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  1. Article: Editorial: New insight into the diagnosis and treatment of age-related macular degeneration.

    Servillo, Andrea / Sacconi, Riccardo / Querques, Giuseppe

    Frontiers in medicine

    2022  Volume 9, Page(s) 993349

    Language English
    Publishing date 2022-08-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.993349
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  2. Article: Editorial: Retinal vascular functional assessment in health and disease.

    Servillo, Andrea / Sacconi, Riccardo / Querques, Giuseppe

    Frontiers in neuroscience

    2022  Volume 16, Page(s) 1008112

    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2022.1008112
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Perifoveal Vascular Anomalous Complex and the Spectrum of Degenerative Microvascular Macular Diseases.

    Zucchiatti, Ilaria / Sacconi, Riccardo / Saladino, Andrea / Bandello, Francesco / Querques, Giuseppe

    Retina (Philadelphia, Pa.)

    2023  Volume 43, Issue 8, Page(s) 1219–1225

    MeSH term(s) Humans ; Retinal Diseases ; Vascular Malformations ; Tomography, Optical Coherence ; Fluorescein Angiography ; Fovea Centralis/blood supply
    Language English
    Publishing date 2023-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article ; Online: Letter to the Editor regarding "Ophthalmic artery angioplasty for age-related macular degeneration".

    Servillo, Andrea / Sacconi, Riccardo / Ribarich, Nicolò / Querques, Giuseppe

    Journal of neurointerventional surgery

    2022  Volume 14, Issue 10, Page(s) 1046

    MeSH term(s) Angioplasty ; Humans ; Macular Degeneration/surgery ; Ophthalmic Artery/diagnostic imaging ; Ophthalmic Artery/surgery
    Language English
    Publishing date 2022-03-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2022-018750
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  5. Article: Optical Coherence Tomography Angiography: A 2023 Focused Update on Age-Related Macular Degeneration.

    Tombolini, Beatrice / Crincoli, Emanuele / Sacconi, Riccardo / Battista, Marco / Fantaguzzi, Federico / Servillo, Andrea / Bandello, Francesco / Querques, Giuseppe

    Ophthalmology and therapy

    2024  Volume 13, Issue 2, Page(s) 449–467

    Abstract: Optical coherence tomography angiography (OCTA) has extensively enhanced our comprehension of eye microcirculation and of its associated diseases. In this narrative review, we explored the key concepts behind OCTA, as well as the most recent evidence in ... ...

    Abstract Optical coherence tomography angiography (OCTA) has extensively enhanced our comprehension of eye microcirculation and of its associated diseases. In this narrative review, we explored the key concepts behind OCTA, as well as the most recent evidence in the pathophysiology of age-related macular degeneration (AMD) made possible by OCTA. These recommendations were updated since the publication in 2020, and are targeted for 2023. Importantly, as a future perspective in OCTA technology, we will discuss how artificial intelligence has been applied to OCTA, with a particular emphasis on its application to AMD study.
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2193-8245
    ISSN 2193-8245
    DOI 10.1007/s40123-023-00870-2
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  6. Article ; Online: Editorial

    Andrea Servillo / Riccardo Sacconi / Giuseppe Querques

    Frontiers in Medicine, Vol

    New insight into the diagnosis and treatment of age-related macular degeneration

    2022  Volume 9

    Keywords age-related macula degeneration ; anti-vascular endothelial growth factor ; neovascularization ; treatment ; diagnosis ; Medicine (General) ; R5-920
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Shedding Light on Photobiomodulation Therapy for Age-Related Macular Degeneration: A Narrative Review.

    Fantaguzzi, Federico / Tombolini, Beatrice / Servillo, Andrea / Zucchiatti, Ilaria / Sacconi, Riccardo / Bandello, Francesco / Querques, Giuseppe

    Ophthalmology and therapy

    2023  Volume 12, Issue 6, Page(s) 2903–2915

    Abstract: Background: Photobiomodulation (PBM) relies on the pathophysiological mechanism whereby red to near-infrared light can target mitochondrial activity and promote ATP synthesis. Preclinical and clinical studies have shown promising results in treating ... ...

    Abstract Background: Photobiomodulation (PBM) relies on the pathophysiological mechanism whereby red to near-infrared light can target mitochondrial activity and promote ATP synthesis. Preclinical and clinical studies have shown promising results in treating intermediate age-related macular degeneration (AMD), since PBM can produce photochemical reactions in endogenous retinal chromophores. Currently, PBM is approved by the Food and Drug Administration and by the European Medicines Agency for the treatment of intermediate AMD. This narrative review aimed to evaluate the available evidence on the effectiveness and safety of PBM in treating intermediate AMD.
    Methods: A comprehensive search was conducted using the PubMed database, employing the keywords "photobiomodulation" and "age-related macular degeneration." All English-language studies published up to June 2023 were reviewed, and the search was expanded to include relevant references from selected articles. The included publications were analyzed for this review.
    Results: The available studies on PBM in AMD demonstrated promising but inconsistent results. PBM showed potential in improving best-corrected visual acuity (BCVA) and contrast sensitivity (CS) in patients with AMD. Some studies also suggested a reduction in AMD lesions, such as drusen volume. However, the long-term efficacy and optimal treatment parameters of PBM in AMD remained to be fully determined due to the limitations of the available studies. These included variations in irradiation techniques, wavelengths, exposure times, and treatment sessions, making it challenging to generalize the effectiveness of PBM. Furthermore, the lack of accurate classification of AMD phenotypes in the available studies hindered the understanding of which phenotypes could truly benefit from this treatment. Finally, the strength of evidence varied among studies, with limited sample sizes, unpublished results, and only three randomized sham-controlled trials.
    Conclusions: Currently, the effectiveness of PBM in promoting drusen resorption or preventing progression to advanced forms of AMD, as observed in the cited studies, remains uncertain.
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2193-8245
    ISSN 2193-8245
    DOI 10.1007/s40123-023-00812-y
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  8. Article: Modelling start-up injection of CO2 into highly-depleted gas fields

    Sacconi, Andrea / Mahgerefteh, Haroun

    Energy. 2019 Nov. 09,

    2019  

    Abstract: The development and verification of a homogeneous relaxation model for simulating the highly transient flow phenomena taking place during the start-up injection of CO2 into deep highly depleted gas fields is presented. The constituent mass, momentum, and ...

    Abstract The development and verification of a homogeneous relaxation model for simulating the highly transient flow phenomena taking place during the start-up injection of CO2 into deep highly depleted gas fields is presented. The constituent mass, momentum, and energy conservation equations, incorporating a relaxation time to account for non-equilibrium effects, are solved numerically for single and two-phase flows along the steel lined injection well leading to the storage reservoir. Wall friction, gravitational field effects and heat transfer between the expanding fluid and the outer well layers are taken into account as source terms in the conservation equations. At the well inlet, the opening of the upstream flow regulator valve is modelled as an isenthalpic expansion process; whilst at the well outlet, a formation-specific pressure-mass flow rate correlation is adopted to characterise the storage site injectivity. The testing of the model is based on its application to CO2 injection into the depleted Golden Eye Reservoir in the North Sea for which the required design and operational data are publically available. Three injection scenarios involving a rapid, medium and slow linear ramping up of the injected CO2 flow rate to the peak nominal value of 33.5 kg/s are simulated. In each case, the predicted pressure and temperature transients at the top and bottom of the well are employed to ascertain the risks of well-bore thermal shocking, and interstitial ice or CO2 hydrate formation leading to its blockage due to the rapid expansion cooling of the CO2. The results demonstrate the efficacy of the proposed model as a tool for the development of optimal injection strategies and best-practice guidelines for the minimisation of the risks associated with the start-up injection of CO2 into depleted gas fields.
    Keywords carbon dioxide ; cooling ; energy conservation ; equations ; friction ; guidelines ; heat transfer ; ice ; models ; momentum ; risk ; steel ; temperature ; transient flow ; North Sea
    Language English
    Dates of publication 2019-1109
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 2019804-8
    ISSN 0360-5442 ; 0360-5442
    ISSN (online) 0360-5442
    ISSN 0360-5442
    DOI 10.1016/j.energy.2019.116530
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Functionality of retinal vessels in central serous retinopathy: A comparison between eplerenone and photodynamic therapy.

    Tombolini, Beatrice / Battista, Marco / Sacconi, Riccardo / Servillo, Andrea / Camisa, Ludovica / Bandello, Francesco / Querques, Giuseppe

    European journal of ophthalmology

    2022  Volume 33, Issue 3, Page(s) 1443–1451

    Abstract: Purpose: To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), ... ...

    Abstract Purpose: To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), respectively.
    Methods: Treatment naïve acute CSC patients presenting between May 2017 and June 2017 were recruited. A complete ophthalmological examination was performed in all participants before and after oral eplerenone (eplerenone group) or half-dose PDT (PDT group).
    Results: Eighteen eyes of 18 patients affected by acute CSC underwent either oral eplerenone (10 eyes of 10 patients, 47.6 ± 8.9 years old) or half-dose PDT (8 eyes of 8 patients, 57.4 ± 6.2 years old), respectively. After 2 months of treatment, non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were reported in eplerenone group. Similarly, in PDT group non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were found after 2 months of treatment.
    Conclusions: Static and dynamic retinal functionalities in acute CSC may not be significantly improved by oral eplerenone and half-dose PDT. Although their choroidal effects, these treatments could not exert a significant effect on retinal vessels motility. Thus, both local and systemic therapies might not help avoiding the onset of vascular and other retinal known alterations of CSC.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Central Serous Chorioretinopathy/diagnosis ; Central Serous Chorioretinopathy/drug therapy ; Eplerenone/therapeutic use ; Photochemotherapy ; Fluorescein Angiography ; Tomography, Optical Coherence ; Retinal Vessels ; Photosensitizing Agents/therapeutic use ; Porphyrins/therapeutic use ; Chronic Disease
    Chemical Substances Eplerenone (6995V82D0B) ; Photosensitizing Agents ; Porphyrins
    Language English
    Publishing date 2022-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1089461-5
    ISSN 1724-6016 ; 1120-6721
    ISSN (online) 1724-6016
    ISSN 1120-6721
    DOI 10.1177/11206721221145049
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    Zs.A 3342: Show issues Location:
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  10. Article ; Online: Comparison of peripheral extension, acquisition time, and image chromaticity of Optos, Clarus, and EIDON systems.

    Fantaguzzi, Federico / Servillo, Andrea / Sacconi, Riccardo / Tombolini, Beatrice / Bandello, Francesco / Querques, Giuseppe

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2022  Volume 261, Issue 5, Page(s) 1289–1297

    Abstract: Purpose: To evaluate differences in acquisition time, peripheral extension, and chromaticity between 3 different commercialized ultra-wide-field (UWF) fundus cameras.: Methods: Patients were prospectively enrolled from 07/2021 to 11/2021. Patients ... ...

    Abstract Purpose: To evaluate differences in acquisition time, peripheral extension, and chromaticity between 3 different commercialized ultra-wide-field (UWF) fundus cameras.
    Methods: Patients were prospectively enrolled from 07/2021 to 11/2021. Patients underwent fundus photography with the following scanning protocols: (1) single shot with Silverstone (Optos, California), two-shot montage with Clarus 500 (Carl Zeiss, Dublin, CA), and three-shot montage with iCare EIDON FA with UWF module (CenterVue Spa, a company of iCare Finland Oy; Vantaa, Finland). Acquisition time was calculated as the interval between the beginning and the end of the acquisition. Peripheral extension was quantified as the average ratio between the total retinal pixel area and the optic nerve head (ONH) pixel area. The average chromaticity of all pixels in the red-green-blue (RGB) space was calculated.
    Results: Twenty-three eyes of 13 prospectively enrolled healthy controls were included in the study. Optos Silverstone had a higher total retina area/ONH area ratio (509.1 [480.9;559.3]) compared to Zeiss Clarus (442.0 [431.9;510.5], p = 0.02) and iCare EIDON (369.7 [345.3;387.8], p < 0.0001). Silverstone demonstrated the shortest acquisition time (median [interquartile range]: 32 [20;58.5] s) compared to Zeiss Clarus (42 [28.5;53.5] s, p = 0.6733) and iCare EIDON (72 [68.5;78] s, p = 0.0003). iCare EIDON demonstrated the lowest variability of acquisition time (9.5 s), compared to Zeiss Clarus (25 s) and Optos Silverstone (38.5 s). A statistically significant difference was found in the RGB distribution between each of the 3 devices (p < 0.001). iCare EIDON demonstrated an average barycenter position (RGB = [0.412, 0.314, 0.275]) that represented the best color balance of the image. Zeiss Clarus had a noticeable red shift at the expense of the blue and green channels (RGB = [0.515, 0.294, 0.191]). Optos Silverstone showed an absence of the blue channel (RGB = [0.621, 0.372, 0.007]) which results in a distortion of the color of the image.
    Conclusion: Optos Silverstone and Zeiss Clarus required less time than iCare EIDON to acquire a comparable size image and captured larger areas of the retina than iCare EIDON. iCare EIDON provided more color-balanced retinal images with greater richness of color content than the other two devices.
    MeSH term(s) Humans ; Retina ; Fluorescein Angiography/methods ; Diagnostic Techniques, Ophthalmological ; Optic Disk ; Photography/methods ; Fundus Oculi
    Language English
    Publishing date 2022-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-022-05923-z
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