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  1. Article ; Online: Defining Myeloma and Advancing Treatment Options: A Conversation Between S. Vincent Rajkumar and Lale Kostakoglu.

    Rajkumar, S Vincent / Kostakoglu, Lale

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 6, Page(s) 831–834

    MeSH term(s) Humans ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/therapy ; Communication
    Language English
    Publishing date 2023-05-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.123.265877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 114: Show issues Location:
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  2. Article ; Online: The Path Forward in Multiple Myeloma: 2021 Jan Waldenstrom Award Lecture.

    Rajkumar, S Vincent

    Clinical lymphoma, myeloma & leukemia

    2022  Volume 22, Issue 9, Page(s) 666–669

    MeSH term(s) Awards and Prizes ; Humans ; Multiple Myeloma/diagnosis ; Waldenstrom Macroglobulinemia
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Journal Article ; Lecture ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2022.04.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Multiple myeloma: 2022 update on diagnosis, risk stratification, and management.

    Rajkumar, S Vincent

    American journal of hematology

    2022  Volume 97, Issue 8, Page(s) 1086–1107

    Abstract: Disease overview: Multiple myeloma accounts for approximately 10% of hematologic malignancies.: Diagnosis: The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy-proven plasmacytoma plus evidence of one or more multiple myeloma ... ...

    Abstract Disease overview: Multiple myeloma accounts for approximately 10% of hematologic malignancies.
    Diagnosis: The diagnosis requires ≥10% clonal bone marrow plasma cells or a biopsy-proven plasmacytoma plus evidence of one or more multiple myeloma defining events (MDE): CRAB (hypercalcemia, renal failure, anemia, or lytic bone lesions) attributable to the plasma cell disorder, bone marrow clonal plasmacytosis ≥60%, serum involved/uninvolved free light chain (FLC) ratio ≥ 100 (provided involved FLC is ≥100 mg/L), or >1 focal lesion on magnetic resonance imaging.
    Risk stratification: The presence of del(17p), t(4;14), t(14;16), t(14;20), gain 1q, or p53 mutation is considered high-risk multiple myeloma. The presence of any two high risk factors is considered double-hit myeloma, and three or more high risk factors is triple-hit myeloma.
    Risk-adapted initial therapy: In patients who are candidates for autologous stem cell transplantation, induction therapy consists of bortezomib, lenalidomide, dexamethasone (VRd) given for approximately 3-4 cycles followed by autologous stem cell transplantation (ASCT). In high-risk patients, daratumumab, bortezomib, lenalidomide, dexamethasone (Dara-VRd) is an alternative to VRd. Selected standard-risk patients can collect stem cells, get additional cycles of induction therapy, and delay transplant until first relapse. Patients who are not candidates for transplant are treated with VRd for approximately 8-12 cycles followed by maintenance or alternatively with daratumumab, lenalidomide, dexamethasone (DRd) until progression.
    Maintenance therapy: Standard-risk patients need lenalidomide maintenance, while bortezomib plus lenalidomide maintenance is needed for high-risk myeloma.
    Management of relapsed disease: A triplet regimen is usually needed at relapse, with the choice of regimen varying with each successive relapse.
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Bortezomib/therapeutic use ; Dexamethasone/therapeutic use ; Hematopoietic Stem Cell Transplantation ; Humans ; Lenalidomide/therapeutic use ; Multiple Myeloma/diagnosis ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Neoplasm Recurrence, Local/etiology ; Risk Assessment ; Transplantation, Autologous
    Chemical Substances Bortezomib (69G8BD63PP) ; Dexamethasone (7S5I7G3JQL) ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26590
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1251: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Discarded Treatments: When the Problem and the Solution Are More Than Meets the Eye.

    Sandahl, Tyler B / Rajkumar, S Vincent

    Mayo Clinic proceedings

    2023  Volume 98, Issue 12, Page(s) 1748–1750

    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Editorial
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.10.012
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  5. Book: Multiple myeloma

    Gertz, Morie A. / Rajkumar, S. Vincent

    diagnosis and treatment

    2014  

    Author's details Morie A. Gertz ; S. vincent Rajkumar ed
    Language English
    Size XI, 311 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT017847212
    ISBN 978-1-4614-8519-3 ; 9781461485209 ; 1-4614-8519-3 ; 1461485207
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2013 A 3269 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: Sequencing of myeloma therapy: Finding the right path among many standards.

    Rajkumar, S Vincent

    Hematological oncology

    2021  Volume 39 Suppl 1, Page(s) 68–72

    MeSH term(s) Algorithms ; Clinical Decision-Making ; Combined Modality Therapy ; Disease Management ; Disease Susceptibility ; Humans ; Multiple Myeloma/diagnosis ; Multiple Myeloma/etiology ; Multiple Myeloma/therapy ; Prognosis ; Retreatment ; Standard of Care ; Time-to-Treatment ; Treatment Outcome
    Language English
    Publishing date 2021-06-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2848
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    Zs.A 1816: Show issues Location:
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  7. Article ; Online: Current approach to Waldenström macroglobulinemia.

    Kapoor, Prashant / Rajkumar, S Vincent

    Blood reviews

    2023  Volume 62, Page(s) 101129

    Abstract: ... of Bruton's tyrosine kinase (BTK) inhibitors to the treatment paradigm. Prior knowledge of the patients' MYD88 ...

    Abstract Waldenström macroglobulinemia (WM) is a unique CD20+, B-cell non-Hodgkin lymphoma, characterized by lymphoplasmacytic infiltration of the bone marrow and circulating monoclonal immunoglobulin M. The clinical manifestations and outcomes of patients are highly variable. High-level evidence supports integration of monoclonal anti-CD20 antibody, rituximab, to the chemotherapy backbone to treat WM. However, its contemporary management has become more nuanced, with deeper understanding of the pathophysiology and incorporation of Bruton's tyrosine kinase (BTK) inhibitors to the treatment paradigm. Prior knowledge of the patients' MYD88
    MeSH term(s) Humans ; Waldenstrom Macroglobulinemia/diagnosis ; Waldenstrom Macroglobulinemia/drug therapy ; Lymphoma, B-Cell ; Antineoplastic Agents/therapeutic use ; Rituximab/therapeutic use ; Signal Transduction ; Mutation
    Chemical Substances Antineoplastic Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-08-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2207: Show issues Location:
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  8. Book: Treatment of multiple myeloma and related disorders

    Rajkumar, S. Vincent

    2009  

    Author's details ed. by S. Vincent Rajkumar
    Keywords Multiple Myeloma / therapy ; Multiple Myeloma / diagnosis ; Paraproteinemias / therapy ; Paraproteinemias / diagnosis ; Multiple myeloma/Treatment ; Multiple myeloma/Diagnosis ; Paraproteinemia/Treatment ; Paraproteinemia/Diagnosis
    Subject code 616.99418
    Language English
    Size IX, 204 S. : Ill., graph. Darst., 27cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT016178903
    ISBN 978-0-521-51503-0 ; 0-521-51503-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 6850 order for loan Magazin

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  9. Article ; Online: Multiple myeloma with acute light chain cast nephropathy.

    Leung, Nelson / Rajkumar, S Vincent

    Blood cancer journal

    2023  Volume 13, Issue 1, Page(s) 46

    Abstract: Light chain cast nephropathy (LCCN) is a leading cause of acute kidney injury (AKI) in patients with multiple myeloma (MM) and is now defined as a myeloma defining event. While the long-term prognosis has improved with novel agents, short-term mortality ... ...

    Abstract Light chain cast nephropathy (LCCN) is a leading cause of acute kidney injury (AKI) in patients with multiple myeloma (MM) and is now defined as a myeloma defining event. While the long-term prognosis has improved with novel agents, short-term mortality remains significantly higher in patients with LCCN especially if the renal failure is not reversed. Recovery of renal function requires a rapid and significant reduction of the involved serum free light chain. Therefore, proper treatment of these patients is of the utmost importance. In this paper, we provide an algorithm for treatment of MM patients who present with biopsy-proven LCCN or in those where other causes of AKI have been ruled out. The algorithm is based on data from randomized trial whenever possible. When trial data is not available, our recommendations is based on non-randomized data and expert opinions on best practices. We recommend that all patients should enroll in a clinical trial if available prior to resorting to the treatment algorithm we outlined.
    MeSH term(s) Humans ; Multiple Myeloma/complications ; Multiple Myeloma/diagnosis ; Multiple Myeloma/therapy ; Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Immunoglobulin Light Chains ; Prognosis ; Renal Dialysis/adverse effects
    Chemical Substances Immunoglobulin Light Chains
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-023-00806-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The high cost of prescription drugs: causes and solutions.

    Vincent Rajkumar, S

    Blood cancer journal

    2020  Volume 10, Issue 6, Page(s) 71

    MeSH term(s) Costs and Cost Analysis ; Drug Development/economics ; Drug Industry/economics ; Humans ; Patents as Topic ; Prescription Drugs/economics ; United States
    Chemical Substances Prescription Drugs
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural
    ZDB-ID 2600560-8
    ISSN 2044-5385 ; 2044-5385
    ISSN (online) 2044-5385
    ISSN 2044-5385
    DOI 10.1038/s41408-020-0338-x
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