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  1. Article ; Online: Muffling of healthcare: Assessing the impact of personal protective equipment on speaking volume in an Endoscopy Centre.

    Koh, Calvin J / Khoo, Deborah

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2020  Volume 32, Issue 6, Page(s) 997

    MeSH term(s) Delivery of Health Care ; Endoscopy ; Health Personnel ; Humans ; Personal Protective Equipment
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country Australia
    Document type Letter
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.13774
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3854: Show issues Location:
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  3. Article ; Online: Probiotics in health and disease: fooling Mother Nature?

    Abid, Muhammad Bilal / Koh, Calvin J

    Infection

    2019  Volume 47, Issue 6, Page(s) 911–917

    Abstract: Probiotics are ubiquitous, consumption by the general public is common, and the dogma remains that they are beneficial for general and gut health. However, evolving evidence suggests a potentially "harmful" impact of many commercially available ... ...

    Abstract Probiotics are ubiquitous, consumption by the general public is common, and the dogma remains that they are beneficial for general and gut health. However, evolving evidence suggests a potentially "harmful" impact of many commercially available probiotics. There is also significant variability in formulations that leads to a lack of a universally acceptable definition of probiotics. In this perspective, we review the flaws with definition, relevant observational and randomized studies that showed both positive and negative impacts on health and disease, unbiased interpretation of key trials, emerging evidence from microbiome and immuno-oncological studies, and impact on systemic immunity. We propose that caution be exercised prior to endorsements of their illness-directed consumption and rampant general usage. As a deeper understanding of the human microbiome accrues and our ability to manipulate this complex ecosystem improves, the probiotic of tomorrow might be the precision tool that deals with diseases on a broad front. Gut microbiome, akin to fingerprints, is indigenous to an individual and 'one size fits all' prescription strategy should be discouraged until a more universally acceptable 'favorable taxa' or a 'personalized probiotic,' to complement an individual's native microbiota, gets fashioned.
    MeSH term(s) Gastrointestinal Microbiome ; Humans ; Observational Studies as Topic ; Probiotics/therapeutic use ; Randomized Controlled Trials as Topic ; Terminology as Topic
    Language English
    Publishing date 2019-09-02
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-019-01351-0
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    Zs.A 881: Show issues Location:
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    Zs.MO 528: Show issues

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  4. Article ; Online: Failure of over-the-scope clip to control duodenal ulcer bleeding despite successful application.

    Koh, Calvin J / Tan, Eunice X X

    VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

    2019  Volume 5, Issue 1, Page(s) 24–25

    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Journal Article
    ISSN 2468-4481
    ISSN (online) 2468-4481
    DOI 10.1016/j.vgie.2019.09.005
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  5. Article: Bleeding on the Edge-The Use of Hemostatic Powder for Treating a Bleeding Hypopharyngeal Tumor.

    Bong, Shirley H / Tan, Bernice W / Yong, Jui May / Ng, Li Shia / Koh, Calvin J

    Clinical endoscopy

    2020  Volume 54, Issue 3, Page(s) 441–442

    Language English
    Publishing date 2020-08-19
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2643507-X
    ISSN 2234-2443 ; 2234-2400
    ISSN (online) 2234-2443
    ISSN 2234-2400
    DOI 10.5946/ce.2020.159
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  6. Article ; Online: Implementing dispersion measurement as part of scanning proton therapy commissioning and quality assurance.

    Tan, Hong Qi / Lew, Kah Seng / Koh, Calvin Wei Yang / Wibawa, Andrew / Yeap, Ping Lin / Master, Zubin / Lee, James Cheow Lei / Beltran, Chris J / Park, Sung Yong / Furutani, Keith M

    Physics in medicine and biology

    2023  Volume 68, Issue 22

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Proton Therapy/methods ; Radiometry ; Protons ; Motion
    Chemical Substances Protons
    Language English
    Publishing date 2023-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad0536
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article ; Online: The effect of spill change on reliable absolute dosimetry in a synchrotron proton spot scanning system.

    Tan, Hong Qi / Lew, Kah Seng / Koh, Calvin Wei Yang / Wibawa, Andrew / Master, Zubin / Beltran, Chris J / Park, Sung Yong / Furutani, Keith M

    Medical physics

    2023  Volume 50, Issue 7, Page(s) 4067–4078

    Abstract: Background: Absolute dosimetry measurement is an integral part of Treatment Planning System (TPS) commissioning and it involves measuring the integrated absorbed dose to water for all energies in a pencil beam scanning delivery system. During the ... ...

    Abstract Background: Absolute dosimetry measurement is an integral part of Treatment Planning System (TPS) commissioning and it involves measuring the integrated absorbed dose to water for all energies in a pencil beam scanning delivery system. During the commissioning of Singapore's first proton therapy center, a uniform scanned field with an Advanced Markus chamber method was employed for this measurement, and a large dose fluctuation of at least 5% was observed for 10% of the energy layers during repeated measurements.
    Purpose: This study aims to understand the root cause of this fluctuation by relating the actual delivered spot information in the log file with the charge measurement by the ion chambers.
    Methods: A dedicated pencil beam dose algorithm was developed, taking into account the log file parameters, to calculate the dose for a single energy layer in a homogeneous water phantom. Three energies, 70.2, 182.7, and 228.7 MeV were used in this study, with the 182.7 MeV energy exhibiting large dose fluctuation. The dose fluctuation was investigated as a function of detector's sizes (pinpoint 3D, Advanced Markus, PTW 34070, and PTW 34089) and water depth (2 , 6, and 20 cm). Twelve ion chambers measurements were performed for each chamber and depth. The comparison of the theoretically predicted integrated dose and the charge measurement served as a validation of the algorithm.
    Results: About 5.9% and 9.6% dose fluctuation were observed in Advanced Markus and pinpoint 3D measurements at 2 cm depth for 182.7 MeV, while fluctuation of 1.6% and 1.1% were observed in Advanced Markus with 228.7 and 70.2 MeV at similar depth. Fluctuation of less than 0.1% was observed for PTW34070 and PTW 34089 for all energies. The fluctuation was found to diminish with larger spot size at 20 cm depth to 1.3% for 182.7 MeV. The theoretical and measured charge comparison showed a high linear correlation of
    Conclusion: This is the first report of a dose fluctuation greater than 5% in absolute dosimetry measurement with a uniform scanned field and the cause of the fluctuation has been conclusively determined. It is important to choose the MU and scanning pattern carefully to avoid spill change happening when the spot delivery is near the detector.
    MeSH term(s) Protons ; Synchrotrons ; Radiometry/methods ; Proton Therapy/methods ; Water ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods
    Chemical Substances Protons ; Water (059QF0KO0R)
    Language English
    Publishing date 2023-06-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 188780-4
    ISSN 2473-4209 ; 0094-2405
    ISSN (online) 2473-4209
    ISSN 0094-2405
    DOI 10.1002/mp.16531
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    Zs.A 1210: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Comparing artificial intelligence to humans for endoscopic diagnosis of gastric neoplasia: An external validation study.

    Quek, Sabrina Xin Zi / Lee, Jonathan W J / Feng, Zhu / Soh, Min Min / Tokano, Masayuki / Guan, Yeoh Khay / So, Jimmy B Y / Tada, Tomohiro / Koh, Calvin J

    Journal of gastroenterology and hepatology

    2023  Volume 38, Issue 9, Page(s) 1587–1591

    Abstract: Objectives: Artificial intelligence (AI) uses deep learning functionalities that may enhance the detection of early gastric cancer during endoscopy. An AI-based endoscopic system for upper endoscopy was recently developed in Japan. We aim to validate ... ...

    Abstract Objectives: Artificial intelligence (AI) uses deep learning functionalities that may enhance the detection of early gastric cancer during endoscopy. An AI-based endoscopic system for upper endoscopy was recently developed in Japan. We aim to validate this AI-based system in a Singaporean cohort.
    Methods: There were 300 de-identified still images prepared from endoscopy video files obtained from subjects that underwent gastroscopy in National University Hospital (NUH). Five specialists and 6 non-specialists (trainees) from NUH were assigned to read and categorize the images into "neoplastic" or "non-neoplastic." Results were then compared with the readings performed by the endoscopic AI system.
    Results: The mean accuracy, sensitivity, and specificity for the 11 endoscopists were 0.847, 0.525, and 0.872, respectively. These values for the AI-based system were 0.777, 0.591, and 0.791, respectively. While AI in general did not perform better than endoscopists on the whole, in the subgroup of high-grade dysplastic lesions, only 29.1% were picked up by the endoscopist rating, but 80% were classified as neoplastic by AI (P = 0.0011). The average diagnostic time was also faster in AI compared with endoscopists (677.1 s vs 42.02 s (P < 0.001).
    Conclusion: We demonstrated that an AI system developed in another health system was comparable in diagnostic accuracy in the evaluation of static images. AI systems are faster and not fatigable and may have a role in augmenting human diagnosis during endoscopy. With more advances in AI and larger studies to support its efficacy it would likely play a larger role in screening endoscopy in future.
    MeSH term(s) Humans ; Stomach Neoplasms/diagnostic imaging ; Artificial Intelligence ; Gastroscopy ; Asian People ; Fatigue
    Language English
    Publishing date 2023-07-05
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 632882-9
    ISSN 1440-1746 ; 0815-9319
    ISSN (online) 1440-1746
    ISSN 0815-9319
    DOI 10.1111/jgh.16274
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    Zs.A 2180: Show issues Location:
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    Zs.MO 299: Show issues

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  9. Article ; Online: Bleeding on the Edge—The Use of Hemostatic Powder for Treating a Bleeding Hypopharyngeal Tumor

    Shirley H. Bong / Bernice W. Tan / Jui May Yong / Li Shia Ng / Calvin J. Koh

    Clinical Endoscopy, Vol 54, Iss 3, Pp 441-

    2021  Volume 442

    Keywords Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Korean Society of Gastrointestinal Endoscopy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Presence, origins and effect of stable surface hydration on regenerated cellulose for underwater oil-repellent membranes.

    Justin Koh, J / Pang, Pengfei / Chakraborty, Souvik / Kong, Junhua / Sng, Anqi / Anukunwithaya, Patsaya / Huang, Shujuan / Koh, Xue Qi / Thenarianto, Calvin / Thitsartan, Warintorn / Daniel, Dan / He, Chaobin

    Journal of colloid and interface science

    2022  Volume 635, Page(s) 197–207

    Abstract: Hypothesis: Underwater oil-repellency of polyelectrolyte brushes has been attributed mainly to electric double-layer repulsion forces based on Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. Many non-polyelectrolyte materials also exhibit oil-repellent ... ...

    Abstract Hypothesis: Underwater oil-repellency of polyelectrolyte brushes has been attributed mainly to electric double-layer repulsion forces based on Derjaguin-Landau-Verwey-Overbeek (DLVO) theory. Many non-polyelectrolyte materials also exhibit oil-repellent behaviour, but it is not clear if there exist similar electric double-layer repulsion and if it is the sole mechanism governing their underwater oil-repellency.
    Experiments/simulations: In this article, the oil-repellency of highly amorphous cellulose exhibiting is investigated in detail, through experiments and molecular dynamics simulations (MDS).
    Findings: It was found that the stable surface hydration on regenerated cellulose was due to a combination of long-range electrostatic repulsions (DLVO theory) and short-range interfacial hydrogen bonding between cellulose and water molecules (as revealed by MDS). The presence of a stable water layer of about 200 nm thick (similar to that of polyelectrolyte brushes) was confirmed. Such stable surface hydration effectively separates cellulose surface from oil droplets, resulting in extremely low adhesion between them. As a demonstration of its practicality, regenerated cellulose membranes were fabricated via electrospinning, and they exhibit high oil/water separation efficiencies (including oil-in-water emulsions) as well as self-cleaning ability.
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2022.12.109
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