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  1. Article ; Online: Editorial: CD8+ T-cells in HIV/SIV infection, prophylaxis, and therapy.

    Shacklett, Barbara L / Buggert, Marcus / Dias, Joana

    Frontiers in immunology

    2023  Volume 14, Page(s) 1159452

    MeSH term(s) Animals ; HIV Infections/drug therapy ; Simian Acquired Immunodeficiency Syndrome/drug therapy ; CD8-Positive T-Lymphocytes
    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1159452
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Mucosal Immunity in HIV/SIV Infection: T Cells, B Cells and Beyond.

    Shacklett, Barbara L

    Current immunology reviews

    2019  Volume 15, Issue 1, Page(s) 63–75

    Abstract: As our understanding of mucosal immunity increases, it is becoming clear that the host response to HIV-1 is more complex and nuanced than originally believed. The mucosal landscape is populated with a variety of specialized cell types whose functions ... ...

    Abstract As our understanding of mucosal immunity increases, it is becoming clear that the host response to HIV-1 is more complex and nuanced than originally believed. The mucosal landscape is populated with a variety of specialized cell types whose functions include combating infectious agents while preserving commensal microbiota, maintaining barrier integrity, and ensuring immune homeostasis. Advances in multiparameter flow cytometry, gene expression analysis and bioinformatics have allowed more detailed characterization of these cell types and their roles in host defense than was previously possible. This review provides an overview of existing literature on immunity to HIV-1 and SIVmac in mucosal tissues of the female reproductive tract and the gastrointestinal tract, focusing on major effector cell populations and briefly summarizing new information on tissue resident memory T cells, T
    Language English
    Publishing date 2019-04-24
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2274820-9
    ISSN 1875-631X ; 1573-3955
    ISSN (online) 1875-631X
    ISSN 1573-3955
    DOI 10.2174/1573395514666180528081204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Emerging Role of MAIT Cell Responses in Viral Infections.

    Sandberg, Johan K / Leeansyah, Edwin / Eller, Michael A / Shacklett, Barbara L / Paquin-Proulx, Dominic

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 211, Issue 4, Page(s) 511–517

    Abstract: Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I-related protein 1)-restricted recognition of microbial riboflavin metabolites giving them the ... ...

    Abstract Mucosal-associated invariant T (MAIT) cells are unconventional T cells with innate-like antimicrobial responsiveness. MAIT cells are known for MR1 (MHC class I-related protein 1)-restricted recognition of microbial riboflavin metabolites giving them the capacity to respond to a broad range of microbes. However, recent progress has shown that MAIT cells can also respond to several viral infections in humans and in mouse models, ranging from HIV-1 and hepatitis viruses to influenza virus and SARS-CoV-2, in a primarily cognate Ag-independent manner. Depending on the disease context MAIT cells can provide direct or indirect antiviral protection for the host and may help recruit other immune cells, but they may also in some circumstances amplify inflammation and aggravate immunopathology. Furthermore, chronic viral infections are associated with varying degrees of functional and numerical MAIT cell impairment, suggesting secondary consequences for host defense. In this review, we summarize recent progress and highlight outstanding questions regarding the emerging role of MAIT cells in antiviral immunity.
    MeSH term(s) Mice ; Animals ; Humans ; Mucosal-Associated Invariant T Cells ; COVID-19/metabolism ; SARS-CoV-2/metabolism ; Histocompatibility Antigens Class I/metabolism ; Antiviral Agents/metabolism ; Minor Histocompatibility Antigens/metabolism
    Chemical Substances Histocompatibility Antigens Class I ; Antiviral Agents ; Minor Histocompatibility Antigens
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300147
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  4. Article ; Online: Defining T Cell Tissue Residency in Humans: Implications for HIV Pathogenesis and Vaccine Design.

    Shacklett, Barbara L / Ferre, April L / Kiniry, Brenna E

    Current HIV/AIDS reports

    2020  Volume 17, Issue 2, Page(s) 109–117

    Abstract: Purpose of review: This review summarizes recent literature defining tissue-resident memory T cells (T: Recent findings: Investigations using animal models and human tissues have identified a ... ...

    Abstract Purpose of review: This review summarizes recent literature defining tissue-resident memory T cells (T
    Recent findings: Investigations using animal models and human tissues have identified a T
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; HIV Infections/immunology ; HIV Infections/pathology ; Humans ; Immunologic Memory/immunology ; Mice ; Mucous Membrane/immunology ; Neoplasms/immunology ; Tumor Microenvironment/immunology ; Viral Vaccines/immunology
    Chemical Substances Viral Vaccines
    Language English
    Publishing date 2020-02-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-020-00481-7
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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: Tissue issues: mucosal T-cell responses in HIV-1 infection.

    Shacklett, Barbara L / Ferre, April L / Kiniry, Brenna E

    Current opinion in HIV and AIDS

    2019  Volume 14, Issue 2, Page(s) 100–107

    Abstract: Purpose of review: This review summarizes our current understanding of HIV-1-specific T-cell responses in mucosal tissues, emphasizing recent work and specifically highlighting papers published over the past 18 months.: Recent findings: Recent work ... ...

    Abstract Purpose of review: This review summarizes our current understanding of HIV-1-specific T-cell responses in mucosal tissues, emphasizing recent work and specifically highlighting papers published over the past 18 months.
    Recent findings: Recent work has improved the standardization of tissue sampling approaches and provided new insights on the abundance, phenotype and distribution of HIV-1-specific T-cell populations in mucosal tissues. In addition, it has recently been established that some lymphocytes exist in tissues as "permanent resident" memory cells that differ from their counterparts in blood.
    Summary: HIV-1-specific T-cell responses have been extensively characterized; however, the vast majority of reports have focused on T-cells isolated from peripheral blood. Mucosal tissues of the genitourinary and gastrointestinal tracts serve as the primary sites of HIV-1 transmission, and provide "front line" barrier defenses against HIV-1 and other pathogens. In addition, the gastrointestinal tract remains a significant viral reservoir throughout the chronic phase of infection. Tissue-based immune responses may be critical in fighting infection, and understanding these defenses may lead to improved vaccines and immunotherapeutic strategies.
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/genetics ; HIV-1/physiology ; Humans ; Mucous Membrane/immunology ; Mucous Membrane/virology
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0000000000000530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

    Omidvari, Negar / Jones, Terry / Price, Pat M / Ferre, April L / Lu, Jacqueline / Abdelhafez, Yasser G / Sen, Fatma / Cohen, Stuart H / Schmiedehausen, Kristin / Badawi, Ramsey D / Shacklett, Barbara L / Wilson, Ian / Cherry, Simon R

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: With the majority of ... ...

    Abstract With the majority of CD8
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.14.23287121
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody.

    Omidvari, Negar / Jones, Terry / Price, Pat M / Ferre, April L / Lu, Jacqueline / Abdelhafez, Yasser G / Sen, Fatma / Cohen, Stuart H / Schmiedehausen, Kristin / Badawi, Ramsey D / Shacklett, Barbara L / Wilson, Ian / Cherry, Simon R

    Science advances

    2023  Volume 9, Issue 41, Page(s) eadh7968

    Abstract: With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the ... ...

    Abstract With most of the T cells residing in the tissue, not the blood, developing noninvasive methods for in vivo quantification of their biodistribution and kinetics is important for studying their role in immune response and memory. This study presents the first use of dynamic positron emission tomography (PET) and kinetic modeling for in vivo measurement of CD8
    MeSH term(s) Humans ; Tissue Distribution ; COVID-19/diagnostic imaging ; Positron-Emission Tomography/methods ; CD8-Positive T-Lymphocytes ; Zirconium ; Cell Line, Tumor
    Chemical Substances Zirconium (C6V6S92N3C)
    Language English
    Publishing date 2023-10-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adh7968
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  8. Article ; Online: Immune responses to HIV and SIV in mucosal tissues: 'location, location, location'.

    Shacklett, Barbara L

    Current opinion in HIV and AIDS

    2010  Volume 5, Issue 2, Page(s) 128–134

    Abstract: Purpose of review: This review summarizes research literature regarding mucosal immunity to HIV and simian immunodeficiency virus (SIV), with an emphasis on work published within the past 18 months.: Recent findings: Notable recent studies have ... ...

    Abstract Purpose of review: This review summarizes research literature regarding mucosal immunity to HIV and simian immunodeficiency virus (SIV), with an emphasis on work published within the past 18 months.
    Recent findings: Notable recent studies have focused on the pivotal events occurring within mucosal tissues during acute HIV/SIV infection that serve to establish a balance between detrimental immune activation and beneficial adaptive responses. In cervicovaginal mucosa, an early inflammatory response leads to recruitment of susceptible target cells. At this acute stage, the in-vivo ratio between CD8 effector cells and infected CD4 T-cells may be critical for limiting viral dissemination. Acute infection is also accompanied by loss of germinal center architecture and T/B cell apoptosis in Peyer's patches of the gastrointestinal tract. During chronic infection, mucosal CD8 T-cells may play a role in immune control, as suggested by studies of elite controllers.
    Summary: Mucosal tissues serve as the major portal of entry for HIV, and house a majority of the body's lymphocytes, including CD4 T-cells that are targets for infection. Recent studies have focused renewed attention on events occurring immediately after transmission, and underscore the concept that the balance between inflammation and protective immunity is established by host responses in mucosal tissues.
    MeSH term(s) Animals ; Female ; Genitalia, Female/immunology ; Genitalia, Female/pathology ; HIV/immunology ; HIV Infections/immunology ; HIV Infections/pathology ; Humans ; Immunity, Mucosal ; Intestinal Mucosa/immunology ; Intestinal Mucosa/pathology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Acquired Immunodeficiency Syndrome/pathology ; Simian Immunodeficiency Virus/immunology
    Language English
    Publishing date 2010-08-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0b013e328335c178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6812: Show issues Location:
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  9. Article ; Online: The Role of Tissue Resident Memory CD4 T Cells in Herpes Simplex Viral and HIV Infection.

    O'Neil, Thomas R / Hu, Kevin / Truong, Naomi R / Arshad, Sana / Shacklett, Barbara L / Cunningham, Anthony L / Nasr, Najla

    Viruses

    2021  Volume 13, Issue 3

    Abstract: Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major focus was on ... ...

    Abstract Tissue-resident memory T cells (TRM) were first described in 2009. While initially the major focus was on CD8
    MeSH term(s) Animals ; CD4-Positive T-Lymphocytes/immunology ; Coinfection/immunology ; Coinfection/virology ; HIV Infections/immunology ; HIV Infections/virology ; Herpes Simplex/immunology ; Herpes Simplex/virology ; Humans ; Immunologic Memory/immunology
    Language English
    Publishing date 2021-02-25
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v13030359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Mucosal immunity to HIV: a review of recent literature.

    Shacklett, Barbara L

    Current opinion in HIV and AIDS

    2009  Volume 3, Issue 5, Page(s) 541–547

    Abstract: Purpose of review: This review summarizes recent literature in the field of mucosal immunology as it applies to HIV transmission and pathogenesis.: Recent findings: Pertinent recent findings include elucidation of the role of mucosal antigen- ... ...

    Abstract Purpose of review: This review summarizes recent literature in the field of mucosal immunology as it applies to HIV transmission and pathogenesis.
    Recent findings: Pertinent recent findings include elucidation of the role of mucosal antigen-presenting cells and retinoic acid in imprinting a gut-homing phenotype on antigen-specific T and B cells, and the identification of Th17 and T regulatory cells as key modulators of the balance between tolerance and inflammation in mucosal tissues.
    Summary: Mucosal surfaces of the body serve as the major portal of entry for HIV. These tissues also house a majority of the body's lymphocytes, including the CD4 T-cells that are the major cellular target for HIV infection. Elucidating mucosal immune responses is critical to our understanding of the host-pathogen relationship for two reasons: first, mucosal barriers are defended by a range of innate and adaptive defenses that might be exploited to develop effective vaccines or microbicides; second, adaptive immune responses in mucosal lymphoid tissues might serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host.
    Language English
    Publishing date 2009-01-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0b013e32830ab9ee
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