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  1. Article ; Online: Measurement of ATGL activity using adiposomes.

    Ma, Xuejing / Zhi, Zelun / Zhang, Shuyan / Liu, Pingsheng

    Biophysics reports

    2023  Volume 9, Issue 1, Page(s) 3–14

    Abstract: Adipose triacylglycerol lipase (ATGL) is a dynamic lipid droplet-associated protein involved in cellular lipolysis, which is conserved from bacteria to humans. Recent methods that measure the enzymatic activity of ... ...

    Abstract Adipose triacylglycerol lipase (ATGL) is a dynamic lipid droplet-associated protein involved in cellular lipolysis, which is conserved from bacteria to humans. Recent methods that measure the enzymatic activity of ATGL
    Language English
    Publishing date 2023-06-22
    Publishing country China
    Document type Journal Article
    ISSN 2364-3420
    ISSN (online) 2364-3420
    DOI 10.52601/bpr.2023.220016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Dioscorea

    Liu, Xing / Zhou, Pingsheng / He, Keqing / Wen, Zhili / Gao, Yong

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 678620

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.678620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Isolation and proteomic study of fish liver lipid droplets.

    Sun, Yuwei / Heng, Jian / Liu, Feng / Zhang, Shuyan / Liu, Pingsheng

    Biophysics reports

    2023  Volume 9, Issue 3, Page(s) 120–133

    Abstract: Lipid droplets (LDs) are a neutral lipid storage organelle that is conserved in almost all species. Excessive storage of neutral lipids in LDs is directly associated with many metabolic syndromes. Zebrafish is a better model animal for the study of LD ... ...

    Abstract Lipid droplets (LDs) are a neutral lipid storage organelle that is conserved in almost all species. Excessive storage of neutral lipids in LDs is directly associated with many metabolic syndromes. Zebrafish is a better model animal for the study of LD biology due to its transparent embryonic stage compared to other organisms. However, the study of LDs in fish has been difficult due to the lack of specific LD marker proteins and the limitation of purification technology. In this paper, the purification and proteomic analysis of liver LDs of fish including zebrafish and
    Language English
    Publishing date 2023-11-22
    Publishing country China
    Document type Journal Article
    ISSN 2364-3420
    ISSN (online) 2364-3420
    DOI 10.52601/bpr.2023.230004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Membrane biophysics session.

    Liu, Pingsheng / Separovic, Frances

    Biophysical reviews

    2019  Volume 11, Issue 3, Page(s) 283–284

    Language English
    Publishing date 2019-04-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-019-00515-4
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  5. Article ; Online: LiNAC100 contributes to linalool biosynthesis by directly regulating LiLiS in Lilium 'Siberia'.

    Liu, Xuping / Yan, Wenxin / Liu, Sijia / Wu, Jing / Leng, Pingsheng / Hu, Zenghui

    Planta

    2024  Volume 259, Issue 4, Page(s) 73

    Abstract: Main conclusion: The transcription factor LiNAC100 has a novel function of regulating floral fragrance by directly regulating linalool synthase gene LiLiS. Lilium 'Siberia', an Oriental hybrid, is renowned as both a cut flower and garden plant, prized ... ...

    Abstract Main conclusion: The transcription factor LiNAC100 has a novel function of regulating floral fragrance by directly regulating linalool synthase gene LiLiS. Lilium 'Siberia', an Oriental hybrid, is renowned as both a cut flower and garden plant, prized for its color and fragrance. The fragrance comprises volatile organic compounds (VOCs), primarily monoterpenes found in the plant. While the primary terpene synthases in Lilium 'Siberia' were identified, the transcriptional regulation of these terpene synthase (TPS) genes remains unclear. Thus, understanding the regulatory mechanisms of monoterpene biosynthesis is crucial for breeding flower fragrance, thereby improving ornamental and commercial values. In this study, we isolated a nuclear-localized LiNAC100 transcription factor from Lilium 'Siberia'. The virus-induced gene silencing (VIGS) of LiNAC100 was found to down-regulate the expression of linalool synthase gene (LiLiS) and significantly inhibit linalool synthesis. Conversely, transient overexpression of LiNAC100 produced opposite effects. Additionally, yeast one-hybrid and dual-luciferase assays confirmed that LiNAC100 directly activates LiLiS expression. Our findings reveal that LiNAC100 plays a key role in monoterpene biosynthesis in Lilium 'Siberia', promoting linalool synthesis through the activation of LiLiS expression. These results offer insights into the molecular mechanisms of terpene biosynthesis in Lilium 'Siberia' and open avenues for biotechnological enhancement of floral scent.
    MeSH term(s) Lilium/genetics ; Lilium/metabolism ; Gene Expression Regulation, Plant ; Plant Breeding ; Acyclic Monoterpenes/metabolism ; Monoterpenes/metabolism ; Flowers/genetics ; Transcription Factors/genetics
    Chemical Substances linalool (D81QY6I88E) ; Acyclic Monoterpenes ; Monoterpenes ; Transcription Factors
    Language English
    Publishing date 2024-02-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/s00425-024-04340-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: ROS conversion promotes the bactericidal efficiency of Eosin Y based photodynamic therapy.

    Fan, Birong / Peng, Wan / Zhang, Yu / Liu, Pingsheng / Shen, Jian

    Biomaterials science

    2023  Volume 11, Issue 14, Page(s) 4930–4937

    Abstract: Photodynamic therapy (PDT) is becoming an efficient antibacterial strategy without drug-resistance. Here, we report a promising reactive oxygen species (ROS) conversion strategy to increase the antibacterial efficiency of an Eosin Y (EOS)-based PDT ... ...

    Abstract Photodynamic therapy (PDT) is becoming an efficient antibacterial strategy without drug-resistance. Here, we report a promising reactive oxygen species (ROS) conversion strategy to increase the antibacterial efficiency of an Eosin Y (EOS)-based PDT system. Based on visible-light illumination, EOS generates a high concentration of singlet oxygen (
    MeSH term(s) Rats ; Animals ; Staphylococcus aureus/physiology ; Methicillin-Resistant Staphylococcus aureus ; Reactive Oxygen Species ; Photochemotherapy ; Eosine Yellowish-(YS) ; Hydrogen Peroxide ; HEPES ; Anti-Bacterial Agents/pharmacology ; Oxygen ; Photosensitizing Agents/pharmacology
    Chemical Substances Reactive Oxygen Species ; Eosine Yellowish-(YS) (TDQ283MPCW) ; Hydrogen Peroxide (BBX060AN9V) ; HEPES (RWW266YE9I) ; Anti-Bacterial Agents ; Oxygen (S88TT14065) ; Photosensitizing Agents
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d3bm00804e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Myocardial Injury After Temporary Transvenous Cardiac Pacing.

    Liu, Meng / Wu, Pingsheng

    Therapeutics and clinical risk management

    2021  Volume 17, Page(s) 415–421

    Abstract: Introduction: Temporary transvenous cardiac pacing (TTCP) can lead to potential penetration and occasional perforation of the right ventricular wall. No study to date has analyzed the effect of TTCP on myocardial injury by cardiac troponin (cTn) ... ...

    Abstract Introduction: Temporary transvenous cardiac pacing (TTCP) can lead to potential penetration and occasional perforation of the right ventricular wall. No study to date has analyzed the effect of TTCP on myocardial injury by cardiac troponin (cTn) measurement. The present study was designed to investigate perioperative myocardial injury in elective TTCP in noncardiac surgical settings.
    Patients and methods: This retrospective study investigated the data collected from August 2018 through March 2020 from 22 eligible patients who underwent elective TTCP for noncardiac procedures. The patients had a median age of 66 (50-83) years; six (27.3%) of them were women, and all of them had a baseline cTn <1 upper reference limit (URL). Cardiac biomarker assays were performed before and after TTCP, and their results were compared.
    Results: After TTCP, cTn > 1 URL was detected in 20 (91%, N=22) patients. Among these 22 patients, paired
    Conclusion: The study demonstrates a high incidence of myocardial injury associated with TTCP, which should be a matter of concern for the involved physicians.
    Language English
    Publishing date 2021-05-18
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2186560-7
    ISSN 1178-203X ; 1176-6336
    ISSN (online) 1178-203X
    ISSN 1176-6336
    DOI 10.2147/TCRM.S306065
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    Zs.A 6067: Show issues Location:
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  8. Article ; Online: Neuropathic pain development following nerve injury is mediated by SOX11-ARID1A-SOCS3 transcriptional regulation in the spinal cord.

    Le, Dongsheng / Zhang, Chao / Liu, Li / Zhao, Mailin / Liang, Yingping / Liao, Pingsheng / Yang, Fan

    Molecular biology reports

    2024  Volume 51, Issue 1, Page(s) 281

    Abstract: Background: Neuropathic pain, a complex condition originating from nervous system damage, remains a significant clinical challenge due to limited understanding of its underlying mechanisms. Recent research highlights the SOX11 transcription factor, ... ...

    Abstract Background: Neuropathic pain, a complex condition originating from nervous system damage, remains a significant clinical challenge due to limited understanding of its underlying mechanisms. Recent research highlights the SOX11 transcription factor, known for its role in nervous system development, as a crucial player in neuropathic pain development and maintenance. This study investigates the role of the SOX11-ARID1A-SOCS3 pathway in neuropathic pain modulation within the spinal cord.
    Methods and results: Using a spinal nerve ligation (SNL) model in mice, we observed a significant upregulation of Sox11 in the spinal cord dorsal horn post-injury. Intrathecal administration of Sox11 shRNA mitigated SNL-induced neuropathic pain behaviors, including mechanical allodynia and heat hyperalgesia. Further, we demonstrated that Sox11 regulates neuropathic pain via transcriptional control of ARID1A, with subsequent modulation of SOCS3 expression. Knockdown of ARID1A and SOCS3 via shRNA resulted in alleviation of Sox11-induced pain sensitization. Additionally, Sox11 overexpression led to an increase in ARID1A binding to the SOCS3 promoter, enhancing chromatin accessibility and indicating a direct regulatory relationship. These findings were further supported by in vitro luciferase reporter assays and chromatin accessibility analysis.
    Conclusions: The SOX11-ARID1A-SOCS3 pathway plays a pivotal role in the development and maintenance of neuropathic pain. Sox11 acts as a master regulator, modulating ARID1A, which in turn influences SOCS3 expression, thereby contributing to the modulation of neuropathic pain. These findings provide a deeper understanding of the molecular mechanisms underlying neuropathic pain and highlight potential therapeutic targets for its treatment. The differential regulation of this pathway in the spinal cord and dorsal root ganglia (DRG) underscores its complexity and the need for targeted therapeutic strategies.
    MeSH term(s) Animals ; Mice ; Chromatin ; Hyperalgesia ; Neuralgia ; RNA, Small Interfering ; SOXC Transcription Factors/genetics ; Spinal Cord ; Suppressor of Cytokine Signaling 3 Protein/genetics ; DNA-Binding Proteins/genetics
    Chemical Substances Chromatin ; RNA, Small Interfering ; SOXC Transcription Factors ; Sox11 protein, mouse ; Socs3 protein, mouse ; Arid1a protein, mouse ; Suppressor of Cytokine Signaling 3 Protein ; DNA-Binding Proteins
    Language English
    Publishing date 2024-02-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 186544-4
    ISSN 1573-4978 ; 0301-4851
    ISSN (online) 1573-4978
    ISSN 0301-4851
    DOI 10.1007/s11033-023-09183-w
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1140: Show issues Location:
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  9. Article ; Online: Regional differential decomposition and the formation mechanism of the dynamic carbon emissions efficiency of industrial energy in China

    Xiaoye Li / Yixuan Tang / Pingsheng Liu / Zhengrong Cheng

    Frontiers in Environmental Science, Vol

    2022  Volume 10

    Abstract: Industrial carbon emissions efficiency requires a balance between economic development and carbon reduction to be achieved through structural adjustment and technological change, which is the key to low-carbon economic development and the essence of ... ...

    Abstract Industrial carbon emissions efficiency requires a balance between economic development and carbon reduction to be achieved through structural adjustment and technological change, which is the key to low-carbon economic development and the essence of China’s carbon reduction commitment. Existing research has focused more on static carbon emission efficiency and provides insufficient analysis of the internal causes of inter-regional differences in carbon emission efficiency. This paper aims to fill this gap in the existing research. The data of 30 provinces in China, obtained from the Chinese Official Statistical Yearbook, were taken as the sample. We accurately measured the dynamic carbon emission efficiency of industrial energy (DCEEIE) in China by combining the three-stage slacks-based measure data envelopment analysis (SBM-DEA) model and the Malmquist-Luenberger model. This study further uses Dagum’s Gini coefficient decomposition and the panel vector auto regression (PVAR) model to empirically estimate regional differences in DCEEIE and the effects of its internal structure. The results show, first, that DCEEIE in China is increasing, and that overall energy efficiency is at a high level. Although both efficiency change and technological change are fundamental to efficiency, an attenuation of efficiency and a diffusion of technology are evident. Second, the total Gini coefficients of dynamic efficiency, efficiency change (EC), and technological change (TC) are all decreasing; regional differences and transvariation intensity are the main reasons for long-term gaps. Third, TC improves dynamic efficiency in the initial stages, but the main driving force in the long run is EC. The limitation of this paper is that we do not fully discuss the external factors which might impact TC and EC, nor do we continue the discussion on how to transform the energy mix by improving carbon efficiency, which is the future direction for green development. These issues represent avenues for future research.
    Keywords dynamic efficiency ; technological change ; dagum gini coefficient ; PVAR model ; three-stage SBM-DEA ; malmquist-luenberger index ; Environmental sciences ; GE1-350
    Subject code 338 ; 670
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Absorption, distribution, metabolism and excretion of linaprazan glurate in rats.

    Zhang, Xinyue / Liu, Donghui / Lu, Ming / Yuan, Yali / Yang, Chen / Yang, Ying / Xiu, Jin / Hu, Pingsheng / Zheng, Yuandong / Diao, Xingxing

    Journal of pharmaceutical and biomedical analysis

    2024  Volume 242, Page(s) 116012

    Abstract: Linaprazan (AZD0865, TX07) is one of potassium-competitive acid blockers. However, linaprazan is rapidly excreted from the body, shortening its acid inhibition property. Linaprazan glurate (X842) is a prodrug of linaprazan with a prolonged inhibitory ... ...

    Abstract Linaprazan (AZD0865, TX07) is one of potassium-competitive acid blockers. However, linaprazan is rapidly excreted from the body, shortening its acid inhibition property. Linaprazan glurate (X842) is a prodrug of linaprazan with a prolonged inhibitory effect on gastric acid secretion. Linaprazan glurate has entered clinical trials, but few studies have reported its metabolism in non-clinical and clinical settings. In this study, we studied the pharmacokinetics, tissue distribution, mass balance, and metabolism of linaprazan glurate in rats after a single oral dose of 2.4 mg/kg (100 µCi/kg) [
    MeSH term(s) Rats ; Male ; Female ; Animals ; Body Fluids ; Feces/chemistry ; Bile/metabolism ; Plasma ; Administration, Oral ; Heterocyclic Compounds, 2-Ring
    Chemical Substances linaprazan (E0OU4SC8DP) ; Heterocyclic Compounds, 2-Ring
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2024.116012
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    Zs.A 1850: Show issues Location:
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