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Article ; Online: 'Disease X'-time to act now and prepare for the next pandemic threat.

Mipatrini, Daniele / Montaldo, Chiara / Bartolini, Barbara / Rezza, Giovanni / Iavicoli, Sergio / Ippolito, Giuseppe / Zumla, Alimuddin / Petersen, Eskild

European journal of public health

2022 Volume 32, Issue 6, Page(s) 841–842

MeSH term(s)	Humans ; Pandemics/prevention & control
Language	English
Publishing date	2022-10-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1129243-x
ISSN	1464-360X ; 1101-1262
ISSN (online)	1464-360X
ISSN	1101-1262
DOI	10.1093/eurpub/ckac151
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Article ; Online: The Relationship Between Childhood Trauma, Pathological Dissociation, and Behavioral Addictions in Young Adults: Findings from a Cross-Sectional Study.

Imperatori, Claudio / Barchielli, Benedetta / Corazza, Ornella / Carbone, Giuseppe Alessio / Prevete, Elisabeth / Montaldo, Simone / De Rossi, Elena / Massullo, Chiara / Tarsitani, Lorenzo / Ferracuti, Stefano / Pasquini, Massimo / Biondi, Massimo / Farina, Benedetto / Bersani, Francesco Saverio

Journal of trauma & dissociation : the official journal of the International Society for the Study of Dissociation (ISSD)

2023 Volume 24, Issue 3, Page(s) 348–361

Abstract: Interactions between childhood trauma (CT) and dissociation can contribute to psychiatric disturbances. We explored this phenomenon in relation to behavioral addictions (BAs) in a sample ( ...

Abstract	Interactions between childhood trauma (CT) and dissociation can contribute to psychiatric disturbances. We explored this phenomenon in relation to behavioral addictions (BAs) in a sample (
MeSH term(s)	Humans ; Young Adult ; Adolescent ; Adult ; Cross-Sectional Studies ; Adverse Childhood Experiences ; Behavior, Addictive/diagnosis ; Behavior, Addictive/psychology ; Gambling/psychology ; Dissociative Disorders
Language	English
Publishing date	2023-02-22
Publishing country	England
Document type	Journal Article
ISSN	1529-9740
ISSN (online)	1529-9740
DOI	10.1080/15299732.2023.2181479
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Article ; Online: Contrast-enhanced ultrasound applications in liver transplant imaging.

Como, Giuseppe / Montaldo, Luca / Baccarani, Umberto / Lorenzin, Dario / Zuiani, Chiara / Girometti, Rossano

Abdominal radiology (New York)

2020 Volume 46, Issue 1, Page(s) 84–95

Abstract: Contrast-enhanced ultrasound (CEUS) is gaining ever-increasing acceptance in the preoperative and postoperative evaluation of liver-transplanted patients. While indications are still a matter of research, CEUS is used in tertiary centers to supplement ... ...

Abstract	Contrast-enhanced ultrasound (CEUS) is gaining ever-increasing acceptance in the preoperative and postoperative evaluation of liver-transplanted patients. While indications are still a matter of research, CEUS is used in tertiary centers to supplement ultrasound (US) and Color Doppler US examination, with the potential of providing a comprehensive first-line ultrasound-based diagnosis. Alternatively, CEUS is used as a problem-solving tool when previous cross-sectional or US imaging was inconclusive, especially in assessing hepatocellular carcinoma, parenchymal perfusion abnormalities, the vascular status, and even the biliary tree. This review describes the potential use for CEUS in the setting of orthotopic liver transplantation (OLT).
MeSH term(s)	Contrast Media ; Cross-Sectional Studies ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Liver Transplantation ; Ultrasonography
Chemical Substances	Contrast Media
Language	English
Publishing date	2020-01-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2839786-1
ISSN	2366-0058 ; 2366-004X
ISSN (online)	2366-0058
ISSN	2366-004X
DOI	10.1007/s00261-020-02402-z
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Article ; Online: COVID-19 welbeing study: a protocol examining perceived coercion and psychological well-being during the COVID-19 pandemic by means of an online survey, asynchronous virtual focus groups and individual interviews.

Ranieri, Veronica / Sem Stoltenberg, Andrea / Pizzo, Elena / Montaldo, Chiara / Bizzi, Emanuele / Edwards, Sarah / Kamboj, Sunjeev

BMJ open

2021 Volume 11, Issue 1, Page(s) e043418

Abstract: Introduction: The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been ... ...

Abstract	Introduction: The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been chronicled in studies pertaining to previous infectious disease pandemics that have reported the presence of depressive symptoms, anxiety, insomnia, and post-traumatic stress symptoms. Potentially linked to psychological well-being and not yet studied is the possibility that lockdown and working on the frontline of the pandemic are associated with perceptions of coercion. Methods and analysis: The present study aimed to examine perceived coercion in those who have experienced COVID-19-related lockdown and/or worked as a frontline healthcare worker across three European countries. It aimed to describe how such perceptions may impact on psychological well-being, coping and post-traumatic growth. It will employ an explanatory mixed-methods research methodology consisting of an online survey and online asynchronous virtual focus groups (AVFGs) and individual interviews. χ Ethics and dissemination: The study has been approved by University College London's Research Ethics Committee under Project ID Number 7335/004. Results will be disseminated by means of peer-reviewed publications and at national and/or international conferences.
MeSH term(s)	Adaptation, Psychological ; COVID-19/epidemiology ; COVID-19/psychology ; Coercion ; Europe/epidemiology ; Focus Groups ; Health Personnel/psychology ; Humans ; Mental Health ; Pandemics ; Perception ; Physical Distancing ; Psychological Distress ; SARS-CoV-2 ; Stress, Psychological
Language	English
Publishing date	2021-01-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-043418
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Article ; Online: COVID-19 welbeing study

Sarah Edwards / Elena Pizzo / Veronica Ranieri / Andrea Sem Stoltenberg / Chiara Montaldo / Emanuele Bizzi / Sunjeev Kamboj

BMJ Open, Vol 11, Iss

a protocol examining perceived coercion and psychological well-being during the COVID-19 pandemic by means of an online survey, asynchronous virtual focus groups and individual interviews

2021 Volume 1

Abstract: Introduction The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been ... ...

Abstract	Introduction The COVID-19 pandemic has resulted in many countries applying restrictive measures, such as lockdown, to contain and prevent further spread. The psychological impact of lockdown and working as a healthcare worker on the frontline has been chronicled in studies pertaining to previous infectious disease pandemics that have reported the presence of depressive symptoms, anxiety, insomnia, and post-traumatic stress symptoms. Potentially linked to psychological well-being and not yet studied is the possibility that lockdown and working on the frontline of the pandemic are associated with perceptions of coercion.Methods and analysis The present study aimed to examine perceived coercion in those who have experienced COVID-19-related lockdown and/or worked as a frontline healthcare worker across three European countries. It aimed to describe how such perceptions may impact on psychological well-being, coping and post-traumatic growth. It will employ an explanatory mixed-methods research methodology consisting of an online survey and online asynchronous virtual focus groups (AVFGs) and individual interviews. χ2 tests and analyses of variance will be used to examine whether participants from different countries differ according to demographic factors, whether there are differences between cohorts on perceived coercion, depression, anxiety and post-traumatic growth scores. The relationship between coercion and symptoms of distress will be assessed using multiple regression. Both the AVFGs and the narrative interviews will be analysed using thematic narrative analysis.Ethics and dissemination The study has been approved by University College London’s Research Ethics Committee under Project ID Number 7335/004. Results will be disseminated by means of peer-reviewed publications and at national and/or international conferences.
Keywords	Medicine ; R
Subject code	150
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Group 3 innate lymphoid cells (ILC3s): Origin, differentiation, and plasticity in humans and mice.

Montaldo, Elisa / Juelke, Kerstin / Romagnani, Chiara

European journal of immunology

2015 Volume 45, Issue 8, Page(s) 2171–2182

Abstract: Since their discovery, innate lymphoid cells (ILCs) have been the subject of intense research. As their name implies, ILCs are innate cells of lymphoid origin, and can be grouped into subsets based on their cytotoxic activity, cytokine profile, and the ... ...

Abstract	Since their discovery, innate lymphoid cells (ILCs) have been the subject of intense research. As their name implies, ILCs are innate cells of lymphoid origin, and can be grouped into subsets based on their cytotoxic activity, cytokine profile, and the transcriptional requirements during ILC differentiation. The main ILC groups are "killer" ILCs, comprising NK cells, and "helper-like" ILCs (including ILC1s, ILC2s, and ILC3s). This review examines the origin, differentiation stages, and plasticity of murine and human ILC3s. ILC3s express the retinoic acid receptor (RAR) related orphan receptor RORγt and the signature cytokines IL-22 and IL-17. Fetal ILC3s or lymphoid tissue inducer cells are required for lymphoid organogenesis, while postnatally developing ILC3s are important for the generation of intestinal cryptopatches and isolated lymphoid follicles as well as for the defence against pathogens and epithelial homeostasis. Here, we discuss the transcription factors and exogenous signals (including cytokines, nutrients and cell-to-cell interaction) that drive ILC3 lineage commitment and acquisition of their distinctive effector program.
MeSH term(s)	Animals ; Gene Expression Regulation/immunology ; Humans ; Immunity, Innate/physiology ; Interleukin-17/immunology ; Interleukins/immunology ; Lymphocytes/cytology ; Lymphocytes/immunology ; Mice ; Nuclear Receptor Subfamily 1, Group F, Member 3/immunology ; Interleukin-22
Chemical Substances	Interleukin-17 ; Interleukins ; Nuclear Receptor Subfamily 1, Group F, Member 3 ; RORC protein, human
Language	English
Publishing date	2015-06-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201545598
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effect of Tyrosin Kinase Inhibitors on NK Cell and ILC3 Development and Function.

Damele, Laura / Montaldo, Elisa / Moretta, Lorenzo / Vitale, Chiara / Mingari, Maria Cristina

Frontiers in immunology

2018 Volume 9, Page(s) 2433

Abstract: Tyrosin kinase inhibitors (TKI) sharply improved the prognosis of Chronic Myeloid Leukemia (CML) and of ... ...

Abstract	Tyrosin kinase inhibitors (TKI) sharply improved the prognosis of Chronic Myeloid Leukemia (CML) and of Philadelphia
MeSH term(s)	Antineoplastic Agents/therapeutic use ; CD56 Antigen/metabolism ; Cell Differentiation ; Cells, Cultured ; Cytotoxicity, Immunologic ; Dasatinib/pharmacology ; Dasatinib/therapeutic use ; Drug Resistance, Neoplasm ; Hematopoietic Stem Cells/physiology ; Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Interleukins/metabolism ; Killer Cells, Natural/immunology ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Lymphocytes/physiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Protein Kinase Inhibitors/therapeutic use ; Pyrimidines/pharmacology ; Pyrimidines/therapeutic use ; Receptors, IgG/metabolism ; STAT5 Transcription Factor/metabolism ; Signal Transduction ; Interleukin-22
Chemical Substances	Antineoplastic Agents ; CD56 Antigen ; Interleukins ; Protein Kinase Inhibitors ; Pyrimidines ; Receptors, IgG ; STAT5 Transcription Factor ; Imatinib Mesylate (8A1O1M485B) ; nilotinib (F41401512X) ; Dasatinib (RBZ1571X5H)
Language	English
Publishing date	2018-10-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02433
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Article ; Online: Multi-omics approach to COVID-19: a domain-based literature review.

Journal of translational medicine

2021 Volume 19, Issue 1, Page(s) 501

Abstract: Background: Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and ... ...

Abstract	Background: Omics data, driven by rapid advances in laboratory techniques, have been generated very quickly during the COVID-19 pandemic. Our aim is to use omics data to highlight the involvement of specific pathways, as well as that of cell types and organs, in the pathophysiology of COVID-19, and to highlight their links with clinical phenotypes of SARS-CoV-2 infection. Methods: The analysis was based on the domain model, where for domain it is intended a conceptual repository, useful to summarize multiple biological pathways involved at different levels. The relevant domains considered in the analysis were: virus, pathways and phenotypes. An interdisciplinary expert working group was defined for each domain, to carry out an independent literature scoping review. Results: The analysis revealed that dysregulated pathways of innate immune responses, (i.e., complement activation, inflammatory responses, neutrophil activation and degranulation, platelet degranulation) can affect COVID-19 progression and outcomes. These results are consistent with several clinical studies. Conclusions: Multi-omics approach may help to further investigate unknown aspects of the disease. However, the disease mechanisms are too complex to be explained by a single molecular signature and it is necessary to consider an integrated approach to identify hallmarks of severity.
MeSH term(s)	COVID-19 ; Humans ; Immunity, Innate ; Pandemics ; SARS-CoV-2
Language	English
Publishing date	2021-12-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-021-03168-8
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Article: Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 Infection.

Matusali, Giulia / Trionfetti, Flavia / Bordoni, Veronica / Nardacci, Roberta / Falasca, Laura / Colombo, Daniele / Terri, Michela / Montaldo, Claudia / Castilletti, Concetta / Mariotti, Davide / Del Nonno, Franca / Capobianchi, Maria Rosaria / Agrati, Chiara / Tripodi, Marco / Strippoli, Raffaele

Frontiers in molecular biosciences

2021 Volume 8, Page(s) 752616

Abstract: Although lung fibrosis has a major impact in COVID-19 disease, its pathogenesis is incompletely understood. In particular, no direct evidence of pleura implication in COVID-19-related fibrotic damage has been reported so far. In this study, the ... ...

Abstract	Although lung fibrosis has a major impact in COVID-19 disease, its pathogenesis is incompletely understood. In particular, no direct evidence of pleura implication in COVID-19-related fibrotic damage has been reported so far. In this study, the expression of epithelial cytokeratins and Wilms tumor 1 (WT1), specific markers of mesothelial cells (MCs), was analyzed in COVID-19 and unrelated pleura autoptic samples. SARS-CoV-2 replication was analyzed by RT-PCR and confocal microscopy in MeT5A, a pleura MC line. SARS-CoV-2 receptors were analyzed by RT-PCR and western blot. Inflammatory cytokines from the supernatants of SARS-CoV-2-infected MeT5A cells were analysed by Luminex and ELLA assays. Immunohistochemistry of COVID-19 pleura patients highlighted disruption of pleura monolayer and fibrosis of the sub-mesothelial stroma, with the presence of MCs with fibroblastoid morphology in the sub-mesothelial stroma, but no evidence of direct infection
Language	English
Publishing date	2021-11-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2021.752616
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Article ; Online: Looking for pathways related to COVID-19: confirmation of pathogenic mechanisms by SARS-CoV-2-host interactome.

Messina, Francesco / Giombini, Emanuela / Montaldo, Chiara / Sharma, Ashish Arunkumar / Zoccoli, Antonio / Sekaly, Rafick-Pierre / Locatelli, Franco / Zumla, Alimuddin / Maeurer, Markus / Capobianchi, Maria R / Lauria, Francesco Nicola / Ippolito, Giuseppe

Cell death & disease

2021 Volume 12, Issue 8, Page(s) 788

Abstract: In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of interaction between host and SARS-CoV-2, determining the grade of COVID-19 severity, are still unknown. We ... ...

Abstract	In the last months, many studies have clearly described several mechanisms of SARS-CoV-2 infection at cell and tissue level, but the mechanisms of interaction between host and SARS-CoV-2, determining the grade of COVID-19 severity, are still unknown. We provide a network analysis on protein-protein interactions (PPI) between viral and host proteins to better identify host biological responses, induced by both whole proteome of SARS-CoV-2 and specific viral proteins. A host-virus interactome was inferred, applying an explorative algorithm (Random Walk with Restart, RWR) triggered by 28 proteins of SARS-CoV-2. The analysis of PPI allowed to estimate the distribution of SARS-CoV-2 proteins in the host cell. Interactome built around one single viral protein allowed to define a different response, underlining as ORF8 and ORF3a modulated cardiovascular diseases and pro-inflammatory pathways, respectively. Finally, the network-based approach highlighted a possible direct action of ORF3a and NS7b to enhancing Bradykinin Storm. This network-based representation of SARS-CoV-2 infection could be a framework for pathogenic evaluation of specific clinical outcomes. We identified possible host responses induced by specific proteins of SARS-CoV-2, underlining the important role of specific viral accessory proteins in pathogenic phenotypes of severe COVID-19 patients.
MeSH term(s)	COVID-19/metabolism ; COVID-19/virology ; Host Microbial Interactions ; Immunity/immunology ; Protein Interaction Maps/physiology ; Proteome ; Proteomics/methods ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Viral Proteins/metabolism ; Viral Regulatory and Accessory Proteins/metabolism
Chemical Substances	Proteome ; Viral Proteins ; Viral Regulatory and Accessory Proteins
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-03881-8
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