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  1. Article ; Online: The Human Connectome Project and beyond: initial applications of 300 mT/m gradients.

    McNab, Jennifer A / Edlow, Brian L / Witzel, Thomas / Huang, Susie Y / Bhat, Himanshu / Heberlein, Keith / Feiweier, Thorsten / Liu, Kecheng / Keil, Boris / Cohen-Adad, Julien / Tisdall, M Dylan / Folkerth, Rebecca D / Kinney, Hannah C / Wald, Lawrence L

    NeuroImage

    2013  Volume 80, Page(s) 234–245

    Abstract: The engineering of a 3 T human MRI scanner equipped with 300 mT/m gradients - the strongest ... Yet, the 300 mT/m gradient system is well suited to many additional types of diffusion measurements. Here ... we present three initial applications of the 300 mT/m gradients that fall outside the immediate scope ...

    Abstract The engineering of a 3 T human MRI scanner equipped with 300 mT/m gradients - the strongest gradients ever built for an in vivo human MRI scanner - was a major component of the NIH Blueprint Human Connectome Project (HCP). This effort was motivated by the HCP's goal of mapping, as completely as possible, the macroscopic structural connections of the in vivo healthy, adult human brain using diffusion tractography. Yet, the 300 mT/m gradient system is well suited to many additional types of diffusion measurements. Here, we present three initial applications of the 300 mT/m gradients that fall outside the immediate scope of the HCP. These include: 1) diffusion tractography to study the anatomy of consciousness and the mechanisms of brain recovery following traumatic coma; 2) q-space measurements of axon diameter distributions in the in vivo human brain and 3) postmortem diffusion tractography as an adjunct to standard histopathological analysis. We show that the improved sensitivity and diffusion-resolution provided by the gradients are rapidly enabling human applications of techniques that were previously possible only for in vitro and animal models on small-bore scanners, thereby creating novel opportunities to map the microstructure of the human brain in health and disease.
    MeSH term(s) Adult ; Animals ; Brain/cytology ; Brain/physiology ; Connectome/methods ; Diffusion Tensor Imaging/methods ; Female ; Humans ; Image Enhancement/methods ; Male ; Models, Anatomic ; Models, Neurological ; Nerve Net/cytology ; Nerve Net/physiology ; Pilot Projects ; Young Adult
    Language English
    Publishing date 2013-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1147767-2
    ISSN 1095-9572 ; 1053-8119
    ISSN (online) 1095-9572
    ISSN 1053-8119
    DOI 10.1016/j.neuroimage.2013.05.074
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    Zs.A 3664: Show issues Location:
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  2. Article ; Online: Deep Brain Stimulation for Children with Generalized Epilepsy.

    Piper, Rory J / Ibrahim, George M / Tisdall, Martin M

    Neurosurgery clinics of North America

    2023  Volume 35, Issue 1, Page(s) 17–25

    Abstract: Intracranial neuromodulation is an evolving therapy for patients with drug-resistant epilepsy (DRE). Deep brain stimulation (DBS) is now available as a therapy for patients with DRE and focal-onset seizures in select health care systems; however, there ... ...

    Abstract Intracranial neuromodulation is an evolving therapy for patients with drug-resistant epilepsy (DRE). Deep brain stimulation (DBS) is now available as a therapy for patients with DRE and focal-onset seizures in select health care systems; however, there remains a substantial need of efficacy data before DBS can be more widely adopted into routine clinical practice. This review and commentary focuses on a particular shifting paradigm: DBS as a therapy for children with generalized-onset seizures.
    MeSH term(s) Humans ; Child ; Deep Brain Stimulation ; Epilepsy, Generalized/therapy ; Epilepsy, Generalized/etiology ; Seizures/therapy ; Drug Resistant Epilepsy/therapy ; Drug Resistant Epilepsy/etiology ; Treatment Outcome
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1196855-2
    ISSN 1558-1349 ; 1042-3680
    ISSN (online) 1558-1349
    ISSN 1042-3680
    DOI 10.1016/j.nec.2023.09.002
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  3. Article: Bias and SNR of

    Tisdall, M Dylan

    Proceedings of the International Society for Magnetic Resonance in Medicine ... Scientific Meeting and Exhibition. International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition

    2018  Volume 25, Page(s) 1445

    Abstract: Previous work has suggested fitting joint AFI/FLASH data for T1 and B1+ by minimizing the 2-norm of the difference between the signal model and measurements will produce unbiased estimates of T1. We demonstrate that, contrary to previous results, the ... ...

    Abstract Previous work has suggested fitting joint AFI/FLASH data for T1 and B1+ by minimizing the 2-norm of the difference between the signal model and measurements will produce unbiased estimates of T1. We demonstrate that, contrary to previous results, the estimator has a substantial bias that varies with both the true T1 and B1+, and the receive channel count. We also demonstrate that the correct ML estimator removes the effect of channel count, and that the choice of AFI protocol has a larger impact of the quality of estimates than the addition of an extra FLASH scan.
    Language English
    Publishing date 2018-04-10
    Publishing country United States
    Document type Journal Article
    ISSN 1524-6965 ; 1065-9889
    ISSN 1524-6965 ; 1065-9889
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  4. Article: Leveraging Multi-echo EPI to Enhance BOLD Sensitivity in Task-based Olfactory fMRI.

    Zhao, Ludwig Sichen / Raithel, Clara U / Tisdall, M Dylan / Detre, John A / Gottfried, Jay A

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast relies on gradient echo echo-planar imaging (GE-EPI) to quantify dynamic susceptibility changes associated with the hemodynamic response to neural ... ...

    Abstract Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast relies on gradient echo echo-planar imaging (GE-EPI) to quantify dynamic susceptibility changes associated with the hemodynamic response to neural activity. However, acquiring BOLD fMRI in human olfactory regions is particularly challenging due to their proximity to the sinuses where large susceptibility gradients induce magnetic field distortions. BOLD fMRI of the human olfactory system is further complicated by respiratory artifacts that are highly correlated with event onsets in olfactory tasks. Multi-Echo EPI (ME-EPI) acquires gradient echo data at multiple echo times (TEs) during a single acquisition and can leverage signal evolution over the multiple echo times to enhance BOLD sensitivity and reduce artifactual signal contributions. In the current study, we developed a ME-EPI acquisition protocol for olfactory task-based fMRI and demonstrated significant improvement in BOLD signal sensitivity over conventional single-echo EPI (1E-EPI). The observed improvement arose from both an increase in BOLD signal changes through a
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.15.575530
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  5. Book: Researching with children and young people

    Tisdall, E. Kay M. / Davis, John M. / Gallagher, Michael

    research design, methods and analysis

    2009  

    Author's details E. Kay M. Tisdall ; John M. Davis and Michael Gallagher
    Keywords Children/Research ; Children/Research/Methodology ; Youth/Research ; Youth/Research/Methodology
    Subject code 305.23072
    Language English
    Size X, 235 S. : Ill.
    Publisher SAGE
    Publishing place Los Angeles, Calif. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT015354237
    ISBN 978-1-412-92388-0 ; 978-1-4129-2388-0 ; 978-1-412-92389-7 ; 978-1-4129-2389-7 ; 1-4129-2388-3 ; 1-412-92388-3 ; 1-4129-2389-1 ; 1-412-92389-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 393 order for loan Magazin

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  6. Article ; Online: Patient, parent and carer perspectives surrounding expedited paediatric epilepsy surgery.

    Salim, Omar / Chari, Aswin / Ben Zvi, Ido / Batchelor, Rachel / Jones, Monika / Baldeweg, Torsten / Cross, J Helen / Tisdall, Martin

    Epilepsy research

    2024  Volume 200, Page(s) 107309

    Abstract: Objective: Most paediatric epilepsies with MRI visible lesions do not respond to antiseizure pharmacotherapy. Such medication resistance, which often takes years to become formally defined, is commonly required for surgical candidacy. Expedited surgical ...

    Abstract Objective: Most paediatric epilepsies with MRI visible lesions do not respond to antiseizure pharmacotherapy. Such medication resistance, which often takes years to become formally defined, is commonly required for surgical candidacy. Expedited surgical referral at lesional epilepsy diagnosis may result in better seizure, cognitive and developmental prognoses. This study explored the views of patients, parents and carers regarding epilepsy surgery, treatment priorities, and participation in a proposed expedited surgery trial.
    Methods: 205 patients, parents and carers (61% UK-based, 26% North American) responded to electronic surveys from February to May 2022. Participants were recruited through social media sites, epilepsy charities and societies. Categorical choice and free-text questions were used to investigate participant perspectives, and Pearson's chi-squared test was utilised to detect meaningful differences amongst respondent subgroups.
    Results: Almost 90% of respondents who had experienced epilepsy surgery (either themselves or their child) reported seizure cessation or reduction. Postoperative outcome measures prioritised most frequently were seizure freedom (66%), quality of life (47%), seizure severity (30%), seizure frequency (28%) and independence (27%). Most participants support expedited surgery in suitable patients (65%), with just over half (51%) willing to participate in the proposed trial. Many participants (37%) were undecided, often due to fears surrounding neurosurgery. Subgroup perspectives were broadly similar, with more parents and caregivers favouring expedited surgery compared to patients (p = .016) and more UK-based participants willing to take part in an expedited surgery trial compared to those from North America (p = .01).
    Conclusions: Patients, parents and carers are open to considering expedited surgery for lesional epilepsies and would support a trial exploring this approach. Priorities from treatment were largely similar between participant subgroups, with seizure, quality of life and neuropsychological outcomes ranked highly. Accounting for these preferences will facilitate the delivery of a trial that is patient- and caregiver-focused, enhancing feasibility, satisfaction and benefit for prospective participants.
    MeSH term(s) Humans ; Child ; Caregivers ; Prospective Studies ; Quality of Life ; Epilepsy/diagnosis ; Seizures
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2024.107309
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    Zs.A 2193: Show issues Location:
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  7. Article ; Online: The influence of disease course and surgery on quality of life in children with focal cortical dysplasia and long-term epilepsy-associated tumours: A systematic review and meta-analysis.

    Vasilica, Anca-Mihaela / Winsor, Alice / Chari, Aswin / Scott, Rodney / Baldeweg, Torsten / Tisdall, Martin

    Epilepsy research

    2023  Volume 192, Page(s) 107132

    Abstract: Introduction: Carefully selected patients with lesional epilepsy, including focal cortical dysplasia (FCD) and long-term epilepsy-associated tumours (LEAT), can benefit from epilepsy surgery. The influence of disease course and subsequent epilepsy ... ...

    Abstract Introduction: Carefully selected patients with lesional epilepsy, including focal cortical dysplasia (FCD) and long-term epilepsy-associated tumours (LEAT), can benefit from epilepsy surgery. The influence of disease course and subsequent epilepsy surgery on quality of life (QoL) and intelligence quotient (IQ) is not well understood.
    Methods: A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Studies reporting QoL or IQ measures in paediatric patients with FCD and LEAT at epilepsy onset, at establishment of drug resistance (pre-operative/non-surgically managed) and post-operatively were included. To evaluate the "effect size" and clinical significance of surgery, a meta-analysis of the data was conducted using fixed effects models for weighted mean differences, 95% confidence intervals and sensitivity analyses.
    Results: Nineteen eligible studies (911 patients) were included, 17 assessing IQ and 2 evaluating QoL. Twelve studies reported preoperative and postoperative IQ measures and five reported IQ in non-surgically managed cohorts after drug resistance was established; no papers reported IQ at epilepsy onset. No significant IQ/DQ changes were detected after surgery (pre-operative pooled mean 69.32; post-operative pooled mean 69.98; p = 0.32). Age at epilepsy surgery, type of surgery and epilepsy-related pathology did not influence the post-operative IQ. QoL was reported in 2 studies with the pooled mean estimates for pre- and post-operative QoL being 42.52 and 55.50, respectively.
    Conclusions: The present study demonstrated no statistical change in IQ and QoL following surgery in paediatric patients with FCD and LEAT. There was no data on IQ and QoL at disease onset. Attempting to understand the impact of epilepsy, ongoing seizures and surgery on IQ and QoL will facilitate planning of future studies that aim to optimise quality of life and developmental outcomes in these children. Studies assessing children at epilepsy onset with longitudinal follow-up are required to optimise the timing of epilepsy surgery on QoL and IQ.
    MeSH term(s) Humans ; Child ; Quality of Life ; Focal Cortical Dysplasia ; Epilepsy/surgery ; Epilepsy/complications ; Seizures/complications ; Disease Progression ; Retrospective Studies ; Treatment Outcome
    Language English
    Publishing date 2023-03-30
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 632939-1
    ISSN 1872-6844 ; 0920-1211
    ISSN (online) 1872-6844
    ISSN 0920-1211
    DOI 10.1016/j.eplepsyres.2023.107132
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  8. Article ; Online: Visual field defects in temporal lobe epilepsy surgery.

    Vakharia, Vejay N / Diehl, Beate / Tisdall, Martin

    Current opinion in neurology

    2021  Volume 34, Issue 2, Page(s) 188–196

    Abstract: Purpose of review: Surgery can provide a robust long-standing seizure remission in drug-refractory mesial temporal lobe epilepsy (MTLE). Despite this, a significant proportion of postoperative patients are ineligible to gain a driving licence due to the ...

    Abstract Purpose of review: Surgery can provide a robust long-standing seizure remission in drug-refractory mesial temporal lobe epilepsy (MTLE). Despite this, a significant proportion of postoperative patients are ineligible to gain a driving licence due to the size of the subsequent visual field defect (VFD). The amygdala and hippocampus are intimately related to several important white fibre association tracts and damage to the optic radiation results in a contralateral superior quadrantanopia. For this reason, several different modifications to established surgical approaches and novel techniques have recently been applied to mitigate or prevent damage to the optic radiation. There is still no consensus on which operative technique results in optimal outcomes regarding seizure remission, neuropsychological sequelae and VFD rates. We explore contemporary surgical approaches to the mesial temporal lobe and describe the intraoperative use of tractography and iMRI in preventing VFDs.
    Recent findings: Established approaches for the surgical treatment of MTLE include standardized approaches in the form of anterior temporal lobectomies, selective approaches and various modifications thereof. Recent advancements in microsurgical techniques have seen numerous modifications to these approaches to spare the optic radiation as well as the introduction of minimally invasive alternatives such as laser interstitial thermal therapy (LITT) and stereotactic radiosurgery (SRS). The intraoperative use of optic radiation tractography through overlays in the operative microscope and interventional MRI suites to correct for brain shift have been shown to reduce VFDs.
    Summary: VFDs following the surgical treatment of drug-refractory MTLE can have a significant impact on the quality of life. Each of the surgical techniques carries a risk to the visual pathways but the use of minimally invasive techniques as well as surgical adjuncts may reduce or prevent acquired VFDs.
    MeSH term(s) Epilepsy, Temporal Lobe/diagnostic imaging ; Epilepsy, Temporal Lobe/surgery ; Hippocampus ; Humans ; Quality of Life ; Treatment Outcome ; Vision Disorders/etiology ; Visual Fields
    Language English
    Publishing date 2021-02-07
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1182686-1
    ISSN 1473-6551 ; 1350-7540
    ISSN (online) 1473-6551
    ISSN 1350-7540
    DOI 10.1097/WCO.0000000000000905
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  9. Article ; Online: Neurostimulation devices for children: lessons learned.

    Piper, Rory J / Fleming, John / Valentín, Antonio / Kaliakatsos, Marios / Tisdall, Martin M

    The Lancet. Child & adolescent health

    2022  Volume 6, Issue 6, Page(s) 359–361

    MeSH term(s) Child ; Humans ; Implantable Neurostimulators
    Language English
    Publishing date 2022-06-13
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2352-4650
    ISSN (online) 2352-4650
    DOI 10.1016/S2352-4642(22)00123-7
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  10. Article ; Online: Letter to the Editor. Systematic and safe approaches to innovation in pediatric pinning.

    Chari, Aswin / Tisdall, Martin M / Marcus, Hani J

    Journal of neurosurgery. Pediatrics

    2020  Volume 26, Issue 5, Page(s) 601–602

    Language English
    Publishing date 2020-08-14
    Publishing country United States
    Document type Journal Article ; Letter
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2020.5.PEDS20375
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