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Book ; Thesis: (19F) Bildgebung der Entzündungsreaktion nach akutem Herzinfarkt im Schweinemodell

Jahn, Annika

(Edition scientifique)

2019

Title variant	(19 F) Bildgebung der Entzündungsreaktion nach akutem Herzinfarkt im Schweinemodell ; Bildgebung der Entzündung im Herz mit 19F
Author's details	Annika Kristina Jahn
Series title	Edition scientifique
Keywords	Doktorarbeit ; Uni ; Wissenschaft
Language	German
Size	XIII, 157 Seiten, Illustrationen, Diagramme, 21 cm, 240 g
Edition	1. Auflage
Publisher	VVB Laufersweiler Verlag
Publishing place	Giessen
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Justus-Liebig-Universität Gießen, 2019
Note	Im Titel ist "19" hochgestellt
HBZ-ID	HT020366688
ISBN	978-3-8359-6834-9 ; 3-8359-6834-3
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

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2020 A 219	available for loan (reading room)	Lesesaal EG

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Book ; Thesis: Retrospektive Studie zum Thema: Laparoskopisch-radikale Hysterektomie nach Wertheim versus abdominal-radikale Hysterektomie nach Wertheim

Jahn, Kristina

Vergleich der Operationsmethoden anhand von Daten aus der Universitäts Frauenklinik Tübingen aus den Jahren 2000 - 2010

2013

Author's details	vorgelegt von Kristina Jahn
Language	German
Size	103 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Tübingen, Univ., Diss., 2013
HBZ-ID	HT018170873
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2014 D 91	order for loan	Magazin

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Article ; Online: To be or not to be stressed: Designing autonomy to reduce stress at work.

Zeuge, Anna / Lemmer, Kristina / Klesel, Michael / Kordyaka, Bastian / Jahn, Katharina / Niehaves, Bjoern

Work (Reading, Mass.)

2023 Volume 75, Issue 4, Page(s) 1199–1213

Abstract: Background: Many organizations are undertaking efforts to reduce the stress of (oftentimes overworked) employees. Information Technology (IT) (e.g., smartphones) has the potential to be a key instrument for reducing stress. One design-relevant factor ... ...

Abstract	Background: Many organizations are undertaking efforts to reduce the stress of (oftentimes overworked) employees. Information Technology (IT) (e.g., smartphones) has the potential to be a key instrument for reducing stress. One design-relevant factor considered to reduce stress is the concept of autonomy. Unfortunately, little research exists using autonomy as a characteristic of technology design. Objective: Against this background, this study aimed to investigate specific autonomy-related design options with the potential to prevent stress. Methods: In a factorial survey, this experimental study tested three design options in an overwork scenario: 1) autonomy (no intervention by design), 2) nudge ("nudging" by design), and 3) enforcement (hard stop by design). 51 participants (mean age 38 years, 50% women, mean work experience 18 years) from the Netherlands, United Kingdom, United States of America, and Germany participated in the experiment for 330 seconds on average. To test our hypothesis, we used a two-step approach. First, a multiple linear regression was applied. Second, we carried out a one-way ANCOVA comparing the effects of our design options. Results: Our results indicate that autonomy can be manipulated through technology design and is negatively correlated with stress. Additionally, the design options autonomy and nudge were associated with lower levels of perceived stress than was enforcement. Conclusion: The study proposes a careful use of IT and policies that limit the perceived autonomy of employees. Overall, this study offers a set of design recommendations arguing that organizations should implement technology that helps employees prevent overwork and maintain their autonomy.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Germany ; Netherlands ; United Kingdom ; United States ; Occupational Stress/prevention & control ; Personal Autonomy
Language	English
Publishing date	2023-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1394194-x
ISSN	1875-9270 ; 1051-9815
ISSN (online)	1875-9270
ISSN	1051-9815
DOI	10.3233/WOR-220177
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Article ; Online: Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients.

Friebus-Kardash, Justa / Kuang, Fei / Peitz, Tobias / Hamdan, Thamer A / Eisenberger, Ute / Boss, Kristina / Kribben, Andreas / Lang, Karl Sebastian / Jahn, Michael

Cells

2023 Volume 12, Issue 14

Abstract: Patients on dialysis have dysfunctions of innate and adaptive immune system responses. The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in plasmacytoid cells (pDCs) and myeloid dendritic cells (mDCs), playing a ... ...

Abstract	Patients on dialysis have dysfunctions of innate and adaptive immune system responses. The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in plasmacytoid cells (pDCs) and myeloid dendritic cells (mDCs), playing a crucial role in the maturation of dendritic cells, monocytes, and macrophages, and contributing to protection against bacterial infections. The current study analyzed the expression patterns of IRF8 and assessed its association with the risk of infections in 79 dialysis patients compared to 44 healthy controls. Different subsets of leukocytes and the intracellular expression of IRF8 were measured using flow cytometry. Compared to the healthy controls, the dialysis patients showed significantly reduced numbers of pDCs and significantly increased numbers of natural killer cells and classical and intermediate monocytes. The dialysis patients exhibited decreased numbers of IRF8-positive dendritic cells (pDC
MeSH term(s)	Humans ; Renal Dialysis ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Monocytes/metabolism ; Lymphocytes/metabolism
Chemical Substances	interferon regulatory factor-8 ; Interferon Regulatory Factors
Language	English
Publishing date	2023-07-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12141892
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Article ; Online: Generation of human induced pluripotent stem cell line MHHi029-A from a male Fabry disease patient carrying c.959A > T mutation.

Jahn, Christopher / Juchem, Malte / Sonnenschein, Kristina / Gietz, Anika / Buchegger, Theresa / Lachmann, Nico / Göhring, Gudrun / Behrens, Yvonne Lisa / Bär, Christian / Thum, Thomas / Hoepfner, Jeannine

Stem cell research

2024 Volume 77, Page(s) 103404

Abstract: Fabry disease (FD) is a rare and inherited monogenetic disease caused by mutations in the X-chromosomal alpha-galactosidase A gene GLA concomitant with accumulation of its substrate globotriaosylceramide (Gb3) and multi-organ symptoms. We derived an ... ...

Abstract	Fabry disease (FD) is a rare and inherited monogenetic disease caused by mutations in the X-chromosomal alpha-galactosidase A gene GLA concomitant with accumulation of its substrate globotriaosylceramide (Gb3) and multi-organ symptoms. We derived an induced pluripotent stem cell line, MHHi029-A, from a male FD patient carrying a c.959A > T missense mutation in the GLA gene. The hiPSCs show a normal karyotype, expression of pluripotency markers and trilineage differentiation capacity. Importantly, they present the patient-specific mutation in the GLA gene and are therefore a valuable resource for investigating the FD mechanism and identifying novel therapies.
Language	English
Publishing date	2024-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2393143-7
ISSN	1876-7753 ; 1873-5061
ISSN (online)	1876-7753
ISSN	1873-5061
DOI	10.1016/j.scr.2024.103404
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Article: Detektion und Differenzialdiagnose des ANV in der Intensivmedizin

Jahn, Michael / Boss, Kristina / Kribben, Andreas

Dialyse aktuell

2019 Volume 23, Issue 10, Page(s) 443–452

Abstract: Das akute Nierenversagen (ANV) in der Intensivmedizin ist typischerweise die Folge einer schweren Minderperfusion der Nieren, welche nach Ereignissen wie Sepsis, Trauma oder großen Operationen auftritt. Davon abzugrenzen sind seltenere ANV-Formen wie ... ...

Abstract	Das akute Nierenversagen (ANV) in der Intensivmedizin ist typischerweise die Folge einer schweren Minderperfusion der Nieren, welche nach Ereignissen wie Sepsis, Trauma oder großen Operationen auftritt. Davon abzugrenzen sind seltenere ANV-Formen wie Glomerulonephritiden, interstitielle Nephritiden oder thrombotische Mikroangiopathien, für die es spezifische Therapieoptionen gibt. Abhängig von der Komorbidität des Patienten, geht das Krankheitsbild zumeist mit multiplen Organdysfunktionen einher und zeigt komplikationsreiche Verläufe mit einer hohen Mortalität. Der Einsatz neuer Biomarker ermöglicht ein früheres und sensitiveres Erkennen einer Nierenfunktionsstörung und/oder einer Nierenschädigung. Für die ANV-Diagnose gilt jedoch weiterhin die etablierte Definition nach den KDIGO-Kriterien.
Language	German
Publishing date	2019-12-01
Publisher	© Georg Thieme Verlag
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/a-1007-0593
Database	Thieme publisher's database

In stock of ZB MED Cologne/Königswinter

Zs.A 6979: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.A 6979/X: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Extracorporeal cytokine adsorption: Significant reduction of catecholamine requirement in patients with AKI and septic shock after cardiac surgery.

Boss, Kristina / Jahn, Michael / Wendt, Daniel / Haidari, Zaki / Demircioglu, Ender / Thielmann, Matthias / Ruhparwar, Arjang / Kribben, Andreas / Tyczynski, Bartosz

PloS one

2021 Volume 16, Issue 2, Page(s) e0246299

Abstract: Background: Extracorporeal cytokine adsorption is an option in septic shock as an additional measure to treat a pathological immune response. Purpose of this study was to investigate the effects of extracorporeal cytokine adsorption on hemodynamic ... ...

Abstract	Background: Extracorporeal cytokine adsorption is an option in septic shock as an additional measure to treat a pathological immune response. Purpose of this study was to investigate the effects of extracorporeal cytokine adsorption on hemodynamic parameters in patients with acute kidney injury (AKI) on continuous renal replacement therapy (CRRT) and septic shock after cardiac surgery. Methods: In this retrospective study, a total of 98 patients were evaluated. Hemoadsorption was performed by the CytoSorb® adsorber. In all patients cytokine adsorption was applied for at least 15 hours and at least one adsorber was used per patient. To compare cumulative inotrope need in order to maintain a mean arterial pressure (MAP) of ≥ 65 mmHg, we applied vasoactive score (VAS) for each patient before and after cytokine adsorption. A paired t-test has been performed to determine statistical significance. Results: Before cytokine adsorption the mean VAS was 56.7 points. This was statistically significant decreased after cytokine adsorption (27.7 points, p< 0.0001). Before cytokine adsorption, the mean noradrenalin dose to reach a MAP of ≥ 65 mmHg was 0.49 μg/kg bw/min, the mean adrenalin dose was 0.12 μg/kg bw/min. After cytokine adsorption, significantly reduced catecholamine doses were necessary to maintain a MAP of ≥ 65 mmHg (0.24 μg/kg bw/min noradrenalin; p< 0.0001 and 0.07 μg/kg bw/min adrenalin; p < 0.0001). Moreover, there was a significant reduction of serum lactate levels after treatment (p< 0.0001). The mean SOFA-score for these patients with septic shock and AKI before cytokine adsorption was 16.7 points, the mean APACHE II-score was 30.2 points. The mean predicted in-hospital mortality rate based on this SOFA-score of 16.7 points was 77,0%, respectively 73,0% on APACHE II-score, while the all-cause in-hospital mortality rate of the patients in this study was 59.2%. Conclusion: In patients with septic shock and AKI undergoing cardiac surgery, extracorporeal cytokine adsorption could significantly lower the need for postoperative inotropes. Additionally, observed versus SOFA- and APACHE II-score predicted in-hospital mortality rate was decreased.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/metabolism ; Acute Kidney Injury/therapy ; Adsorption ; Adult ; Aged ; Aged, 80 and over ; Cardiac Surgical Procedures/adverse effects ; Continuous Renal Replacement Therapy ; Cytokines/metabolism ; Epinephrine/metabolism ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis/methods ; Retrospective Studies ; Shock, Septic/etiology ; Shock, Septic/metabolism ; Shock, Septic/therapy
Chemical Substances	Cytokines ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2021-02-08
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0246299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tranexamic Acid Promotes Murine Bone Marrow-Derived Osteoblast Proliferation and Inhibits Osteoclast Formation In Vitro.

Baranowsky, Anke / Appelt, Jessika / Tseneva, Kristina / Jiang, Shan / Jahn, Denise / Tsitsilonis, Serafeim / Frosch, Karl-Heinz / Keller, Johannes

International journal of molecular sciences

2021 Volume 22, Issue 1

Abstract: Despite modern surgical trauma care, bleeding contributes to one-third of trauma-related death. A significant improvement was obtained through the introduction of tranexamic acid (TXA), which today is widely used in emergency and elective orthopedic ... ...

Abstract	Despite modern surgical trauma care, bleeding contributes to one-third of trauma-related death. A significant improvement was obtained through the introduction of tranexamic acid (TXA), which today is widely used in emergency and elective orthopedic surgery to control bleeding. However, concerns remain regarding potential adverse effects on bone turnover and regeneration. Therefore, we employed standardized cell culture systems including primary osteoblasts, osteoclasts, and macrophages to evaluate potential effects of TXA on murine bone cells. While osteoblasts derived from calvarial digestion were not affected, TXA increased cell proliferation and matrix mineralization in bone marrow-derived osteoblasts. Short-term TXA treatment (6 h) failed to alter the expression of osteoblast markers; however, long-term TXA stimulation (10 days) was associated with the increased expression of genes involved in osteoblast differentiation and extracellular matrix synthesis. Similarly, whereas short-term TXA treatment did not affect gene expression in terminally differentiated osteoclasts, long-term TXA stimulation resulted in the potent inhibition of osteoclastogenesis. Finally, in bone marrow-derived macrophages activated with LPS, simultaneous TXA treatment led to a reduced expression of inflammatory cytokines and chemokines. Collectively, our study demonstrates a differential action of TXA on bone cells including osteoanabolic, anti-resorptive, and anti-inflammatory effects in vitro which suggests novel treatment applications.
MeSH term(s)	Animals ; Bone Marrow/drug effects ; Bone Marrow/metabolism ; Bone and Bones/drug effects ; Bone and Bones/metabolism ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Cytokines/metabolism ; Extracellular Matrix/drug effects ; Extracellular Matrix/metabolism ; Female ; Gene Expression/drug effects ; Macrophages/drug effects ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Osteoblasts/drug effects ; Osteoblasts/metabolism ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteogenesis/drug effects ; Tranexamic Acid/pharmacology
Chemical Substances	Cytokines ; Tranexamic Acid (6T84R30KC1)
Language	English
Publishing date	2021-01-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22010449
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Article: Monitoring membrane rafts in colorectal cancer cells by means of correlative fluorescence electron microscopy (CFEM).

Jahn, Kristina A / Braet, Filip

Micron (Oxford, England : 1993)

2008 Volume 39, Issue 8, Page(s) 1393–1397

Abstract: Detergent-resistant membrane (DRM) rafts have been shown to play a pivotal role in regulating key cell biological processes, such as signal transduction, cellular transport and cell survival. The fine structure of membrane rafts are studied using various ...

Abstract	Detergent-resistant membrane (DRM) rafts have been shown to play a pivotal role in regulating key cell biological processes, such as signal transduction, cellular transport and cell survival. The fine structure of membrane rafts are studied using various different imaging approaches and the outcomes are largely dependent on the detection methodology applied. All these microscopy techniques which employ light-, laser- and photon-optics, electrons as well as atomic force probing are characterized on their turn by their strengths and limitations for membrane raft identification. This explains in part the diversity of definitions available to describe these peculiar membrane structures. We present herewith an alternative and uncomplicated microscopy tool to study fluorescently labelled DRMs with information at the transmission electron microscopical level of the same cell, enabling us to obtain a snapshot of the morpho-functional relationships between the cell's interior and DRMs. The proposed approach of correlative fluorescence electron microscopy (CFEM) can therefore be considered as an additional alternative imaging approach to unravel DRM structure-function relationships from micro- to nanometre length scales, from the cell to the molecule.
MeSH term(s)	Caco-2 Cells ; Colorectal Neoplasms/ultrastructure ; Humans ; Membrane Microdomains/ultrastructure ; Microscopy, Electron, Transmission ; Microscopy, Fluorescence
Language	English
Publishing date	2008-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	207808-9
ISSN	1878-4291 ; 0968-4328 ; 0047-7206
ISSN (online)	1878-4291
ISSN	0968-4328 ; 0047-7206
DOI	10.1016/j.micron.2008.04.003
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Zs.A 1927: Show issues

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Article ; Online: Multiplex PCR on the Bronchoalveolar Lavage Fluid of Immunocompromised Patients.

Affolter, Kristina / Schumann, Desiree M / Tamm, Michael / Jahn, Kathleen / Siebeneichler, Aline / Junker, Lilian / Wagner, Karoline / Keller, Peter M / Frei, Reno / Stolz, Daiana

Chest

2018 Volume 154, Issue 3, Page(s) 722–725

MeSH term(s)	Bronchoalveolar Lavage Fluid/chemistry ; Female ; Humans ; Immunocompromised Host ; Lung Diseases/diagnosis ; Male ; Middle Aged ; Multiplex Polymerase Chain Reaction ; Prospective Studies
Language	English
Publishing date	2018-09-06
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2018.06.018
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Zs.MO 349: Show issues

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