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  1. Article ; Online: Mucosal-Associated Invariant T Cells as a Possible Target to Suppress Secondary Infections at COVID-19.

    Akasov, Roman A / Khaydukov, Evgeny V

    Frontiers in immunology

    2020  Volume 11, Page(s) 1896

    Keywords covid19
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01896
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Strategies for Anisotropic Fibrillar Hydrogels: Design, Cell Alignment, and Applications in Tissue Engineering.

    Abalymov, Anatolii / Pinchasik, Bat-El / Akasov, Roman A / Lomova, Maria / Parakhonskiy, Bogdan V

    Biomacromolecules

    2023  Volume 24, Issue 11, Page(s) 4532–4552

    Abstract: Efficient cellular alignment in biomaterials presents a considerable challenge, demanding the refinement of appropriate material morphologies, while ensuring effective cell-surface interactions. To address this, biomaterials are continuously researched ... ...

    Abstract Efficient cellular alignment in biomaterials presents a considerable challenge, demanding the refinement of appropriate material morphologies, while ensuring effective cell-surface interactions. To address this, biomaterials are continuously researched with diverse coatings, hydrogels, and polymeric surfaces. In this context, we investigate the influence of physicochemical parameters on the architecture of fibrillar hydrogels that significantly orient the topography of flexible hydrogel substrates, thereby fostering cellular adhesion and spatial organization. Our Review comprehensively assesses various techniques for aligning polymer fibrils within hydrogels, specifically interventions applied during and after the cross-linking process. These methodologies include mechanical strains, precise temperature modulation, controlled fluidic dynamics, and chemical modulators, as well as the use of magnetic and electric fields. We highlight the intrinsic appeal of these methodologies in fabricating cell-aligning interfaces and discuss their potential implications within the fields of biomaterials and tissue engineering, particularly concerning the pursuit of optimal cellular alignment.
    MeSH term(s) Tissue Engineering/methods ; Hydrogels/pharmacology ; Biocompatible Materials/pharmacology ; Polymers/pharmacology ; Cell Adhesion
    Chemical Substances Hydrogels ; Biocompatible Materials ; Polymers
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c00503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mucosal-Associated Invariant T Cells as a Possible Target to Suppress Secondary Infections at COVID-19

    Akasov, Roman A. / Khaydukov, Evgeny V.

    Frontiers in Immunology

    2020  Volume 11

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01896
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Evaluation of molecular mechanisms of riboflavin anti-COVID-19 action reveals anti-inflammatory efficacy rather than antiviral activity.

    Akasov, Roman A / Chepikova, Olga E / Pallaeva, Tatiana N / Gorokhovets, Neonila V / Siniavin, Andrei E / Gushchin, Vladimir A / Savvateeva, Lyudmila V / Vinokurov, Ivan A / Khochenkov, Dmitry A / Zamyatnin, Andrey A / Khaydukov, Evgeny V

    Biochimica et biophysica acta. General subjects

    2024  Volume 1868, Issue 5, Page(s) 130582

    Abstract: Background: Riboflavin (vitamin B2) is one of the most important water-soluble vitamins and a coenzyme involved in many biochemical processes. It has previously been shown that adjuvant therapy with flavin mononucleotide (a water-soluble form of ... ...

    Abstract Background: Riboflavin (vitamin B2) is one of the most important water-soluble vitamins and a coenzyme involved in many biochemical processes. It has previously been shown that adjuvant therapy with flavin mononucleotide (a water-soluble form of riboflavin) correlates with normalization of clinically relevant immune markers in patients with COVID-19, but the mechanism of this effect remains unclear. Here, the antiviral and anti-inflammatory effects of riboflavin were investigated to elucidate the molecular mechanisms underlying the riboflavin-induced effects.
    Methods: Riboflavin was evaluated for recombinant SARS-CoV-2 PLpro inhibition in an enzyme kinetic assay and for direct inhibition of SARS-CoV-2 replication in Vero E6 cells, as well as for anti-inflammatory activity in polysaccharide-induced inflammation models, including endothelial cells in vitro and acute lung inflammation in vivo.
    Results: For the first time, the ability of riboflavin at high concentrations (above 50 μM) to inhibit SARS-CoV-2 PLpro protease in vitro was demonstrated; however, no inhibition of viral replication in Vero E6 cells in vitro was found. At the same time, riboflavin exerted a pronounced anti-inflammatory effect in the polysaccharide-induced inflammation model, both in vitro, preventing polysaccharide-induced cell death, and in vivo, reducing inflammatory markers (IL-1β, IL-6, and TNF-α) and normalizing lung histology.
    Conclusions: It is concluded that riboflavin reveals anti-inflammatory rather than antiviral activity for SARS-CoV-2 infection.
    General significance: Riboflavin could be suggested as a promising compound for the therapy of inflammatory diseases of broad origin.
    MeSH term(s) Humans ; Endothelial Cells ; COVID-19 ; Anti-Inflammatory Agents/pharmacology ; Inflammation/drug therapy ; Antiviral Agents/pharmacology ; Riboflavin/pharmacology ; Polysaccharides ; Water
    Chemical Substances Anti-Inflammatory Agents ; Antiviral Agents ; Riboflavin (TLM2976OFR) ; Polysaccharides ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-08
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1872-8006 ; 1879-2596 ; 1879-260X ; 1879-2642 ; 1879-2618 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbagen.2024.130582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.247: Show issues Location:
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  6. Article ; Online: Mucosal-Associated Invariant T Cells as a Possible Target to Suppress Secondary Infections at COVID-19

    Roman A. Akasov / Evgeny V. Khaydukov

    Frontiers in Immunology, Vol

    2020  Volume 11

    Keywords COVID-19 ; SARS-CoV-2 ; mucosal associated invariant T cells ; riboflavin ; flavin mononucleotide ; FMN riboswitch ; Immunologic diseases. Allergy ; RC581-607 ; covid19
    Language English
    Publishing date 2020-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Nanoparticle enhanced blue light therapy.

    Akasov, Roman / Khaydukov, Evgeny V / Yamada, Miko / Zvyagin, Andrei V / Leelahavanichkul, Asada / Leanse, Leon G / Dai, Tianhong / Prow, Tarl

    Advanced drug delivery reviews

    2022  Volume 184, Page(s) 114198

    MeSH term(s) Humans ; Light ; Nanoparticles ; Photochemotherapy ; Photosensitizing Agents ; Phototherapy
    Chemical Substances Photosensitizing Agents
    Language English
    Publishing date 2022-03-14
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639113-8
    ISSN 1872-8294 ; 0169-409X
    ISSN (online) 1872-8294
    ISSN 0169-409X
    DOI 10.1016/j.addr.2022.114198
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2241: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: New Cysteine-Containing PEG-Glycerolipid Increases the Bloodstream Circulation Time of Upconverting Nanoparticles.

    Nikolaeva, Maria E / Nechaev, Andrey V / Shmendel, Elena V / Akasov, Roman A / Maslov, Mikhail A / Mironov, Andrey F

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 9

    Abstract: Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on ... ...

    Abstract Upconverting nanoparticles have unique spectral and photophysical properties that make them suitable for development of theranostics for imaging and treating large and deep-seated tumors. Nanoparticles based on NaYF
    MeSH term(s) Cysteine ; Fluorides/chemistry ; Nanoparticles/chemistry ; Oleic Acid ; Polyethylene Glycols/chemistry ; Yttrium/chemistry
    Chemical Substances Oleic Acid (2UMI9U37CP) ; Polyethylene Glycols (3WJQ0SDW1A) ; Yttrium (58784XQC3Y) ; Cysteine (K848JZ4886) ; Fluorides (Q80VPU408O)
    Language English
    Publishing date 2022-04-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27092763
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  9. Article ; Online: Natural and Synthetic Polymer Scaffolds Comprising Upconversion Nanoparticles as a Bioimaging Platform for Tissue Engineering.

    Trifanova, Ekaterina M / Khvorostina, Maria A / Mariyanats, Aleksandra O / Sochilina, Anastasia V / Nikolaeva, Maria E / Khaydukov, Evgeny V / Akasov, Roman A / Popov, Vladimir K

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 19

    Abstract: Modern biocompatible materials of both natural and synthetic origin, in combination with advanced techniques for their processing and functionalization, provide the basis for tissue engineering constructs (TECs) for the effective replacement of specific ... ...

    Abstract Modern biocompatible materials of both natural and synthetic origin, in combination with advanced techniques for their processing and functionalization, provide the basis for tissue engineering constructs (TECs) for the effective replacement of specific body defects and guided tissue regeneration. Here we describe TECs fabricated using electrospinning and 3D printing techniques on a base of synthetic (polylactic-co-glycolic acids, PLGA) and natural (collagen, COL, and hyaluronic acid, HA) polymers impregnated with core/shell β-NaYF
    MeSH term(s) Biocompatible Materials/pharmacology ; Collagen/chemistry ; Hyaluronic Acid ; Nanoparticles/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer ; Polymers ; Tissue Engineering ; Tissue Scaffolds/chemistry
    Chemical Substances Biocompatible Materials ; Polymers ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Hyaluronic Acid (9004-61-9) ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27196547
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Biomimetic approaches for targeting tumor-promoting inflammation.

    Parodi, Alessandro / Kostyushev, Dmitry / Brezgin, Sergey / Kostyusheva, Anastasiya / Borodina, Tatiana / Akasov, Roman / Frolova, Anastasia / Chulanov, Vladimir / Zamyatnin, Andrey A

    Seminars in cancer biology

    2022  Volume 86, Issue Pt 2, Page(s) 555–567

    Abstract: With the ultimate goal of increasing tumor accumulation of therapeutics, various nanocarriers have been designed to overcome biological barriers encountered at each stage, from drug administration to the cancerous lesion. Stabilizing circulation and ... ...

    Abstract With the ultimate goal of increasing tumor accumulation of therapeutics, various nanocarriers have been designed to overcome biological barriers encountered at each stage, from drug administration to the cancerous lesion. Stabilizing circulation and functionalization of the targeting surface impart high tumor accumulation properties to nanocarriers. However, various cells can recognize and infiltrate the tumor microenvironment more efficiently than synthetic carriers via overexpression of adhesive ligands, particularly in inflamed stroma of tumors. Thus, a new field of nanomedicine, called biomimicry, has evolved to generate nanoparticles with the same biological characteristics as cells that naturally infiltrate tumors. Revolutionary synthetic processes have been developed to transfer the cell membrane of leukocytes and mesenchymal cells to synthetic carriers. In addition, cells can generate their own "nanocarriers," known as exosomes, to transport molecular messages to distant sites, while biomimicry of viral and bacterial agents allows high targeting efficiency towards inflammatory immune cells. Alterations in the protein expression in cancer cells caused by inflammation can also be exploited for drug delivery. Finally, new developments in biomimetic drug delivery focus on turning the infiltrating cells into microcarriers that can actively perfuse the tumor and eventually release their therapeutic payload. In this review, we summarize recent developments in biomimetic drug delivery with a particular focus on targeting the tumor inflammatory microenvironment.
    MeSH term(s) Humans ; Drug Carriers/therapeutic use ; Biomimetics ; Nanomedicine ; Neoplasms/drug therapy ; Neoplasms/pathology ; Inflammation/drug therapy ; Tumor Microenvironment
    Chemical Substances Drug Carriers
    Language English
    Publishing date 2022-04-25
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1033980-2
    ISSN 1096-3650 ; 1044-579X
    ISSN (online) 1096-3650
    ISSN 1044-579X
    DOI 10.1016/j.semcancer.2022.04.007
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    Zs.A 2922: Show issues Location:
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