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  1. Article ; Conference proceedings: Proceedings of the 9th Liver Anesthesia and Intensive Care International Meeting

    Busani, Stefano

    Transplantation proceedings 40 ,4, S. [1157] - 1227 : graph. Darst.

    November 29 to December 1, 2007, Modena, Italy

    2008  

    Event/congress Liver Anesthesia and Intensive Care International Meeting (9, 2007, Modena)
    Author's details guest ed.: Stefano Busani
    Collection Transplantation proceedings
    Language English
    Publishing place New York, NY
    Publishing country United States
    Document type Article ; Conference proceedings
    HBZ-ID HT015601182
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Zs A 835 -40-

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  2. Article: Editorial: Outcome of sepsis and prediction of mortality risk.

    Munari, Elena / Minicucci, Marcos Ferreira / Ming, Zhong / Girardis, Massimo / Busani, Stefano

    Frontiers in medicine

    2023  Volume 10, Page(s) 1338938

    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1338938
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Putting the Spotlight on the Role of Oxygen in Critically-Ill Patients: From Basic Mechanisms to Clinical Effects.

    Busani, Stefano / Munari, Elena / Taccone, Fabio Silvio / Donati, Abele / Girardis, Massimo

    Frontiers in medicine

    2022  Volume 9, Page(s) 859632

    Language English
    Publishing date 2022-02-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.859632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Editorial

    Elena Munari / Marcos Ferreira Minicucci / Zhong Ming / Massimo Girardis / Stefano Busani

    Frontiers in Medicine, Vol

    Outcome of sepsis and prediction of mortality risk

    2023  Volume 10

    Keywords sepsis ; outcome ; prediction of mortality ; ICU ; septic shock ; Medicine (General) ; R5-920
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Difference in PaO

    Gatto, Ilenia / Biagioni, Emanuela / Coloretti, Irene / Viappiani, Serena / Busani, Stefano / Girardis, Massimo

    Journal of Anesthesia, Analgesia and Critical Care (Online)

    2022  Volume 2, Issue 1, Page(s) 23

    Abstract: The ratio between arterial blood partial pressure of oxygen and fraction of inspired oxygen ( ... ...

    Abstract The ratio between arterial blood partial pressure of oxygen and fraction of inspired oxygen (PaO
    Language English
    Publishing date 2022-05-24
    Publishing country England
    Document type Journal Article
    ISSN 2731-3786
    ISSN (online) 2731-3786
    DOI 10.1186/s44158-022-00051-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Oxygen Supplementation Among Patients in the Intensive Care Unit.

    Girardis, Massimo / Busani, Stefano

    JAMA

    2017  Volume 317, Issue 6, Page(s) 647–648

    MeSH term(s) Critical Care ; Humans ; Intensive Care Units ; Length of Stay ; Oxygen Inhalation Therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2017--14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2016.20829
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.88: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Exogenous pulmonary surfactant in COVID-19 ARDS. The similarities to neonatal RDS suggest a new scenario for an 'old' strategy.

    Bhatt, Reena M / Clark, Howard W / Girardis, Massimo / Busani, Stefano

    BMJ open respiratory research

    2021  Volume 8, Issue 1

    Abstract: Acute respiratory distress syndrome (ARDS) related to SARS-CoV-2 infection has some unusual characteristics that differentiate it from the pathophysiology described in the more 'typical' ARDS. Among multiple hypotheses, a close similarity has been ... ...

    Abstract Acute respiratory distress syndrome (ARDS) related to SARS-CoV-2 infection has some unusual characteristics that differentiate it from the pathophysiology described in the more 'typical' ARDS. Among multiple hypotheses, a close similarity has been suggested between COVID-19 ARDS and neonatal respiratory distress syndrome (RDS). With this opinion paper, we investigated the pathophysiological similarities between infant respiratory diseases (RDS and direct neonatal ARDS (NARDS)) and COVID-19 in adults. We also analysed, for the first time, similarities in the response to exogenous surfactant administration in terms of improved static compliance in RDS and direct NARDS, and adult COVID-19 ARDS. In conclusion, we believe that if the pathological processes are similar both from the pathophysiological point of view and from the response in respiratory mechanics to a recruitment treatment such as surfactant, perhaps the latter could be considered a plausible option and lead to recruitment in clinical trials currently ongoing on patients with COVID-19.
    MeSH term(s) Adult ; COVID-19/complications ; COVID-19/drug therapy ; Humans ; Infant, Newborn ; Pulmonary Surfactants/therapeutic use ; Respiratory Distress Syndrome/drug therapy ; Respiratory Distress Syndrome, Newborn/drug therapy
    Chemical Substances Pulmonary Surfactants
    Language English
    Publishing date 2021-09-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2736454-9
    ISSN 2052-4439 ; 2052-4439
    ISSN (online) 2052-4439
    ISSN 2052-4439
    DOI 10.1136/bmjresp-2020-000867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Pathophysiological profile of non-ventilated lung injury in healthy female pigs undergoing mechanical ventilation.

    Spinelli, Elena / Damia, Anna / Damarco, Francesco / Gregori, Beatrice / Occhipinti, Federica / Busani, Zara / Leali, Marco / Battistin, Michele / Lonati, Caterina / Zhao, Zhanqi / Storaci, Alessandra Maria / Lopez, Gianluca / Vaira, Valentina / Ferrero, Stefano / Rosso, Lorenzo / Gatti, Stefano / Mauri, Tommaso

    Communications medicine

    2024  Volume 4, Issue 1, Page(s) 18

    Abstract: Background: Lung regions excluded from mechanical insufflation are traditionally assumed to be spared from ventilation-associated lung injury. However, preliminary data showed activation of potential mechanisms of injury within these non-ventilated ... ...

    Abstract Background: Lung regions excluded from mechanical insufflation are traditionally assumed to be spared from ventilation-associated lung injury. However, preliminary data showed activation of potential mechanisms of injury within these non-ventilated regions (e.g., hypoperfusion, inflammation).
    Methods: In the present study, we hypothesized that non-ventilated lung injury (NVLI) may develop within 24 h of unilateral mechanical ventilation in previously healthy pigs, and we performed extended pathophysiological measures to profile NVLI. We included two experimental groups undergoing exclusion of the left lung from the ventilation with two different tidal volumes (15 vs 7.5 ml/kg) and a control group on bilateral ventilation. Pathophysiological alteration including lung collapse, changes in lung perfusion, lung stress and inflammation were measured. Lung injury was quantified by histological score.
    Results: Histological injury score of the non-ventilated lung is significantly higher than normally expanded lung from control animals. The histological score showed lower intermediate values (but still higher than controls) when the tidal volume distending the ventilated lung was reduced by 50%. Main pathophysiological alterations associated with NVLI were: extensive lung collapse; very low pulmonary perfusion; high inspiratory airways pressure; and higher concentrations of acute-phase inflammatory cytokines IL-6, IL-1β and TNF-α and of Angiopoietin-2 (a marker of endothelial activation) in the broncho-alveolar lavage. Only the last two alterations were mitigated by reducing tidal volume, potentially explaining partial protection.
    Conclusions: Non-ventilated lung injury develops within 24 h of controlled mechanical ventilation due to multiple pathophysiological alterations, which are only partially prevented by low tidal volume.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ISSN 2730-664X
    ISSN (online) 2730-664X
    DOI 10.1038/s43856-024-00449-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial

    Stefano Busani / Elena Munari / Fabio Silvio Taccone / Abele Donati / Massimo Girardis

    Frontiers in Medicine, Vol

    Putting the Spotlight on the Role of Oxygen in Critically-Ill Patients: From Basic Mechanisms to Clinical Effects

    2022  Volume 9

    Keywords hyperoxia ; hyperoxemia ; ICU ; critically-ill patients ; children ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Exogenous pulmonary surfactant in COVID-19 ARDS. The similarities to neonatal RDS suggest a new scenario for an ‘old’ strategy

    Massimo Girardis / Howard W Clark / Reena M Bhatt / Stefano Busani

    BMJ Open Respiratory Research, Vol 8, Iss

    2021  Volume 1

    Keywords Medicine ; R ; Diseases of the respiratory system ; RC705-779
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher BMJ Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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