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  1. Article ; Online: Scientific Ambiguity in the Time of Coronavirus Disease 2019-Reply.

    Tagarro, Alfredo / Moraleda, Cinta / Calvo, Cristina

    JAMA pediatrics

    2020  Volume 175, Issue 3, Page(s) 318–319

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.2937
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  3. Article ; Online: Features of COVID-19 in Children During the Omicron Wave Compared With Previous Waves in Madrid, Spain.

    Tagarro, Alfredo / Coya, Olga-Nerea / Pérez-Villena, Ana / Iglesias, Beatriz / Navas, Adriana / Aguilera-Alonso, David / Moraleda, Cinta

    The Pediatric infectious disease journal

    2022  Volume 41, Issue 5, Page(s) e249–e251

    MeSH term(s) COVID-19/epidemiology ; Child ; Humans ; SARS-CoV-2 ; Spain/epidemiology
    Language English
    Publishing date 2022-03-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003482
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  4. Article ; Online: Screening and Severity of Coronavirus Disease 2019 (COVID-19) in Children in Madrid, Spain.

    Tagarro, Alfredo / Epalza, Cristina / Santos, Mar / Sanz-Santaeufemia, Francisco José / Otheo, Enrique / Moraleda, Cinta / Calvo, Cristina

    JAMA pediatrics

    2020  

    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701223-2
    ISSN 2168-6211 ; 2168-6203
    ISSN (online) 2168-6211
    ISSN 2168-6203
    DOI 10.1001/jamapediatrics.2020.1346
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  5. Article ; Online: Urgent need for multi-site controlled trials for CMV pneumonia treatment in African children.

    Tembo, John / Moraleda, Cinta / Rojo, Pablo / Zumla, Alimuddin / Bates, Matthew

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

    2018  Volume 22, Issue 4, Page(s) 469–470

    MeSH term(s) Child ; Cytomegalovirus Infections ; HIV ; Humans ; Infant ; Neglected Diseases ; Pneumonia
    Language English
    Publishing date 2018-03-20
    Publishing country France
    Document type Letter ; Comment
    ZDB-ID 1385624-8
    ISSN 1815-7920 ; 1027-3719
    ISSN (online) 1815-7920
    ISSN 1027-3719
    DOI 10.5588/ijtld.17.0847
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  6. Article ; Online: Feasible alternatives to DBS in the retrospective diagnosis of congenital cytomegalovirus infection.

    Reyes, Alhena / Taravillo, Irene / Moral, Noelia / Moraleda, Cinta / Blázquez-Gamero, Daniel / Folgueira, Lola

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2020  Volume 129, Page(s) 104504

    Abstract: Background: Retrospective diagnosis of congenital cytomegalovirus (cCMV) infection may be challenging mainly because of the high variable sensitivity of PCR on dried blood spots (DBS) samples.: Objectives: To compare cytomegalovirus (CMV) viral load ( ...

    Abstract Background: Retrospective diagnosis of congenital cytomegalovirus (cCMV) infection may be challenging mainly because of the high variable sensitivity of PCR on dried blood spots (DBS) samples.
    Objectives: To compare cytomegalovirus (CMV) viral load (VL) values in different samples obtained at birth from infants with cCMV infection. To evaluate dried umbilical cord (DUC) samples as an alternative to DBS.
    Study design: Saliva and/or urine, peripheral blood (PB), and DBS from 16 infants with confirmed cCMV infection were collected at birth. CMV VL were determined by DNA extraction and real-time polymerase chain reaction (rt-PCR). In two cases, VL was determined from DUC samples.
    Results: Six (37.5 %) of the 16 infants were symptomatic, and 10 (62.5 %) were asymptomatic. The CMV VL found in saliva (median: 1,958,525 [IQR: 597,683-3,483,843] IU/mL) and in urine (median: 691,865 [IQR: 188,489.5-3,175,696] UI/mL) were both higher than those found in PB (median: 1115 [IQR: 364-4,002] IU/mL), p: 0.0001). Symptomatic infants presented 100 % of detectable VL in PB and 50 % in DBS. Asymptomatic infants showed 75 % of detectable VL in PB and 30 % in DBS. The VL in DUC were 22,341, 9754 IU/mL and 994 IU/mL.
    Conclusions: When VL was detectable in PB, the values were lower than in saliva or urine, in both symptomatic and asymptomatic cases of cCMV. The low sensitivity in DBS samples could be due to low blood volume content, making CMV VL undetectable even when using optimised extraction and PCR protocols. In our limited experience, DUC could play a complementary diagnostic role when DBS VL is undetectable.
    MeSH term(s) Cytomegalovirus/genetics ; Cytomegalovirus Infections ; DNA, Viral ; Humans ; Infant ; Infant, Newborn ; Neonatal Screening ; Retrospective Studies ; Saliva
    Chemical Substances DNA, Viral
    Language English
    Publishing date 2020-06-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2020.104504
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  7. Article ; Online: MIS-C, Can Latency Interval Help in Diagnosis?

    Mosquera Fernández, Pablo / García García, Sonsoles / Epalza, Cristina / Blázquez-Gamero, Daniel / Carrasco, Jaime / Fernandez-Cook, Elisa / Prieto-Tato, Luis / Torres, David / Villaverde, Serena / Belda, Sylvia / Toral-Vázquez, Belén / Moraleda, Cinta

    The Pediatric infectious disease journal

    2021  Volume 40, Issue 7, Page(s) e281–e282

    MeSH term(s) COVID-19 ; Humans ; Retrospective Studies
    Language English
    Publishing date 2021-06-07
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392481-6
    ISSN 1532-0987 ; 0891-3668
    ISSN (online) 1532-0987
    ISSN 0891-3668
    DOI 10.1097/INF.0000000000003150
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  8. Article ; Online: Tuberculosis screening after detection of a case in a paediatric haemato-oncology unit in a low prevalence country.

    Grasa Lozano, Carlos Daniel / Baro-Fernández, María / Rubio-San-Simón, Alba / Blázquez-Gamero, Daniel / López-Roa, Paula / Liébana, Constanza / Guerra-García, Pilar / Moraleda, Cinta / Epalza, Cristina

    Enfermedades infecciosas y microbiologia clinica (English ed.)

    2022  Volume 40, Issue 8, Page(s) 423–427

    Abstract: Background: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected.: Methods: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to ... ...

    Abstract Background: There are no guidelines to screen haemato-oncologic children when a tuberculosis (TB) outbreak is suspected.
    Methods: After exposition to an adult with active TB, children exposed from a haemato-oncology unit were screened according to immunosuppression status and time of exposure. Until an evaluation after 8-12 weeks from last exposure, isoniazid was indicated to those with negative initial work-up.
    Results: After 210 interventions, we detected a case of pulmonary TB, and another with latent TB infection. Pulmonary findings and treatment approach were challenging in some patients.
    Conclusions: The TB screening of oncologic children required a multidisciplinary approach, and clinicians managed challenging situations.
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Child ; Humans ; Isoniazid ; Latent Tuberculosis/diagnosis ; Prevalence ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology ; Tuberculosis/prevention & control
    Chemical Substances Antitubercular Agents ; Isoniazid (V83O1VOZ8L)
    Language English
    Publishing date 2022-09-10
    Publishing country Spain
    Document type Case Reports ; Journal Article
    ISSN 2529-993X
    ISSN (online) 2529-993X
    DOI 10.1016/j.eimce.2020.12.006
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  9. Article ; Online: Are Infants Less than 6 Months of Age a Neglected Group for Anemia Prevention in Low-Income Countries?

    Moraleda, Cinta / Rabinovich, N Regina / Menéndez, Clara

    The American journal of tropical medicine and hygiene

    2017  Volume 98, Issue 3, Page(s) 647–649

    Abstract: Anemia is a major public health problem that affects mainly children, predominantly in low-income countries and most often due to iron deficiency (ID). Administration of iron supplements to prevent and treat ID anemia in malaria endemic areas has been ... ...

    Abstract Anemia is a major public health problem that affects mainly children, predominantly in low-income countries and most often due to iron deficiency (ID). Administration of iron supplements to prevent and treat ID anemia in malaria endemic areas has been controversial for decades; however, recent World Health Organization guidelines recommend universal iron supplementation for children in highly prevalent anemia settings, including those where malaria is endemic. However, infants younger than 6 months of age have been exempted from this recommendation because ID is not considered prevalent at this age and because of assumptions-without evidence-that they are protected from ID through breast milk. To achieve full impact of anemia prevention targeting infants less than 6 months of age who are at highest risk of ID, operational studies that conclusively demonstrate the effectiveness and safety of delivering iron supplements to young infants in settings with a high burden of infectious diseases, including malaria, are needed.
    MeSH term(s) Anemia, Iron-Deficiency/epidemiology ; Anemia, Iron-Deficiency/prevention & control ; Cost-Benefit Analysis ; Dietary Supplements ; Humans ; Immunization Programs ; Infant ; Infant, Newborn ; Iron/administration & dosage ; Malaria/epidemiology ; Poverty
    Chemical Substances Iron (E1UOL152H7)
    Language English
    Publishing date 2017-12-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.17-0487
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  10. Article ; Online: Brief Report: Suboptimal Lopinavir Exposure in Infants on Rifampicin Treatment Receiving Double-dosed or Semisuperboosted Lopinavir/Ritonavir: Time for a Change.

    Jacobs, Tom G / Mumbiro, Vivian / Chitsamatanga, Moses / Namuziya, Natasha / Passanduca, Alfeu / Domínguez-Rodríguez, Sara / Tagarro, Alfredo / Nathoo, Kusum J / Nduna, Bwendo / Ballesteros, Alvaro / Madrid, Lola / Mujuru, Hilda A / Chabala, Chishala / Buck, W Chris / Rojo, Pablo / Burger, David M / Moraleda, Cinta / Colbers, Angela

    Journal of acquired immune deficiency syndromes (1999)

    2023  Volume 93, Issue 1, Page(s) 42–46

    Abstract: Background: Although super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to ... ...

    Abstract Background: Although super-boosted lopinavir/ritonavir (LPV/r; ratio 4:4 instead of 4:1) is recommended for infants living with HIV and receiving concomitant rifampicin, in clinical practice, many different LPV/r dosing strategies are applied due to poor availability of pediatric separate ritonavir formulations needed to superboost. We evaluated LPV pharmacokinetics in infants with HIV receiving LPV/r dosed according to local guidelines in various sub-Saharan African countries with or without rifampicin-based tuberculosis (TB) treatment.
    Methods: This was a 2-arm pharmacokinetic substudy nested within the EMPIRICAL trial (#NCT03915366). Infants aged 1-12 months recruited into the main study were administered LPV/r according to local guidelines and drug availability either with or without rifampicin-based TB treatment; during rifampicin cotreatment, they received double-dosed (ratio 8:2) or semisuperboosted LPV/r (adding a ritonavir 100 mg crushed tablet to the evening LPV/r dose). Six blood samples were taken over 12 hours after intake of LPV/r.
    Results: In total, 14/16 included infants had evaluable pharmacokinetic curves; 9/14 had rifampicin cotreatment (5 received double-dosed and 4 semisuperboosted LPV/r). The median (IQR) age was 6.4 months (5.4-9.8), weight 6.0 kg (5.2-6.8), and 10/14 were male. Of those receiving rifampicin, 6/9 infants (67%) had LPV Ctrough <1.0 mg/L compared with 1/5 (20%) in the control arm. LPV apparent oral clearance was 3.3-fold higher for infants receiving rifampicin.
    Conclusion: Double-dosed or semisuperboosted LPV/r for infants aged 1-12 months receiving rifampicin resulted in substantial proportions of subtherapeutic LPV levels. There is an urgent need for data on alternative antiretroviral regimens in infants with HIV/TB coinfection, including twice-daily dolutegravir.
    MeSH term(s) Male ; Infant ; Humans ; Child ; Female ; Lopinavir/therapeutic use ; Ritonavir/therapeutic use ; Rifampin/therapeutic use ; HIV Infections/drug therapy ; Anti-HIV Agents/therapeutic use ; HIV Protease Inhibitors/therapeutic use
    Chemical Substances Lopinavir (2494G1JF75) ; Ritonavir (O3J8G9O825) ; Rifampin (VJT6J7R4TR) ; Anti-HIV Agents ; HIV Protease Inhibitors
    Language English
    Publishing date 2023-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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