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  1. Article ; Online: Multisystem inflammatory syndrome in children and adolescents after infection with SARS-CoV-2.

    Hu, Yi / Rojahn, Astrid Elisabeth / Flatø, Berit

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2021  Volume 141, Issue 2021-14

    Abstract: Multisystem inflammatory syndrome is a rare immune-mediated complication of infection with SARS-CoV-2 in children and adolescents. The patients can rapidly become seriously ill with high fever, gastrointestinal symptoms and cardiogenic shock. The goal of ...

    Title translation Multiorgan inflammatorisk syndrom hos barn og ungdom etter SARS-CoV-2-infeksjon.
    Abstract Multisystem inflammatory syndrome is a rare immune-mediated complication of infection with SARS-CoV-2 in children and adolescents. The patients can rapidly become seriously ill with high fever, gastrointestinal symptoms and cardiogenic shock. The goal of treatment is to ensure adequate circulation and prevent late complications by providing anti-inflammatory therapy.
    MeSH term(s) Adolescent ; COVID-19/complications ; Child ; Humans ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Language Norwegian
    Publishing date 2021-09-02
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.1040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: No association between disease severity and respiratory syncytial virus subtypes RSV-A and RSV-B in hospitalized young children in Norway.

    Bøås, Håkon / Havdal, Lise Beier / Størdal, Ketil / Døllner, Henrik / Leegaard, Truls Michael / Bekkevold, Terese / Flem, Elmira / Inchley, Christopher / Nordbø, Svein Arne / Rojahn, Astrid Elisabeth / Debes, Sara / Barstad, Bjørn / Haarr, Elisebet / Kran, Anne-Marte Bakken

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0298104

    Abstract: Objective: There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between disease severity and RSV subtypes ... ...

    Abstract Objective: There is conflicting evidence whether subtypes of Respiratory syncytial virus have different seasonality or are differentially associated with clinical severity. We aimed to explore the associations between disease severity and RSV subtypes RSV-A and RSV-B and to describe the circulation of RSV subtypes pattern by season and age.
    Methods: Active prospective hospital surveillance for RSV-A and RSV-B in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were eligible if presenting with fever or respiratory symptoms. Risk factors and upper and lower respiratory tract infection was identified by linkage to national registry data and analyzed using penalized maximum likelihood logistic regression.
    Results: Both RSV-A and B were found to co-circulate throughout all three study seasons, and no clear seasonal pattern was identified. Likewise, we found no association between sex or measures of severity with RSV-A or RSV-B. There was significantly more RSV-A than RSV-B among children with comorbidities.
    Conclusions: No association was found between disease severity or sex and RSV subtypes RSV-A and RSV-B in hospitalized young children in Norway.
    MeSH term(s) Child ; Humans ; Infant ; Child, Preschool ; Respiratory Syncytial Virus Infections ; Prospective Studies ; Respiratory Syncytial Virus, Human ; Respiratory Tract Infections/epidemiology ; Norway/epidemiology ; Patient Acuity ; Seasons ; Fever ; Hospitalization
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0298104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [No title information]

    Rojahn, Astrid Elisabeth / Gammelsrud, Karianne Wiger / Brunvand, Leif Inge / Hanche-Olsen, Terje Peder / Schistad, Ole / Sæter, Christine Bendixen / Haaland, Kirsti

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140

    Title translation Rettelse: Multiorgan inflammatorisk syndrom assosiert med sars-CoV-2 hos et barn.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Inflammation ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Syndrome
    Language Norwegian
    Publishing date 2020-07-29
    Publishing country Norway
    Document type Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum to 'The burden of respiratory syncytial virus in children under 5 years of age in Norway' [Journal of Infection Volume 84, Issue 2 (2022) Pages 205-215].

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Kran, Anne-Marte Bakken / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    The Journal of infection

    2022  Volume 86, Issue 4, Page(s) 420

    Language English
    Publishing date 2022-12-24
    Publishing country England
    Document type Published Erratum
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2022.12.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Multiorgan inflammatory syndrome associated with SARS-CoV-2 in a child.

    Rojahn, Astrid Elisabeth / Gammelsrud, Karianne Wiger / Brunvand, Leif Inge / Hanche-Olsen, Terje Peder / Schistad, Ole / Sæter, Christine Bendixen / Haaland, Kirsti

    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke

    2020  Volume 140, Issue 11

    Title translation Multiorgan inflammatorisk syndrom assosiert med sars-CoV-2 hos et barn.
    MeSH term(s) Betacoronavirus ; Child ; Coronavirus Infections/pathology ; Humans ; Pandemics ; Pneumonia, Viral/pathology ; Systemic Inflammatory Response Syndrome/virology
    Keywords covid19
    Language Norwegian
    Publishing date 2020-06-25
    Publishing country Norway
    Document type Case Reports ; Journal Article
    ZDB-ID 603504-8
    ISSN 0807-7096 ; 0029-2001
    ISSN (online) 0807-7096
    ISSN 0029-2001
    DOI 10.4045/tidsskr.20.0485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: The burden of hospital-attended influenza in Norwegian children.

    Bøås, Håkon / Bekkevold, Terese / Havdal, Lise Beier / Kran, Anne-Marte Bakken / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Vázquez Fernández, Liliana / Nakstad, Britt / Leegaard, Truls Michael / Hungnes, Olav / Flem, Elmira

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 963274

    Abstract: Background: Norwegian health authorities do not recommend universal pediatric vaccination against seasonal influenza. We aimed to estimate the incidence of influenza by age and underlying medical conditions in hospitalized Norwegian children aged <18 ... ...

    Abstract Background: Norwegian health authorities do not recommend universal pediatric vaccination against seasonal influenza. We aimed to estimate the incidence of influenza by age and underlying medical conditions in hospitalized Norwegian children aged <18 years.
    Methods: Active surveillance for influenza in children <18 years was implemented in five hospitals during 2015-18. Children with respiratory symptoms and/or fever were prospectively enrolled and tested for influenza. Surveillance data were linked to health registry data to estimate the national burden of influenza in hospitals.
    Results: In 309 (10%) out of 3,010 hospital contacts, the child tested positive for influenza, corresponding to an average incidence of 0.96 hospital-attended influenza cases per 1,000 children <18 years of age. Children <1 year of age (3.8 per 1,000 children) and children with underlying medical conditions (17 per 1,000 children with bronchopulmonary dysplasia) had the highest average incidence. Among <1 year old children, 3% tested positive for influenza, compared to 25% for children aged 6-17. Few children were vaccinated against influenza.
    Conclusions: Children <1 year of age and children with underlying medical conditions had a higher incidence of influenza requiring hospital treatment compared to the general population. Effective interventions against seasonal influenza for children in Norway should be considered.
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.963274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Rettelse: Multiorgan inflammatorisk syndrom assosiert med sars-CoV-2 hos et barn

    Rojahn, Astrid Elisabeth / Gammelsrud, Karianne Wiger / Brunvand, Leif Inge / Hanche-Olsen, Terje Peder / Schistad, Ole / Sæter, Christine Bendixen / Haaland, Kirsti

    Tidsskr. nor. laegeforen.

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #725427
    Database COVID19

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  8. Article: Risk factors associated with severe disease in respiratory syncytial virus infected children under 5 years of age.

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Bakken Kran, Anne-Marte / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 1004739

    Abstract: Objective: To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.: Study design: We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during ...

    Abstract Objective: To evaluate risk factors for severe disease in children under 59 months of age hospitalized with respiratory syncytial virus (RSV) infection.
    Study design: We prospectively enrolled 1,096 cases of laboratory confirmed RSV infection during three consecutive RSV seasons in 2015-2018. Potential risk factors for severe disease were retrieved through patient questionnaires and linkage to national health registries. Need for respiratory support (invasive ventilation, bi-level positive airway pressure, or continuous positive airway pressure), and length of stay exceeding 72 h were used as measures of disease severity. Associations were investigated using multivariable logistic regression analyses. Multiple imputation was used to avoid bias and inference induced by missing data.
    Results: Risk factors associated with a need for respiratory support included age younger than 3 months of age [aOR: 6.73 (95% CI 2.71-16.7)], having siblings [aOR: 1.65 (95% CI 1.05-2.59)] and comorbidity [aOR: 2.40 (95% CI 1.35-4.24)]. The length of hospital stay >72 h was significantly associated with being younger than 3 months of age [aOR: 3.52 (95% CI 1.65-7.54)], having siblings [aOR: 1.45 (95% CI 1.01-2.08)], and comorbidity [aOR: 2.18 (95% CI 1.31-3.61)]. Sub-group analysis of children younger than 6 months of age confirmed the association between both young age and having siblings and the need for respiratory support.
    Conclusion: In a large cohort of children <59 months hospitalized with RSV infection, young age, comorbidity, and having siblings were associated with more severe disease.
    Language English
    Publishing date 2022-08-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.1004739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Multiorgan inflammatorisk syndrom assosiert med sars-CoV-2 hos et barn./ Multiorgan inflammatorisk syndrom assosiert med sars-CoV-2 hos et barn./ Multiorgan inflammatory syndrome associated with SARS-CoV-2 in a child

    Rojahn, Astrid Elisabeth / Gammelsrud, Karianne Wiger / Brunvand, Leif Inge / Hanche-Olsen, Terje Peder / Schistad, Ole / Sæter, Christine Bendixen / Haaland, Kirsti

    Tidsskr. nor. laegeforen.

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #725426
    Database COVID19

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  10. Article ; Online: The burden of respiratory syncytial virus in children under 5 years of age in Norway.

    Havdal, Lise Beier / Bøås, Håkon / Bekkevold, Terese / Kran, Anne-Marte Bakken / Rojahn, Astrid Elisabeth / Størdal, Ketil / Debes, Sara / Døllner, Henrik / Nordbø, Svein Arne / Barstad, Bjørn / Haarr, Elisebet / Fernández, Liliana Vázquez / Nakstad, Britt / Inchley, Christopher / Flem, Elmira

    The Journal of infection

    2021  Volume 84, Issue 2, Page(s) 205–215

    Abstract: Objectives: To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.: Methods: Active prospective hospital surveillance for RSV in ... ...

    Abstract Objectives: To estimate age-specific incidence of medically attended respiratory syncytial virus (RSV) infections in hospitalised Norwegian children and describe disease epidemiology.
    Methods: Active prospective hospital surveillance for RSV in children <59 months of age was conducted during 2015-2018. All febrile children 12-59 months of age were enrolled, whereas children <12 months were enrolled based on respiratory symptoms regardless of fever. Surveillance data were linked to national registry data to estimate the clinical burden of RSV.
    Results: Of the children enrolled, 1096 (40%) were infected with RSV. The highest incidence rates were found in children 1 month of age, with a peak incidence of 43 per 1000 during the 2016-2017 season. In comparison, children 24-59 months of age had an infection rate of 1.4 per 1000 during the same winter season. The peak season was during the 2016-2017 winter, with an incidence rate of 6.0 per 1000 children 0-59 months of age. In the study population a total of 168 (15%) of the infected children had pre-existing medical conditions predisposing for more severe disease. High infection rates were found in this population.
    Conclusions: Children with comorbidities showed high hospital contact rates, but the majority of children in need of medical attention associated with RSV infection were previously healthy.
    MeSH term(s) Child ; Child, Preschool ; Hospitalization ; Humans ; Incidence ; Infant ; Prospective Studies ; Respiratory Syncytial Virus Infections ; Respiratory Syncytial Virus, Human
    Language English
    Publishing date 2021-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2021.12.008
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