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  1. Article ; Online: Surgical management of recurrent apical abscess and root defect in a vital premolar caused by intermaxillary fixation screw placement.

    Guo, Jianliang / Liu, He / Lu, Le / Shen, Ya

    Journal of dental sciences

    2023  Volume 18, Issue 4, Page(s) 1901–1903

    Language English
    Publishing date 2023-07-24
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2213-8862
    ISSN (online) 2213-8862
    DOI 10.1016/j.jds.2023.07.020
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  2. Article ; Online: Electrochemiluminescence sensing platform for microorganism detection.

    Li, Jun / Shen, Jianliang / Qi, Ruogu

    Biosafety and health

    2022  Volume 4, Issue 2, Page(s) 61–63

    Language English
    Publishing date 2022-02-26
    Publishing country Netherlands
    Document type Editorial
    ISSN 2590-0536
    ISSN (online) 2590-0536
    DOI 10.1016/j.bsheal.2022.02.002
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  3. Article ; Online: NQO-1 activatable NIR photosensitizer for visualization and selective killing of breast cancer cells.

    Li, Zhipeng / Feng, Qincong / Hou, Jiting / Shen, Jianliang

    Bioorganic chemistry

    2023  Volume 143, Page(s) 107021

    Abstract: The diagnosis and treatment of breast cancer is of immense importance in improving patient outcomes. The biological marker NAD(P)H:quinone oxidoreductase 1 was utilized to design BrCyS-Q, a near-infrared activatable photosensitizer for breast cancer. ... ...

    Abstract The diagnosis and treatment of breast cancer is of immense importance in improving patient outcomes. The biological marker NAD(P)H:quinone oxidoreductase 1 was utilized to design BrCyS-Q, a near-infrared activatable photosensitizer for breast cancer. BrCyS-Q was successfully employed to diagnose breast cancer cells using fluorescence and photodynamic inhibition. The findings of this research may offer novel insights for the diagnosis and treatment of clinical breast cancer via photodynamic therapy.
    MeSH term(s) Humans ; Female ; Photosensitizing Agents/pharmacology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Photochemotherapy ; Quinones ; Fluorescence
    Chemical Substances Photosensitizing Agents ; Quinones
    Language English
    Publishing date 2023-12-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.107021
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    Zs.A 4207: Show issues Location:
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  4. Article ; Online: An NIR-II-enhanced nanozyme to promote wound healing in methicillin-resistant Staphylococcus aureus infections.

    Du, Mengxuan / He, Xiaojun / Wang, Danyan / Jiang, Zhengting / Zhao, Xiaoliang / Shen, Jianliang

    Acta biomaterialia

    2024  Volume 179, Page(s) 300–312

    Abstract: Deep tissue bacterial infections, especially methicillin-resistant Staphylococcus aureus (MRSA) infections, pose challenges to clinical therapy due to their low debridement efficiency and relapsing. Molybdenum disulfide ( ... ...

    Abstract Deep tissue bacterial infections, especially methicillin-resistant Staphylococcus aureus (MRSA) infections, pose challenges to clinical therapy due to their low debridement efficiency and relapsing. Molybdenum disulfide (MoS
    MeSH term(s) Methicillin-Resistant Staphylococcus aureus/drug effects ; Wound Healing/drug effects ; Molybdenum/chemistry ; Molybdenum/pharmacology ; Animals ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/pathology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Mice ; Disulfides/chemistry ; Disulfides/pharmacology ; Infrared Rays ; Biofilms/drug effects ; Photothermal Therapy
    Chemical Substances Molybdenum (81AH48963U) ; Anti-Bacterial Agents ; molybdenum disulfide (ZC8B4P503V) ; Disulfides
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173841-5
    ISSN 1878-7568 ; 1742-7061
    ISSN (online) 1878-7568
    ISSN 1742-7061
    DOI 10.1016/j.actbio.2024.03.014
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  5. Article ; Online: Iron-Single-Atom Nanozyme with NIR Enhanced Catalytic Activities for Facilitating MRSA-Infected Wound Therapy.

    Liu, Qian / Liu, Xueliang / He, Xiaojun / Wang, Danyan / Zheng, Chen / Jin, Lin / Shen, Jianliang

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  Volume 11, Issue 15, Page(s) e2308684

    Abstract: Patients with methicillin-resistant Staphylococcus aureus (MRSA) infections may have higher death rates than those with non-drug-resistant infections. Nanozymes offer a promising approach to eliminating bacteria by producing reactive oxygen species. ... ...

    Abstract Patients with methicillin-resistant Staphylococcus aureus (MRSA) infections may have higher death rates than those with non-drug-resistant infections. Nanozymes offer a promising approach to eliminating bacteria by producing reactive oxygen species. However, most of the conventional nanozyme technologies encounter significant challenges with respect to size, composition, and a naturally low number of active sites. The present study synthesizes a iron-single-atom structure (Fe-SAC) via nitrogen doped-carbon, a Fe-N
    MeSH term(s) Humans ; Methicillin-Resistant Staphylococcus aureus ; Iron ; Hydrogen Peroxide ; Anti-Bacterial Agents/pharmacology ; Biofilms
    Chemical Substances Iron (E1UOL152H7) ; Hydrogen Peroxide (BBX060AN9V) ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-02-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202308684
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  6. Article ; Online: Electrochemiluminescence sensing platform for microorganism detection

    Jun Li / Jianliang Shen / Ruogu Qi

    Biosafety and Health, Vol 4, Iss 2, Pp 61-

    2022  Volume 63

    Keywords Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: A plasma-derived exosomal microRNA signature by small RNA sequencing for early detection of postmenopausal osteoporosis.

    Gao, Pan / Li, Sijia / Dong, Zhanying / Luo, Yonglun / Zhang, Xiuqing / Han, Linbo / Peng, Songlin / Shen, Jianliang / Xu, Fengping / Deng, Zaian

    Clinical and translational medicine

    2024  Volume 14, Issue 4, Page(s) e1637

    MeSH term(s) Female ; Humans ; MicroRNAs/genetics ; Osteoporosis, Postmenopausal/diagnosis ; Osteoporosis, Postmenopausal/genetics ; Exosomes/genetics ; Sequence Analysis, RNA
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.1637
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  8. Article ; Online: Advances in Gas Therapeutics for Wound Healing

    Jiayi Ding / Kang Xu / Hongtao Xu / Jiansong Ji / Yuna Qian / Jianliang Shen

    Small Structures, Vol 5, Iss 1, Pp n/a-n/a (2024)

    Mechanisms, Delivery Materials, and Prospects

    2024  

    Abstract: Wound repair, particularly chronic nonhealing wound repair, is a global health issue that affects millions of people worldwide. As an effective and safe therapeutic reagent, gas molecules in tissue repair have attracted considerable attention. Recent ... ...

    Abstract Wound repair, particularly chronic nonhealing wound repair, is a global health issue that affects millions of people worldwide. As an effective and safe therapeutic reagent, gas molecules in tissue repair have attracted considerable attention. Recent studies have shown that gas therapy (GT) plays an essential role in all phases of wound repair, including anti‐inflammatory and antimicrobial modulation, cell proliferation and migration, proangiogenesis, and extracellular matrix remodeling. This review aims to summarize recent progress in developing GT for wound repair. The characteristics of gas molecules with therapeutic functions, such as oxygen, nitric oxide, carbon monoxide, hydrogen sulfide, and others (such as sulfur dioxide, hydrogen, carbon dioxide, and plasma) in wound healing are introduced. GT has transitioned from pure gases to inorganic/organic materials as gas‐releasing materials, including gas‐producing and gas‐loaded materials, and controlled/long‐lasting stable‐releasing biomaterials. Finally, the limitations and prospects in the field of GT are analyzed and summarized.
    Keywords biological functions ; gas donor platforms ; gas therapies ; mechanisms ; wound healing ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Wiley-VCH
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Carnosine ameliorates postoperative cognitive dysfunction of aged rats by limiting astrocytes pyroptosis.

    Shen, Jiahong / Xu, Jiawen / Wen, Yuxin / Tang, Zili / Li, Jiaqi / Sun, Jianliang

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2024  , Page(s) e00359

    Abstract: Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients, and neuroinflammation is a key hallmark. Recent studies suggest that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome- ... ...

    Abstract Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients, and neuroinflammation is a key hallmark. Recent studies suggest that the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome-mediated astrocytes pyroptosis is involved in the regulation of neuroinflammation in many neurocognitive diseases, while its role in POCD remains obscure. Carnosine is a natural endogenous dipeptide with anti-inflammatory and neuroprotective effects. To explore the effect of carnosine on POCD and its mechanism, we established a POCD model by exploratory laparotomy in 24-month-old male Sprague-Dawley rats. We found that the administrated of carnosine notably attenuated surgery-induced NLRP3 inflammasome activation and pyroptosis in astrocytes, central inflammation, and neuronal damage in the hippocampus of aged rats. In addition, carnosine dramatically ameliorated the learning and memory deficits of surgery-induced aged rats. Then in the in vitro experiments, we stimulated primary astrocytes with lipopolysaccharide (LPS) after carnosine pretreatment. The results also showed that the application of carnosine alleviated the activation of the NLRP3 inflammasome, pyroptosis, and inflammatory response in astrocytes stimulated by LPS. Taken together, these findings suggest that carnosine improves POCD in aged rats via inhibiting NLRP3-mediated astrocytes pyroptosis and neuroinflammation.
    Language English
    Publishing date 2024-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1016/j.neurot.2024.e00359
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  10. Article ; Online: Recent advances in access to overcome cancer drug resistance by nanocarrier drug delivery system.

    Sun, Xiangyu / Zhao, Ping / Lin, Jierou / Chen, Kun / Shen, Jianliang

    Cancer drug resistance (Alhambra, Calif.)

    2023  Volume 6, Issue 2, Page(s) 390–415

    Abstract: Cancer is currently one of the most intractable diseases causing human death. Although the prognosis of tumor patients has been improved to a certain extent through various modern treatment methods, multidrug resistance (MDR) of tumor cells is still a ... ...

    Abstract Cancer is currently one of the most intractable diseases causing human death. Although the prognosis of tumor patients has been improved to a certain extent through various modern treatment methods, multidrug resistance (MDR) of tumor cells is still a major problem leading to clinical treatment failure. Chemotherapy resistance refers to the resistance of tumor cells and/or tissues to a drug, usually inherent or developed during treatment. Therefore, an urgent need to research the ideal drug delivery system to overcome the shortcoming of traditional chemotherapy. The rapid development of nanotechnology has brought us new enlightenments to solve this problem. The novel nanocarrier provides a considerably effective treatment to overcome the limitations of chemotherapy or other drugs resulting from systemic side effects such as resistance, high toxicity, lack of targeting, and off-target. Herein, we introduce several tumor MDR mechanisms and discuss novel nanoparticle technology applied to surmount cancer drug resistance. Nanomaterials contain liposomes, polymer conjugates, micelles, dendrimers, carbon-based, metal nanoparticles, and nucleotides which can be used to deliver chemotherapeutic drugs, photosensitizers, and small interfering RNA (siRNA). This review aims to elucidate the advantages of nanomedicine in overcoming cancer drug resistance and discuss the latest developments.
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2578-532X
    ISSN (online) 2578-532X
    DOI 10.20517/cdr.2023.16
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