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Article: Sub-therapeutic trimethoprim and sulfamethoxazole plasma concentrations during continuous venovenous hemofiltration in a patient with COVID-19 and pulmonary

le Noble, Jos L M L / Foudraine, Norbert / van der Elst, Kim C M / Bouwman, Sander

International journal of clinical pharmacology and therapeutics

2023 Volume 61, Issue 11, Page(s) 525–530

Abstract: Objective: To investigate drug concentration of trimethoprim-sulfamethoxazole (TMP-SMX) using therapeutic drug monitoring (TDM) for severe : Materials and methods: A 72-year-old man with hypoxemic respiratory failure due to COVID-19 infection was ... ...

Abstract	Objective: To investigate drug concentration of trimethoprim-sulfamethoxazole (TMP-SMX) using therapeutic drug monitoring (TDM) for severe Materials and methods: A 72-year-old man with hypoxemic respiratory failure due to COVID-19 infection was admitted to the intensive care unit for invasive mechanical ventilation. The patient developed acute renal failure that required RCA-CVVH. Pulmonary co-infection with PJP was diagnosed, and a high TMP-SMX dose was initiated according to (inter)national guidelines with dose reduction after 3 days because of renal failure. Population pharmacokinetics were assessed for TMP and SMX as well as clearance by RCA-CVVH, volume of distribution, and time above threshold levels for measured plasma concentrations. Results: During renal failure requiring RCA-CVVH, a corresponding dose reduction of TMP-SMX to 320/1,600 mg twice a day, according to current Dutch SWAB and Dutch Association of Hospital Pharmacists guidelines, resulted in unintended under-dosing with sub-therapeutic TMP-SMX concentrations. Pharmacokinetic modeling and dose adjustment of TMP-SMX to 640/3,200 mg 3 times daily resulted in steady-state TMP-SMX peak concentrations associated with efficacy against PJP. Hence, the patient was successfully weaned from the ventilator and discharged. Conclusion: We hypothesize that our new dose recommendation of 640/3,200 mg TMP-SMX 3 times daily is associated with an increased probability of critical patients being successfully liberated from mechanical weaning following PJP pneumonia and COVID-19 infection.
MeSH term(s)	Male ; Humans ; Aged ; Trimethoprim, Sulfamethoxazole Drug Combination ; Pneumocystis carinii ; Pneumonia, Pneumocystis/complications ; Pneumonia, Pneumocystis/diagnosis ; Pneumonia, Pneumocystis/drug therapy ; Continuous Renal Replacement Therapy ; Coinfection/drug therapy ; COVID-19/complications ; COVID-19/therapy ; Renal Insufficiency ; Retrospective Studies
Chemical Substances	Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
Language	English
Publishing date	2023-07-24
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	124384-6
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
ISSN	0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
DOI	10.5414/CP204407
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Article ; Conference proceedings ; Online: Assessment of Oxidative Stress and Metabolic Risks With Machine Learning Algorithms in Ethnically Diverse Population

Kim, Yunsoo / van den Broek, Tim / Feskens, Edith J.M. / Bouwman, Jildau / Kwon, Oran

Cross-Sectional Data in Korea and the Netherlands

2022

Keywords	Life Science
Language	English
Publishing country	nl
Document type	Article ; Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Interference between avian corona and influenza viruses: The role of the epithelial architecture of the chicken trachea.

Weerts, Erik A W S / Bouwman, Kim M / Paerels, Lieke / Gröne, Andrea / Jan Boelm, Gert / Verheije, M Hélène

Veterinary microbiology

2022 Volume 272, Page(s) 109499

Abstract: Respiratory viral infections are among the major causes of disease in poultry. While viral dual infections are known to occur, viral interference in chicken airways is mechanistically hardly understood. The effects of infectious bronchitis virus (IBV) ... ...

Abstract	Respiratory viral infections are among the major causes of disease in poultry. While viral dual infections are known to occur, viral interference in chicken airways is mechanistically hardly understood. The effects of infectious bronchitis virus (IBV) infection on tissue morphology, sialic acid (sia) expression and susceptibility of the chicken trachea for superinfection with IBV or avian influenza virus (AIV) were studied. In vivo, tracheal epithelium of chickens infected with IBV QX showed marked inflammatory cell infiltration and loss of cilia and goblet cells five days post inoculation. Plant lectin staining indicated that sialic acids redistributed from the apical membrane of the ciliated epithelium and the goblet cell cytoplasm to the basement membrane region of the epithelium. After administration of recombinant viral attachment proteins to slides of infected tissue, retained binding of AIV hemagglutinin, absence of binding of the receptor binding domain (RBD) of IBV M41 and partial reduction of IBV QX RBD were observed. Adult chicken trachea rings were used as ex vivo model to study the effects of IBV QX-induced pathological changes and receptor redistribution on secondary viral infection. AIV H9N2 infection after primary IBV infection was delayed; however, final viral loads reached similar levels as in previously uninfected trachea rings. In contrast, IBV M41 superinfection resulted in 1000-fold lower viral titers over the course of 48 h. In conclusion, epithelial changes in the chicken trachea after viral infection coincide with redistribution and likely specific downregulation of viral receptors, with the extend of subsequent viral interference dependent on viral species.
MeSH term(s)	Animals ; Chickens ; Coinfection/veterinary ; Coronavirus Infections/veterinary ; Infectious bronchitis virus/physiology ; Influenza A Virus, H9N2 Subtype/physiology ; Poultry Diseases ; Superinfection/veterinary ; Trachea
Language	English
Publishing date	2022-06-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2022.109499
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Article ; Online: GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development.

Beaumont, Joel E J / Ju, Jinzhe / Barbeau, Lydie M O / Demers, Imke / Savelkouls, Kim G / Derks, Kasper / Bouwman, Freek G / Wauben, Marca H M / Zonneveld, Marijke I / Keulers, Tom G H / Rouschop, Kasper M A

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2023 Volume 190, Page(s) 109968

Abstract: Background and purpose: Hypoxia is a common feature of tumours, associated with poor prognosis due to increased resistance to radio- and chemotherapy and enhanced metastasis development. Previously we demonstrated that GABARAPL1 is required for the ... ...

Abstract	Background and purpose: Hypoxia is a common feature of tumours, associated with poor prognosis due to increased resistance to radio- and chemotherapy and enhanced metastasis development. Previously we demonstrated that GABARAPL1 is required for the secretion of extracellular vesicles (EV) with pro-angiogenic properties during hypoxia. Here, we explored the role of GABARAPL1 Materials and methods: GABARAPL1 deficient or control MDA-MB-231 cells were injected in murine mammary fat pads. Lungs were dissected and analysed for human cytokeratin 18. EV from control and GABARAPL1 deficient cells exposed to normoxia (21% O Results: The number of pulmonary metastases derived from GABARAPL1 deficient tumours decreased by 84%. GABARAPL1 deficient cells migrate slower but display a comparable invasive capacity. Both normoxic and hypoxic EV contain proteins and miRNAs associated with metastasis development and, in line, increase cancer cell invasiveness. Although GABARAPL1 deficiency alters EV content, it does not alter the EV-induced increase in cancer cell invasiveness. Conclusion: GABARAPL1 is essential for metastasis development. This is unrelated to changes in migration and invasion and suggests that GABARAPL1 or GABARAPL1
MeSH term(s)	Humans ; Animals ; Mice ; MicroRNAs ; Hypoxia/metabolism ; Cell Hypoxia ; Neoplasms ; Extracellular Vesicles/metabolism ; Microtubule-Associated Proteins ; Adaptor Proteins, Signal Transducing/metabolism
Chemical Substances	MicroRNAs ; GABARAPL1 protein, human ; Microtubule-Associated Proteins ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2023-10-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2023.109968
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Article ; Online: Revealing the Specificity of Human H1 Influenza A Viruses to Complex

Canales, Angeles / Sastre, Javier / Orduña, Jose M / Spruit, Cindy M / Pérez-Castells, Javier / Domínguez, Gema / Bouwman, Kim M / van der Woude, Roosmarijn / Cañada, Francisco Javier / Nycholat, Corwin M / Paulson, James C / Boons, Geert-Jan / Jiménez-Barbero, Jesús / de Vries, Robert P

JACS Au

2023 Volume 3, Issue 3, Page(s) 868–878

Abstract: Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses. Viral hemagglutinins from different viruses display variability in glycan ... ...

Abstract	Influenza virus infection remains a threat to human health since viral hemagglutinins are constantly drifting, escaping infection and vaccine-induced antibody responses. Viral hemagglutinins from different viruses display variability in glycan recognition. In this context, recent H3N2 viruses have specificity for α2,6 sialylated branched
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ISSN	2691-3704
ISSN (online)	2691-3704
DOI	10.1021/jacsau.2c00664
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Article ; Online: Clavien-Dindo, comprehensive complication index and classification of intraoperative adverse events: a uniform and holistic approach in adverse event registration for (deep) endometriosis surgery.

Metzemaekers, Jeroen / Bouwman, Lotte / de Vos, Marit / van Nieuwenhuizen, Kim / Twijnstra, Andries R H / Smeets, Maddy / Jansen, Frank Willem / Blikkendaal, Mathijs

Human reproduction open

2023 Volume 2023, Issue 2, Page(s) hoad019

Abstract: Study question: What is the additional value of the comprehensive complication index (CCI) and ClassIntra system (classification for intraoperative adverse events (ioAEs)) in adverse event (AE) reporting in (deep) endometriosis (DE) surgery compared to ... ...

Abstract	Study question: What is the additional value of the comprehensive complication index (CCI) and ClassIntra system (classification for intraoperative adverse events (ioAEs)) in adverse event (AE) reporting in (deep) endometriosis (DE) surgery compared to only using the Clavien-Dindo (CD) system? Summary answer: The CCI and ClassIntra are useful additional tools alongside the CD system for a complete and uniform overview of the total AE burden in patients with extensive surgery (such as DE), and with this uniform data registration, it is possible to provide greater insight into the quality of care. What is known already: Uniform comparison of AEs reported in the literature is hampered by scattered registration. In endometriosis surgery, the usage of the CD complication system and the CCI is internationally recommended; however, the CCI is not routinely adapted in endometriosis care and research. Furthermore, a recommendation for ioAEs registration in endometriosis surgery is lacking, although this is vital information in surgical quality assessments. Study design size duration: A prospective mono-center study was conducted with 870 surgical DE cases from a non-university DE expertise center between February 2019 and December 2021. Participants/materials setting methods: Endometriosis cases were collected with the EQUSUM system, a publicly available web-based application for registration of surgical procedures for endometriosis. Postoperative adverse events (poAEs) were classified with the CD complication system and CCI. Differences in reporting and classifying AEs between the CCI and the CD were assessed. ioAEs were assessed with the ClassIntra. The primary outcome measure was to assess the additional value toward the CD classification with the introduction of the CCI and ClassIntra. In addition, we report a benchmark for the CCI in DE surgery. Main results and the role of chance: A total of 870 DE procedures were registered, of which 145 procedures with one or more poAEs, resulting in a poAE rate of 16.7% (145/870), of which in 36 cases (4.1%), the poAE was classified as severe (≥Grade 3b). The median CCI (interquartile range) of patients with poAEs was 20.9 (20.9-31.7) and 33.7 (33.7-39.7) in the group of patients with severe poAEs. In 20 patients (13.8%), the CCI was higher than the CD because of multiple poAEs. There were 11 ioAEs reported (11/870, 1.3%) in all procedures, mostly minor and directly repaired serosa injuries. Limitations reasons for caution: This study was conducted at a single center; thus, trends in AE rates and type of AEs could differ from other centers. Furthermore, no conclusion could be drawn on ioAEs in relation to the postoperative course because the power of this database is not robust enough for that purpose. Wider implications of the findings: From our data, we would advise to use the Clavien-Dindo classification system together with the CCI and ClassIntra for a complete overview of AE registration. The CCI appeared to provide a more complete overview of the total burden of poAEs compared to only reporting the most severe poAEs (as with CD). If the use of the CD, CCI, and ClassIntra is widely adapted, uniform data comparison will be possible at (inter)national level, providing better insight into the quality of care. Our data could be used as a first benchmark for other DE centers to optimize information provision in the shared decision-making process. Study funding/competing interests: No funding was received for this study. The authors have no conflicts of interest to declare. Trial registration number: N/A.
Language	English
Publishing date	2023-05-11
Publishing country	England
Document type	Journal Article
ISSN	2399-3529
ISSN (online)	2399-3529
DOI	10.1093/hropen/hoad019
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Article: Heparan Sulfate Proteoglycans as Attachment Factor for SARS-CoV-2.

Liu, Lin / Chopra, Pradeep / Li, Xiuru / Bouwman, Kim M / Tompkins, S Mark / Wolfert, Margreet A / de Vries, Robert P / Boons, Geert-Jan

ACS central science

2021 Volume 7, Issue 6, Page(s) 1009–1018

Abstract: Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an unprecedented global pandemic demanding the urgent development of therapeutic strategies. Microarray binding experiments, using an extensive heparan sulfate (HS) ... ...

Abstract	Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an unprecedented global pandemic demanding the urgent development of therapeutic strategies. Microarray binding experiments, using an extensive heparan sulfate (HS) oligosaccharide library, showed that the receptor binding domain (RBD) of the spike of SARS-CoV-2 can bind HS in a length- and sequence-dependent manner. A hexasaccharide composed of IdoA2S-GlcNS6S repeating units was identified as the minimal binding epitope. Surface plasmon resonance showed the SARS-CoV-2 spike protein binds with a much higher affinity to heparin (
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.1c00010
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Article: Interference between avian corona and influenza viruses: The role of the epithelial architecture of the chicken trachea

Weerts, Erik A.W.S. / Bouwman, Kim M. / Paerels, Lieke / Gröne, Andrea / Jan Boelm, Gert / Verheije, M. Hélène

Veterinary microbiology. 2022 Sept., v. 272

2022

Abstract	Respiratory viral infections are among the major causes of disease in poultry. While viral dual infections are known to occur, viral interference in chicken airways is mechanistically hardly understood. The effects of infectious bronchitis virus (IBV) infection on tissue morphology, sialic acid (sia) expression and susceptibility of the chicken trachea for superinfection with IBV or avian influenza virus (AIV) were studied. In vivo, tracheal epithelium of chickens infected with IBV QX showed marked inflammatory cell infiltration and loss of cilia and goblet cells five days post inoculation. Plant lectin staining indicated that sialic acids redistributed from the apical membrane of the ciliated epithelium and the goblet cell cytoplasm to the basement membrane region of the epithelium. After administration of recombinant viral attachment proteins to slides of infected tissue, retained binding of AIV hemagglutinin, absence of binding of the receptor binding domain (RBD) of IBV M41 and partial reduction of IBV QX RBD were observed. Adult chicken trachea rings were used as ex vivo model to study the effects of IBV QX-induced pathological changes and receptor redistribution on secondary viral infection. AIV H9N2 infection after primary IBV infection was delayed; however, final viral loads reached similar levels as in previously uninfected trachea rings. In contrast, IBV M41 superinfection resulted in 1000-fold lower viral titers over the course of 48 h. In conclusion, epithelial changes in the chicken trachea after viral infection coincide with redistribution and likely specific downregulation of viral receptors, with the extend of subsequent viral interference dependent on viral species.
Keywords	Infectious bronchitis virus ; Influenza A virus ; adults ; basement membrane ; chickens ; cytoplasm ; ex vivo studies ; hemagglutinins ; influenza ; lectins ; microbiology ; sialic acid ; superinfection
Language	English
Dates of publication	2022-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	753154-0
ISSN	1873-2542 ; 0378-1135
ISSN (online)	1873-2542
ISSN	0378-1135
DOI	10.1016/j.vetmic.2022.109499
Database	NAL-Catalogue (AGRICOLA)

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Article: Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2.

Liu, Lin / Chopra, Pradeep / Li, Xiuru / Bouwman, Kim M / Tompkins, Stephen Mark / Wolfert, Margreet A / de Vries, Robert P / Boons, Geert-Jan

bioRxiv : the preprint server for biology

2021

Abstract	Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is causing an unprecedented global pandemic demanding the urgent development of therapeutic strategies. Microarray binding experiments using an extensive heparan sulfate (HS) oligosaccharide library showed that the receptor binding domain (RBD) of the spike of SARS-CoV-2 can bind HS in a length- and sequence-dependent manner. Hexa- and octa-saccharides composed of IdoA2S-GlcNS6S repeating units were identified as optimal ligands. Surface plasma resonance (SPR) showed the SARS-CoV-2 spike protein binds with much higher affinity to heparin (KD = 55 nM) compared to the RBD (KD = 1 uM) alone. We also found that heparin does not interfere in angiotensin-converting enzyme 2 (ACE2) binding or proteolytic processing of the spike. Our data supports a model in which HS functions as the point of initial attachment for SARS-CoV-2 infection. Tissue staining studies using biologically relevant tissues indicate that heparan sulfate proteoglycan (HSPG) is a critical attachment factor for the virus. Collectively, our results highlight the potential of using HS oligosaccharides as a therapeutic agent by inhibiting SARS-CoV-2 binding to target cells.
Keywords	covid19
Language	English
Publishing date	2021-01-04
Publishing country	United States
Document type	Preprint
DOI	10.1101/2020.05.10.087288
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Article ; Online: N

Spruit, Cindy M / Zhu, Xueyong / Tomris, Ilhan / Ríos-Carrasco, María / Han, Alvin X / Broszeit, Frederik / van der Woude, Roosmarijn / Bouwman, Kim M / Luu, Michel M T / Matsuno, Keita / Sakoda, Yoshihiro / Russell, Colin A / Wilson, Ian A / Boons, Geert-Jan / de Vries, Robert P

Journal of virology

2022 Volume 96, Issue 5, Page(s) e0212021

Abstract: Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on the cell surface. Hosts of IAV variably express two major forms of sialic acid, ...

Abstract	Influenza A viruses (IAV) initiate infection by binding to glycans with terminal sialic acids on the cell surface. Hosts of IAV variably express two major forms of sialic acid,
MeSH term(s)	Animals ; Hemagglutinin Glycoproteins, Influenza Virus/chemistry ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Horses ; Humans ; Influenza A Virus, H7N7 Subtype/chemistry ; Influenza A Virus, H7N7 Subtype/metabolism ; N-Acetylneuraminic Acid ; Neuraminic Acids/chemistry ; Neuraminic Acids/metabolism ; Phylogeny ; Polysaccharides/metabolism ; Protein Binding
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus ; Neuraminic Acids ; Polysaccharides ; N-glycolylneuraminic acid (1113-83-3) ; N-Acetylneuraminic Acid (GZP2782OP0)
Language	English
Publishing date	2022-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/jvi.02120-21
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