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Article: Investigating the Role of Tumor-Infiltrating Lymphocytes as Predictors of Lymph Node Metastasis in Deep Submucosal Invasive Colorectal Cancer: A Retrospective Cross-Sectional Study.

Tamari, Hirosato / Kitadai, Yasuhiko / Takigawa, Hidehiko / Yuge, Ryo / Urabe, Yuji / Shimamoto, Fumio / Oka, Shiro

2023 Volume 15, Issue 21

Abstract: The role of tumor-infiltrating T cells (TILs) in colorectal cancer (CRC) and their significance in early-stage CRC remain unknown. We investigated the role of TILs in early-stage CRC, particularly in deep submucosal invasive (T1b) CRC. Sixty patients ... ...

Abstract	The role of tumor-infiltrating T cells (TILs) in colorectal cancer (CRC) and their significance in early-stage CRC remain unknown. We investigated the role of TILs in early-stage CRC, particularly in deep submucosal invasive (T1b) CRC. Sixty patients with CRC (20 each with intramucosal [IM group], submucosal invasive [SM group], and advanced cancer [AD group]) were randomly selected. We examined changes in TILs with tumor invasion and the relationship between TILs and LN metastasis risk. Eighty-four patients with T1b CRC who underwent initial surgical resection with LN dissection or additional surgical resection with LN dissection after endoscopic resection were then selected. TIL phenotype and number were evaluated using triple immunofluorescence for CD4, CD8, and Foxp3. All subtypes were more numerous according to the degree of CRC invasion and more abundant at the invasive front of the tumor (IF) than in the center of the tumor (CT) in the SM and AD groups. The increased Foxp3 cells at the IF and high ratios of Foxp3/CD4 and Foxp3/CD8 positively correlated with LN metastasis. In conclusion, tumor invasion positively correlated with the number of TILs in CRC. The number and ratio of Foxp3 cells at the IF may predict LN metastasis in T1b CRC.
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15215238
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Unusual Complication of Frailty: Superior Mesenteric Artery Syndrome.

Okazaki, Yuji / Higashi, Yusuke / Takigawa, Hidehiko

Internal medicine (Tokyo, Japan)

2019 Volume 58, Issue 14, Page(s) 2119–2120

Language	English
Publishing date	2019-03-28
Publishing country	Japan
Document type	Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.2493-18
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Article ; Online: Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient.

Miyamoto, Ryo / Takigawa, Hidehiko / Kotachi, Takahiro / Kadota, Hiroki / Yuge, Ryo / Hayashi, Ryohei / Urabe, Yuji / Ishikawa, Akira / Sentani, Kazuhiro / Oka, Shiro

Clinical journal of gastroenterology

2023 Volume 16, Issue 4, Page(s) 521–526

Abstract: We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at ... ...

Abstract	We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous-inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind.
MeSH term(s)	Male ; Humans ; Aged ; Stomach Neoplasms/diagnosis ; Lymphoma, B-Cell, Marginal Zone/diagnostic imaging ; Lymphoma, B-Cell, Marginal Zone/surgery ; Helicobacter Infections/complications ; Helicobacter pylori/genetics ; Positron Emission Tomography Computed Tomography/adverse effects ; Adenocarcinoma/pathology
Language	English
Publishing date	2023-04-26
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2429411-1
ISSN	1865-7265 ; 1865-7257
ISSN (online)	1865-7265
ISSN	1865-7257
DOI	10.1007/s12328-023-01808-8
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Article ; Online: Clinical factors associated with stable treatment of chronic constipation in Japanese patients.

Ishibashi, Kazuki / Urabe, Yuji / Vu, Nhu Thi Hanh / Miyauchi, Shunsuke / Nakamura, Takeo / Konishi, Hirona / Mizuno, Junichi / Fukuhara, Motomitsu / Takigawa, Hidehiko / Yuge, Ryo / Quach, Duc Trong / Oka, Shiro / Hiyama, Toru

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 52

Abstract: Background/aims: Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. ...

Abstract	Background/aims: Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. This study aimed to evaluate the clinical factors associated with stable treatment for CC in Japanese patients. Methods: A retrospective, cross-sectional, and multicenter study was carried out. Patients were eligible for inclusion if they fulfilled the Rome IV criteria for diagnosing CC and had been treated for at least one and a half years. Patients with up to two prescription modifications for CC in one year were defined as the stable treatment group, whereas those with three or more prescription changes were defined as the unstable treatment group. Univariate and multivariate analyses were carried out to identify factors associated with CC. Results: A total of 114 patients have been recruited. There were 82 patients (77.0%) in the stable treatment group and 32 patients (23.0%) in the unstable treatment group. Based on multivariate likelihood analysis, only using acid-suppressive drugs contributed to stability treatment in CC patients (odds ratio: 2.81, 95% confidence interval: 1.12-7.08, p = 0.03). Conclusion: Administration of acid-suppressive drugs was the only factor related to the stability of CC treatment. Further studies are needed to validate the results as well as clarify the causes.
MeSH term(s)	Humans ; Retrospective Studies ; Cross-Sectional Studies ; Japan ; Constipation/etiology ; Gastrointestinal Diseases/complications
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03140-y
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Article ; Online: Diagnostic performance of the normal range of gastrin calculated using strict criteria based on a combination of serum markers and pathological evaluation for detecting gastritis: a retrospective study.

Nagasaki, Naoko / Takigawa, Hidehiko / Ito, Masanori / Boda, Tomoyuki / Kotachi, Takahiro / Hayashi, Ryohei / Yuge, Ryo / Urabe, Yuji / Oka, Shiro / Tanaka, Shinji

BMC gastroenterology

2023 Volume 23, Issue 1, Page(s) 167

Abstract: Background: The ABC method, which combines the pepsinogen method and anti-Helicobacter pylori antibody titers, has been used for risk screening for gastric cancer in Japan. However, it has been reported that there are cases of gastritis and ... ...

Abstract	Background: The ABC method, which combines the pepsinogen method and anti-Helicobacter pylori antibody titers, has been used for risk screening for gastric cancer in Japan. However, it has been reported that there are cases of gastritis and carcinogenesis risk even in group A, which is considered to be a low-risk group based on the ABC method. Currently, in group A, endoscopic examination is needed to strictly discriminate "patients without gastritis" (defined as true A patients) from those "with gastritis." A simple and minimally invasive diagnostic criterion for gastritis using serological markers is desirable. In this study, we aimed to identify the normal serum gastrin concentrations in normal stomach cases based on pathological diagnosis and investigate the usefulness of serum gastrin concentrations in diagnosing gastritis. Methods: Patients who underwent endoscopy and blood tests at Hiroshima University Hospital were enrolled in the study and categorized into the "pathologically-evaluated group" and "endoscopically-evaluated group," according to the evaluation method of atrophic gastritis. Initially, we measured serum gastrin concentrations in the normal stomach cases in the pathologically-evaluated group and calculated the normal range of serum gastrin concentrations. We used the upper limit of this normal range of serum gastrin concentrations and performed a validation study to determine its usefulness as a diagnostic marker for distinguishing between cases of gastritis and true A in the endoscopically-evaluated group. Results: The 95th percentile of serum gastrin concentrations in pathologically-evaluated normal stomach cases was 34.12-126.03 pg/mL. Using the upper limit of this normal range of serum gastrin concentrations, the sensitivity, specificity, positive predictive value, and negative predictive value for gastritis were 52.8%, 92.6%, 97.0%, and 31.0%, respectively. Additionally, the receiver operating characteristic (ROC) curve for the endoscopically-evaluated group showed an area under the ROC curve of 0.80. Conclusion: The gastrin cut-off value of 126 pg/mL has a good positive predictive value (97.0%) for detecting gastritis positing its use as a marker for cases requiring endoscopy. However, the identification of patients with gastritis having normal serum gastrin concentrations due to insufficient sensitivity remains a challenge for the future.
MeSH term(s)	Humans ; Gastrins ; Retrospective Studies ; Reference Values ; Gastritis/diagnosis ; Gastritis/pathology ; Gastritis, Atrophic/diagnosis ; Biomarkers ; Pepsinogen A ; Stomach Neoplasms/pathology ; Helicobacter Infections/diagnosis
Chemical Substances	Gastrins ; Biomarkers ; Pepsinogen A (9001-10-9)
Language	English
Publishing date	2023-05-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-023-02816-1
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Article: Efficacy of the specialized scissor-type knife for gastric endoscopic submucosal dissection: a propensity score matched retrospective study.

Tamari, Hirosato / Oka, Shiro / Kotachi, Takahiro / Teshima, Hajime / Mizuno, Junichi / Fukuhara, Motomitsu / Tanaka, Hidenori / Tsuboi, Akiyoshi / Yamashita, Ken / Takigawa, Hidehiko / Yuge, Ryo / Urabe, Yuji / Arihiro, Koji / Tanaka, Shinji

Endoscopy international open

2023 Volume 11, Issue 4, Page(s) E315–E321

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2023-04-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-1971-1508
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Article: Comprehensive Analysis of Gene Expression Profiling to Explore Predictive Markers for Eradication Therapy Efficacy against

Takigawa, Hidehiko / Yuge, Ryo / Miyamoto, Ryo / Otani, Rina / Kadota, Hiroki / Hiyama, Yuichi / Hayashi, Ryohei / Urabe, Yuji / Sentani, Kazuhiro / Oue, Naohide / Kitadai, Yasuhiko / Oka, Shiro / Tanaka, Shinji

Cancers

2023 Volume 15, Issue 4

Abstract: Although radiotherapy is the standard treatment ... ...

Abstract	Although radiotherapy is the standard treatment for
Language	English
Publishing date	2023-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041206
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Article ; Online: Predictive factors for esophageal stenosis in patients receiving prophylactic steroid therapy after endoscopic submucosal dissection for esophageal squamous cell carcinoma.

Mizuno, Junichi / Urabe, Yuji / Oka, Shiro / Konishi, Hirona / Ishibashi, Kazuki / Fukuhara, Motomitsu / Tanaka, Hidenori / Tsuboi, Akiyoshi / Yamashita, Ken / Hiyama, Yuichi / Kotachi, Takahiro / Takigawa, Hidehiko / Yuge, Ryo / Hiyama, Toru / Tanaka, Shinji

BMC gastroenterology

2024 Volume 24, Issue 1, Page(s) 41

Abstract: Background: Methods to prevent esophageal stenosis (ES) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) have received increasing attention. Although steroid administration is a prophylactic ... ...

Abstract	Background: Methods to prevent esophageal stenosis (ES) after endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma (ESCC) have received increasing attention. Although steroid administration is a prophylactic treatment, the risk factors for ES during prophylactic steroid therapy remain unknown. Therefore, this study aimed to retrospectively evaluate the risk factors for refractory ES in patients administered prophylactic steroids after ESD for ESCC. Methods: Among 795 patients with ESCC (854 lesions), 180 patients (211 lesions) administered local triamcinolone acetonide (TrA) and/or oral prednisolone were recruited for this study. We compared the total number of endoscopic balloon dilatation (EBD) procedures performed for post-ESD ES and clinical findings (tumor size, ESD history or chemoradiation therapy [CRT], entire circumferential resection, muscle layer damage, supplemental oral prednisolone administration, EBD with TrA injection, and additional CRT) between patients with refractory and non-refractory ES. EBD was continued until dysphagia resolved. We categorized cases requiring ≥ 8 EBD procedures as refractory postoperative stenosis and divided the lesions into two groups. Results: Multivariate logistic regression analysis revealed that factors such as ESD history, CRT history, tumor size, and entire circumferential resection were independently associated with the development of refractory ES. The withdrawal rates of EBD at 3 years were 96.1% (52/53) and 58.5% (39/59) in the non-refractory and refractory groups, respectively. Conclusions: Our data suggest that entire circumferential resection and CRT history are risk factors for refractory post-ESD ES in ESCC, even with prophylactic steroid administration.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/surgery ; Esophageal Stenosis/etiology ; Esophageal Stenosis/prevention & control ; Endoscopic Mucosal Resection/adverse effects ; Esophageal Neoplasms/surgery ; Esophageal Neoplasms/complications ; Carcinoma, Squamous Cell/surgery ; Carcinoma, Squamous Cell/pathology ; Retrospective Studies ; Prednisolone/therapeutic use
Chemical Substances	Prednisolone (9PHQ9Y1OLM)
Language	English
Publishing date	2024-01-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-024-03135-9
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Article ; Online: Identification of Helicobacter pylori-related gastric cancer risk using serological gastritis markers and endoscopic findings: a large-scale retrospective cohort study.

Nagasaki, Naoko / Ito, Masanori / Boda, Tomoyuki / Kotachi, Takahiro / Takigawa, Hidehiko / Oka, Shiro / Tanaka, Shinji

BMC gastroenterology

2022 Volume 22, Issue 1, Page(s) 299

Abstract: Background: Gastric cancer remains a severe public health problem worldwide, particularly in Japan. Recent studies have demonstrated that serum markers are beneficial for risk stratification in gastric cancer development. We aimed to evaluate the ... ...

Abstract	Background: Gastric cancer remains a severe public health problem worldwide, particularly in Japan. Recent studies have demonstrated that serum markers are beneficial for risk stratification in gastric cancer development. We aimed to evaluate the usefulness of serum markers either alone or in combination (serum markers plus endoscopy) for effective risk stratification of gastric cancer development. Methods: We enrolled 22,736 patients aged 20-95 years who underwent blood sampling and endoscopic examination at Hiroshima University Hospital in Japan between 1990 and 2014. The serum pepsinogen (PG) levels and anti-Helicobacter pylori antibody (Hp-Ab) titers were evaluated in each patient. The enrolled patients were matched with the database of the Hiroshima Prefecture Regional Cancer Registry. We processed the medical records and excluded patients with possible confounding factors for PG levels, such as proton pump inhibitor use, prior successful eradication therapy, post-gastrectomy, severe hepatorenal dysfunction, Zollinger-Ellison syndrome, and autoimmune gastritis. Among the remaining 5131 patients, we reviewed records of endoscopic examinations and selected 1507 patients (mean age, 62.5 years; 985 men and 522 women) who underwent endoscopic examination more than three months after blood sampling. First, based on the ABC method, patients were classified as follows: High PG levels and negative Hp-Ab, group A, high PG levels and positive Hp-Ab, group B, low PG levels and positive Hp-Ab, group C, and low PG levels and negative Hp-Ab, group D. Group A was further classified into two subgroups using endoscopic findings: true A without atrophic gastritis and pseudo A with atrophic gastritis. All patients underwent annual endoscopy follow-up. Results: Among the 1,507 patients (mean age, 62.5 years; 985 men), 24 were diagnosed with newly developed gastric cancer. No significant difference in cancer development was found between group A (PG negative and Hp-Ab negative) and the other groups. Remarkably, no true A group subjects developed gastric cancer. Conclusions: The combination of serum markers and endoscopic findings is essential for the risk evaluation of gastric cancer.
MeSH term(s)	Antibodies, Bacterial ; Biomarkers ; Endoscopy ; Female ; Gastritis ; Gastritis, Atrophic ; Helicobacter Infections/complications ; Helicobacter pylori ; Humans ; Male ; Middle Aged ; Pepsinogen A ; Retrospective Studies ; Stomach Neoplasms/microbiology
Chemical Substances	Antibodies, Bacterial ; Biomarkers ; Pepsinogen A (9001-10-9)
Language	English
Publishing date	2022-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2041351-8
ISSN	1471-230X ; 1471-230X
ISSN (online)	1471-230X
ISSN	1471-230X
DOI	10.1186/s12876-022-02381-z
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Article: Serum Gastrin and Pepsinogen Levels after Administration of Acid Secretion Inhibitors for Ulcers due to Endoscopic Submucosal Dissection in Patients with Early Gastric Cancer.

Abuduwaili, Maidina / Boda, Tomoyuki / Ito, Masanori / Takigawa, Hidehiko / Kotachi, Takahiro / Matsuo, Taiji / Oka, Shiro / Tanaka, Shinji

Gastroenterology research and practice

2022 Volume 2022, Page(s) 2830227

Abstract: Acid secretion inhibitors, such as proton pump inhibitors (PPIs) and potassium competitive acid blockers (PCABs), are used to treat ulcers after endoscopic submucosal dissection (ESD) for early gastric cancer. These drugs can influence serum gastrin and ... ...

Abstract	Acid secretion inhibitors, such as proton pump inhibitors (PPIs) and potassium competitive acid blockers (PCABs), are used to treat ulcers after endoscopic submucosal dissection (ESD) for early gastric cancer. These drugs can influence serum gastrin and pepsinogen (PG) levels; however, their definite effects remain unclear. This open-label, randomized study investigated the effect of acid secretion inhibitors on the serum gastrin and pepsinogen levels. In total, 76 patients were enrolled in the study. They underwent gastric ESD and received a PPI (
Language	English
Publishing date	2022-01-28
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2435460-0
ISSN	1687-630X ; 1687-6121
ISSN (online)	1687-630X
ISSN	1687-6121
DOI	10.1155/2022/2830227
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