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  1. Book: Xing ke xue yu Zhongguo chuan tong xing xiu lian

    Cai, Jun / Li, Wenkun

    1998  

    Title translation Sexology and sexual behavior in traditional Chinese style.
    Author's details zhu bian Cai Jun, Li Wenkun
    MeSH term(s) Sex ; Sexual Behavior/history
    Keywords China
    Language Chinese
    Size 9, 2, 6, 464 p. :, ill. ;, 21 cm.
    Edition Di 1 ban.
    Publisher Zhongguo Zhong yi yao chu ban she ; jing xiao zhe Xin hua shu dian zong dian Beijing fa xing suo
    Publishing place Beijing
    Document type Book
    ISBN 9787800897160 ; 7800897168
    Database Catalogue of the US National Library of Medicine (NLM)

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  2. Book: Zhonghua min zu yi chuan duo yang xing yan jiu

    Jin, Li

    (Zhongguo ji yin zu yan jiu cong shu)

    2006  

    Author's details Jin Li, Chu Jiayou zhu bian
    Series title Zhongguo ji yin zu yan jiu cong shu
    MeSH term(s) Genetic Variation ; Genetic Engineering
    Keywords China
    Language Chinese
    Size 2, 2, 5, 4, 352 p. :, ill. ;, 25 cm.
    Edition Di 1 ban.
    Publisher Shanghai ke xue ji shu chu ban she
    Publishing place Shanghai
    Document type Book
    ISBN 9787532385522 ; 7532385523
    Database Catalogue of the US National Library of Medicine (NLM)

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  3. Book: Xian dai xing chuan bo ji bing

    Li, Zhiwen

    1991  

    Title translation Sexually transmitted diseases of our time.
    Author's details Li Zhiwen, Ye Shunzhang, Yu Song bian
    MeSH term(s) Sexually Transmitted Diseases
    Language Chinese
    Size 10, 377 p. :, ill.
    Edition Di 1 ban.
    Publisher Ren min wei sheng chu ban she
    Publishing place Beijing Shi
    Document type Book
    ISBN 9787117014786 ; 7117014784
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: Consensus clustering with missing labels (ccml): a consensus clustering tool for multi-omics integrative prediction in cohorts with unequal sample coverage.

    Li, Chuan-Xing / Chen, Hongyan / Zounemat-Kermani, Nazanin / Adcock, Ian M / Sköld, C Magnus / Zhou, Meng / Wheelock, Åsa M

    Briefings in bioinformatics

    2024  Volume 25, Issue 1

    Abstract: Multi-omics data integration is a complex and challenging task in biomedical research. Consensus clustering, also known as meta-clustering or cluster ensembles, has become an increasingly popular downstream tool for phenotyping and endotyping using ... ...

    Abstract Multi-omics data integration is a complex and challenging task in biomedical research. Consensus clustering, also known as meta-clustering or cluster ensembles, has become an increasingly popular downstream tool for phenotyping and endotyping using multiple omics and clinical data. However, current consensus clustering methods typically rely on ensembling clustering outputs with similar sample coverages (mathematical replicates), which may not reflect real-world data with varying sample coverages (biological replicates). To address this issue, we propose a new consensus clustering with missing labels (ccml) strategy termed ccml, an R protocol for two-step consensus clustering that can handle unequal missing labels (i.e. multiple predictive labels with different sample coverages). Initially, the regular consensus weights are adjusted (normalized) by sample coverage, then a regular consensus clustering is performed to predict the optimal final cluster. We applied the ccml method to predict molecularly distinct groups based on 9-omics integration in the Karolinska COSMIC cohort, which investigates chronic obstructive pulmonary disease, and 24-omics handprint integrative subgrouping of adult asthma patients of the U-BIOPRED cohort. We propose ccml as a downstream toolkit for multi-omics integration analysis algorithms such as Similarity Network Fusion and robust clustering of clinical data to overcome the limitations posed by missing data, which is inevitable in human cohorts consisting of multiple data modalities. The ccml tool is available in the R language (https://CRAN.R-project.org/package=ccml, https://github.com/pulmonomics-lab/ccml, or https://github.com/ZhoulabCPH/ccml).
    MeSH term(s) Adult ; Humans ; Consensus ; Multiomics ; Cluster Analysis ; Algorithms ; Asthma/genetics
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2068142-2
    ISSN 1477-4054 ; 1467-5463
    ISSN (online) 1477-4054
    ISSN 1467-5463
    DOI 10.1093/bib/bbad501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6262: Show issues Location:
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  5. Article: Editorial: Omics Data Integration Towards Mining of Phenotype Specific Biomarkers in Cancers and Diseases.

    Cheng, Liang / Deng, Lei / Li, Chuan-Xing / Zhang, Yan

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 763447

    Language English
    Publishing date 2021-10-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.763447
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Editorial

    Liang Cheng / Lei Deng / Chuan-Xing Li / Yan Zhang

    Frontiers in Cell and Developmental Biology, Vol

    Omics Data Integration Towards Mining of Phenotype Specific Biomarkers in Cancers and Diseases

    2021  Volume 9

    Keywords multiple omics data ; system biology method ; molecular basis of disease ; artificial intelligence ; data integration ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p

    Fei Lu / Jing Gao / Yang Luo / Wei-Lin Jin / Haiping Wang / Chuan-Xing Li / Xun Li

    Molecular and Cellular Probes, Vol 71, Iss , Pp 101920- (2023)

    2023  

    Abstract: Background: Aberrant expression of circRNAs is involved in the progression of hepatocellular carcinoma (HCC). This study aimed at screening the pro-tumorigenic circular RNAs (circRNAs) in HCC and the mechanisms of circCPSF6 expression influencing HCC ... ...

    Abstract Background: Aberrant expression of circRNAs is involved in the progression of hepatocellular carcinoma (HCC). This study aimed at screening the pro-tumorigenic circular RNAs (circRNAs) in HCC and the mechanisms of circCPSF6 expression influencing HCC characteristics. Method: circCPSF6 was identified in HCC tissues using high-throughput sequencing data, and its expression was verified in both HCC tissues and cell lines using quantitative real-time PCR (qRT-PCR). CCK-8 and Transwell assays were used to evaluate the effects of circCPSF6 on HCC proliferation and migration. A xenograft mouse model was used to investigate the effects of circCPSF6 on HCC progression in vivo, and the significance of circCPSF6 in HCC was verified both in vivo and in vitro. circCPSF6-associated miRNAs and mRNAs were identified using bioinformatic analyses. Luciferase reporter, RNA pull-down, Fluorescence in situ hybridization, and RNA immunoprecipitation assays were performed to elucidate the circCPSF6 regulatory axis in HCC. Result: CircCPSF6 expression was increased in HCC cell lines and tissues, and the expression of its parental mRNA was positively correlated with tumor severity and negatively correlated with survival. Mechanistic analyses of HCC cell lines showed that tumorigenesis was inhibited by circCPSF6 knockdown and promoted by its overexpression. Functional analyses revealed that circCPSF6 mediated HCC development by sponging miR-145-5p as a competing endogenous RNA. Furthermore, this sponging upregulated the miR-145-5p target gene MAP4K4, a classical pro-tumorigenic gene. Conclusion: Our findings reveal a regulatory network that includes the circCPSF6–miR-145-5p–MAP4K4 axis. Elements of this axis are potential HCC biomarkers, as well as targets for HCC treatment.
    Keywords Hepatocellular carcinoma ; circCPSF6 ; miR-145-5p ; MAP4K4 ; Progression ; Biology (General) ; QH301-705.5 ; Medicine ; R
    Subject code 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p

    Lu, Fei / Gao, Jing / Luo, Yang / Jin, Wei-Lin / Wang, Haiping / Li, Chuan-Xing / Li, Xun

    Molecular and Cellular Probes. 2023 Oct., v. 71 p.101920-

    2023  

    Abstract: Aberrant expression of circRNAs is involved in the progression of hepatocellular carcinoma (HCC). This study aimed at screening the pro-tumorigenic circular RNAs (circRNAs) in HCC and the mechanisms of circCPSF6 expression influencing HCC characteristics. ...

    Abstract Aberrant expression of circRNAs is involved in the progression of hepatocellular carcinoma (HCC). This study aimed at screening the pro-tumorigenic circular RNAs (circRNAs) in HCC and the mechanisms of circCPSF6 expression influencing HCC characteristics. circCPSF6 was identified in HCC tissues using high-throughput sequencing data, and its expression was verified in both HCC tissues and cell lines using quantitative real-time PCR (qRT-PCR). CCK-8 and Transwell assays were used to evaluate the effects of circCPSF6 on HCC proliferation and migration. A xenograft mouse model was used to investigate the effects of circCPSF6 on HCC progression in vivo, and the significance of circCPSF6 in HCC was verified both in vivo and in vitro. circCPSF6-associated miRNAs and mRNAs were identified using bioinformatic analyses. Luciferase reporter, RNA pull-down, Fluorescence in situ hybridization, and RNA immunoprecipitation assays were performed to elucidate the circCPSF6 regulatory axis in HCC. CircCPSF6 expression was increased in HCC cell lines and tissues, and the expression of its parental mRNA was positively correlated with tumor severity and negatively correlated with survival. Mechanistic analyses of HCC cell lines showed that tumorigenesis was inhibited by circCPSF6 knockdown and promoted by its overexpression. Functional analyses revealed that circCPSF6 mediated HCC development by sponging miR-145-5p as a competing endogenous RNA. Furthermore, this sponging upregulated the miR-145-5p target gene MAP4K4, a classical pro-tumorigenic gene. Our findings reveal a regulatory network that includes the circCPSF6–miR-145-5p–MAP4K4 axis. Elements of this axis are potential HCC biomarkers, as well as targets for HCC treatment.
    Keywords bioinformatics ; biomarkers ; carcinogenesis ; fluorescence ; genes ; hepatoma ; hybridization ; luciferase ; mice ; microRNA ; models ; neoplasm progression ; precipitin tests ; quantitative polymerase chain reaction ; xenotransplantation ; Hepatocellular carcinoma ; circCPSF6 ; miR-145-5p ; MAP4K4 ; Progression
    Language English
    Dates of publication 2023-10
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 639082-1
    ISSN 1096-1194 ; 0890-8508
    ISSN (online) 1096-1194
    ISSN 0890-8508
    DOI 10.1016/j.mcp.2023.101920
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Streptomyces griseicoloratus sp. nov., isolated from soil in cotton fields in Xinjiang, China.

    Xing, Li / Xia, Ying-Ying / Zhang, Qiao-Yan / Xia, Zhan-Feng / Wan, Chuan-Xing / Zhang, Li-Li / Luo, Xiao-Xia

    Archives of microbiology

    2022  Volume 204, Issue 5, Page(s) 254

    Abstract: A novel bacterium of the genus Streptomyces, designated TRM S81- ... ...

    Abstract A novel bacterium of the genus Streptomyces, designated TRM S81-3
    MeSH term(s) DNA, Bacterial/genetics ; Fatty Acids/chemistry ; Gossypium ; Phospholipids/chemistry ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Sequence Analysis, DNA ; Soil ; Soil Microbiology ; Streptomyces
    Chemical Substances DNA, Bacterial ; Fatty Acids ; Phospholipids ; RNA, Ribosomal, 16S ; Soil
    Language English
    Publishing date 2022-04-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 124824-8
    ISSN 1432-072X ; 0302-8933
    ISSN (online) 1432-072X
    ISSN 0302-8933
    DOI 10.1007/s00203-022-02818-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 805: Show issues Location:
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  10. Article ; Online: Three novel

    Ding, La-Mei / Ding, Pei-Zhi / Liu, Wen-Long / Shen, Hong-Ling / Xia, Zhan-Feng / Wan, Chuan-Xing / Zhang, Li-Li

    International journal of systematic and evolutionary microbiology

    2023  Volume 73, Issue 2

    Abstract: Three novel actinomycete strains, designated TRM66264- ... ...

    Abstract Three novel actinomycete strains, designated TRM66264-DLM
    MeSH term(s) Fatty Acids/chemistry ; Actinoplanes ; Phosphatidylethanolamines ; Water ; Phylogeny ; RNA, Ribosomal, 16S/genetics ; Arabinose ; Sequence Analysis, DNA ; DNA, Bacterial/genetics ; Base Composition ; Bacterial Typing Techniques ; Glucose ; Vitamin K 2 ; Phospholipids/analysis
    Chemical Substances Fatty Acids ; Phosphatidylethanolamines ; polyaspartate (26063-13-8) ; Water (059QF0KO0R) ; RNA, Ribosomal, 16S ; Arabinose (B40ROO395Z) ; DNA, Bacterial ; Glucose (IY9XDZ35W2) ; Vitamin K 2 (11032-49-8) ; Phospholipids
    Language English
    Publishing date 2023-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2002336-4
    ISSN 1466-5034 ; 1466-5026
    ISSN (online) 1466-5034
    ISSN 1466-5026
    DOI 10.1099/ijsem.0.005705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 409: Show issues Location:
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