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  1. Article ; Online: The Epigenetic Role of Vitamin C in Neurodevelopment.

    Coker, Sharna J / Smith-Díaz, Carlos C / Dyson, Rebecca M / Vissers, Margreet C M / Berry, Mary J

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: ... been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation ... methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse ... of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity ...

    Abstract The maternal diet during pregnancy is a key determinant of offspring health. Early studies have linked poor maternal nutrition during gestation with a propensity for the development of chronic conditions in offspring. These conditions include cardiovascular disease, type 2 diabetes and even compromised mental health. While multiple factors may contribute to these outcomes, disturbed epigenetic programming during early development is one potential biological mechanism. The epigenome is programmed primarily in utero, and during this time, the developing fetus is highly susceptible to environmental factors such as nutritional insults. During neurodevelopment, epigenetic programming coordinates the formation of primitive central nervous system structures, neurogenesis, and neuroplasticity. Dysregulated epigenetic programming has been implicated in the aetiology of several neurodevelopmental disorders such as Tatton-Brown-Rahman syndrome. Accordingly, there is great interest in determining how maternal nutrient availability in pregnancy might affect the epigenetic status of offspring, and how such influences may present phenotypically. In recent years, a number of epigenetic enzymes that are active during embryonic development have been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse the oxidative removal of methyl groups on cytosines and histone lysine residues, respectively. These enzymes are integral to epigenetic regulation and have fundamental roles in cellular differentiation, the maintenance of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity illustrates a potentially critical contribution of the nutrient during mammalian development. These insights also highlight a potential risk associated with vitamin C insufficiency during pregnancy. The link between vitamin C insufficiency and development is particularly apparent in the context of neurodevelopment and high vitamin C concentrations in the brain are indicative of important functional requirements in this organ. Accordingly, this review considers the evidence for the potential impact of maternal vitamin C status on neurodevelopmental epigenetics.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Ascorbic Acid/pharmacology ; Ascorbic Acid Deficiency/complications ; Ascorbic Acid Deficiency/genetics ; Ascorbic Acid Deficiency/pathology ; Epigenesis, Genetic ; Female ; Gene Expression Regulation, Developmental ; Humans ; Maternal Nutritional Physiological Phenomena ; Neurodevelopmental Disorders/etiology ; Neurodevelopmental Disorders/pathology ; Neurodevelopmental Disorders/prevention & control ; Neurogenesis ; Pregnancy
    Chemical Substances Antioxidants ; Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2022-01-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031208
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  2. Article ; Online: The Epigenetic Role of Vitamin C in Neurodevelopment

    Sharna J. Coker / Carlos C. Smith-Díaz / Rebecca M. Dyson / Margreet C. M. Vissers / Mary J. Berry

    International Journal of Molecular Sciences, Vol 23, Iss 1208, p

    2022  Volume 1208

    Abstract: ... been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation ... methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse ... of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity ...

    Abstract The maternal diet during pregnancy is a key determinant of offspring health. Early studies have linked poor maternal nutrition during gestation with a propensity for the development of chronic conditions in offspring. These conditions include cardiovascular disease, type 2 diabetes and even compromised mental health. While multiple factors may contribute to these outcomes, disturbed epigenetic programming during early development is one potential biological mechanism. The epigenome is programmed primarily in utero, and during this time, the developing fetus is highly susceptible to environmental factors such as nutritional insults. During neurodevelopment, epigenetic programming coordinates the formation of primitive central nervous system structures, neurogenesis, and neuroplasticity. Dysregulated epigenetic programming has been implicated in the aetiology of several neurodevelopmental disorders such as Tatton-Brown-Rahman syndrome. Accordingly, there is great interest in determining how maternal nutrient availability in pregnancy might affect the epigenetic status of offspring, and how such influences may present phenotypically. In recent years, a number of epigenetic enzymes that are active during embryonic development have been found to require vitamin C as a cofactor. These enzymes include the ten-eleven translocation methylcytosine dioxygenases (TETs) and the Jumonji C domain-containing histone lysine demethylases that catalyse the oxidative removal of methyl groups on cytosines and histone lysine residues, respectively. These enzymes are integral to epigenetic regulation and have fundamental roles in cellular differentiation, the maintenance of pluripotency and development. The dependence of these enzymes on vitamin C for optimal catalytic activity illustrates a potentially critical contribution of the nutrient during mammalian development. These insights also highlight a potential risk associated with vitamin C insufficiency during pregnancy. The link between vitamin C insufficiency and development is ...
    Keywords ascorbate ; epigenetic programming ; maternal nutrition ; neurodevelopment ; ten-eleven translocation methylcytosine dioxygenases ; TET enzymes ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  3. Article ; Online: Maternal Vitamin C Intake during Pregnancy Influences Long-Term Offspring Growth with Timing- and Sex-Specific Effects in Guinea Pigs.

    Coker, Sharna J / Berry, Mary J / Vissers, Margreet C M / Dyson, Rebecca M

    Nutrients

    2024  Volume 16, Issue 3

    Abstract: Our previous work in guinea pigs revealed that low vitamin C intake during preconception and ... investigated the effects of the timing of maternal vitamin C restriction (early vs. late gestation ... kg feed) or low (100 mg/kg feed) vitamin C diet ad libitum during preconception. Pregnant dams were ...

    Abstract Our previous work in guinea pigs revealed that low vitamin C intake during preconception and pregnancy adversely affects fertility, pregnancy outcomes, and foetal and neonatal growth in a sex-dependent manner. To investigate the long-term impact on offspring, we monitored their growth from birth to adolescence (four months), recorded organ weights at childhood equivalence (28 days) and adolescence, and assessed physiological parameters like oral glucose tolerance and basal cortisol concentrations. We also investigated the effects of the timing of maternal vitamin C restriction (early vs. late gestation) on pregnancy outcomes and the health consequences for offspring. Dunkin Hartley guinea pigs were fed an optimal (900 mg/kg feed) or low (100 mg/kg feed) vitamin C diet ad libitum during preconception. Pregnant dams were then randomised into four feeding regimens: consistently optimal, consistently low, low during early pregnancy, or low during late pregnancy. We found that low maternal vitamin C intake during early pregnancy accelerated foetal and neonatal growth in female offspring and altered glucose homeostasis in the offspring of both sexes at an age equivalent to early childhood. Conversely, low maternal vitamin C intake during late pregnancy resulted in foetal growth restriction and reduced weight gain in male offspring throughout their lifespan. We conclude that altered vitamin C during development has long-lasting, sex-specific consequences for offspring and that the timing of vitamin C depletion is also critical, with low levels during early development being associated with the development of a metabolic syndrome-related phenotype, while later deprivation appears to be linked to a growth-faltering phenotype.
    MeSH term(s) Humans ; Child, Preschool ; Pregnancy ; Animals ; Male ; Female ; Guinea Pigs ; Pregnancy Outcome ; Diet ; Fetus ; Glucose Tolerance Test ; Ascorbic Acid/pharmacology ; Prenatal Exposure Delayed Effects
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2024-01-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16030369
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  4. Article ; Online: Effects of Low Vitamin C Intake on Fertility Parameters and Pregnancy Outcomes in Guinea Pigs.

    Coker, Sharna J / Dyson, Rebecca M / Smith-Díaz, Carlos C / Vissers, Margreet C M / Berry, Mary J

    Nutrients

    2023  Volume 15, Issue 19

    Abstract: ... investigates how dietary vitamin C intake affects various fertility parameters and pregnancy and neonatal ... outcomes in the guinea pig, a natural model of vitamin C dependency. Dunkin Hartley guinea pigs were fed ... an optimal (900 mg/kg feed) or low (100 mg/kg feed) vitamin C diet ad libitum for at least three weeks prior ...

    Abstract Identifying how specific nutrients can impact fertility, pregnancy, and neonatal outcomes will yield important insights into the biological mechanisms linking diet and reproductive health. Our study investigates how dietary vitamin C intake affects various fertility parameters and pregnancy and neonatal outcomes in the guinea pig, a natural model of vitamin C dependency. Dunkin Hartley guinea pigs were fed an optimal (900 mg/kg feed) or low (100 mg/kg feed) vitamin C diet ad libitum for at least three weeks prior to mating and throughout pregnancy. We found that animals receiving the low vitamin C diet had an increased number of unsuccessful matings, a higher incidence of foetal reabsorption, and, among pregnancies resulting in delivery at term, produced fewer offspring. Neonates from mothers on the low vitamin C diet had significantly decreased plasma vitamin C concentrations at birth and exhibited mild growth impairments in a sex-dependent manner. We conclude that a diet low of vitamin C induces a state of subfertility, reduces overall fecundity, and adversely impacts both pregnancy outcomes and growth in the offspring. Our study provides an essential foundation for future investigations to determine whether these findings translate to humans. If so, they could have important clinical implications for assisted reproductive technologies and nutritional recommendations for couples trying to conceive, pregnant women, and breastfeeding mothers.
    MeSH term(s) Animals ; Pregnancy ; Guinea Pigs ; Female ; Humans ; Pregnancy Outcome ; Fertility ; Ascorbic Acid/pharmacology ; Fetus ; Nutritional Status ; Vitamins
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15194107
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  5. Book ; Online: HARQ Retransmissions in C-V2X

    Fouda, Abdurrahman / Berry, Randall / Vukovic, Ivan

    A BSM Latency Analysis

    2023  

    Abstract: Cellular vehicular-to-everything (C-V2X) systems offer the potential for improving road safety ... latency and reliability when HARQ retransmissions are used with the semi-persistent scheduling (SPS) in C ...

    Abstract Cellular vehicular-to-everything (C-V2X) systems offer the potential for improving road safety, in part through the exchange of periodic basic safety messages (BSMs) between nearby vehicles. The reliability and latency of these messages is a key metric. Hybrid automatic repeat request (HARQ) retransmissions are one technique used to this end. However, HARQ may come at the expense of consuming the limited available wireless resources, especially in highly congested scenarios. This paper studies BSM transmission latency and reliability when HARQ retransmissions are used with the semi-persistent scheduling (SPS) in C-V2X transmission mode 4. We do so through extensive system-level simulations that closely follow the SPS process. Furthermore, we provide an analytical model for the tail behavior of the BSM latency distribution with HARQ retransmissions that is a good approximation to the simulation results. Our study reveals the impact of several deployment settings (e.g., bandwidth configurations and vehicle density).
    Keywords Electrical Engineering and Systems Science - Signal Processing ; Mathematics - Numerical Analysis
    Subject code 380
    Publishing date 2023-11-28
    Publishing country us
    Document type Book ; Online
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  6. Article ; Online: Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.

    Adhikari, Neill K J / Hashmi, Madiha / Tirupakuzhi Vijayaraghavan, Bharath Kumar / Haniffa, Rashan / Beane, Abi / Webb, Steve A / Angus, Derek C / Gordon, Anthony C / Cook, Deborah J / Guyatt, Gordon H / Berry, Lindsay R / Lorenzi, Elizabeth / Mouncey, Paul R / Au, Carly / Pinto, Ruxandra / Ménard, Julie / Sprague, Sheila / Masse, Marie-Hélène / Huang, David T /
    Heyland, Daren K / Nichol, Alistair D / McArthur, Colin J / de Man, Angelique / Al-Beidh, Farah / Annane, Djillali / Anstey, Matthew / Arabi, Yaseen M / Battista, Marie-Claude / Berry, Scott / Bhimani, Zahra / Bonten, Marc J M / Bradbury, Charlotte A / Brant, Emily B / Brunkhorst, Frank M / Burrell, Aidan / Buxton, Meredith / Cecconi, Maurizio / Cheng, Allen C / Cohen, Dian / Cove, Matthew E / Day, Andrew G / Derde, Lennie P G / Detry, Michelle A / Estcourt, Lise J / Fagbodun, Elizabeth O / Fitzgerald, Mark / Goossens, Herman / Green, Cameron / Higgins, Alisa M / Hills, Thomas E / Ichihara, Nao / Jayakumar, Devachandran / Kanji, Salmaan / Khoso, Muhammad Nasir / Lawler, Patrick R / Lewis, Roger J / Litton, Edward / Marshall, John C / McAuley, Daniel F / McGlothlin, Anna / McGuinness, Shay P / McQuilten, Zoe K / McVerry, Bryan J / Murthy, Srinivas / Parke, Rachael L / Parker, Jane C / Reyes, Luis Felipe / Rowan, Kathryn M / Saito, Hiroki / Salahuddin, Nawal / Santos, Marlene S / Saunders, Christina T / Seymour, Christopher W / Shankar-Hari, Manu / Tolppa, Timo / Trapani, Tony / Turgeon, Alexis F / Turner, Anne M / Udy, Andrew A / van de Veerdonk, Frank L / Zarychanski, Ryan / Lamontagne, François

    JAMA

    2023  Volume 330, Issue 18, Page(s) 1745–1759

    Abstract: Importance: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain ... Objective: To determine whether vitamin C improves outcomes for patients with COVID-19.: Design, setting ... were randomized to receive vitamin C administered intravenously or control (placebo or no vitamin C ...

    Abstract Importance: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain.
    Objective: To determine whether vitamin C improves outcomes for patients with COVID-19.
    Design, setting, and participants: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support in intensive care units (90 sites) and patients who were not critically ill (40 sites) between July 23, 2020, and July 15, 2022, on 4 continents.
    Interventions: Patients were randomized to receive vitamin C administered intravenously or control (placebo or no vitamin C) every 6 hours for 96 hours (maximum of 16 doses).
    Main outcomes and measures: The primary outcome was a composite of organ support-free days defined as days alive and free of respiratory and cardiovascular organ support in the intensive care unit up to day 21 and survival to hospital discharge. Values ranged from -1 organ support-free days for patients experiencing in-hospital death to 22 organ support-free days for those who survived without needing organ support. The primary analysis used a bayesian cumulative logistic model. An odds ratio (OR) greater than 1 represented efficacy (improved survival, more organ support-free days, or both), an OR less than 1 represented harm, and an OR less than 1.2 represented futility.
    Results: Enrollment was terminated after statistical triggers for harm and futility were met. The trials had primary outcome data for 1568 critically ill patients (1037 in the vitamin C group and 531 in the control group; median age, 60 years [IQR, 50-70 years]; 35.9% were female) and 1022 patients who were not critically ill (456 in the vitamin C group and 566 in the control group; median age, 62 years [IQR, 51-72 years]; 39.6% were female). Among critically ill patients, the median number of organ support-free days was 7 (IQR, -1 to 17 days) for the vitamin C group vs 10 (IQR, -1 to 17 days) for the control group (adjusted proportional OR, 0.88 [95% credible interval {CrI}, 0.73 to 1.06]) and the posterior probabilities were 8.6% (efficacy), 91.4% (harm), and 99.9% (futility). Among patients who were not critically ill, the median number of organ support-free days was 22 (IQR, 18 to 22 days) for the vitamin C group vs 22 (IQR, 21 to 22 days) for the control group (adjusted proportional OR, 0.80 [95% CrI, 0.60 to 1.01]) and the posterior probabilities were 2.9% (efficacy), 97.1% (harm), and greater than 99.9% (futility). Among critically ill patients, survival to hospital discharge was 61.9% (642/1037) for the vitamin C group vs 64.6% (343/531) for the control group (adjusted OR, 0.92 [95% CrI, 0.73 to 1.17]) and the posterior probability was 24.0% for efficacy. Among patients who were not critically ill, survival to hospital discharge was 85.1% (388/456) for the vitamin C group vs 86.6% (490/566) for the control group (adjusted OR, 0.86 [95% CrI, 0.61 to 1.17]) and the posterior probability was 17.8% for efficacy.
    Conclusions and relevance: In hospitalized patients with COVID-19, vitamin C had low probability of improving the primary composite outcome of organ support-free days and hospital survival.
    Trial registration: ClinicalTrials.gov Identifiers: NCT04401150 (LOVIT-COVID) and NCT02735707 (REMAP-CAP).
    MeSH term(s) Humans ; Female ; Middle Aged ; Male ; COVID-19 ; Ascorbic Acid/therapeutic use ; Critical Illness/therapy ; Critical Illness/mortality ; Hospital Mortality ; Bayes Theorem ; Randomized Controlled Trials as Topic ; Vitamins/therapeutic use ; Sepsis/drug therapy
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R) ; Vitamins
    Language English
    Publishing date 2023-10-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2023.21407
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  7. Article ; Online: Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s.

    Tewey, Madison A / Coulibaly, Drissa / Lawton, Jonathan G / Stucke, Emily M / Zhou, Albert E / Berry, Andrea A / Bailey, Jason A / Pike, Andrew / Dara, Antoine / Ouattara, Amed / Lyke, Kirsten E / Ifeonu, Olukemi / Laurens, Matthew B / Adams, Matthew / Takala-Harrison, Shannon / Niangaly, Amadou / Kouriba, Bourema / Koné, Abdoulaye K / Rowe, J Alexandra /
    Doumbo, Ogobara K / Patel, Jigar J / Tan, John C / Felgner, Philip L / Plowe, Christopher V / Thera, Mahamadou A / Travassos, Mark A

    mSphere

    2023  Volume 8, Issue 5, Page(s) e0045123

    Abstract: Antibody responses to variant surface antigens (VSAs) produced by the malaria ... ...

    Abstract Antibody responses to variant surface antigens (VSAs) produced by the malaria parasite
    MeSH term(s) Adult ; Child ; Humans ; Child, Preschool ; Endothelial Protein C Receptor/metabolism ; Protozoan Proteins/metabolism ; Malaria ; Malaria, Falciparum/parasitology ; Epitopes ; Peptides
    Chemical Substances Endothelial Protein C Receptor ; Protozoan Proteins ; Epitopes ; Peptides
    Language English
    Publishing date 2023-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00451-23
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  8. Article ; Online: Richard C. Lewontin (1929-2021).

    Berry, Andrew / Petrov, Dmitri A

    Science (New York, N.Y.)

    2021  Volume 373, Issue 6556, Page(s) 745

    Language English
    Publishing date 2021-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.abl5430
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  9. Article ; Online: Pembrolizumab and Enzalutamide in Patients with Abiraterone Acetate-Pretreated Metastatic Castration-Resistant Prostate Cancer: Cohort C of the Phase 1b/2 KEYNOTE-365 Study.

    Yu, Evan Y / Berry, William R / Gurney, Howard / Retz, Margitta / Conter, Henry J / Laguerre, Brigitte / Fong, Peter C C / Ferrario, Cristiano / Todenhöfer, Tilman / Gravis, Gwenaelle / Piulats, Josep M / Emmenegger, Urban / Shore, Neal D / Romano, Emanuela / Mourey, Loic / Li, Xin Tong / Poehlein, Christian H / Schloss, Charles / Appleman, Leonard J /
    de Bono, Johann S

    European urology oncology

    2023  

    Abstract: ... enzalutamide in mCRPC.: Design, setting, and participants: Patients in cohort C of the phase 1b/2 KEYNOTE ...

    Abstract Background: Limited responses have been observed in patients treated with enzalutamide after disease progression on abiraterone for metastatic castration-resistant prostate cancer (mCRPC), but androgen receptor signaling impacts T-cell function.
    Objective: To evaluate the efficacy and safety of pembrolizumab plus enzalutamide in mCRPC.
    Design, setting, and participants: Patients in cohort C of the phase 1b/2 KEYNOTE-365 study, who received ≥4 wk of treatment with abiraterone acetate in the prechemotherapy mCRPC state and experienced treatment failure or became drug-intolerant, were included.
    Intervention: Pembrolizumab 200 mg intravenously every 3 wk plus enzalutamide 160 mg orally once daily.
    Outcome measurements and statistical analysis: The primary endpoints were safety, the confirmed prostate-specific antigen (PSA) response rate, and the objective response rate (ORR) according to Response Evaluation Criteria in Solid Tumors version 1.1 on blinded independent central review (BICR). Secondary endpoints included radiographic progression-free survival (rPFS) on BICR and overall survival (OS).
    Results and limitations: A total of 102 patients received pembrolizumab plus enzalutamide. Median follow-up was 51 mo (interquartile range 37-56). The confirmed PSA response rate was 24% (95% confidence interval [CI] 16-33%). The confirmed ORR was 11% (95% CI 2.9-25%; 4/38 patients; two complete responses). Median rPFS was 6.0 mo (95% CI 4.1-6.3). Median OS was 20 mo (95% CI 17-24). Treatment-related adverse events (TRAEs) occurred in 94 patients (92%); grade 3-5 TRAEs occurred in 44 patients (43%). The incidence of treatment-related rash was higher with combination therapy than expected from the safety profile of each drug. One patient (1.0%) died of a TRAE (cause unknown). Study limitations include the single-arm design.
    Conclusions: Pembrolizumab plus enzalutamide had limited antitumor activity in patients who received prior abiraterone treatment without previous chemotherapy for mCRPC, with a safety profile consistent with the individual profiles of each agent.
    Patient summary: Pembrolizumab plus enzalutamide showed limited antitumor activity and manageable safety in patients with metastatic castration-resistant prostate cancer. The KEYNOTE-365 trial is registered on ClinicalTrials.gov as NCT02861573.
    Language English
    Publishing date 2023-11-06
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2588-9311
    ISSN (online) 2588-9311
    DOI 10.1016/j.euo.2023.10.008
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  10. Article ; Online: Editorial: How does the risk of hepatocellular carcinoma change over time in patients with a hepatitis C cure? Authors' reply.

    Vutien, Philip / Kim, Nicole J / Moon, Andrew M / Johnson, Kay M / Berry, Kristin / Green, Pamela K / Ioannou, George N

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 3, Page(s) 419–420

    MeSH term(s) Humans ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Hepacivirus ; Hepatitis C/complications ; Hepatitis C/drug therapy
    Language English
    Publishing date 2024-01-10
    Publishing country England
    Document type Editorial
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17841
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