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  1. Article ; Online: Suppressing the dephasing of optically trapped atoms inside a hollow-core fiber.

    Song, Yitong / Li, Wei / Xu, Xiaobin / Han, Rui / Gao, Chengchun / Dai, Cheng / Song, Ningfang

    Optics letters

    2024  Volume 49, Issue 2, Page(s) 206–209

    Abstract: We demonstrate the suppression of inhomogeneous dephasing of ... ...

    Abstract We demonstrate the suppression of inhomogeneous dephasing of cold
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.507090
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure.

    Han, Xiaobin / Akinseye, Leah / Sun, Zhongjie

    Hypertension (Dallas, Tex. : 1979)

    2024  Volume 81, Issue 3, Page(s) 541–551

    Abstract: Background: KDM6A (Lysine-Specific Demethylase 6A) is a specific demethylase for histone 3 lysine (K) 27 trimethylation (H3K27me3). The purpose of this study is to investigate whether KDM6A in renal tubule cells plays a role in the regulation of kidney ... ...

    Abstract Background: KDM6A (Lysine-Specific Demethylase 6A) is a specific demethylase for histone 3 lysine (K) 27 trimethylation (H3K27me3). The purpose of this study is to investigate whether KDM6A in renal tubule cells plays a role in the regulation of kidney function and blood pressure.
    Methods: We first crossed
    Results: Notably, conditional knockout of
    Conclusions: This study provides the first evidence that KDM6A plays an essential role in maintaining normal tubular function and blood pressure. Renal tubule cell specific KDM6A deficiency causes hypertension due to increased H3K27me3 levels and the resultant downregulation of
    MeSH term(s) Mice ; Animals ; Blood Pressure/physiology ; Protein Serine-Threonine Kinases/metabolism ; Histones/metabolism ; Aquaporin 2/metabolism ; Lysine/metabolism ; Kidney/metabolism ; Hypertension/genetics ; Hypertension/metabolism ; Sodium/metabolism ; Sodium Chloride/metabolism
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Histones ; Aquaporin 2 ; Lysine (K3Z4F929H6) ; Sodium (9NEZ333N27) ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.123.22026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1488: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Targeting Taurine Transporter (TauT) for Cancer Immunotherapy of p53 Mutation Mediated Cancers - Molecular Basis and Preclinical Implication.

    Han, Xiaobin

    Advances in experimental medicine and biology

    2019  Volume 1155, Page(s) 543–553

    Abstract: Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated by c-Myc and c- ... ...

    Abstract Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated by c-Myc and c-Jun oncogenes. To explore whether blocking of TauT inhibits tumor development, the RNA interference (RNAi) and immune targeting approaches were tested in tumor cells in vitro and in p53 mutant mice in vivo. Knockdown of TauT expression by RNAi resulted in cell cycle G2 arrest and suppressed human breast cancer MCF-7 cells proliferation determined by colonies production and cell migration assays. Knockdown of TauT also rendered MCF-7 cells more susceptible to chemotherapeutic drug-induced apoptosis. An antibody specifically against TauT blocked taurine uptake and induced cell cycle G2 arrest leading to cell death of variety type of tumor cells without affecting the viability of normal mammalian cells. TauT peptide vaccination significantly increased median lifespan (1.5-fold) of the p53 null mice and rescued p53+/- mice by extending the median lifespan from 315 days to 621 days. Furthermore, single dose treatment of tumor-bearing (thymic lymphoma) p53 null mice with TauT peptide reduced tumor size by about 50% and significantly prolonged survival of these mice from average 7 days (after observing the thymic lymphoma) to 21 days. This finding demonstrates that a novel TauT peptide vaccine can delay, inhibit, and/or treat p53 mutation related spontaneous tumorigenesis in vivo. Therefore, TauT peptide may be used as a universal cancer vaccine to prevent and/or treat patients with p53 mutation-mediated cancers.
    MeSH term(s) Animals ; Antibodies, Monoclonal/pharmacology ; Cancer Vaccines ; Cell Cycle Checkpoints ; Gene Knockdown Techniques ; Genes, jun ; Genes, myc ; Humans ; Immunotherapy ; MCF-7 Cells ; Membrane Glycoproteins ; Membrane Transport Proteins ; Mice ; Mice, Knockout ; Molecular Targeted Therapy ; Mutation ; RNA Interference ; Taurine ; Tumor Suppressor Protein p53/genetics ; Vaccines, Subunit
    Chemical Substances Antibodies, Monoclonal ; Cancer Vaccines ; Membrane Glycoproteins ; Membrane Transport Proteins ; Tumor Suppressor Protein p53 ; Vaccines, Subunit ; taurine transporter (148686-53-7) ; Taurine (1EQV5MLY3D)
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-981-13-8023-5_50
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  4. Article ; Online: Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2-Modulated Canonical Wnt/β-Catenin Signaling.

    Han, Xiaobin / Sun, Zhongjie

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2022  Volume 9, Issue 15, Page(s) e2104034

    Abstract: Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains unknown. ...

    Abstract Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains unknown. Here, previously unidentified adult kidney Sca1
    MeSH term(s) Animals ; Endothelial Cells ; Kidney ; Mammals ; Mice ; Pluripotent Stem Cells ; Podocytes ; Sirtuin 2 ; beta Catenin
    Chemical Substances beta Catenin ; Sirtuin 2 (EC 3.5.1.-)
    Language English
    Publishing date 2022-03-22
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202104034
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  5. Article ; Online: Pan-cancer analyses of immunogenic cell death-derived gene signatures: Potential biomarkers for prognosis and immunotherapy.

    Han, Xiaodan / Song, Di / Cui, Yongliang / Shi, Yonggang / Gu, Xiaobin

    Cancer reports (Hoboken, N.J.)

    2024  Volume 7, Issue 4, Page(s) e2073

    Abstract: Background: Immunogenic cell death (ICD) is a type of regulated cell death that is capable of initiating an adaptive immune response. Induction of ICD may be a potential treatment strategy, as it has been demonstrated to activate the tumor-specific ... ...

    Abstract Background: Immunogenic cell death (ICD) is a type of regulated cell death that is capable of initiating an adaptive immune response. Induction of ICD may be a potential treatment strategy, as it has been demonstrated to activate the tumor-specific immune response.
    Aims: The biomarkers of ICD and their relationships with the tumor microenvironment, clinical features, and immunotherapy response are not fully understood in a clinical context. Therefore, we conducted pan-cancer analyses of ICD gene signatures across 33 cancer types from The Cancer Genome Atlas database.
    Methods and results: We identified key genes that had strong relationships with survival and the tumor microenvironment, contributing to a better understanding of the role of ICD genes in cancer therapy. In addition, we predicted therapeutic agents that target ICD genes and explored the potential mechanisms by which gemcitabine induce ICD. Moreover, we developed an ICD score based on the ICD genes and found it to be associated with patient prognosis, clinical features, tumor microenvironment, radiotherapy access, and immunotherapy response. A high ICD score was linked to the immune-hot phenotype, while a low ICD score was linked to the immune-cold phenotype.
    Conclusion: We uncovered the potential of ICD gene signatures as comprehensive biomarkers for ICD in pan-cancer. Our research provides novel insights into immuno-phenotypic assessment and cancer therapeutic strategies, which could help to broaden the application of immunotherapy to benefit more patients.
    MeSH term(s) Humans ; Immunogenic Cell Death ; Prognosis ; Biomarkers ; Immunotherapy ; Neoplasms/genetics ; Neoplasms/therapy ; Tumor Microenvironment/genetics
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-04-16
    Publishing country United States
    Document type Journal Article
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.2073
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  6. Article ; Online: Adult Mouse Kidney Stem Cells Orchestrate the De Novo Assembly of a Nephron via Sirt2‐Modulated Canonical Wnt/β‐Catenin Signaling

    Xiaobin Han / Zhongjie Sun

    Advanced Science, Vol 9, Iss 15, Pp n/a-n/a (2022)

    2022  

    Abstract: Abstract Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains ...

    Abstract Abstract Generation of kidney organoids using autologous kidney stem cells represents an attractive strategy for treating and potentially replacing the failing kidneys. However, whether adult mammalian kidney stem cells have regenerative capacity remains unknown. Here, previously unidentified adult kidney Sca1+ Oct4+ stem/progenitor cells are isolated. Interestingly, culturing these cells leads to generation of kidney‐like structures. First, the assembly of self‐organizing 3D kidney‐like structures is observed. These kidney organoids contain podocytes, proximal tubules, and endothelial cells that form networks of capillary loop‐like structures. Second, the differentiation of kidney stem cells into functionally mature tubules and self‐organizing kidney‐shaped structures in monolayer culture that selectively endocytoses dextran, is shown. Finally, the de novo generation of an entire self‐organizing nephron from monolayer cultures is observed. Mechanistically, it is demonstrated that Sirt2‐mediated canonical Wnt/β‐catenin signaling is critical for the development of kidney organoids. Thus, the first evidence is provided that the adult mouse kidney stem cells are capable of de novo generating kidney organoids.
    Keywords de novo generation ; kidney organoids ; kidney stem cells ; Sirt2 ; Wnt signaling ; Science ; Q
    Subject code 570
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Ultrafast Dynamics of Different Phase States Ge

    Wu, Hao / Han, Weina / Zhang, Xiaobin

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 19

    Abstract: A femtosecond laser could realize a high transition rate of the phase change material (PCM), and the properties of the amorphous and the crystalline ... ...

    Abstract A femtosecond laser could realize a high transition rate of the phase change material (PCM), and the properties of the amorphous and the crystalline Ge
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15196760
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  8. Article ; Online: Metabolic Engineering of

    Zeng, Mingxi / Wu, Hui / Han, Zhenlin / Du, Zhiyan / Yu, Xiaobin / Luo, Wei

    Journal of agricultural and food chemistry

    2024  Volume 72, Issue 8, Page(s) 4267–4276

    Abstract: 2,5-Dimethylpyrazine (2,5-DMP) is a high-value-added alkylpyrazine compound with important applications in both the food and pharmaceutical fields. In response to the increasing consumer preference for natural products over chemically synthesized ones, ... ...

    Abstract 2,5-Dimethylpyrazine (2,5-DMP) is a high-value-added alkylpyrazine compound with important applications in both the food and pharmaceutical fields. In response to the increasing consumer preference for natural products over chemically synthesized ones, efforts have been made to develop efficient microbial cell factories for the production of 2,5-DMP. However, the previously reported recombinant strains have exhibited low yields and relied on expensive antibiotics and inducers. In this study, we employed metabolic engineering strategies to develop an
    MeSH term(s) Escherichia coli/genetics ; Escherichia coli/metabolism ; Metabolic Engineering ; Glucose/metabolism ; Threonine/genetics ; Anti-Bacterial Agents/metabolism ; Pyrazines
    Chemical Substances 2,5-dimethylpyrazine (V99Y0MUY1Q) ; Glucose (IY9XDZ35W2) ; Threonine (2ZD004190S) ; Anti-Bacterial Agents ; Pyrazines
    Language English
    Publishing date 2024-02-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 241619-0
    ISSN 1520-5118 ; 0021-8561
    ISSN (online) 1520-5118
    ISSN 0021-8561
    DOI 10.1021/acs.jafc.3c08481
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1172: Show issues Location:
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  9. Article ; Online: Rational design of a hydrophilic nanoarray-structured electro-Fenton membrane for antibiotics removal and fouling mitigation: An intensified catalysis process in an oxygen vacancy-mediated cathodic microreactor.

    Yang, Liu / Zhao, Jing / Xu, Daliang / Luo, Xinsheng / Han, Yonghui / Tang, Xiaobin / Liang, Heng

    Journal of hazardous materials

    2024  Volume 470, Page(s) 134138

    Abstract: Electro-Fenton membranes (EFMs) can synchronously realize organic micropollutants destruction and fouling mitigation in a single filtration process with the assistance of hydroxyl radicals (•OH). Herein, a nanoarray-structured EFM (NS-EFM) was designed ... ...

    Abstract Electro-Fenton membranes (EFMs) can synchronously realize organic micropollutants destruction and fouling mitigation in a single filtration process with the assistance of hydroxyl radicals (•OH). Herein, a nanoarray-structured EFM (NS-EFM) was designed by assembling Fenton reactive CoFe-LDH nanowires using a low-temperature hydrothermal method. Combined with a defect-engineering strategy, the oxygen vacancies (O
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134138
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  10. Article: Ultrafast Temporal-Spatial Dynamics of Phase Transition in N-Doped Ge

    Wu, Hao / Zhang, Xiaobin / Han, Weina

    Micromachines

    2022  Volume 13, Issue 12

    Abstract: Element-doped phase change material (PCM) could improve the performances, e.g., better thermal stability, higher electrical resistance, and faster crystallization speed; thus, the influence of the doping element needs to be further investigated. In this ... ...

    Abstract Element-doped phase change material (PCM) could improve the performances, e.g., better thermal stability, higher electrical resistance, and faster crystallization speed; thus, the influence of the doping element needs to be further investigated. In this paper, a femtosecond laser, which could realize the ultrafast phase transition rate of PCM between amorphization and crystallization, was used to explore the properties of nitrogen-doped Ge
    Language English
    Publishing date 2022-12-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi13122168
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