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Article: The Role of Vitamin D on the Wound Healing Process: A Case Series.

Siregar, Fitri Dona / Hidayat, Wahyu

International medical case reports journal

2023 Volume 16, Page(s) 227–232

Abstract: Introduction: Vitamin D is an essential steroid hormone that consists of two forms, namely vitamin ... synthesis of vitamin D in the skin, food and dietary supplements. Prevalence of vitamin D deficiency ... in several countries including Indonesia is still high, while the role of vitamin D is very important including ...

Abstract	Introduction: Vitamin D is an essential steroid hormone that consists of two forms, namely vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol), which can be obtained from exposure to sunlight, synthesis of vitamin D in the skin, food and dietary supplements. Prevalence of vitamin D deficiency in several countries including Indonesia is still high, while the role of vitamin D is very important including accelerating the wound healing process, increasing the immune system, anti-inflammatory, and anti-bacterial. Purpose: This case report aims to find out the role of vitamin D in the wound-healing process in the oral mucosa. Case reports: Two men went to the Oral Disease Clinic with complaints of canker sores on the oral mucosa for more than a month accompanied by pain. Intra-oral condition in the first patient showed multiple ulcers with yellowish white base surrounded by erythematous areas, well-defined, irregular with a size of 1.5 × 1 cm and 1 × 0.5 cm on the right and left buccal mucosa, while intra-oral in the second patient, a single ulcer with a base was found yellowish colour surrounded by erythematous area, oval measuring 3x1 cm, clearly demarcated with induration. Results: Laboratory examination of vitamin D in both patients showed decreased levels of vitamin D with values of 28.7 and 9.8 ng/mL. Conclusion: Vitamin D supplementation has shown effectiveness in wound-healing processes in the oral mucosa.
Language	English
Publishing date	2023-04-01
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2495077-4
ISSN	1179-142X
ISSN	1179-142X
DOI	10.2147/IMCRJ.S402005
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Prenatal vitamin D deficiency alters immune cell proportions of young adult offspring through alteration of long-term stem cell fates.

Ueda, Koki / Chin, Shu Shien / Sato, Noriko / Nishikawa, Miyu / Yasuda, Kaori / Miyasaka, Naoyuki / Bera, Betelehem Solomon / Chorro, Laurent / Doña-Termine, Reanna / Koba, Wade R / Reynolds, David / Steidl, Ulrich G / Lauvau, Gregoire / Greally, John M / Suzuki, Masako

bioRxiv : the preprint server for biology

2023

Abstract: Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age ... Herein, we explore the effects of prenatal vitamin D deficiency on immune cell proportions in offspring ... using vitamin D deficient mice established by dietary manipulation. We show that prenatal vitamin D ...

Abstract	Vitamin D deficiency is a common deficiency worldwide, particularly among women of reproductive age. During pregnancy, it increases the risk of immune-related diseases in offspring later in life. However, exactly how the body remembers exposure to an adverse environment during development is poorly understood. Herein, we explore the effects of prenatal vitamin D deficiency on immune cell proportions in offspring using vitamin D deficient mice established by dietary manipulation. We show that prenatal vitamin D deficiency alters immune cell proportions in offspring by changing the transcriptional properties of genes downstream of vitamin D receptor signaling in hematopoietic stem and progenitor cells of both the fetus and adults. Further investigations of the associations between maternal vitamin D levels and cord blood immune cell profiles from 75 healthy pregnant women and their term babies also confirm that maternal vitamin D levels significantly affect immune cell proportions in the babies. Thus, lack of prenatal vitamin D, particularly at the time of hematopoietic stem cell migration from the liver to the bone marrow, has long-lasting effects on immune cell proportions. This highlights the importance of providing vitamin D supplementation at specific stages of pregnancy.
Language	English
Publishing date	2023-09-13
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.11.557255
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Article ; Online: Adaption of an ongoing clinical trial to quickly respond to gaps in changing international recommendations: the experience of D

Papot, Emmanuelle / Jacoby, Simone / Arlinda, Dona / Avihingsanon, Anchalee / Azwa, Iskandar / Borok, Margaret / Brown, Dannae / Cissé, Mohamed / Dao, Sounkalo / Eriobu, Nnakelu / Kaplan, Richard / Karyana, Muhammad / Kumarasamy, Nagalingeswaran / Lee, Johnnie / Losso, Marcelo H / Matthews, Gail V / Perelis, Leonardo / Perez-Casas, Carmen / Ruxrungtham, Kiat /

Watkins, Melynda / Lane, H Clifford / Kelleher, Anthony / Law, Matthew / Polizzotto, Mark N

HIV research & clinical practice

2022 Volume 23, Issue 1, Page(s) 37–46

Abstract: ... the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D ...

Abstract	A rapidly changing landscape of antiretrovirals and their procurement at scale has permitted the evaluation of new optimised second-line antiretroviral therapy (ART) in low- and middle-income countries. D
MeSH term(s)	Anti-HIV Agents/therapeutic use ; Darunavir/therapeutic use ; Drug Therapy, Combination ; HIV Infections/drug therapy ; Humans ; Retrospective Studies ; Reverse Transcriptase Inhibitors/therapeutic use ; Viral Load
Chemical Substances	Anti-HIV Agents ; Reverse Transcriptase Inhibitors ; Darunavir (YO603Y8113)
Language	English
Publishing date	2022-08-25
Publishing country	England
Document type	Clinical Trial, Phase III ; Equivalence Trial ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ISSN	2578-7470
ISSN (online)	2578-7470
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Article: Vitamin D Deficiency During Development Permanently Alters Liver Cell Composition and Function.

Lundy, Kassidy / Greally, John F / Essilfie-Bondzie, Grace / Olivier, Josephine B / Doña-Termine, Reanna / Greally, John M / Suzuki, Masako

Frontiers in endocrinology

2022 Volume 13, Page(s) 860286

Abstract: Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system ... of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be solved ... In particular, reproductive age and pregnant women low in vitamin D status may confer risks of diseases like ...

Abstract	Vitamin D, a fat-soluble vitamin, plays a critical role in calcium homeostasis, the immune system, and normal development. Many epidemiological cohort studies globally have found high prevalence rates of vitamin D deficiency and insufficiency, recognized as an important health issue that needs to be solved. In particular, reproductive age and pregnant women low in vitamin D status may confer risks of diseases like obesity on their offspring. While observational studies have suggested associations between prenatal vitamin D deficiency and metabolic phenotypes in offspring, not yet determined is whether prenatal vitamin D deficiency permanently alters the development of the liver, a major metabolic organ. We tested the histopathology and the transcriptomic profiles of livers from male C57BL/6J mice exposed to prenatal vitamin D deficiency through a maternal dietary intervention model. We found that prenatal vitamin D deficiency increases the prevalence of histopathological changes in the liver, and alters its gene expression profile. Cell subtype proportion analysis showed that the liver of prenatal vitamin D deficiency alters non-parenchymal cells of the liver, specifically macrophages, a subset of endothelial cells, and dendritic cells. Our results indicate the long-term memory of prenatal vitamin D deficiency exposure in the adult liver, a potential contributor to offspring health risks.
MeSH term(s)	Animals ; Endothelial Cells/metabolism ; Female ; Humans ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Vitamin D/metabolism ; Vitamin D Deficiency/epidemiology ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-05-12
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2022.860286
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Article ; Online: Effect of the administration of different forms of vitamin D on central blood pressure and aortic stiffness, and its implication in the reduction of albuminuria in chronic kidney disease.

Martin-Romero, Almudena / Perelló-Martínez, Jary / Hidalgo-Santiago, Juan Carlos / Michan-Doña, Alfredo / Bosco López Sáez, Juan / Gómez-Fernández, Pablo

Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis

2022 Volume 34, Issue 6, Page(s) 311–321

Abstract: Background and objectives: Vitamin D(vitD) participates in phospho-calcium metabolism and exerts ... multiple pleiotropic effects. There is tissue 1-α (OH)ase that converts 25-OH cholecalciferol (25 (OH) D ... in calcitriol that exerts autocrine and paracrine effects. 25 (OH)D deficiency could limit these tissue effects ...

Title translation	Efecto de la administración de diferentes formas de vitamina D en la presión arterial y rigidez aórticas, y su implicación en la reducción de la albuminuria en la enfermedad renal crónica.
Abstract	Background and objectives: Vitamin D(vitD) participates in phospho-calcium metabolism and exerts multiple pleiotropic effects. There is tissue 1-α (OH)ase that converts 25-OH cholecalciferol (25 (OH) D) in calcitriol that exerts autocrine and paracrine effects. 25 (OH)D deficiency could limit these tissue effects of vitD. The administration of nutritional vitD and the activator of the vitD receptor, paricalcitol, may promote beneficial effects on vascular and renal function. The objective of this work was to study in subjects with chronic kidney disease (CKD) the effect that the administration of different forms of vitD has on arterial function and albuminuria, and the possible relationship between the modifications of these variables. Patients and methods: We studied in 97 patients with CKD stages 3-4 the effect of the administration of cholecalciferol (group 2; n: 35) and paricalcitol (n: 31; group 3) on parameters derived from brachial blood pressure, aortic blood pressure and on aortic stiffness studied using carotid-femoral pulse velocity (Vp Results: In the baseline phase, no differences were observed between the groups in brachial systolic blood pressure (bSBP), central systolic blood pressure (SBP), brachial pulse pressure (bPP), and central pulse pressure (pCP) or in aortic stiffness that was increased in all groups with a baseline Vp Conclusions: In patients with CKD stages 3-4, treated with RAS blockers and with residual albuminuria, the administration of or paricalcitol reduces brachial and aortic pulse pressures, and albuminuria. The decrease in albuminuria does not seem to be mediated, at least not decisively, by changes in central hemodynamics or aortic stiffness.
MeSH term(s)	Humans ; Vitamin D/pharmacology ; Blood Pressure/physiology ; Vascular Stiffness/physiology ; Albuminuria/drug therapy ; Albuminuria/etiology ; Calcium/pharmacology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Vitamins/pharmacology ; Cholecalciferol/pharmacology ; Phosphorus/pharmacology
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP) ; Vitamins ; Cholecalciferol (1C6V77QF41) ; Phosphorus (27YLU75U4W)
Language	Spanish
Publishing date	2022-07-08
Publishing country	Spain
Document type	Journal Article
ISSN	1578-1879
ISSN (online)	1578-1879
DOI	10.1016/j.arteri.2022.05.002
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Article ; Online: Treating vitamin D deficiency in children with type I diabetes could improve their glycaemic control.

Giri, Dinesh / Pintus, Dona / Burnside, Girvan / Ghatak, Atrayee / Mehta, Fulya / Paul, Princy / Senniappan, Senthil

BMC research notes

2017 Volume 10, Issue 1, Page(s) 465

Abstract: Background and aims: The relationship between vitamin D deficiency and type I DM is an ongoing ... area of interest. The study aims to identify the prevalence of vitamin D deficiency in children and ... adolescents with T1DM and to assess the impact of treatment of vitamin D deficiency on their glycaemic ...

Abstract	Background and aims: The relationship between vitamin D deficiency and type I DM is an ongoing area of interest. The study aims to identify the prevalence of vitamin D deficiency in children and adolescents with T1DM and to assess the impact of treatment of vitamin D deficiency on their glycaemic control. Methods: Retrospective data was collected from 271 children and adolescents with T1DM. The vitamin D deficient (25(OH)D <30 nmol/L) and insufficient (25(OH)D 30-50 nmol/L) patients were treated with 6000 units of cholecalciferol and 400 units of cholecalciferol, once daily for 3 months respectively. HbA1c and 25(OH)D concentrations were measured before and at the end of the vitamin D treatment. Results: 14.8% from the whole cohort (n = 271) were vitamin D deficient and 31% were insufficient. Among the children included in the final analysis (n = 73), the mean age and plasma 25(OH)D concentration (±SD) were 7.7 years (±4.4) and 32.2 nmol/l (±8.2) respectively. The mean 25(OH)D concentration post-treatment was 65.3 nmol/l (±9.3). The mean HbA1c (±SD) before and after cholecalciferol was 73.5 mmol/mol (±14.9) and 65 mmol/mol (±11.2) respectively (p < 0.001). Children with higher pre-treatment HbA1c had greater reduction in HbA1c (p < 0.001) and those with lower 25(OH)D concentration showed higher reduction in HbA1c (p = 0.004) after treatment. Conclusions: Low 25(OH)D concentrations are fairly prevalent in children and adolescents with T1DM, treatment of which, can potentially improve the glycaemic control.
Language	English
Publishing date	2017-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-017-2794-3
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Article ; Online: Interrelationship Between Vitamin D Insufficiency, Calcium Homeostasis, Hyperaldosteronism, and Autoimmunity.

Armanini, Decio / Andrisani, Alessandra / Ambrosini, Guido / Donà, Gabriella / Camozzi, Valentina / Bordin, Luciana / Sabbadin, Chiara

Journal of clinical hypertension (Greenwich, Conn.)

2016 Volume 18, Issue 7, Page(s) 614–616

MeSH term(s)	Autoimmunity ; Calcium ; Homeostasis ; Humans ; Hyperaldosteronism ; Hypertension ; Vitamin D ; Vitamin D Deficiency
Chemical Substances	Vitamin D (1406-16-2) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-04-21
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2077222-1
ISSN	1751-7176 ; 1524-6175
ISSN (online)	1751-7176
ISSN	1524-6175
DOI	10.1111/jch.12822
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Article ; Online: Hypoallergenic Variant of the Major Egg White Allergen Gal d 1 Produced by Disruption of Cysteine Bridges.

Dhanapala, Pathum / Withanage-Dona, Dulashi / Tang, Mimi L K / Doran, Tim / Suphioglu, Cenk

Nutrients

2017 Volume 9, Issue 2

Abstract: Background: Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic ...

Abstract	Background: Gal d 1 (ovomucoid) is the dominant allergen in the chicken egg white. Hypoallergenic variants of this allergen can be used in immunotherapy as an egg allergy treatment approach. We hypothesised that disruption of two of the nine cysteine-cysteine bridges by site-directed mutagenesis will allow the production of a hypoallergenic variant of the protein; Methods: Two cysteine residues at C192 and C210 in domain III of the protein were mutated to alanine using site-directed mutagenesis, to disrupt two separate cysteine-cysteine bridges. The mutated and non-mutated proteins were expressed in
MeSH term(s)	Allergens/genetics ; Animals ; Chickens ; Cysteine/metabolism ; Egg Hypersensitivity/immunology ; Egg Hypersensitivity/prevention & control ; Egg White/chemistry ; Escherichia coli ; Female ; Genetic Techniques ; Humans ; Immune Tolerance ; Immunoglobulin E/metabolism ; Immunotherapy ; Mutagenesis ; Mutation ; Ovomucin/genetics ; Ovomucin/immunology
Chemical Substances	Allergens ; Ovomucin (37281-36-0) ; Immunoglobulin E (37341-29-0) ; Cysteine (K848JZ4886)
Language	English
Publishing date	2017-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu9020171
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Book ; Online: Sugar, Spice, and the Not So Nice

Pursall, Dona / Van de Wiele, Eva

Comics Picturing Girlhood

(Studies in European Comics and Graphic Novels)

2023

Series title	Studies in European Comics and Graphic Novels
Keywords	Literature & literary studies ; Children's & teenage literature studies ; Gender studies: women ; Graphic novels ; Comic book & cartoon art ; Cartoons & comic strips (Children's / Teenage) ; Comic strip fiction / graphic novels (Children's / Teenage) ; Girlhood;Comics;Practice based research;Graphic essays;Gender studies
Language	English
Size	1 electronic resource (251 pages)
Publisher	Leuven University Press
Publishing place	Leuven
Document type	Book ; Online
Note	English
HBZ-ID	HT030722073
ISBN	9789462700307 ; 9462700303
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Identification of Novel Biomarkers for Drug Hypersensitivity After Sequencing of the Promoter Area in 16 Genes of the Vitamin D Pathway and the High-Affinity IgE Receptor.

Amo, Gemma / Martí, Manuel / García-Menaya, Jesús M / Cordobés, Concepción / Cornejo-García, José A / Blanca-López, Natalia / Canto, Gabriela / Doña, Inmaculada / Blanca, Miguel / Torres, María José / Agúndez, José A G / García-Martín, Elena

Frontiers in genetics

2019 Volume 10, Page(s) 582

Abstract: ... we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor ...

Abstract	The prevalence of allergic diseases and drug hypersensitivity reactions (DHRs) during recent years is increasing. Both, allergic diseases and DHRs seem to be related to an interplay between environmental factors and genetic susceptibility. In recent years, a large effort in the elucidation of the genetic mechanisms involved in these disorders has been made, mostly based on case-control studies, and typically focusing on isolated SNPs. These studies provide a limited amount of information, which now can be greatly expanded by the complete coverage that Next Generation Sequencing techniques offer. In this study, we analyzed the promoters of sixteen genes related to the Vitamin D pathway and the high-affinity IgE receptor, including
Language	English
Publishing date	2019-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2019.00582
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