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  1. Article ; Online: Smoking-related

    Chen, Silu / Xin, Junyi / Gu, Dongying / Li, Huiqin / Zheng, Rui / Li, Shuwei / Zhang, Zhengdong / Du, Mulong / Wang, Meilin

    Gut

    2024  

    Language English
    Publishing date 2024-03-18
    Publishing country England
    Document type Letter
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2023-331865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
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  2. Article ; Online: Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders.

    Shen, Haoran / Zheng, Rui / Du, Mulong / Christiani, David C

    Thorax

    2024  

    Abstract: Background: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the extracellular vesicle ( ... ...

    Abstract Background: Individual exposure to environmental pollutants, as one of the most influential drivers of respiratory disorders, has received considerable attention due to its preventability and controllability. Considering that the extracellular vesicle (EV) was an emerging intercellular communication medium, recent studies have highlighted the crucial role of environmental pollutants derived EVs (EPE-EVs) in respiratory disorders.
    Methods: PubMed and Web of Science were searched from January 2018 to December 2023 for publications with key words of environmental pollutants, respiratory disorders and EVs.
    Results: Environmental pollutants could disrupt airway intercellular communication by indirectly stimulating airway barrier cells to secrete endogenous EVs, or directly transmitting exogenous EVs, mainly by biological pollutants. Mechanistically, EPE-EVs transferred specific contents to modulate biological functions of recipient cells, to induce respiratory inflammation and impair tissue and immune function, which consequently contributed to the development of respiratory diseases, such as asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary hypertension, lung cancer and infectious lung diseases. Clinically, EVs could emerged as promising biomarkers and biological agents for respiratory diseases attributed by their specificity, convenience, sensibility and stability.
    Conclusions: Further studies of EPE-EVs are helpful to understand the aetiology and pathology of respiratory diseases, and facilitate the precision respiratory medicine in risk screening, early diagnosis, clinical management and biotherapy.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thorax-2023-221302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Erratum for: Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk.

    Xia, Tianyi / Du, Mulong / Li, Huiqin / Wang, Yuancheng / Zha, Junhao / Wu, Tong / Ju, Shenghong

    Radiology

    2023  Volume 309, Issue 2, Page(s) e239027

    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.239027
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    Ue I Zs.106: Show issues Location:
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  4. Article ; Online: Cigarette smoking combined with genetic variation regulates the m

    Yang, Jialei / Ji, Zihan / Gao, Fang / Wu, Jiajin / Du, Mulong / Zhang, Zhengdong / Yuan, Lin / Zheng, Rui / Wang, Meilin

    Environmental toxicology

    2024  Volume 39, Issue 5, Page(s) 2782–2793

    Abstract: Cigarette smoking was known to accelerate the occurrence and development of bladder cancer by regulating RNA modification. However, the association between the combination of cigarette smoking and RNA modification-related single nucleotide polymorphisms ( ...

    Abstract Cigarette smoking was known to accelerate the occurrence and development of bladder cancer by regulating RNA modification. However, the association between the combination of cigarette smoking and RNA modification-related single nucleotide polymorphisms (RNAm-SNPs) and bladder cancer risk remains unclear. In this study, 1681 participants, including 580 cases and 1101 controls, were recruited for genetic association analysis. In total, 1 287 990 RNAm-SNPs involving nine RNA modifications (m
    MeSH term(s) Humans ; Cigarette Smoking/genetics ; Risk Factors ; Urinary Bladder Neoplasms/genetics ; Polymorphism, Single Nucleotide ; Methylation ; RNA ; Case-Control Studies ; Nuclear Proteins/genetics
    Chemical Substances RNA (63231-63-0) ; CRNKL1 protein, human ; Nuclear Proteins
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24138
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  5. Article ; Online: An early-onset specific polygenic risk score optimizes age-based risk estimate and stratification of prostate cancer: population-based cohort study.

    Cheng, Yifei / Wu, Lang / Xin, Junyi / Ben, Shuai / Chen, Silu / Li, Huiqin / Zhao, Lingyan / Wang, Meilin / Cheng, Gong / Du, Mulong

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 366

    Abstract: Background: Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined ... ...

    Abstract Background: Early-onset prostate cancer (EOPC, ≤ 55 years) has a unique clinical entity harboring high genetic risk, but the majority of EOPC patients still substantial opportunity to be early-detected thus suffering an unfavorable prognosis. A refined understanding of age-based polygenic risk score (PRS) for prostate cancer (PCa) would be essential for personalized risk stratification.
    Methods: We included 167,517 male participants [4882 cases including 205 EOPC and 4677 late-onset PCa (LOPC)] from UK Biobank. A General-, an EOPC- and an LOPC-PRS were derived from age-specific genome-wide association studies. Weighted Cox proportional hazard models were applied to estimate the risk of PCa associated with PRSs. The discriminatory capability of PRSs were validated using time-dependent receiver operating characteristic (ROC) curves with additional 4238 males from PLCO and TCGA. Phenome-wide association studies underlying Mendelian Randomization were conducted to discover EOPC linking phenotypes.
    Results: The 269-PRS calculated via well-established risk variants was more strongly associated with risk of EOPC [hazard ratio (HR) = 2.35, 95% confidence interval (CI) 1.99-2.78] than LOPC (HR = 1.95, 95% CI 1.89-2.01; I
    Conclusions: This study comprehensively profiled the distinct genetic and phenotypic architecture of EOPC. The EOPC-PRS may optimize risk estimate of PCa in young males, particularly those without family history, thus providing guidance for precision population stratification.
    MeSH term(s) Humans ; Male ; Genetic Risk Score ; Genome-Wide Association Study ; Cohort Studies ; Prostatic Neoplasms ; Risk Factors ; Genetic Predisposition to Disease
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-05190-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk.

    Xia, Tianyi / Du, Mulong / Li, Huiqin / Wang, Yuancheng / Zha, Junhao / Wu, Tong / Ju, Shenghong

    Radiology

    2023  Volume 309, Issue 1, Page(s) e231007

    Abstract: Background A better understanding of the association between liver MRI proton density fat fraction (PDFF) and liver diseases might support the clinical implementation of MRI PDFF. Purpose To quantify the genetically predicted causal effect of liver MRI ... ...

    Abstract Background A better understanding of the association between liver MRI proton density fat fraction (PDFF) and liver diseases might support the clinical implementation of MRI PDFF. Purpose To quantify the genetically predicted causal effect of liver MRI PDFF on liver disease risk. Materials and Methods This population-based prospective observational study used summary-level data mainly from the UK Biobank and FinnGen. Mendelian randomization analysis was conducted using the inverse variance-weighted method to explore the causal association between genetically predicted liver MRI PDFF and liver disease risk with Bonferroni correction. The individual-level data were downloaded between August and December 2020 from the UK Biobank. Logistic regression analysis was performed to validate the association between liver MRI PDFF polygenic risk score and liver disease risk. Mediation analyses were performed using multivariable mendelian randomization. Results Summary-level and individual-level data were obtained from 32 858 participants and 378 436 participants (mean age, 57 years ± 8 [SD]; 203 108 female participants), respectively. Genetically predicted high liver MRI PDFF was associated with increased risks of malignant liver neoplasm (odds ratio [OR], 4.5;
    MeSH term(s) Female ; Humans ; Middle Aged ; Diabetes Mellitus, Type 2/pathology ; Liver/diagnostic imaging ; Liver/pathology ; Liver Cirrhosis/pathology ; Magnetic Resonance Imaging/methods ; Non-alcoholic Fatty Liver Disease/diagnostic imaging ; Non-alcoholic Fatty Liver Disease/genetics ; Non-alcoholic Fatty Liver Disease/pathology ; Male
    Language English
    Publishing date 2023-10-24
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.231007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.106: Show issues Location:
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  7. Article ; Online: LncRNA‐422 suppresses the proliferation and growth of colorectal cancer cells by targeting SFPQ

    Yixuan Meng / Shuwei Li / Qiuyi Zhang / Shuai Ben / Qiuyuan Zhu / Mulong Du / Dongying Gu

    Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)

    2022  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population.

    Wang, Qiangdong / Jiang, Yan / Du, Mulong / Yang, Lei / Yuan, Qinbo

    BMC urology

    2022  Volume 22, Issue 1, Page(s) 127

    Abstract: Trefoil Factor 1 (TFF1) is considered to be able to inhibit the formation of kidney stone. However, genetic variants in TFF1 and corresponding function in kidney stone development are still not well studied. In this study, the discovery set including 230 ...

    Abstract Trefoil Factor 1 (TFF1) is considered to be able to inhibit the formation of kidney stone. However, genetic variants in TFF1 and corresponding function in kidney stone development are still not well studied. In this study, the discovery set including 230 cases and 250 controls was used to analyze the association between seven tagSNPs of TFF1 gene and the nephrolithiasis risk. Further evaluation was confirmed by the validation set comprising 307 cases and 461 controls. The consequences of the two-stage case-control study indicated that individuals with the rs3761376 A allele have significantly increased nephrolithiasis risk than those with the GG genotypes [adjusted odds ratio (OR) = 1.35, 95% confidence interval (CI) = 1.05-1.73]. Moreover, we also carried out a stratified analysis and found the increased nephrolithiasis risks at A allele among males, overweight individuals, no hypertensive individuals, nondiabetic individuals, smokers, and drinkers. In the following functional experiments, the notably lower expression of TFF1 was exhibited by the vectors carrying A allele compared with those carrying G allele in both luciferase (P = 0.022) and expression vectors (P = 0.041). In addition to tissue detection, we confirmed a significant inverse association of rs3761376 G > A and TFF1 gene expression (P < 0.001). These results suggest that TFF1 rs3761376 may serve as a potential biomarker to predict the risk of nephrolithiasis.
    MeSH term(s) Case-Control Studies ; China ; Humans ; Kidney Calculi/genetics ; Male ; Nephrolithiasis/genetics ; Polymorphism, Single Nucleotide/genetics ; Trefoil Factor-1/genetics
    Chemical Substances TFF1 protein, human ; Trefoil Factor-1
    Language English
    Publishing date 2022-08-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059857-9
    ISSN 1471-2490 ; 1471-2490
    ISSN (online) 1471-2490
    ISSN 1471-2490
    DOI 10.1186/s12894-022-01081-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: LncRNA-422 suppresses the proliferation and growth of colorectal cancer cells by targeting SFPQ.

    Meng, Yixuan / Li, Shuwei / Zhang, Qiuyi / Ben, Shuai / Zhu, Qiuyuan / Du, Mulong / Gu, Dongying

    Clinical and translational medicine

    2022  Volume 12, Issue 1, Page(s) e664

    MeSH term(s) Cell Movement/drug effects ; Cell Proliferation/drug effects ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/metabolism ; Drug Therapy/methods ; Drug Therapy/statistics & numerical data ; Humans ; PTB-Associated Splicing Factor/drug effects ; PTB-Associated Splicing Factor/genetics ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/pharmacology
    Chemical Substances LINC00539 lncRNA, human ; PTB-Associated Splicing Factor ; RNA, Long Noncoding
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Integration of pathologic characteristics, genetic risk and lifestyle exposure for colorectal cancer survival assessment.

    Xin, Junyi / Gu, Dongying / Li, Shuwei / Qian, Sangni / Cheng, Yifei / Shao, Wei / Ben, Shuai / Chen, Silu / Zhu, Linjun / Jin, Mingjuan / Chen, Kun / Hu, Zhibin / Zhang, Zhengdong / Du, Mulong / Shen, Hongbing / Wang, Meilin

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 3042

    Abstract: The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two ... ...

    Abstract The development of an effective survival prediction tool is key for reducing colorectal cancer mortality. Here, we apply a three-stage study to devise a polygenic prognostic score (PPS) for stratifying colorectal cancer overall survival. Leveraging two cohorts of 3703 patients, we first perform a genome-wide survival association analysis to develop eight candidate PPSs. Further using an independent cohort with 470 patients, we identify the 287 variants-derived PPS (i.e., PPS
    MeSH term(s) Humans ; Colorectal Neoplasms/pathology ; Proportional Hazards Models ; Survival Rate ; Risk Factors ; Life Style
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-47204-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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