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Article ; Online: Identification of the monolayer thickness difference in a mechanically exfoliated thick flake of hexagonal boron nitride and graphite for van der Waals heterostructures.

Hattori, Yoshiaki / Taniguchi, Takashi / Watanabe, Kenji / Kitamura, Masatoshi

2023 Volume 34, Issue 29

Abstract: Exfoliated flakes of layered materials, such as hexagonal boron nitride (hBN) and graphite with a thickness of several tens of nanometers, are used to construct van der Waals heterostructures. A flake with a desirable thickness, size, and shape is often ... ...

Abstract	Exfoliated flakes of layered materials, such as hexagonal boron nitride (hBN) and graphite with a thickness of several tens of nanometers, are used to construct van der Waals heterostructures. A flake with a desirable thickness, size, and shape is often selected from many exfoliated flakes placed randomly on a substrate using an optical microscope. This study examined the visualization of thick hBN and graphite flakes on SiO
Language	English
Publishing date	2023-05-09
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/accf23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Crystal Orientation Imaging of Organic Monolayer Islands by Polarized Light Microscopy.

Hattori, Yoshiaki / Kitamura, Masatoshi

ACS applied materials & interfaces

2020 Volume 12, Issue 32, Page(s) 36428–36436

Abstract: The initial stage of organic semiconductor film formation greatly affects the properties of films, which are used in organic devices including thin-film transistors and light-emitting diodes. Organic monolayer islands that are formed on a suitable ... ...

Abstract	The initial stage of organic semiconductor film formation greatly affects the properties of films, which are used in organic devices including thin-film transistors and light-emitting diodes. Organic monolayer islands that are formed on a suitable substrate can be observed with a conventional optical microscope. Furthermore, the use of a polarized microscope allows the determination of the refractive index and crystal orientation of islands. Here, we report organic monolayer islands of 2,9-diphenyl-dinaphtho[2,3-
Language	English
Publishing date	2020-07-30
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.0c08672
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A study of acoustic characteristics of voluntary expiratory sounds produced before and immediately after swallowing.

Hattori, Shoma / Nozue, Shinji / Ihara, Yoshiaki / Takahashi, Koji

Scientific reports

2022 Volume 12, Issue 1, Page(s) 765

Abstract: To evaluate the expiratory sounds produced during swallowing recorded simultaneously with videofluorographic examination of swallowing (VF) using fast Fourier transform (FFT), and to examine the relationship between dysphagia and its acoustic ... ...

Abstract	To evaluate the expiratory sounds produced during swallowing recorded simultaneously with videofluorographic examination of swallowing (VF) using fast Fourier transform (FFT), and to examine the relationship between dysphagia and its acoustic characteristics. A total of 348 samples of expiratory sounds were collected from 61 patients with dysphagia whose expiratory sounds were recorded during VF. The VF results were evaluated by one dentist and categorized into three groups: safe group (SG), penetration group (PG), and aspiration group (AG). The duration and maximum amplitude of expiratory sounds produced were measured as the domain characteristics on the time waveform of these sounds and compared among the groups. Time window-length appropriate for FFT and acoustic discriminate values (AD values) of SG, PG, and AG were also investigated. The groups were analyzed using analysis of variance and Scheffé's multiple comparison method. The maximum amplitude of SG was significantly smaller than those of PG and AG. The mean duration in SG (2.05 s) was significantly longer than those in PG (0.84 s) and AG (0.96 s). The AD value in SG was significantly lower than those in PG and AG. AD value detects penetration or aspiration, and can be useful in screening for dysphagia.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Deglutition/physiology ; Deglutition Disorders/diagnosis ; Deglutition Disorders/physiopathology ; Exhalation/physiology ; Female ; Fourier Analysis ; Humans ; Male ; Middle Aged ; Respiratory Sounds ; Time Factors ; Young Adult
Language	English
Publishing date	2022-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-04624-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A study of acoustic characteristics of voluntary expiratory sounds produced before and immediately after swallowing

Shoma Hattori / Shinji Nozue / Yoshiaki Ihara / Koji Takahashi

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 9

Abstract: Abstract To evaluate the expiratory sounds produced during swallowing recorded simultaneously with videofluorographic examination of swallowing (VF) using fast Fourier transform (FFT), and to examine the relationship between dysphagia and its acoustic ... ...

Abstract	Abstract To evaluate the expiratory sounds produced during swallowing recorded simultaneously with videofluorographic examination of swallowing (VF) using fast Fourier transform (FFT), and to examine the relationship between dysphagia and its acoustic characteristics. A total of 348 samples of expiratory sounds were collected from 61 patients with dysphagia whose expiratory sounds were recorded during VF. The VF results were evaluated by one dentist and categorized into three groups: safe group (SG), penetration group (PG), and aspiration group (AG). The duration and maximum amplitude of expiratory sounds produced were measured as the domain characteristics on the time waveform of these sounds and compared among the groups. Time window-length appropriate for FFT and acoustic discriminate values (AD values) of SG, PG, and AG were also investigated. The groups were analyzed using analysis of variance and Scheffé's multiple comparison method. The maximum amplitude of SG was significantly smaller than those of PG and AG. The mean duration in SG (2.05 s) was significantly longer than those in PG (0.84 s) and AG (0.96 s). The AD value in SG was significantly lower than those in PG and AG. AD value detects penetration or aspiration, and can be useful in screening for dysphagia.
Keywords	Medicine ; R ; Science ; Q
Subject code	780
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Visualization of a hexagonal born nitride monolayer on an ultra-thin gold film via reflected light microscopy.

Hattori, Yoshiaki / Taniguchi, Takashi / Watanabe, Kenji / Kitamura, Masatoshi

Nanotechnology

2021 Volume 33, Issue 6

Abstract: Hexagonal boron nitride (h-BN) is an important insulating layered material for two-dimensional heterostructure devices. Among many applications, few-layer h-BN films have been employed as superior tunneling barrier films. However, it is difficult to ... ...

Abstract	Hexagonal boron nitride (h-BN) is an important insulating layered material for two-dimensional heterostructure devices. Among many applications, few-layer h-BN films have been employed as superior tunneling barrier films. However, it is difficult to construct a heterostructure with ultra-thin h-BN owing to the poor visibility of flakes on substrates, especially on a metallic surface substrate. Since reflectance from a metallic surface is generally high, a h-BN film on a metallic surface does not largely influence reflection spectra. In the present study, a thin Au layer with a thickness of ∼10 nm deposited on a Si substrate with a thermally grown SiO
Language	English
Publishing date	2021-11-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/ac3357
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insertion of a methylene group into the backbone of an antisense oligonucleotide reveals the importance of deoxyribose recognition by RNase H.

Masaki, Yoshiaki / Tabira, Ayano / Hattori, Shihori / Wakatsuki, Shunsuke / Seio, Kohji

Organic & biomolecular chemistry

2022 Volume 20, Issue 45, Page(s) 8917–8924

Abstract: RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs). Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control is yet to be achieved. In this study, we tried to ... ...

Abstract	RNase H acts as a key effector in gene knockdown by antisense oligonucleotides (ASOs). Although various chemical modifications have been developed to regulate RNase H-mediated cleavage, precise control is yet to be achieved. In this study, we tried to address the question of whether the interaction of phosphate groups or deoxyriboses is more important in the recognition of DNA/RNA duplex by RNase H. To answer this question, we investigated the effect of methylene group insertion at the 5'-upstream or 3'-downstream phosphorothioate groups on RNase H-mediated cleavage. By inserting a methylene group at the 5'-upside or 3'-downside, the distance between phosphates or deoxyriboses could be changed in a different pattern. Maximum suppression of the cleavage reaction was observed when a methylene group was inserted at the 5'-phosphate group of the nucleoside which is known to distinguish ribose and deoxyribose
MeSH term(s)	Ribonuclease H/chemistry ; Oligonucleotides, Antisense/chemistry ; Deoxyribose ; Oligonucleotides/chemistry ; Phosphates
Chemical Substances	Ribonuclease H (EC 3.1.26.4) ; Oligonucleotides, Antisense ; Deoxyribose (533-67-5) ; Oligonucleotides ; Phosphates
Language	English
Publishing date	2022-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2097583-1
ISSN	1477-0539 ; 1477-0520
ISSN (online)	1477-0539
ISSN	1477-0520
DOI	10.1039/d2ob01667b
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction for Nakajima et al., "Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations".

Nakajima, Shogo / Watashi, Koichi / Kato, Takanobu / Muramatsu, Masamichi / Wakita, Takaji / Tamura, Noriko / Hattori, Shin-Ichiro / Maeda, Kenji / Mitsuya, Hiroaki / Yasutake, Yoshiaki / Toyoda, Tetsuya

Journal of virology

2024 Volume 98, Issue 3, Page(s) e0182323

Language	English
Publishing date	2024-02-02
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.01823-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparative efficacy and safety of adjunctive drugs to levodopa for fluctuating Parkinson's disease - network meta-analysis.

Sako, Wataru / Kogo, Yuki / Koebis, Michinori / Kita, Yoshiaki / Yamakage, Hajime / Ishida, Takayuki / Hattori, Nobutaka

NPJ Parkinson's disease

2023 Volume 9, Issue 1, Page(s) 143

Abstract: It remains unclear which adjunctive drug for Parkinson's disease (PD) in combination with levodopa is more effective, tolerable, and safe. We aimed to compare the efficacy, tolerability, and safety among anti-PD drugs from several classes in patients ... ...

Abstract	It remains unclear which adjunctive drug for Parkinson's disease (PD) in combination with levodopa is more effective, tolerable, and safe. We aimed to compare the efficacy, tolerability, and safety among anti-PD drugs from several classes in patients with fluctuating PD who received levodopa through network meta-analysis (NMA). Twelve anti-PD drugs belonging to 4 different drug classes (dopamine agonists, monoamine oxidase type B inhibitors, catechol-O-methyl transferase inhibitors, and an adenosine A2A receptor antagonist) were selected. We systematically searched PubMed, Embase, and the Cochrane Library for eligible randomized controlled trials (RCTs) comparing placebo with anti-PD drug or among anti-PD drugs in patients with PD who experienced motor fluctuations or wearing-off and received levodopa. We included 54 RCTs in the analysis. The NMA was performed under a frequentist framework using a random-effects model. The efficacy outcome was change in daily off-time, and the tolerability outcome was discontinuation due to all causes. Safety outcomes included discontinuation due to adverse events (AEs) and the incidence of AEs, dyskinesia, hallucination, and orthostatic hypotension. According to the surface under the cumulative ranking curve (SUCRA) in the NMA, ropinirole transdermal patch (SUCRA, 0.861) ranked the highest in efficacy, followed by pramipexole (0.762), ropinirole extended release (ER) (0.750), and safinamide (0.691). In terms of tolerability, ropinirole (0.954) ranked the highest, followed by pramipexole (0.857), safinamide (0.717), and ropinirole ER (0.708). Each anti-PD drug had different SUCRA ranking profiles for the safety outcomes. These findings suggest that ropinirole, pramipexole, and safinamide are well-balanced anti-PD drugs that satisfy both efficacy and tolerability outcomes.
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2819218-7
ISSN	2373-8057
ISSN	2373-8057
DOI	10.1038/s41531-023-00589-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Crystal Orientation Imaging of Organic Monolayer Islands by Polarized Light Microscopy

Hattori, Yoshiaki / Kitamura, Masatoshi

ACS applied materials & interfaces. 2020 July 21, v. 12, no. 32

2020

Abstract	The initial stage of organic semiconductor film formation greatly affects the properties of films, which are used in organic devices including thin-film transistors and light-emitting diodes. Organic monolayer islands that are formed on a suitable substrate can be observed with a conventional optical microscope. Furthermore, the use of a polarized microscope allows the determination of the refractive index and crystal orientation of islands. Here, we report organic monolayer islands of 2,9-diphenyl-dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DPh-DNTT) deposited on a Si substrate with thermally grown SiO₂ to investigate the crystal orientation of islands by polarized light microscopy. The observation of DPh-DNTT islands under polarized quasi-monochromatic light reveals that reflection intensity depends on both the crystal orientation and irradiation wavelength. A comparison between experimental and calculated reflection intensities provides an estimate of an anisotropic complex refractive index in the plane. The crossed-polarized microscopy image of a SiO₂/Si substrate with DPh-DNTT islands shows that the contrast between the islands and SiO₂ surface is sensitive to the angle between the polarizer and analyzer and depends on the direction of crystal orientation. The dependence of reflection contrast, which can be explained by the anisotropic extinction coefficient, is used to confirm crystal orientation.
Keywords	anisotropy ; films (materials) ; image analysis ; irradiation ; light emitting diodes ; light microscopes ; polarized light microscopy ; refractive index ; silica ; silicon ; thiophene ; transistors ; wavelengths
Language	English
Dates of publication	2020-0721
Size	p. 36428-36436.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.0c08672
Database	NAL-Catalogue (AGRICOLA)

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Article: Chain-Length Dependence of Optical Properties for an Alkanethiol Monolayer on an Ultrathin Gold Film Revealed via Reflected Light Microscopy

Hattori, Yoshiaki / Takahashi, Hayato / Ikematsu, Naoki / Kitamura, Masatoshi

Journal of physical chemistry. 2021 July 01, v. 125, no. 27

2021

Abstract: In this work, a monolayer of n-alkanethiol formed on an approximately 8 nm thick Au film, deposited onto a Si substrate with a thermally grown SiO₂ layer, was characterized using reflected light microscope with a narrow band-pass filter. The ... ...

Abstract	In this work, a monolayer of n-alkanethiol formed on an approximately 8 nm thick Au film, deposited onto a Si substrate with a thermally grown SiO₂ layer, was characterized using reflected light microscope with a narrow band-pass filter. The semitransparent, thin Au film, which is electrically conductive, provides interference in the films, and the optical properties of the monolayer depend on the alkanethiol length. When the surface of a Au film is photographed with a digital camera attached to the microscope, the color changes slightly with formation of a monolayer. The difference depends on the wavelength of a light source. Observations with narrow band-pass filters of 490 and 520 nm were found to provide a large difference, which is useful to characterize a monolayer. The difference increases with the length of the alkyl chains in the monolayer. Thus, the presented approach enables the fact that the number of the alkyl-chain units is identified through observations at an appropriate wavelength. This simple technique, which uses a general commercial microscope, can thus be used to confirm the presence of a monolayer with a molecular-order thickness.
Keywords	cameras ; color ; light microscopes ; light microscopy ; physical chemistry ; wavelengths
Language	English
Dates of publication	2021-0701
Size	p. 14991-14999.
Publishing place	American Chemical Society
Document type	Article
ISSN	1932-7455
DOI	10.1021/acs.jpcc.1c03080
Database	NAL-Catalogue (AGRICOLA)

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