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Article: Multifaceted Nature of Social Media Content Propagating COVID-19 Vaccine Hesitancy: Ukrainian Case.

Zakharchenko, Olena / Avramenko, Roksolana / Zakharchenko, Artem / Korobchuk, Anastasiya / Fedushko, Solomiia / Syerov, Yuriy / Trach, Olha

Procedia computer science

2022 Volume 198, Page(s) 682–687

Abstract: COVID-19 became an issue affecting different parts of our life. Different communication campaigns use vaccination as an information peg, argument in discussions, and so on. As a result, they have an impact on people's attitudes to immunization. We ... ...

Abstract	COVID-19 became an issue affecting different parts of our life. Different communication campaigns use vaccination as an information peg, argument in discussions, and so on. As a result, they have an impact on people's attitudes to immunization. We applied the message analysis to the dataset of social media posts from Ukraine to detect the messages used in the communication regarding the vaccine and reveal communication campaigns propagating these messages. We found five campaigns launched by different actors and shaping the attitude to COVID-19 immunization expressed in the people's posts. The incoherence of the information about immunization and authorities' inconsistency in the communications about vaccines may lead to vaccine hesitancy and undermine confidence in the sources of the official information about COVID-19. Vaccine hesitancy has multifaceted nature and cannot be reduced just to politicians' conspiracy theories or far-right propaganda.
Language	English
Publishing date	2022-01-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2557358-5
ISSN	1877-0509
ISSN	1877-0509
DOI	10.1016/j.procs.2021.12.306
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Article ; Online: GUARANTEE OF SAFE INNOVATIVE DEVELOPMENT OF THE TOURIST INDUSTRY OF UKRAINE

Natalia TRUSOVA / Tetiana KRASNODIED / Valentina DEMKO / Olena ZAKHARCHENKO / Olena MOROZOVA / Yana KATSEMIR

Geo Journal of Tourism and Geosites, Vol 41, Iss 2, Pp 422-

2022 Volume 432

Abstract: Introduction. The article considers the conditions for providing a guarantee of safe innovative development of the tourism industry of Ukraine. The study was aimed at finding ways to ensure safe innovative development of the tourism industry in Ukraine. ... ...

Abstract	Introduction. The article considers the conditions for providing a guarantee of safe innovative development of the tourism industry of Ukraine. The study was aimed at finding ways to ensure safe innovative development of the tourism industry in Ukraine. Method. A comprehensive approach to assessing the safe state of innovative development of the tourism industry in the economic system of the country was substantiated. Results and interpretation. The system of indicators for assessing the level of the social component of safe innovative development of the tourism industry in the territorial tourist destination was presented. The trend of changing the number of tourism entities in the TTD and Ukraine as a whole in terms of the functionality of a secure system of innovative development is analyzed. Optimization methods of risk management of safe innovative development of tourist enterprises in the territorial tourist destination are offered. The general index of a safe condition of innovative development of territorial tourist destinations is offered and defined.
Keywords	tourism business ; territorial tourist destination ; security ; regulatory barriers ; Geography. Anthropology. Recreation ; G ; Geography (General) ; G1-922
Subject code	910 ; 380
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Editura Universităţii din Oradea
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatial Heterogeneity of Soil Silicon in Ukrainian Phaozems and Chernozems

Oksana Tonkha / Andrii Butenko / Olga Bykova / Yuriy Kravchenko / Olena Pikovska / Vitalii Kovalenko / Iryna Evpak / Ihor Masyk / Elina Zakharchenko

Journal of Ecological Engineering, Vol 22, Iss 2, Pp 111-

2021 Volume 119

Abstract: This study investigated the spatial variability of the soil silicon content in relation with topography, parent materials, soil texture, soil organic matter, exchangeable cations and pH. Using the experimental data from two longterm sites in the Forest- ... ...

Abstract	This study investigated the spatial variability of the soil silicon content in relation with topography, parent materials, soil texture, soil organic matter, exchangeable cations and pH. Using the experimental data from two longterm sites in the Forest-Steppe area of Ukraine, the SiO2 content was estimated in 60 samples taken from a soil depth 0-25 cm. The accumulation of SiO2 was significantly greater in the soils formed in footslopes. A content of extractable silicon fraction significantly increased from a sandy loam- (366-465 mg•kg-1) to medium- (670-697 mg•kg-1) and heavy- (506-849 mg•kg-1) textured soils. The highest amount of available silicon content was found in the soils containing: 35.0-39.9% of physical clay fraction (< 0.01-mm dia) in Hrytsiv area – 143.0 ± 46 mg•kg-1 and < 25.0% of physical clay fraction in Khrolyn area – 125.0 ±6 mg•kg-1. A significant relationship was found between pHKCl, P2O5, K2O, Mg and both forms of SiO2. There was almost no correlation between available/ extractable SiO2 and exchangeable Ca and ∑ Ca+Mg. Our studies found the best correlation between extractable SiO2 and spring barley yield (r = 0.651; P = 0.041), as well as soluble SiO2 and corn for grain yield (r = 0.514; P = 0.128). No significant relationships were found for sugar beet, winter wheat, sunflower. This fact can be explained by the significant influence of other factors on crop yields, such as: fertilizing system, soil organic matter content, available moisture content, major nutrients content in soil, etc.
Keywords	ph ; fertilization ; silicon ; soil texture ; chernozem ; exchangeable cations ; Environmental technology. Sanitary engineering ; TD1-1066 ; Environmental sciences ; GE1-350
Subject code	910
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Polish Society of Ecological Engineering (PTIE)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: State support of agricultural producers as a factor in increasing the competitiveness of the agricultural sector

Oleg V. Zakharchenko / Olena O. Alieksieichuk / Alena V. Kliuchnyk / Nataliya Yu. Shyriaieva / Іrina V. Kudlai

Entrepreneurship and Sustainability Issues, Vol 8, Iss 1, Pp 687-

2020 Volume 704

Keywords	Environmental sciences ; GE1-350 ; Technological innovations. Automation ; HD45-45.2
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Entrepreneurship and Sustainability Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Initial airflow obstruction in new cases of pulmonary tuberculosis: Complication, comorbidity or missed?

Dudnyk, Andrii / Blyzniuk, Svitlana / Pavel'chuk, Oleksandr / Zakharchenko, Olena / Butov, Dmytro / Zaіkov, Sergiі

The Indian journal of tuberculosis

2017 Volume 65, Issue 1, Page(s) 63–69

Abstract: Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown.: Objectives: To measure frequency of AO in new TB cases at the beginning of ...

Abstract	Tuberculosis (TB) may have a similar spirometry findings as a chronic obstructive pulmonary disease but the prevalence of TB-induced airflow obstruction (AO) is still unknown. Objectives: To measure frequency of AO in new TB cases at the beginning of treatment and to evaluate factors associated with obstructive abnormalities following TB diagnosis. Materials and methods: 317 patients that have no history of prior AO were recruited into the study with a median age of 39.0 years (IQR, 30.0-49.0). AO was defined using the FEV Results: AO was detected in 29.97% (95/317) new TB cases. These patients had a more severe clinical manifestation of TB with a greater likelihood of cough, OR=5.47 (95%CI 1.90-15.70) and wheezing, OR=10.51 (95%CI 5.72-19.27), p<0.001. The frequency of AO was positively associated with bronchoscopic evidence of narrowing of the main airways. Furthermore, from multiple logistic regression analysis we would assume that higher FEV Conclusions: Obstructive pattern on spirometry frequently occurs in new TB cases without previously detected AO. This category of patients should be targeted for detailed follow-up, particularly, in high TB burden countries.
MeSH term(s)	Adolescent ; Adult ; Aged ; Airway Obstruction/diagnosis ; Airway Obstruction/epidemiology ; Airway Obstruction/etiology ; Bronchoscopy ; Comorbidity/trends ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Risk Factors ; Spirometry ; Tuberculosis, Pulmonary/complications ; Tuberculosis, Pulmonary/epidemiology ; Ukraine/epidemiology ; Young Adult
Language	English
Publishing date	2017-04-09
Publishing country	India
Document type	Journal Article
ZDB-ID	603129-8
ISSN	0019-5707 ; 0019-5705
ISSN	0019-5707 ; 0019-5705
DOI	10.1016/j.ijtb.2017.03.005
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Article ; Online: A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistance.

Zakharchenko, Olena / Cojoc, Monica / Dubrovska, Anna / Souchelnytskyi, Serhiy

PloS one

2013 Volume 8, Issue 5, Page(s) e65163

Abstract: Transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis, although mechanisms defining its tumor suppressing and tumor promoting activities are not understood. Here we describe phosphoproteome profiling of TGFβ signaling in mammary ... ...

Abstract	Transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis, although mechanisms defining its tumor suppressing and tumor promoting activities are not understood. Here we describe phosphoproteome profiling of TGFβ signaling in mammary epithelial cells, and show that 60 identified TGFβ-regulated phosphoproteins form a network with scale-free characteristics. The network highlighted interactions, which may distribute signaling inputs to regulation of cell proliferation, metabolism, differentiation and cell organization. In this report, we identified two novel and TGFβ-dependent phosphorylation sites of 14-3-3σ, i.e. Ser69 and Ser74. We observed that 14-3-3σ phosphorylation is a feed-forward mechanism in TGFβ/Smad3-dependent transcription. TGFβ-dependent 14-3-3σ phosphorylation may provide a scaffold for the formation of the protein complexes which include Smad3 and p53 at the Smad3-specific CAGA element. Furthermore, breast tumor xenograft studies in mice and radiobiological assays showed that phosphorylation of 14-3-3σ at Ser69 and Ser74 is involved in regulation of cancer progenitor population and radioresistance in breast cancer MCF7 cells. Our data suggest that TGFβ-dependent phosphorylation of 14-3-3σ orchestrates a functional interaction of TGFβ/Smad3 with p53, plays a role in the maintenance of cancer stem cells and could provide a new potential target for intervention in breast cancer.
MeSH term(s)	14-3-3 Proteins/metabolism ; Animals ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Line ; Exonucleases/metabolism ; Exoribonucleases ; Female ; Gene Expression Regulation/drug effects ; Heterografts ; Humans ; MCF-7 Cells ; Mice ; Models, Biological ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Phosphoproteins/metabolism ; Phosphorylation/drug effects ; Protein Binding ; Protein Interaction Maps ; Proteome ; Radiation Tolerance ; Signal Transduction/drug effects ; Smad3 Protein/metabolism ; Transcription, Genetic ; Transcriptional Activation ; Transforming Growth Factor beta1/metabolism ; Transforming Growth Factor beta1/pharmacology ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	14-3-3 Proteins ; Biomarkers, Tumor ; Phosphoproteins ; Proteome ; Smad3 Protein ; Transforming Growth Factor beta1 ; Tumor Suppressor Protein p53 ; Exonucleases (EC 3.1.-) ; Exoribonucleases (EC 3.1.-) ; SFN protein, human (EC 3.1.-)
Language	English
Publishing date	2013-05-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0065163
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Article ; Online: A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistance.

Olena Zakharchenko / Monica Cojoc / Anna Dubrovska / Serhiy Souchelnytskyi

PLoS ONE, Vol 8, Iss 5, p e

2013 Volume 65163

Abstract	Transforming growth factor-β (TGFβ) is a potent regulator of tumorigenesis, although mechanisms defining its tumor suppressing and tumor promoting activities are not understood. Here we describe phosphoproteome profiling of TGFβ signaling in mammary epithelial cells, and show that 60 identified TGFβ-regulated phosphoproteins form a network with scale-free characteristics. The network highlighted interactions, which may distribute signaling inputs to regulation of cell proliferation, metabolism, differentiation and cell organization. In this report, we identified two novel and TGFβ-dependent phosphorylation sites of 14-3-3σ, i.e. Ser69 and Ser74. We observed that 14-3-3σ phosphorylation is a feed-forward mechanism in TGFβ/Smad3-dependent transcription. TGFβ-dependent 14-3-3σ phosphorylation may provide a scaffold for the formation of the protein complexes which include Smad3 and p53 at the Smad3-specific CAGA element. Furthermore, breast tumor xenograft studies in mice and radiobiological assays showed that phosphorylation of 14-3-3σ at Ser69 and Ser74 is involved in regulation of cancer progenitor population and radioresistance in breast cancer MCF7 cells. Our data suggest that TGFβ-dependent phosphorylation of 14-3-3σ orchestrates a functional interaction of TGFβ/Smad3 with p53, plays a role in the maintenance of cancer stem cells and could provide a new potential target for intervention in breast cancer.
Keywords	Medicine ; R ; Science ; Q
Subject code	571
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Optimized Protocol for Protein Extraction from the Breast Tissue that is Compatible with Two-Dimensional Gel Electrophoresis.

Zakharchenko, Olena / Greenwood, Christina / Alldridge, Louise / Souchelnytskyi, Serhiy

Breast cancer : basic and clinical research

2011 Volume 5, Page(s) 37–42

Abstract: Proteomics is a highly informative approach to analyze cancer-associated transformation in tissues. The main challenge to use a tissue for proteomics studies is the small sample size and difficulties to extract and preserve proteins. The choice of a ... ...

Abstract	Proteomics is a highly informative approach to analyze cancer-associated transformation in tissues. The main challenge to use a tissue for proteomics studies is the small sample size and difficulties to extract and preserve proteins. The choice of a buffer compatible with proteomics applications is also a challenge. Here we describe a protocol optimized for the most efficient extraction of proteins from the human breast tissue in a buffer compatible with two-dimensional gel electrophoresis (2D-GE). This protocol is based on mechanically assisted disintegration of tissues directly in the 2D-GE buffer. Our method is simple, robust and easy to apply in clinical practice. We demonstrate high quality of separation of proteins prepared according to the reported here protocol.
Language	English
Publishing date	2011-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2423804-1
ISSN	1178-2234 ; 1178-2234
ISSN (online)	1178-2234
ISSN	1178-2234
DOI	10.4137/BCBCR.S6263
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Article ; Online: Optimized Protocol for Protein Extraction from the Breast Tissue that is Compatible with Two-Dimensional Gel Electrophoresis

Olena Zakharchenko, / Christina Greenwood / Louise Alldridge / Serhiy Souchelnytskyi

Breast Cancer : Basic and Clinical Research, Vol 2011, Iss 5, Pp 37-

2011 Volume 42

Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Language	English
Publishing date	2011-03-01T00:00:00Z
Publisher	Libertas Academica
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Productivity and Quality of Diverse Ripe Pasture Grass Fodder Depends on the Method of Soil Cultivation

Uliana Karbivska / Volodymyr Kurgak / Valentyna Gamayunova / Andrii Butenko / Lesia Malynka / Ihor Kovalenko / Viktor Onychko / Ihor Masyk / Andrii Chyrva / Elina Zakharchenko / Oleksandr Tkachenko / Olena Pshychenko

Acta Agrobotanica, Vol 73, Iss

2020 Volume 3

Abstract: In this study, we investigated the influence of soil cultivation method on the productivity and quality of pasture grass fodder. We found that increasing the depth of cultivation from 8–10 cm to 20–22 cm (using surface tillage with disk implements) ... ...

Abstract	In this study, we investigated the influence of soil cultivation method on the productivity and quality of pasture grass fodder. We found that increasing the depth of cultivation from 8–10 cm to 20–22 cm (using surface tillage with disk implements) improved the productivity of all the grass species studied – Phleum pratense, Lolium perenne, Festuca orientalis, Dactylis glomerata, Bromus inermis, Phalaris arundinacea, Festuca rubra – by an average of 2%–3% at an LSD05 of 0.30 t ha−1, over a period of 3 years. On average, the most important factor influencing the production of 1 ha of dry mass appeared to be the species of grass, accounting for 57% of the variation. The depth of soil tillage was also important, accounting for 43% of the variation. Of all the species studied, the highest productivity was exhibited by Lolium perenne (0.35 t ha−1 of dry weight). Increasing the soil cultivation depth led to an increase in the content of crude protein and albumen (0.9%–1.1%). According to the analysis of organic matter content and digestibility of the fodder, across the different depths of soil cultivation, the early ripening species Dactylis glomerata, and the average ripening species Festuca orientalis, Lolium perenne, and Bromus inermis, performed best. Considering the different depths of soil cultivation, Lolium perenne [154 g; surface tillage (disking) 8–10 cm] and Festuca orientalis (152 g; ploughing 20–22 cm) provided the most fodder units with digestible protein.
Keywords	pasture grasses ; productivity ; chemical composition ; fodder quality ; cultivation ; Agriculture (General) ; S1-972
Subject code	630
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Polish Botanical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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