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Article ; Online: The Promise of Quantitative Computed Tomographic Analysis in Assessing Progression of Interstitial Lung Abnormalities and Emphysema in Smokers.

Larici, Anna Rita / Cicchetti, Giuseppe

American journal of respiratory and critical care medicine

2023 Volume 208, Issue 6, Page(s) 645–647

MeSH term(s)	Humans ; Smokers ; Deep Learning ; Pulmonary Emphysema/diagnostic imaging ; Pulmonary Emphysema/etiology ; Lung Diseases, Interstitial/diagnostic imaging ; Lung Diseases, Interstitial/etiology ; Lung/diagnostic imaging ; Emphysema
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202306-1063ED
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Article ; Online: COVID-19 pneumonia: current evidence of chest imaging features, evolution and prognosis.

Larici, Anna Rita / Cicchetti, Giuseppe / Marano, Riccardo / Bonomo, Lorenzo / Storto, Maria Luigia

Chinese journal of academic radiology

2021 Volume 4, Issue 4, Page(s) 229–240

Abstract: COVID-19 pneumonia represents a global threatening disease, especially in severe cases. Chest imaging, with X-ray and high-resolution computed tomography (HRCT), plays an important role in the initial evaluation and follow-up of patients with COVID-19 ... ...

Abstract	COVID-19 pneumonia represents a global threatening disease, especially in severe cases. Chest imaging, with X-ray and high-resolution computed tomography (HRCT), plays an important role in the initial evaluation and follow-up of patients with COVID-19 pneumonia. Chest imaging can also help in assessing disease severity and in predicting patient's outcome, either as an independent factor or in combination with clinical and laboratory features. This review highlights the current knowledge of imaging features of COVID-19 pneumonia and their temporal evolution over time, and provides recent evidences on the role of chest imaging in the prognostic assessment of the disease.
Language	English
Publishing date	2021-05-04
Publishing country	Singapore
Document type	Journal Article ; Review
ZDB-ID	2967251-X
ISSN	2520-8993 ; 2520-8985
ISSN (online)	2520-8993
ISSN	2520-8985
DOI	10.1007/s42058-021-00068-0
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Article ; Online: A randomized trial of pamrevlumab in patients with COVID-19 pneumonia.

Sgalla, Giacomo / Leone, Paolo Maria / Gualano, Gina / Simonetti, Jacopo / Comes, Alessia / Verdirosi, Diana / Di Gennaro, Francesco / Larici, Anna Rita / Ianniello, Stefania / Cicchetti, Giuseppe / Fusco, Nicoletta / Pani, Marcello / Palmieri, Fabrizio / Richeldi, Luca

Respirology (Carlton, Vic.)

2023 Volume 28, Issue 10, Page(s) 954–957

MeSH term(s)	Humans ; COVID-19 ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	pamrevlumab (QS5F6VTS0O) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-08-21
Publishing country	Australia
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14575
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Article ; Online: Implementation of artificial intelligence in thoracic imaging-a what, how, and why guide from the European Society of Thoracic Imaging (ESTI).

Gleeson, Fergus / Revel, Marie-Pierre / Biederer, Jürgen / Larici, Anna Rita / Martini, Katharina / Frauenfelder, Thomas / Screaton, Nicholas / Prosch, Helmut / Snoeckx, Annemiek / Sverzellati, Nicola / Ghaye, Benoit / Parkar, Anagha P

European radiology

2023 Volume 33, Issue 7, Page(s) 5077–5086

Abstract: This statement from the European Society of Thoracic imaging (ESTI) explains and summarises the essentials for understanding and implementing Artificial intelligence (AI) in clinical practice in thoracic radiology departments. This document discusses the ...

Abstract	This statement from the European Society of Thoracic imaging (ESTI) explains and summarises the essentials for understanding and implementing Artificial intelligence (AI) in clinical practice in thoracic radiology departments. This document discusses the current AI scientific evidence in thoracic imaging, its potential clinical utility, implementation and costs, training requirements and validation, its' effect on the training of new radiologists, post-implementation issues, and medico-legal and ethical issues. All these issues have to be addressed and overcome, for AI to become implemented clinically in thoracic radiology. KEY POINTS: • Assessing the datasets used for training and validation of the AI system is essential. • A departmental strategy and business plan which includes continuing quality assurance of AI system and a sustainable financial plan is important for successful implementation. • Awareness of the negative effect on training of new radiologists is vital.
MeSH term(s)	Humans ; Artificial Intelligence ; Radiology/methods ; Radiologists ; Radiography, Thoracic ; Societies, Medical
Language	English
Publishing date	2023-02-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-023-09409-2
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Zs.A 3300: Show issues

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Article: Pulmonary Hypertension in Chronic Lung Diseases: What Role Do Radiologists Play?

Valentini, Adele / Franchi, Paola / Cicchetti, Giuseppe / Messana, Gaia / Chiffi, Greta / Strappa, Cecilia / Calandriello, Lucio / Del Ciello, Annemilia / Farchione, Alessandra / Preda, Lorenzo / Larici, Anna Rita

Diagnostics (Basel, Switzerland)

2023 Volume 13, Issue 9

Abstract: Pulmonary hypertension (PH) is a pathophysiological disorder, defined by a mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest, as assessed by right heart catheterization (RHC). PH is not a specific disease, as it may be observed in multiple ... ...

Abstract	Pulmonary hypertension (PH) is a pathophysiological disorder, defined by a mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest, as assessed by right heart catheterization (RHC). PH is not a specific disease, as it may be observed in multiple clinical conditions and may complicate a variety of thoracic diseases. Conditions associated with the risk of developing PH are categorized into five different groups, according to similar clinical presentations, pathological findings, hemodynamic characteristics, and treatment strategy. Most chronic lung diseases that may be complicated by PH belong to group 3 (interstitial lung diseases, chronic obstructive pulmonary disease, combined pulmonary fibrosis, and emphysema) and are associated with the lowest overall survival among all groups. However, some of the chronic pulmonary diseases may develop PH with unclear/multifactorial mechanisms and are included in group 5 PH (sarcoidosis, pulmonary Langerhans' cell histiocytosis, and neurofibromatosis type 1). This paper focuses on PH associated with chronic lung diseases, in which radiological imaging-particularly computed tomography (CT)-plays a crucial role in diagnosis and classification. Radiologists should become familiar with the hemodynamical, physiological, and radiological aspects of PH and chronic lung diseases in patients at risk of developing PH, whose prognosis and treatment depend on the underlying disease.
Language	English
Publishing date	2023-05-01
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13091607
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Article ; Online: Pulmonary Hypertension in Chronic Lung Diseases

Adele Valentini / Paola Franchi / Giuseppe Cicchetti / Gaia Messana / Greta Chiffi / Cecilia Strappa / Lucio Calandriello / Annemilia del Ciello / Alessandra Farchione / Lorenzo Preda / Anna Rita Larici

Diagnostics, Vol 13, Iss 1607, p

What Role Do Radiologists Play?

2023 Volume 1607

Abstract	Pulmonary hypertension (PH) is a pathophysiological disorder, defined by a mean pulmonary arterial pressure (mPAP) > 20 mmHg at rest, as assessed by right heart catheterization (RHC). PH is not a specific disease, as it may be observed in multiple clinical conditions and may complicate a variety of thoracic diseases. Conditions associated with the risk of developing PH are categorized into five different groups, according to similar clinical presentations, pathological findings, hemodynamic characteristics, and treatment strategy. Most chronic lung diseases that may be complicated by PH belong to group 3 (interstitial lung diseases, chronic obstructive pulmonary disease, combined pulmonary fibrosis, and emphysema) and are associated with the lowest overall survival among all groups. However, some of the chronic pulmonary diseases may develop PH with unclear/multifactorial mechanisms and are included in group 5 PH (sarcoidosis, pulmonary Langerhans’ cell histiocytosis, and neurofibromatosis type 1). This paper focuses on PH associated with chronic lung diseases, in which radiological imaging—particularly computed tomography (CT)—plays a crucial role in diagnosis and classification. Radiologists should become familiar with the hemodynamical, physiological, and radiological aspects of PH and chronic lung diseases in patients at risk of developing PH, whose prognosis and treatment depend on the underlying disease.
Keywords	pulmonary hypertension ; chronic lung diseases ; imaging ; computed tomography ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Extension of Lung Damage at Chest Computed Tomography in Severely Ill COVID-19 Patients Treated with Interleukin-6 Receptor Blockers Correlates with Inflammatory Cytokines Production and Prognosis.

Calandriello, Lucio / De Lorenzis, Enrico / Cicchetti, Giuseppe / D'Abronzo, Rosa / Infante, Amato / Castaldo, Federico / Del Ciello, Annemilia / Farchione, Alessandra / Gremese, Elisa / Marano, Riccardo / Natale, Luigi / D'Agostino, Maria Antonietta / Bosello, Silvia Laura / Larici, Anna Rita

Tomography (Ann Arbor, Mich.)

2023 Volume 9, Issue 3, Page(s) 981–994

Abstract: Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in ... ...

Abstract	Elevated inflammatory markers are associated with severe coronavirus disease 2019 (COVID-19), and some patients benefit from Interleukin (IL)-6 pathway inhibitors. Different chest computed tomography (CT) scoring systems have shown a prognostic value in COVID-19, but not specifically in anti-IL-6-treated patients at high risk of respiratory failure. We aimed to explore the relationship between baseline CT findings and inflammatory conditions and to evaluate the prognostic value of chest CT scores and laboratory findings in COVID-19 patients specifically treated with anti-IL-6. Baseline CT lung involvement was assessed in 51 hospitalized COVID-19 patients naive to glucocorticoids and other immunosuppressants using four CT scoring systems. CT data were correlated with systemic inflammation and 30-day prognosis after anti-IL-6 treatment. All the considered CT scores showed a negative correlation with pulmonary function and a positive one with C-reactive protein (CRP), IL-6, IL-8, and Tumor Necrosis Factor α (TNF-α) serum levels. All the performed scores were prognostic factors, but the disease extension assessed by the six-lung-zone CT score (S24) was the only independently associated with intensive care unit (ICU) admission (
MeSH term(s)	Humans ; COVID-19/diagnostic imaging ; Cytokines ; Inflammation ; Lung/diagnostic imaging ; Lung/pathology ; Prognosis ; Receptors, Interleukin-6/antagonists & inhibitors ; Retrospective Studies ; Tomography, X-Ray Computed ; COVID-19 Drug Treatment
Chemical Substances	Cytokines ; Receptors, Interleukin-6
Language	English
Publishing date	2023-05-11
Publishing country	Switzerland
Document type	Journal Article
ISSN	2379-139X
ISSN (online)	2379-139X
DOI	10.3390/tomography9030080
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Article ; Online: Retinal vascular impairment matched to the pulmonary damage in early post-COVID 19 patients.

Savastano, Maria Cristina / Larici, Anna Rita / Crincoli, Emanuele / De Filippis, Alessandro / Cicchetti, Giuseppe / Gambini, Gloria / Savastano, Alfonso / Marano, Riccardo / Natale, Luigi / Rizzo, Stanislao

European journal of ophthalmology

2022 Volume 32, Issue 6, Page(s) 3574–3583

Abstract: Background: Endothelium damage is a crucial element in the pathogenesis of SARS-Cov-2 infection. Most casualties in critical COVID-19 cases are due to ARDS, diffuse coagulopathy and cytokine storm. ARDS itself is a consequence of pulmonary endothelial ... ...

Abstract	Background: Endothelium damage is a crucial element in the pathogenesis of SARS-Cov-2 infection. Most casualties in critical COVID-19 cases are due to ARDS, diffuse coagulopathy and cytokine storm. ARDS itself is a consequence of pulmonary endothelial cells damage. Damage to retinal capillary microcirculation in post-infective period has been investigated through Optical Coherence Tomography Angiography (OCTA). The aim of the present study is to find a correlation between signs of retinal vascular damage and pulmonary impairment. Methods: Patients admitted to hospital and subsequently recovered from COVID-19 infection were summoned 1 month later to undergo coherence tomography (CT) scan and OCTA examination. Results: The study population included 87 COVID-19 patients with a mean age of 54.28 ± 14.44 years. Oxygen therapy, non-invasive and invasive mechanical ventilation were necessary in 33, 11 and 4 patients respectively to provide respiratory support during the acute course of the disease. Pulmonary involvement interested 54 patients (62.1%). Peripheral (27.6%) or diffuse (29.9%) involvement and ground glass (GG) opacities (47.1%) represented the prevalent radiological finding. A reduced RCPI FI was independently correlated with the presence of reticulation pattern in CT scan ( Conclusions: A reduction in RPCP-FI and RNFL and GCC thickness were independently correlated to the presence of CT reticulation pattern. This association can reflect cytokine induced remodeling in both organs as a consequence of systemic endothelial damage and inflammation.
MeSH term(s)	Adult ; Aged ; COVID-19/complications ; Cytokines ; Endothelial Cells ; Humans ; Middle Aged ; Oxygen ; Respiratory Distress Syndrome ; Retinal Vessels ; SARS-CoV-2 ; Tomography, Optical Coherence/methods
Chemical Substances	Cytokines ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-02-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1089461-5
ISSN	1724-6016 ; 1120-6721
ISSN (online)	1724-6016
ISSN	1120-6721
DOI	10.1177/11206721221079153
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Article: Aging Airways: between Normal and Disease. A Multidimensional Diagnostic Approach by Combining Clinical, Functional, and Imaging Data.

Occhipinti, Mariaelena / Larici, Anna Rita / Bonomo, Lorenzo / Incalzi, Raffaele Antonelli

Aging and disease

2017 Volume 8, Issue 4, Page(s) 471–485

Abstract: The lack of data on lung function decline in the aging process as well as the lack of gold standards to define obstructive and restrictive respiratory disease in older people point out the need for a multidimensional assessment and interpretation of the ... ...

Abstract	The lack of data on lung function decline in the aging process as well as the lack of gold standards to define obstructive and restrictive respiratory disease in older people point out the need for a multidimensional assessment and interpretation of the aging airways. By integrating clinical data together with morphologic and morphometric findings clinicians can assess the airways with a more comprehensive perspective, helpful in the interpretation of the "grey zone" between normal aging and disease. This review focuses on the value of a multidimensional approach in the study of the aging airways, including clinical findings, respiratory function tests, and imaging as parts of a whole. Nowadays this multidimensional diagnostic approach can be used in daily clinical practice. In next future, it can be implemented by the analysis of exhaled gases, post-processing imaging techniques, and genetic analysis, that will hopefully reduce the gaps in knowledge of normal aging and airway disease in older people.
Language	English
Publishing date	2017-07-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2625789-0
ISSN	2152-5250
ISSN	2152-5250
DOI	10.14336/AD.2016.1215
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Article ; Online: Imaging of Cardiopulmonary Involvement in Systemic Immune-mediated Diseases: A Comprehensive Review.

Bordonaro, Veronica / Larici, Anna Rita / Franchi, Paola / Paciolla, Fabiano / Giubbolini, Francesca / Meduri, Agostino / Marano, Riccardo / Manfredi, Riccardo / Natale, Luigi

Journal of thoracic imaging

2020 Volume 36, Issue 3, Page(s) W35–W51

Abstract: Systemic immune-mediated diseases (SID) are a large group of disorders characterized by complex inflammatory and autoimmune damage to various organs and tissues. Among the possible manifestations, SIDs may potentially involve each structure of the ... ...

Abstract	Systemic immune-mediated diseases (SID) are a large group of disorders characterized by complex inflammatory and autoimmune damage to various organs and tissues. Among the possible manifestations, SIDs may potentially involve each structure of the cardiopulmonary system. Each disease is characterized by a specific clinical presentation. Coronary artery disease, myocarditis, pericarditis, valvular disease, pulmonary arterial hypertension, and interstitial lung disease represent characteristic findings of cardiopulmonary involvement in these disorders and their prompt recognition is crucial for the diagnosis of SIDs and the patient's prognosis. In this setting, chest high-resolution computed tomography and cardiac magnetic resonance are the most important noninvasive techniques for the assessment of these diseases and their complications. The knowledge of various cardiac and pulmonary radiologic patterns increases the likelihood of diagnosing these disorders and can lead to improved understanding of the underlying pathophysiology to personalize the treatment for each patient.
MeSH term(s)	Heart ; Humans ; Lung ; Lung Diseases, Interstitial/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2020-03-23
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632900-7
ISSN	1536-0237 ; 0883-5993
ISSN (online)	1536-0237
ISSN	0883-5993
DOI	10.1097/RTI.0000000000000496
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