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Article ; Online: Updates on Overcoming Bicalutamide Resistance: A Glimpse into Resistance to a Novel Antiandrogen.

Izady, Mehrnaz / Khatami, Fatemeh / Ahadi, Zeinab / Roudgari, Hassan / Aghamir, Seyed Mohammad Kazem

ACS pharmacology & translational science

2024 Volume 7, Issue 4, Page(s) 905–914

Abstract: The standard androgen deprivation therapy for advanced prostate cancer includes the use of bicalutamide, which is a well-known antagonist of androgen receptors. Despite numerous benefits of the drugs in prostate cancer treatment, there is always a risk ... ...

Abstract	The standard androgen deprivation therapy for advanced prostate cancer includes the use of bicalutamide, which is a well-known antagonist of androgen receptors. Despite numerous benefits of the drugs in prostate cancer treatment, there is always a risk of developing a resistant phenotype, which paves the way for a more aggressive and low-survival type of prostate cancer. Over the years, many studies have investigated the candidate mechanisms of such resistance and have managed to find possible therapeutic solutions. In this Review, we shed light on the heterogeneous dynamics of progression to resistance against bicalutamide treatment, referring to the most recent studies and the approaches that have been so far discussed. This Review tries to offer a deep and comprehensive understanding about how the resistant cells become sensitive to the drug and what corresponding pathways lead to an appropriate solution for the antiandrogen resistance challenge.
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2575-9108
ISSN (online)	2575-9108
DOI	10.1021/acsptsci.3c00299
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A digital image colorimetry system based on smart devices for immediate and simultaneous determination of enzyme-linked immunosorbent assays.

Mirhosseini, Shaghayegh / Nasiri, Aryanaz Faghih / Khatami, Fatemeh / Mirzaei, Akram / Aghamir, Seyed Mohammad Kazem / Kolahdouz, Mohammadreza

Scientific reports

2024 Volume 14, Issue 1, Page(s) 2587

Abstract: Standard enzyme-linked immunosorbent assays based on microplates are frequently utilized for various molecular sensing, disease screening, and nanomedicine applications. Comparing this multi-well plate batched analysis to non-batched or non-standard ... ...

Abstract	Standard enzyme-linked immunosorbent assays based on microplates are frequently utilized for various molecular sensing, disease screening, and nanomedicine applications. Comparing this multi-well plate batched analysis to non-batched or non-standard testing, the diagnosis expenses per patient are drastically reduced. However, the requirement for rather big and pricey readout instruments prevents their application in environments with limited resources, especially in the field. In this work, a handheld cellphone-based colorimetric microplate reader for quick, credible, and novel analysis of digital images of human cancer cell lines at a reasonable price was developed. Using our in-house-developed app, images of the plates are captured and sent to our servers, where they are processed using a machine learning algorithm to produce diagnostic results. Using FDA-approved human epididymis protein of ovary IgG (HE4), prostate cancer cell line (PC3), and bladder cancer cell line (5637) ELISA tests, we successfully examined this mobile platform. The accuracies for the HE4, PC3, and 5637 tests were 93%, 97.5%, and 97.2%, respectively. By contrasting the findings with the measurements made using optical absorption EPOCH microplate readers and optical absorption Tecan microplate readers, this approach was found to be accurate and effective. As a result, digital image colorimetry on smart devices offered a practical, user-friendly, affordable, precise, and effective method for quickly identifying human cancer cell lines. Thus, healthcare providers might use this portable device to carry out high-throughput illness screening, epidemiological investigations or monitor vaccination campaigns.
MeSH term(s)	Male ; Humans ; Colorimetry/methods ; Cell Phone ; Enzyme-Linked Immunosorbent Assay/methods ; Cell Line ; Prostatic Neoplasms
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-52931-6
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Article ; Online: Spiking network optimized for word recognition in noise predicts auditory system hierarchy.

Khatami, Fatemeh / Escabí, Monty A

PLoS computational biology

2020 Volume 16, Issue 6, Page(s) e1007558

Abstract: The auditory neural code is resilient to acoustic variability and capable of recognizing sounds amongst competing sound sources, yet, the transformations enabling noise robust abilities are largely unknown. We report that a hierarchical spiking neural ... ...

Abstract	The auditory neural code is resilient to acoustic variability and capable of recognizing sounds amongst competing sound sources, yet, the transformations enabling noise robust abilities are largely unknown. We report that a hierarchical spiking neural network (HSNN) optimized to maximize word recognition accuracy in noise and multiple talkers predicts organizational hierarchy of the ascending auditory pathway. Comparisons with data from auditory nerve, midbrain, thalamus and cortex reveals that the optimal HSNN predicts several transformations of the ascending auditory pathway including a sequential loss of temporal resolution and synchronization ability, increasing sparseness, and selectivity. The optimal organizational scheme enhances performance by selectively filtering out noise and fast temporal cues such as voicing periodicity, that are not directly relevant to the word recognition task. An identical network arranged to enable high information transfer fails to predict auditory pathway organization and has substantially poorer performance. Furthermore, conventional single-layer linear and nonlinear receptive field networks that capture the overall feature extraction of the HSNN fail to achieve similar performance. The findings suggest that the auditory pathway hierarchy and its sequential nonlinear feature extraction computations enhance relevant cues while removing non-informative sources of noise, thus enhancing the representation of sounds in noise impoverished conditions.
MeSH term(s)	Acoustic Stimulation ; Acoustics ; Auditory Cortex/physiology ; Auditory Pathways/physiology ; Auditory Perception ; Brain/physiology ; Brain Mapping ; Computer Simulation ; Humans ; Language ; Models, Neurological ; Nerve Net ; Neurons ; Noise ; Pattern Recognition, Physiological ; Signal-To-Noise Ratio ; Sound
Language	English
Publishing date	2020-06-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1007558
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Article ; Online: Human prostate cancer cell epithelial-to-mesenchymal transition as a novel target of arsenic trioxide and curcumin therapeutic approach.

Mirzaei, Akram / Jahanshahi, Fatemeh / Khatami, Fatemeh / Reis, Leonardo Oliveira / Aghamir, Seyed Mohammad Kazem

Tissue & cell

2022 Volume 76, Page(s) 101805

Abstract: Background: Arsenic trioxide (As: Material and methods: The human prostate cell lines (LNCaP and PC3) were treated with different concentrations of Curcumin and As: Results: For the first time, we presented that the combination therapy of Curcumin ...

Abstract	Background: Arsenic trioxide (As Material and methods: The human prostate cell lines (LNCaP and PC3) were treated with different concentrations of Curcumin and As Results: For the first time, we presented that the combination therapy of Curcumin and As Conclusions: The antitumor effects of combination therapy with As
MeSH term(s)	Antineoplastic Agents/pharmacology ; Apoptosis ; Arsenic Trioxide/metabolism ; Arsenic Trioxide/pharmacology ; Cadherins/genetics ; Cadherins/metabolism ; Cell Line, Tumor ; Curcumin/pharmacology ; Curcumin/therapeutic use ; Humans ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Tumor Suppressor Protein p53 ; bcl-2-Associated X Protein/metabolism
Chemical Substances	Antineoplastic Agents ; Cadherins ; Tumor Suppressor Protein p53 ; bcl-2-Associated X Protein ; Curcumin (IT942ZTH98) ; Arsenic Trioxide (S7V92P67HO)
Language	English
Publishing date	2022-04-25
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2022.101805
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Article: The Gene Manipulation and Cellular Immunotherapy Combination in the Treatment of Cancer.

Khatami, Fatemeh / Aghamir, Zahra Sadat / Jahanshahi, Fatemeh / Feiz-Abadi, Seyed Ariana / Birang, Fatemeh / Khoshchehreh, Mahdi / Namazi Shabestari, Alireza / Aghamir, Seyed Mohammad Kazem

Iranian journal of biotechnology

2022 Volume 20, Issue 2, Page(s) e3094

Abstract: Context: The immune system is directly linked to the tumors, from tumor formation to the tumor's development and metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted strategy in cancer ... ...

Abstract	Context: The immune system is directly linked to the tumors, from tumor formation to the tumor's development and metastasis. So, the interest of scientists over the protective immunological mechanisms has increased and shown gifted strategy in cancer treatment. Evidence acquisition: Genetic engineering and cellular immunotherapy are two different advanced molecular mechanisms to modify the immune responses and genome. Gene manipulation is the bioengineering technology that allows vectors to transfer new genetic information into the target cells. Cellular immunotherapy is an excellent strategy that connects the body's immune system to fight cancer. Results & conclusions: This review described that combination of genetic engineering and cellular immunotherapy has brought the novel antitumor repressive molecules stopping the tumor tissue immune tolerance and significantly expanding cancer therapy's effectiveness. Usually, cell immunotherapy and genetic engineering are considered two independent processes, and, in this review, we believe them in combinations. Here, we review these two novel approaches, and they are both combinations in terms of technological advances and clinical experience.
Language	English
Publishing date	2022-04-01
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2223669-7
ISSN	2322-2921 ; 1728-3043
ISSN (online)	2322-2921
ISSN	1728-3043
DOI	10.30498/ijb.2022.294933.3094
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Article ; Online: Cornus Mas and Urinary Tract Infections Treatment

Fatemeh Khatami / Fateme Guitynavard

Translational Research in Urology, Vol 2, Iss 1, Pp 9-

2020 Volume 11

Abstract: Urinary tract infections (UTI) are somehow complicated to treat and patients frequently will have the problem of infection recurrence after complete cure. Usually, the UTI treatment is done by antibiotics but the problem of bacterium resistance and ... ...

Abstract	Urinary tract infections (UTI) are somehow complicated to treat and patients frequently will have the problem of infection recurrence after complete cure. Usually, the UTI treatment is done by antibiotics but the problem of bacterium resistance and sensitivity should be always kept in mind. The recent trends in herbal medicine open new insight to cranberry (Cornus mas) as the promising anti-infection and anti-cancer substance. It has shown anti-infection properties in UTI especially for the complete treatment of urinary tract recurrent infection. However, it can increase the risk of kidney stones and have interaction with warfarin.
Keywords	urinary tract infections ; herbal medicine ; cornus mas ; Diseases of the genitourinary system. Urology ; RC870-923
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	Urology Research Center
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Salivary and serum periostin in kidney transplant recipients.

Aghamir, Seyed Mohammad Kazem / Amiri, Mahrokh / Panahi, Ghodratollah / Khatami, Fatemeh / Dehghani, Sanaz / Moosavi, Mahdieh-Sadat

PloS one

2023 Volume 18, Issue 5, Page(s) e0285256

Abstract: Introduction: End-stage renal disease (ESRD) treatment includes dialysis and kidney transplantation. Transplant rejection is a major barrier to transplant success. One of the markers mentioned in previous studies on renal function in patients with renal ...

Abstract	Introduction: End-stage renal disease (ESRD) treatment includes dialysis and kidney transplantation. Transplant rejection is a major barrier to transplant success. One of the markers mentioned in previous studies on renal function in patients with renal failure for various reasons is periostin (POSTN). The expression of POSTN correlates with interstitial fibrosis and reduced renal function. One of the limitations in this regard is the effect of oral lesions on the POSTN level. This study was conducted aimed to measure the relationship between salivary and serum POSTN and renal function in patients with a history of a kidney transplant, taking into account all the conditions affecting POSTN. Methods: In this study, serum and saliva samples were taken from 23 transplant patients with normal function (NF) and 29 transplant patients with graft failure (GF). At least one year had passed since the transplant. Before sampling, a complete oral examination was performed. Salivary and serum POSTN was examined by ELISA. The results were analyzed by SPSS software. Results: The POSTN level in the serum of the NF group (191.00 ± 33.42) was higher than GF patients (178.71 ± 25.68), but the difference was not significant (P = 0.30). Salivary POSTN in NF patients (2.76 ± 0.35) was significantly higher than GF patients (2.44 ± 0.60) (P = 0.01). Conclusions: The superiority of saliva as a diagnostic fluid includes ease of collection and storage, and non-invasiveness, all of which can lead to the replacement of blood with this bio-fluid. The significant results of salivary POSTN may be due to the lack of serum disturbing factors. Saliva is an ultra-filtered fluid from serum and therefore there are fewer proteins and polysaccharides attached to biomarkers in saliva and the accuracy of measuring these biomarkers in the saliva is more valuable than serum.
MeSH term(s)	Humans ; Transplant Recipients ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Cell Adhesion Molecules/blood ; Saliva/chemistry ; Biomarkers/analysis ; Cross-Sectional Studies ; Male ; Female ; Adult ; Middle Aged
Chemical Substances	POSTN protein, human ; Cell Adhesion Molecules ; Biomarkers
Language	English
Publishing date	2023-05-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285256
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Article ; Online: Spiking network optimized for word recognition in noise predicts auditory system hierarchy.

Fatemeh Khatami / Monty A Escabí

PLoS Computational Biology, Vol 16, Iss 6, p e

2020 Volume 1007558

Abstract	The auditory neural code is resilient to acoustic variability and capable of recognizing sounds amongst competing sound sources, yet, the transformations enabling noise robust abilities are largely unknown. We report that a hierarchical spiking neural network (HSNN) optimized to maximize word recognition accuracy in noise and multiple talkers predicts organizational hierarchy of the ascending auditory pathway. Comparisons with data from auditory nerve, midbrain, thalamus and cortex reveals that the optimal HSNN predicts several transformations of the ascending auditory pathway including a sequential loss of temporal resolution and synchronization ability, increasing sparseness, and selectivity. The optimal organizational scheme enhances performance by selectively filtering out noise and fast temporal cues such as voicing periodicity, that are not directly relevant to the word recognition task. An identical network arranged to enable high information transfer fails to predict auditory pathway organization and has substantially poorer performance. Furthermore, conventional single-layer linear and nonlinear receptive field networks that capture the overall feature extraction of the HSNN fail to achieve similar performance. The findings suggest that the auditory pathway hierarchy and its sequential nonlinear feature extraction computations enhance relevant cues while removing non-informative sources of noise, thus enhancing the representation of sounds in noise impoverished conditions.
Keywords	Biology (General) ; QH301-705.5
Subject code	006
Language	English
Publishing date	2020-06-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: U-shape incision on prostate capsule: New intraperitoneal laparoscopic technique in simple prostatectomy: A case report.

Zia, Hamidreza / Khatami, Fatemeh / Aghamir, Seyed Mohammad Kazem

Annals of medicine and surgery (2012)

2021 Volume 69, Page(s) 102787

Abstract: Introduction: and importance: Laparoscopy is a known technique for simple prostatectomy using intraperitoneal or extraperitoneal approaches. In the present study, a novel method is suggested for easier access to the whole body and even the head of the ... ...

Abstract	Introduction: and importance: Laparoscopy is a known technique for simple prostatectomy using intraperitoneal or extraperitoneal approaches. In the present study, a novel method is suggested for easier access to the whole body and even the head of the adenoma. Case presentation: This method was performed on 6 patients with prostate hyperplasia. This was intraperitoneal method, started with 4-6 trocars and two transverse incisions on both sides of the endopelvic fascia. the prostate capsule is detected (using a Foley catheter balloon); the prostate capsule is transversely opened by a U-shape incision in a 0.5-1cm distance from the bladder neck to reach the adenoma and is dissected under the capsule to separate the capsule from the prostate. By ligashour capsule is opened laterally to the endopelvic fascia and separated from the prostate and gland is removed. Clinical discussion: The mean operation time was 114 minutes and the average intraoperative bleeding was 244.1 cc. IPSS (International Prostate Symptom Score), Q Max, and post-void residue, changes were significant with p-value = 0.003, respectively; however, pre and postoperative Hemoglobin was imprecise. The mean postoperative urinary leakage is reported at 22 cc. Conclusion: In short, this technique provides a better vision to prostate adenoma and the results can be compared with other laparoscopic approaches. Yet, larger sample sizes in different centers are required for determining realistic results.
Language	English
Publishing date	2021-09-04
Publishing country	England
Document type	Case Reports
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2021.102787
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Article: A Review of Driver Genetic Alterations in Thyroid Cancers.

Khatami, Fatemeh / Tavangar, Seyed Mohammad

Iranian journal of pathology

2018 Volume 13, Issue 2, Page(s) 125–135

Abstract: Thyroid cancer is a frequent endocrine-related malignancy with continuously increasing incidence, and recently the development in understanding its molecular pathogenesis is mainly through the explanation of the original role of several key signaling ... ...

Abstract	Thyroid cancer is a frequent endocrine-related malignancy with continuously increasing incidence, and recently the development in understanding its molecular pathogenesis is mainly through the explanation of the original role of several key signaling pathways and related molecular distributors. Central to these mechanisms are the genetic and epigenetic alterations in these pathways such as mutation and DNA rearrangements. However, it does not mean that all the somatic abnormalities in a cancer genome are involved in cancer development and just driver mutations are concerned in tumor initiation. By way of illustrations,
Language	English
Publishing date	2018-07-17
Publishing country	Iran
Document type	Journal Article ; Review
ZDB-ID	2478278-6
ISSN	1735-5303
ISSN	1735-5303
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