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  1. Article: Revisiting the calpain hypothesis of learning and memory 40 years later.

    Baudry, Michel / Bi, Xiaoning

    Frontiers in molecular neuroscience

    2024  Volume 17, Page(s) 1337850

    Abstract: In 1984, Gary Lynch and Michel Baudry published in ...

    Abstract In 1984, Gary Lynch and Michel Baudry published in
    Language English
    Publishing date 2024-02-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452967-9
    ISSN 1662-5099
    ISSN 1662-5099
    DOI 10.3389/fnmol.2024.1337850
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  2. Article ; Online: A New Chief Editor for

    Baudry, Michel

    Neural plasticity

    2020  Volume 2020, Page(s) 1351395

    Abstract: ... Neural ... ...

    Abstract Neural Plasticity
    Language English
    Publishing date 2020-08-01
    Publishing country United States
    Document type Editorial
    ZDB-ID 1454938-4
    ISSN 1687-5443 ; 2090-5904 ; 0792-8483
    ISSN (online) 1687-5443
    ISSN 2090-5904 ; 0792-8483
    DOI 10.1155/2020/1351395
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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Did Proust predict the existence of episodic memory?

    Baudry, Michel

    Neurobiology of learning and memory

    2020  Volume 171, Page(s) 107191

    Abstract: Cognitive psychologists have often discussed the idea that when Proust used in his books the concept of involuntary memories, which could be retrieved by an odor or a taste, he was in fact predating the notion of modern episodic memory. Since the ... ...

    Abstract Cognitive psychologists have often discussed the idea that when Proust used in his books the concept of involuntary memories, which could be retrieved by an odor or a taste, he was in fact predating the notion of modern episodic memory. Since the publication of his famous "In Search of Lost Time", considerable progress has been made on our understanding of various types of memory and of the mechanisms involved in different brain circuits and synapses responsible for their long-term storage. This review will focus on the role of hippocampus in episodic memory, including its role in encoding time and various elements of episodes, in particular olfactory information. Our conclusion is that Proust did indeed predict the existence of episodic memory, although he did not realize that, in addition to remembering things past, memory is also used to predict the future.
    MeSH term(s) Animals ; Hippocampus/physiology ; Humans ; Medicine in Literature ; Memory, Episodic ; Odorants ; Smell/physiology
    Language English
    Publishing date 2020-02-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1223366-3
    ISSN 1095-9564 ; 1074-7427
    ISSN (online) 1095-9564
    ISSN 1074-7427
    DOI 10.1016/j.nlm.2020.107191
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2339: Show issues Location:
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  4. Book: Synaptic plasticity

    Baudry, Michel

    basic mechanisms to clinical applications

    (Neurological disease and therapy ; 69)

    2005  

    Author's details ed. by Michel Baudry
    Series title Neurological disease and therapy ; 69
    Collection
    Keywords Synapses / physiology ; Neuronal Plasticity ; Central Nervous System / injuries ; Central Nervous System / rehabilitation ; Central Nervous System / therapy
    Language English
    Size XXII, 508 S. : Ill., graph. Darst.
    Publisher Taylor & Francis
    Publishing place Boca Raton u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT014330108
    ISBN 978-0-8247-5900-1 ; 0-8247-5900-1
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2005 A 2240 order for loan Magazin

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  5. Article ; Online: Multiple aggregated yellow-white globules are a major dermoscopic sign of basal cell carcinoma regardless of their histological subtype.

    Le Maitre, Michel / Baudry, Adrien / Pedaillès, Sabine

    European journal of dermatology : EJD

    2024  Volume 33, Issue 5, Page(s) 514–517

    Abstract: Multiple aggregated yellow-white globules (MAY globules) have been recently described as dermoscopic structures of high specificity associated with high-risk non-pigmented basal cell carcinoma (BCC). To evaluate the diagnostic accuracy of MAY globules in ...

    Abstract Multiple aggregated yellow-white globules (MAY globules) have been recently described as dermoscopic structures of high specificity associated with high-risk non-pigmented basal cell carcinoma (BCC). To evaluate the diagnostic accuracy of MAY globules in a cohort of pigmented and non-pigmented BCC of all histological types. This was a retrospective case-control study. Dermoscopic and clinical images were all histopathologically confirmed as BCCs of patients seen consecutively at dermatology consultation. Control cases were benign or malignant tumours randomly selected from the database of 8,250 patients. A total of 389 BCCs were included. MAY globules were present in 192 (49%) cases in the BCC group and in only 25 cases in the control group (6,4%). The odds ratio for the diagnosis of BCC was 14.2 (95% CI: 9.62-20.95]). The presence of MAY globules was significant in three histological subtypes, including superficial BCCs. This study shows that MAY globules are a major dermoscopic sign for the diagnosis of BCC, regardless of their histological subtype and their pigmentation.
    MeSH term(s) Humans ; Skin Neoplasms/pathology ; Retrospective Studies ; Case-Control Studies ; Dermoscopy/methods ; Carcinoma, Basal Cell/pathology
    Language English
    Publishing date 2024-01-31
    Publishing country France
    Document type Journal Article
    ZDB-ID 1128666-0
    ISSN 1952-4013 ; 1167-1122
    ISSN (online) 1952-4013
    ISSN 1167-1122
    DOI 10.1684/ejd.2023.4558
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  6. Article ; Online: Calpain-1 and Calpain-2 in the Brain: Dr. Jekill and Mr Hyde?

    Baudry, Michel

    Current neuropharmacology

    2019  Volume 17, Issue 9, Page(s) 823–829

    Abstract: While the calpain system has now been discovered for over 50 years, there is still a paucity of information regarding the organization and functions of the signaling pathways regulated by these proteases, although calpains play critical roles in many ... ...

    Abstract While the calpain system has now been discovered for over 50 years, there is still a paucity of information regarding the organization and functions of the signaling pathways regulated by these proteases, although calpains play critical roles in many cell functions. Moreover, calpain overactivation has been shown to be involved in numerous diseases. Among the 15 calpain isoforms identified, calpain-1 (aka µ-calpain) and calpain-2 (aka m-calpain) are ubiquitously distributed in most tissues and organs, including the brain. We have recently proposed that calpain-1 and calpain- 2 play opposite functions in the brain, with calpain-1 activation being required for triggering synaptic plasticity and neuroprotection (Dr. Jekill), and calpain-2 limiting the extent of plasticity and being neurodegenerative (Mr. Hyde). Calpain-mediated cleavage has been observed in cytoskeleton proteins, membrane-associated proteins, receptors/channels, scaffolding/anchoring proteins, and protein kinases and phosphatases. This review will focus on the signaling pathways related to local protein synthesis, cytoskeleton regulation and neuronal survival/death regulated by calpain-1 and calpain-2, in an attempt to explain the origin of the opposite functions of these 2 calpain isoforms. This will be followed by a discussion of the potential therapeutic applications of selective regulators of these 2 calpain isoforms.
    MeSH term(s) Amino Acid Sequence ; Animals ; Calpain/chemistry ; Calpain/pharmacology ; Calpain/physiology ; Calpain/therapeutic use ; Humans ; Neuronal Plasticity ; Signal Transduction ; Synapses
    Chemical Substances Calpain (EC 3.4.22.-)
    Language English
    Publishing date 2019-02-28
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X17666190228112451
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    Zs.A 6150: Show issues Location:
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  7. Book: Advances in synaptic plasticity

    Baudry, Michel

    (Bradford book)

    2000  

    Author's details ed. by Michel Baudry
    Series title Bradford book
    Keywords Synapse ; Plastizität
    Subject Verformbarkeit
    Language English
    Size XIV, 335 S. : Ill., graph. Darst.
    Publisher MIT Pr
    Publishing place Cambridge, Mass. u.a.
    Publishing country United States
    Document type Book
    Note Hier auch später erschienene unveränderte Nachdrucke
    HBZ-ID HT012757947
    ISBN 0-262-02460-8 ; 978-0-262-51523-8 ; 978-0-262-02460-0 ; 0-262-51523-7
    Database Catalogue ZB MED Medicine, Health

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    2000 A 3600 order for loan Magazin

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  8. Article ; Online: Neural Adjustments during Repeated Braking and Throttle Actions on a Motorcycle Setup.

    Marina, Michel / Torrado, Priscila / Duchateau, Jacques / Baudry, Stephane

    International journal of sports medicine

    2023  Volume 45, Issue 2, Page(s) 125–133

    Abstract: The aim of the study was to assess neuromuscular changes during an intermittent fatiguing task designed to replicate fundamental actions and ergonomics of road race motorcycling. Twenty-eight participants repeated a sequence of submaximal brake-pulling ... ...

    Abstract The aim of the study was to assess neuromuscular changes during an intermittent fatiguing task designed to replicate fundamental actions and ergonomics of road race motorcycling. Twenty-eight participants repeated a sequence of submaximal brake-pulling and gas throttle actions, interspaced by one maximal brake-pulling, until failure. During the submaximal brake-pulling actions performed at 30% MVC, force fluctuations, surface EMG, maximal M-wave (M
    MeSH term(s) Humans ; Muscle Fatigue ; Muscle Contraction ; Motorcycles ; Muscle, Skeletal ; Electromyography/methods ; Fatigue ; Isometric Contraction
    Language English
    Publishing date 2023-12-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 603122-5
    ISSN 1439-3964 ; 0172-4622 ; 0943-917X
    ISSN (online) 1439-3964
    ISSN 0172-4622 ; 0943-917X
    DOI 10.1055/a-2197-0967
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    Zs.A 1561: Show issues Location:
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  9. Article ; Online: Calpain-2 Inhibitors as Therapy for Traumatic Brain Injury.

    Baudry, Michel / Luo, Yun Lyna / Bi, Xiaoning

    Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

    2023  Volume 20, Issue 6, Page(s) 1592–1602

    Abstract: While calpains have long been implicated in neurodegeneration, no calpain inhibitor has been developed for the treatment of neurodegeneration. This is partly due to the lack of understanding of the specific functions of most of the 15 members of the ... ...

    Abstract While calpains have long been implicated in neurodegeneration, no calpain inhibitor has been developed for the treatment of neurodegeneration. This is partly due to the lack of understanding of the specific functions of most of the 15 members of the calpain family. Work from our laboratory over the last 5-10 years has revealed that calpain-1 and calpain-2, two of the major calpain isoforms in the brain, play opposite roles in both synaptic plasticity/learning and memory and neuroprotection/neurodegeneration. Thus, calpain-1 activation is required for triggering certain forms of synaptic plasticity and for learning some types of information and is neuroprotective. In contrast, calpain-2 activation limits the extent of synaptic plasticity and of learning and is neurodegenerative. These results have been validated with the use of calpain-1 knock-out mice and mice with a selective calpain-2 deletion in excitatory neurons of the forebrain. Through a medicinal chemistry campaign, we have identified a number of selective calpain-2 inhibitors and shown that these inhibitors do facilitate learning of certain tasks and are neuroprotective in a number of animal models of acute neurodegeneration. One of these inhibitors, NA-184, is currently being developed for the treatment of traumatic brain injury, and clinical trials are being planned.
    MeSH term(s) Mice ; Animals ; Calpain/metabolism ; Brain Injuries, Traumatic/drug therapy ; Neuronal Plasticity/physiology ; Neurons/metabolism ; Brain/metabolism
    Chemical Substances Calpain (EC 3.4.22.-)
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2316693-9
    ISSN 1878-7479 ; 1933-7213
    ISSN (online) 1878-7479
    ISSN 1933-7213
    DOI 10.1007/s13311-023-01407-y
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  10. Book ; Conference proceedings: Brain and memory - from genes to behavior

    Baudry, Michel

    proceedings of the Sixth Conference on the Neurobiology of Learning and Memory ; October 21 - 24, 1997, University of California, Irvine

    (Neurobiology of learning and memory ; 70,1/2 = Special issue)

    1998  

    Event/congress Conference on the Neurobiology of Learning and Memory (6, 1997, IrvineCalif.NewportBeachCalif.)
    Author's details guest ed. Michel Baudry
    Series title Neurobiology of learning and memory ; 70,1/2 = Special issue
    Collection
    Language English
    Size S. 1 - 303 : Ill., graph. Darst.
    Publisher Acad. Press
    Publishing place San Diego, Calif. u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT009127471
    Database Catalogue ZB MED Medicine, Health

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    Zs B 2339 -70- verfügbar in Königswinter Königswinter

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