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Article ; Online: P

Meng, Shan-Shui / Li, Fei / Tang, Xiaowen / Chan, Albert S C

Organic letters

2023 Volume 25, Issue 20, Page(s) 3718–3722

Abstract: A phosphine-promoted reductive coupling of nitro compounds with Grignard reagents is described. Polyfunctional and pharmaceutically relevant diarylamines were generated by this reaction in moderate to high yields. Aliphatic nitro compounds that are ... ...

Abstract	A phosphine-promoted reductive coupling of nitro compounds with Grignard reagents is described. Polyfunctional and pharmaceutically relevant diarylamines were generated by this reaction in moderate to high yields. Aliphatic nitro compounds that are highly challenging substrates undergo a combination of α-arylation and reductive coupling to afford the α-arylated arylamines efficiently. A series of valuable biaryl compounds with polyfluorinated and heteroaryl rings are co-generated in 56-94% yields.
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c01167
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Article ; Online: P

Yoon, Jong Il / Kim, Hyoin / Kim, Meeree / Cho, Hwichan / Kwon, Yonghyun Albert / Choi, Mahnmin / Park, Seongmin / Kim, Taewan / Lee, Seunghan / Jo, Hyunwoo / Kim, BongSoo / Cho, Jeong Ho / Park, Ji-Sang / Jeong, Sohee / Kang, Moon Sung

Science advances

2023 Volume 9, Issue 45, Page(s) eadj8276

Abstract: InAs semiconductor nanocrystals (NCs) exhibit intriguing electrical/optoelectronic properties suitable for next-generation electronic devices. Although there is a need for ... ...

Abstract	InAs semiconductor nanocrystals (NCs) exhibit intriguing electrical/optoelectronic properties suitable for next-generation electronic devices. Although there is a need for both
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adj8276
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Book ; Thesis: Der Einfluss von GDF15 auf die Entzündungsreaktion während mechanischer Druckbelastung und P. Gingivalis Stimulation

Stemmler, Albert / Jacobs, Collin / Schulze-Späte, Ulrike / Wolf, Michael

2023

Title variant	fünfzehn
Institution	Friedrich-Schiller-Universität Jena
Author's details	von Albert Stemmler
Keywords	Parodontitis ; Porphyromonas gingivalis
Subject	Bacteroides gingivalis ; Paradentitis ; Paradontitis ; Rasch fortschreitende Parodontitis ; RPP ; Rapid progredient parodontitis ; Early-onset peridontitis
Language	German ; English
Size	35 Blätter, Illustrationen, Diagramme, 29,5 cm
Publishing place	Jena
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Friedrich-Schiller-Universität Jena, 2023
Note	Zeitschriftenaufsätze in englischer Sprache ; Kumulative Dissertation, enthält Zeitschriftenaufsätze ; Tag der Verteidigung: 27.06.2023
HBZ-ID	HT030693347
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Article ; Online: Clinical performance and head-to-head comparison of CSF p-tau235 with p-tau181, p-tau217 and p-tau231 in two memory clinic cohorts.

Lantero-Rodriguez, Juan / Vrillon, Agathe / Fernández-Lebrero, Aida / Ortiz-Romero, Paula / Snellman, Anniina / Montoliu-Gaya, Laia / Brum, Wagner S / Cognat, Emmanuel / Dumurgier, Julien / Puig-Pijoan, Albert / Navalpotro-Gómez, Irene / García-Escobar, Greta / Karikari, Thomas K / Vanmechelen, Eugeen / Ashton, Nicholas J / Zetterberg, Henrik / Suárez-Calvet, Marc / Paquet, Claire / Blennow, Kaj

Alzheimer's research & therapy

2023 Volume 15, Issue 1, Page(s) 48

Abstract: Background: Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific ... of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do ... study, we investigated the performance of CSF p-tau235 to detect symptomatic AD in clinical settings and ...

Abstract	Background: Cerebrospinal fluid (CSF) p-tau235 is a novel biomarker highly specific of Alzheimer's disease (AD). However, CSF p-tau235 has only been studied in well-characterized research cohorts, which do not fully reflect the patient landscape found in clinical settings. Therefore, in this multicentre study, we investigated the performance of CSF p-tau235 to detect symptomatic AD in clinical settings and compared it with CSF p-tau181, p-tau217 and p-tau231. Methods: CSF p-tau235 was measured using an in-house single molecule array (Simoa) assay in two independent memory clinic cohorts: Paris cohort (Lariboisière Fernand-Widal University Hospital Paris, France; n=212) and BIODEGMAR cohort (Hospital del Mar, Barcelona, Spain; n=175). Patients were classified by the syndromic diagnosis (cognitively unimpaired [CU], mild cognitive impairment [MCI] or dementia) and their biological diagnosis (amyloid-beta [Aβ]+ or Aβ -). Both cohorts included detailed cognitive assessments and CSF biomarker measurements (clinically validated core AD biomarkers [Lumipulse CSF Aβ Results: High CSF p-tau235 levels were strongly associated with CSF amyloidosis regardless of the clinical diagnosis, being significantly increased in MCI Aβ+ and dementia Aβ+ when compared with all other Aβ- groups (Paris cohort: P ˂0.0001 for all; BIODEGMAR cohort: P ˂0.05 for all). CSF p-tau235 was pronouncedly increased in the A+T+ profile group compared with A-T- and A+T- groups (P ˂0.0001 for all). Moreover, CSF p-tau235 demonstrated high diagnostic accuracies identifying CSF amyloidosis in symptomatic cases (AUCs=0.86 to 0.96) and discriminating AT groups (AUCs=0.79 to 0.98). Overall, CSF p-tau235 showed similar performances to CSF p-tau181 and CSF p-tau231 when discriminating CSF amyloidosis in various scenarios, but lower than CSF p-tau217. Finally, CSF p-tau235 associated with global cognition and memory domain in both cohorts. Conclusions: CSF p-tau235 was increased with the presence of CSF amyloidosis in two independent memory clinic cohorts. CSF p-tau235 accurately identified AD in both MCI and dementia patients. Overall, the diagnostic performance of CSF p-tau235 was comparable to that of other CSF p-tau measurements, indicating its suitability to support a biomarker-based AD diagnosis in clinical settings.
MeSH term(s)	Humans ; Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Amyloidosis ; Biomarkers/cerebrospinal fluid ; Cognitive Dysfunction ; tau Proteins/cerebrospinal fluid
Chemical Substances	Amyloid beta-Peptides ; Biomarkers ; tau Proteins ; MAPT protein, human
Language	English
Publishing date	2023-03-10
Publishing country	England
Document type	Multicenter Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2506521-X
ISSN	1758-9193 ; 1758-9193
ISSN (online)	1758-9193
ISSN	1758-9193
DOI	10.1186/s13195-023-01201-0
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Book ; Online: Strategie zur Verbesserung der P-Effizienz im Pflanzenbau

Heinitz, Franziska / Farack, Katharina / Albert, Erhard

(Schriftenreihe des LfULG ; 2013,9)

2013

Title variant	Verbesserung der P-Effizienz im Pflanzenbau
Author's details	Franziska Heinitz ; Katharina Farack ; Erhard Albert
Series title	Schriftenreihe des LfULG ; 2013,9 Schriftenreihe des Landesamtes für Umwelt, Landwirtschaft und Geologie / Freistaat Sachsen
Collection	Schriftenreihe des Landesamtes für Umwelt, Landwirtschaft und Geologie / Freistaat Sachsen
Subject code	630
Language	German
Publisher	Sächsisches Landesamt für Umwelt, Landwirtschaft und Geologie
Publishing place	Dresden
Publishing country	Germany
Document type	Book ; Online
Remark	Elektronischer Volltext
HBZ-ID	HT017653804
DOI	10.4126/98-005147343
Database	Repository for Life Sciences

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Book ; Online: Strategie zur Verbesserung der P-Effizienz im Pflanzenbau

Heinitz, Franziska / Farack, Katharina / Albert, Erhard

(Schriftenreihe des LfULG ; 2013,9)

2013

Title variant	Verbesserung der P-Effizienz im Pflanzenbau
Author's details	Franziska Heinitz ; Katharina Farack ; Erhard Albert
Series title	Schriftenreihe des LfULG ; 2013,9 Schriftenreihe des Landesamtes für Umwelt, Landwirtschaft und Geologie / Freistaat Sachsen
Collection	Schriftenreihe des Landesamtes für Umwelt, Landwirtschaft und Geologie / Freistaat Sachsen
Subject code	630
Language	German
Publisher	Sächsisches Landesamt für Umwelt, Landwirtschaft und Geologie
Publishing place	Dresden
Publishing country	Germany
Document type	Book ; Online
Remark	Elektronischer Volltext
HBZ-ID	HT017653804
DOI	10.4126/98-005147343
Database	Repository for Life Sciences

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Article ; Online: Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Khoury, Nadine / Martínez, María Ángeles / Paz-Graniel, Indira / Martínez-González, Miguel Ángel / Corella, Dolores / Castañer, Olga / Martínez, J Alfredo / Alonso-Gómez, Ángel M / Wärnberg, Julia / Vioque, Jesús / Romaguera, Dora / López-Miranda, José / Estruch, Ramon / Tinahones, Francisco J / Lapetra, José / Serra-Majem, J Lluís / Bueno-Cavanillas, Aurora / Tur, Josep A / Sanjurjo, Sergio Cinza /

Pintó, Xavier / Gaforio, José Juan / Matía-Martín, Pilar / Vidal, Josep / Vázquez, Clotilde / Daimiel, Lidia / Ros, Emilio / Sayon-Orea, Carmen / Sorlí, Jose V / Pérez-Vega, Karla-Alejandra / Garcia-Rios, Antonio / Bellvert, Nuria Gómez / Gómez-Gracia, Enrique / Zulet, M A / Chaplin, Alice / Casas, Rosa / Salcedo-Bellido, Inmaculada / Tojal-Sierra, Lucas / Bernal-Lopez, Maria-Rosa / Vázquez-Ruiz, Zenaida / Asensio, Eva M / Goday, Albert / Peña-Orihuela, Patricia J / Signes-Pastor, Antonio J / Garcia-Arellano, Ana / Fitó, Montse / Babio, Nancy / Salas-Salvadó, Jordi

Environmental research

2023 Volume 227, Page(s) 115697

Abstract: Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and ... polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family ... a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher ...

Abstract	Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55-75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.
MeSH term(s)	Middle Aged ; Humans ; Female ; Male ; Polychlorinated Dibenzodioxins/toxicity ; Dibenzofurans ; Dioxins/analysis ; Adiposity ; Furans ; Overweight ; Obesity, Abdominal ; Cross-Sectional Studies ; Prospective Studies ; Dibenzofurans, Polychlorinated/toxicity ; Eating ; Polychlorinated Biphenyls/analysis
Chemical Substances	Polychlorinated Dibenzodioxins ; Dibenzofurans ; Dioxins ; Furans ; Dibenzofurans, Polychlorinated ; Polychlorinated Biphenyls (DFC2HB4I0K)
Language	English
Publishing date	2023-03-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115697
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Article ; Online: Neuropeltis acuminata (P. Beauv.)

Didjour Albert Kambiré / Ahmont Claude Landry Kablan / Thierry Acafou Yapi / Sophie Vincenti / Jacques Maury / Nicolas Baldovini / Pierre Tomi / Mathieu Paoli / Jean Brice Boti / Félix Tomi

Molecules, Vol 27, Iss 3759, p

Investigation of the Chemical Variability and In Vitro Anti-inflammatory Activity of the Leaf Essential Oil from the Ivorian Species

2022 Volume 3759

Abstract: The variability of chemical composition of the leaf essential oil (EO) from Neuropeltis acuminata , a climbing liana growing wild in Ivory Coast, was investigated for the first time. The in vitro anti-inflammatory activity was also evaluated. Thirty oil ... ...

Abstract	The variability of chemical composition of the leaf essential oil (EO) from Neuropeltis acuminata , a climbing liana growing wild in Ivory Coast, was investigated for the first time. The in vitro anti-inflammatory activity was also evaluated. Thirty oil samples were isolated from leaves collected in three forests of the country and analyzed using a combination of Column Chromatography (CC), Gas Chromatography with Retention Indices (GC(FID)), Gas Chromatography-Mass Spectrometry (GC-MS), and 13 Carbon-Nuclear Magnetic Resonance ( 13 C-NMR). Fractionation by CC led to the first-time isolation from natural source of δ-cadinen-11-ol, whose structural elucidation by one dimension (1D) and 2D-NMR spectroscopy is reported here. Finally, 103 constituents accounting for 95.7 to 99.6% of the samples’ compositions were identified. As significant variations of the major constituents were observed, the 30 oil compositions were submitted to hierarchical cluster and principal components analyses. Five distinct groups were evidenced: Group I, dominated by ( E )-β-caryophyllene, kessane, and δ-cadinene, while the main constituents of Group II were germacrene B, ledol, α-humulene, ( E )-γ-bisabolen-12-ol, and γ-elemene. Group III exhibited guaiol, germacrene D, atractylone, ( E )-γ-bisabolen-12-ol, δ-cadinene and bulnesol as main compounds. Group IV was dominated by ( E )-nerolidol, guaiol, selina-4(15),7(11)-diene and bulnesol, whereas ( E )-β-caryophyllene, α-humulene and α-muurolene were the prevalent compounds of Group V. As the harvest took place in the same dry season in the three forests, the observed chemical variability could be related to harvest sites, which includes climatic and pedologic factors, although genetic factors could not be excluded. The leaf oil sample S24 behaved as a high inhibitor of LipOXygenase (LOX) activity (half maximum Inhibitory Concentration, IC 50 : 0.059 ± 0.001 mg mL −1 ), suggesting an anti-inflammatory potential.
Keywords	Neuropeltis acuminata ; leaf essential oil ; chemical variability ; anti-inflammatory activity ; δ-cadinen-11-ol ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Serum amyloid P component (SAP) modulates antidepressant effects through promoting membrane insertion of the serotonin transporter.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

2022 Volume 48, Issue 3, Page(s) 508–517

Abstract: Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits including ...

Abstract	Serum amyloid P component (SAP) is a universal constituent of human amyloid deposits including those in Alzheimer's disease. SAP has been observed to be elevated in patients with depression, and higher SAP levels are associated with better response to the antidepressant escitalopram. The mechanisms underlying these clinical observations remain unclear. We examined the effect of SAP on serotonin transporter (SERT) expression and localization using Western blot, confocal microscopy, and positron emission tomography with the radioligand [
MeSH term(s)	Humans ; Mice ; Animals ; Serotonin Plasma Membrane Transport Proteins/metabolism ; Serum Amyloid P-Component/metabolism ; Escitalopram ; Antidepressive Agents/pharmacology ; Selective Serotonin Reuptake Inhibitors/pharmacology
Chemical Substances	Serotonin Plasma Membrane Transport Proteins ; Serum Amyloid P-Component ; Escitalopram (4O4S742ANY) ; Antidepressive Agents ; Selective Serotonin Reuptake Inhibitors
Language	English
Publishing date	2022-09-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639471-1
ISSN	1740-634X ; 0893-133X
ISSN (online)	1740-634X
ISSN	0893-133X
DOI	10.1038/s41386-022-01449-4
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Article: Clinical phenotype of adult offspring carriers of the p.Pro392Leu mutation within the

Dessay, Mariam / Jobin Gervais, François / Simonyan, David / Samson, Andréanne / Gleeton, Guylaine / Gagnon, Edith / Albert, Caroline / Brown, Jacques P / Michou, Laëtitia

Bone reports

2020 Volume 13, Page(s) 100717

Abstract: ... the p.Pro392Leu mutation within the ...

Abstract	Paget's disease of bone (PDB) is a common chronic bone disorder. In the French-Canadian population, the p.Pro392Leu mutation within the
Language	English
Publishing date	2020-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2821774-3
ISSN	2352-1872
ISSN	2352-1872
DOI	10.1016/j.bonr.2020.100717
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