and ruptures. The reason for diagnostic delay was misinterpretation of pleural collection, overlooked sclerotherapy, foreign body extraction, and delayed ...

Title translation	Unusually late presentation esophageal perforations and ruptures.
Abstract	The aim of this study is to present the treatment modalities of unusual late esophageal perforations and ruptures. The reason for diagnostic delay was misinterpretation of pleural collection, overlooked sclerotherapy, foreign body extraction, and delayed recognition of the true origin of empyema after pneumonectomy. In all instances of transthoracic reinforced or temporary excluded primary repair were successful. In a 6- week-old iatrogenic perforation with localised empyema, Urschel-Ergin type exclusion with tube thoracostomy and lavage was used. In a 13-day-old rupture, and in a late postpulmonectomy perforation, Johnson type exclusion, decortication, and/or fenestration and second-stage colonic or Roux-en-Y by-pass were carried out. One patient was lost in deep sepsis for a delayed recognised transfixion esophageal injury. It is never too late to attempt to repair and salvage a perforated or ruptured healthy esophagus.
MeSH term(s)	Delayed Diagnosis ; Empyema/etiology ; Esophageal Perforation/diagnosis ; Esophageal Perforation/etiology ; Esophageal Perforation/surgery ; Esophagectomy ; Esophagus/injuries ; Esophagus/surgery ; Humans ; Iatrogenic Disease ; Postoperative Complications ; Rupture/etiology ; Rupture/surgery ; Suture Techniques ; Therapeutic Irrigation ; Thoracostomy ; Thoracotomy ; Time Factors ; Treatment Outcome
Language	Hungarian
Publishing date	2019-06-20
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	414068-0
ISSN	1789-4301 ; 0025-0295
ISSN (online)	1789-4301
ISSN	0025-0295
DOI	10.1556/1046.72.2019.2.2
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Article ; Online: Genetic association of nucleus accumbens 5-hydroxyindoleacetic acid level and alcohol preference drinking in a quasi-congenic male mice

Csaba Vadasz / Beatrix M. Gyetvai

Drug and Alcohol Dependence Reports, Vol 2, Iss , Pp 100012- (2022)

Potential modulation by Grm7 gene polymorphism

2022

Abstract: ... 569 p=.035 (General Linear Model Repeated Measures ANOVA and Tests of Between-Subjects Effects ...

Abstract	Objective: To test the hypothesis that predisposition to high alcohol drinking behavior is genetically associated with hypoactive serotonergic function in the Nucleus Accumbens (NAc). Method: Alcohol avoiding C5A3 and alcohol preferring I5B25A mice of the Quasi-congenic Recombinant QTL Introgression (RQI) mouse strains were subjected to in vivo microdialysis in the NAc. Neurotransmitter and metabolite contents were analyzed by HPLC and samples were collected in three phases: Baseline, Control, and Alcohol. Samples were collected with 20 min intervals. Results: Between-strain differences restricted to small chromosome segments significantly affected both alcohol preference drinking and NAc 5-HIAA levels [F1,13 = 5.569 p=.035 (General Linear Model Repeated Measures ANOVA and Tests of Between-Subjects Effects)]. Whole genome biallelic DNA marker genotyping allowed the identification of 16 differential microsatellite markers associated with low 5-HIAA levels and excessive alcohol drinking. Chromosome 6 markers were linked to Grm7 (51.19 centimorgan), a reported candidate gene for modulation of addiction. The results are consistent with earlier reports of association of low 5-HIAA and high alcohol consumption in rats and primates, including Homo sapiens. Conclusion: Low NAc 5-HIAA and high alcohol consumption are genetically associated in a quasi-congenic mouse model carrying variants of the Grm7 gene. We propose that constitutional polymorphism in Grm7 may modulate CRF neuron activity via altered mGluR7 expression thus targeting CRF pathways to substance use circuits. This raises the possibility of modulation of DRN 5-HT neurons leading to hypo- or hyper-serotonergic condition in NAc and higher or lower alcohol preference drinking.
Keywords	Addiction ; Alcohol ; Genetics ; Serotonin ; 5-HIAA ; Grm7 ; Medicine ; R
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Application of Sunflower Husk Pellet as a Reducer in Metallurgical Processes.

Matula, Tomasz / Labaj, Jerzy / Vadasz, Pavol / Plešingerová, Beatrice / Smalcerz, Albert / Blacha, Leszek

Materials (Basel, Switzerland)

2023 Volume 16, Issue 20

Abstract: In relation to the climate policy being introduced, the search for a replacement for solid fossil fuels with renewable raw materials is ongoing. In this study, a potential biomass (sunflower husk pellet) application in the process of copper slag ... ...

Abstract	In relation to the climate policy being introduced, the search for a replacement for solid fossil fuels with renewable raw materials is ongoing. In this study, a potential biomass (sunflower husk pellet) application in the process of copper slag reduction was assessed. For the purpose of raw material characterisation, thermogravimetric tests were carried out and characteristic temperature points were determined with the use of a high-temperature microscope. The slag reduction tests led to the recovery of 97% of copper and a decrease in this metal content in the slag to less than 0.5% Cu, which enables safe storage or use in other industrial branches.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16206790
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Article ; Online: Learning from crowds for automated histopathological image segmentation.

López-Pérez, Miguel / Morales-Álvarez, Pablo / Cooper, Lee A D / Felicelli, Christopher / Goldstein, Jeffery / Vadasz, Brian / Molina, Rafael / Katsaggelos, Aggelos K

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

2024 Volume 112, Page(s) 102327

Abstract: Automated semantic segmentation of histopathological images is an essential task in Computational Pathology (CPATH). The main limitation of Deep Learning (DL) to address this task is the scarcity of expert annotations. Crowdsourcing (CR) has emerged as a ...

Abstract	Automated semantic segmentation of histopathological images is an essential task in Computational Pathology (CPATH). The main limitation of Deep Learning (DL) to address this task is the scarcity of expert annotations. Crowdsourcing (CR) has emerged as a promising solution to reduce the individual (expert) annotation cost by distributing the labeling effort among a group of (non-expert) annotators. Extracting knowledge in this scenario is challenging, as it involves noisy annotations. Jointly learning the underlying (expert) segmentation and the annotators' expertise is currently a commonly used approach. Unfortunately, this approach is frequently carried out by learning a different neural network for each annotator, which scales poorly when the number of annotators grows. For this reason, this strategy cannot be easily applied to real-world CPATH segmentation. This paper proposes a new family of methods for CR segmentation of histopathological images. Our approach consists of two coupled networks: a segmentation network (for learning the expert segmentation) and an annotator network (for learning the annotators' expertise). We propose to estimate the annotators' behavior with only one network that receives the annotator ID as input, achieving scalability on the number of annotators. Our family is composed of three different models for the annotator network. Within this family, we propose a novel modeling of the annotator network in the CR segmentation literature, which considers the global features of the image. We validate our methods on a real-world dataset of Triple Negative Breast Cancer images labeled by several medical students. Our new CR modeling achieves a Dice coefficient of 0.7827, outperforming the well-known STAPLE (0.7039) and being competitive with the supervised method with expert labels (0.7723). The code is available at https://github.com/wizmik12/CRowd_Seg.
MeSH term(s)	Humans ; Neural Networks, Computer ; Image Processing, Computer-Assisted
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	639451-6
ISSN	1879-0771 ; 0895-6111
ISSN (online)	1879-0771
ISSN	0895-6111
DOI	10.1016/j.compmedimag.2024.102327
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Book ; Online: Fluid Flow and Heat Transfer in Rotating Porous Media

Vadasz, Peter

(SpringerBriefs in Applied Sciences and Technology)

2016

Abstract: ... media in one single reference. Dr. Vadasz develops the fundamental theory of rotating flow and ...

Author's details	by Peter Vadasz
Series title	SpringerBriefs in Applied Sciences and Technology
Abstract	This Book concentrates the available knowledge on rotating fluid flow and heat transfer in porous media in one single reference. Dr. Vadasz develops the fundamental theory of rotating flow and heat transfer in porous media and introduces systematic classification and identification of the relevant problems. An initial distinction between rotating flows in isothermal heterogeneous porous systems and natural convection in homogeneous non--isothermal porous systems provides the two major classes of problems to be considered. A few examples of solutions to selected problems are presented, highlighting the significant impact of rotation on the flow in porous media
Keywords	Engineering ; Hydraulic engineering ; Thermodynamics
Language	English
Size	Online-Ressource (XII, 78 p. 25 illus., 1 illus. in color), online resource
Edition	1st ed. 2016
Publisher	Springer International Publishing
Publishing place	Cham ;s.l
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9783319200552 ; 9783319200569 ; 3319200550 ; 3319200569
DOI	10.1007/978-3-319-20056-9
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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