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  1. Article: A conversation between Darracott Vaughan and Richard D. Williams.

    Williams, Richard D

    BJU international

    2004  Volume 94, Issue 4, Page(s) 479–480

    MeSH term(s) Iowa ; Urology
    Language English
    Publishing date 2004-09
    Publishing country England
    Document type Interview
    ZDB-ID 1462191-5
    ISSN 1464-410X ; 1464-4096 ; 1358-8672
    ISSN (online) 1464-410X
    ISSN 1464-4096 ; 1358-8672
    DOI 10.1111/j.1464-410X.2004.05118.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Conference proceedings ; Online: P-wave velocities and applied bed thickness and velocity changes for synthetic seismograms, ODP Leg 188 and Leg 119 sites, supplementary data to: Handwerger, David A; Cooper, Alan K; O'Brien, Philip E; Williams, Trevor; Barr, Samantha R; Dunbar, Robert B; Leventer, Amy; Jarrard, Richard D (2004): Synthetic seismograms linking ODP sites to seismic profiles, continental rise and shelf of Prydz Bay, Antarctica. In: Cooper, AK; O'Brien, PE; Richter, C (eds.) Proceedings of the Ocean Drilling Program, Scientific Results, College Station, TX (Ocean Drilling Program), 188, 1-28

    Handwerger, David A / Barr, Samantha R / Cooper, Alan K / Dunbar, Robert B / Jarrard, Richard D / Leventer, Amy / O'Brien, Philip E / Williams, Trevor

    2004  

    Abstract: Synthetic seismograms provide a crucial link between lithologic variations within a drill hole and reflectors on seismic profiles crossing the site. In essence, they provide a ground-truth for the interpretation of seismic data. Using a combination of ... ...

    Abstract Synthetic seismograms provide a crucial link between lithologic variations within a drill hole and reflectors on seismic profiles crossing the site. In essence, they provide a ground-truth for the interpretation of seismic data. Using a combination of core and logging data, we created synthetic seismograms for Ocean Drilling Program Sites 1165 and 1166, drilled during Leg 188, and Site 742, drilled during Leg 119, all in Prydz Bay, Antarctica. Results from Site 1165 suggest that coring penetrated a target reflector initially thought to represent the onset of drift sedimentation, but the lithologic change across the boundary does not show a change from predrift to drift sediments. The origin of a shallow reflector packet in the seismic line across Site 1166 and a line connecting Sites 1166 and 742 was resolved into its constituent sources, as this reflector occurs in a region of large-scale, narrowly spaced impedance changes. Furthermore, Site 1166 was situated in a fluvio-deltaic system with widely variable geology, and bed thickness changes were estimated between the site and both seismic lines.
    Language English
    Dates of publication 2004-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Conference proceedings ; Online
    Note This dataset is supplement to doi:10.2973/odp.proc.sr.188.010.2004
    DOI 10.1594/PANGAEA.780548
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Book: Richard Schneider, M.D

    Williams, Phillip

    (Leaders in neuroscience ; 33)

    1982  

    Abstract: Producer) After serving in the Army during World War II, Dr. Schneider entered neurosurgical training under Max Peet and Edgar Kahn. He describes Max Peet's surgical prowess and affinity for performing operations for tic douloureux. He discusses his ... ...

    Institution American Association of Neurological Surgeons
    Author's details American Association of Neurological Surgeons
    Series title Leaders in neuroscience ; 33
    Abstract (Producer) After serving in the Army during World War II, Dr. Schneider entered neurosurgical training under Max Peet and Edgar Kahn. He describes Max Peet's surgical prowess and affinity for performing operations for tic douloureux. He discusses his work with cordotomy, surgery for epilepsy and the use of thorotrast by Dr. Kahn for brain abscess.
    MeSH term(s) Physicians ; History, 20th Century ; Neurosurgery/history
    Keywords United States
    Language English
    Size 1 videocassette (60 min.) :, sd., col. ;, 1/2 in.
    Publisher The Association
    Publishing place Park Ridge, Ill.
    Document type Book
    Database Catalogue of the US National Library of Medicine (NLM)

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  4. Article ; Online: ASO Author Reflections: Neoadjuvant Endocrine Therapy: A Pill in Time Saves Nine.

    Williams, Austin D / Bleicher, Richard J

    Annals of surgical oncology

    2022  Volume 29, Issue 3, Page(s) 1692–1693

    MeSH term(s) Humans ; Neoadjuvant Therapy
    Language English
    Publishing date 2022-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-021-11145-0
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  5. Book ; Online ; E-Book: Blacks in medicine

    Williams, Richard Allen

    clinical, demographic, and socioeconomic correlations

    2020  

    Abstract: This socially conscious, culturally relevant book explores the little-known history and present climate of Black people in the medical field. It reveals the deficiencies in the American healthcare structure that have contributed to the mismanagement of ... ...

    Author's details Richard Allen Williams
    Abstract This socially conscious, culturally relevant book explores the little-known history and present climate of Black people in the medical field. It reveals the deficiencies in the American healthcare structure that have contributed to the mismanagement of healthcare in the Black population, and examines cross-currents that intersect with the major events in minority medical history. Illustrated across 10 expertly written chapters, this text features a longitudinal timeline with the presentation of evidence-based information drawn from historical, political, and clinical sources. The book begins with an analysis of diseases particularly prevalent in the Black community due to socioeconomic inequalities in available medical care. These diseases include sickle cell anemia, hypertension, heart failure, drug addiction, and HIV/AIDS. Bolstered by profiles of historically well-known Black physicians, stories of success in medical education, and the remarkable impact of Black medical organizations, subsequent chapters address the triumphs and tribulations of the Black medical professional in America. Concluding with an examination of the current health status of Black people in the United States, the book makes a case for future systemic improvements in healthcare delivery to minority communities. A unique, noteworthy reference, Blacks in Medicine: Clinical, Demographic, and Socioeconomic Correlations is written for a broad range of physicians and health providers, as well as professionals in the social sciences and public health.
    Keywords African americans/Medical care ; African Americans in medicine ; African Americans ; Internal medicine ; Medical education ; Internal Medicine ; History of Medicine ; Medical Education ; Afro-nord-americans ; Condicions socials ; Història de la medicina ; Estats Units d'Amèrica
    Subject code 362.108996073
    Language English
    Dates of publication 2020-2020
    Size 1 online resource (xxvii, 200 pages) :, illustrations
    Publisher Springer
    Publishing place Cham
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-41960-6 ; 978-3-030-41960-8 ; 3-030-41959-2 ; 978-3-030-41959-2
    DOI 10.1007/978-3-030-41960-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  6. Article ; Online: Breast cancer diagnosis, treatment, and outcomes of patients from sex and gender minority groups.

    Miller, Claire / Bleicher, Richard J / Williams, Austin D

    Translational cancer research

    2023  Volume 12, Issue 10, Page(s) 2458–2460

    Language English
    Publishing date 2023-09-25
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2901601-0
    ISSN 2219-6803 ; 2218-676X
    ISSN (online) 2219-6803
    ISSN 2218-676X
    DOI 10.21037/tcr-23-833
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  7. Article ; Online: Current biopsychosocial science on understanding kink.

    Williams, D J / Sprott, Richard A

    Current opinion in psychology

    2022  Volume 48, Page(s) 101473

    Abstract: The field of kink (or BDSM) studies has grown significantly in recent years, with several areas of study being initiated. This paper summarizes the current state of kink research, including prevalence rates; marginalization and stigma; key biological, ... ...

    Abstract The field of kink (or BDSM) studies has grown significantly in recent years, with several areas of study being initiated. This paper summarizes the current state of kink research, including prevalence rates; marginalization and stigma; key biological, psychological, and social research findings; clinical issues; and recommendations for further research. Theoretical frameworks, such as minority stress, serious leisure, sexual orientation, personal growth, and sensation-seeking theories appear to be useful frameworks outside of approaches that assume psychopathology as an etiological factor. Studies find the following results: higher levels of sensation-seeking; kink activities generating states of flow and transient hypofrontality; notable levels of gender, sexual orientation, and relationship style diversity in kink samples; and higher levels of minority stress-related suicidality.
    MeSH term(s) Female ; Humans ; Male ; Sexual Behavior/psychology ; Social Stigma
    Language English
    Publishing date 2022-09-28
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2831565-0
    ISSN 2352-2518 ; 2352-250X ; 2352-250X
    ISSN (online) 2352-2518 ; 2352-250X
    ISSN 2352-250X
    DOI 10.1016/j.copsyc.2022.101473
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: FLT4 causes developmental disorders of the cardiovascular and lymphovascular systems via pleiotropic molecular mechanisms.

    Monaghan, Richard M / Naylor, Richard W / Flatman, Daisy / Kasher, Paul R / Williams, Simon G / Keavney, Bernard D

    Cardiovascular research

    2024  

    Abstract: Aims: Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD). Distinct genetic variants in FLT4 are also an established cause of Milroy disease, the most ... ...

    Abstract Aims: Rare, deleterious genetic variants in FLT4 are associated with Tetralogy of Fallot (TOF), the most common cyanotic congenital heart disease (CHD). Distinct genetic variants in FLT4 are also an established cause of Milroy disease, the most prevalent form of primary hereditary lymphoedema. Phenotypic features of these two conditions are non-overlapping, implying pleiotropic cellular mechanisms during development.
    Methods and results: Here, we show that FLT4 variants identified in TOF patients, when expressed in primary human endothelial cells, cause aggregation of FLT4 protein in the perinuclear endoplasmic reticulum, activating proteostatic and metabolic signalling, whereas lymphoedema-associated FLT4 variants and wildtype FLT4 do not. FLT4 TOF variants display characteristic gene expression profiles in key developmental signalling pathways, revealing a role for FLT4 in cardiogenesis distinct from its role in lymphatic development. Inhibition of proteostatic signalling abrogates these effects, identifying potential avenues for therapeutic intervention. Depletion of flt4 in zebrafish caused cardiac phenotypes of reduced heart size and altered heart looping. These phenotypes were rescued with coinjection of wildtype human FLT4 mRNA, but incompletely or not at all by mRNA harbouring FLT4 TOF variants.
    Conclusions: Taken together, we identify a pathogenic mechanism for FLT4 variants predisposing to TOF that is distinct from the known dominant negative mechanism of Milroy-causative variants. FLT4 variants give rise to conditions of the two circulatory subdivisions of the vascular system via distinct developmental pleiotropic molecular mechanisms.
    Translational perspective: Proteostatic dysfunction, if confirmed as a mechanism of CHD pathogenesis for other predisposing genes, may identify pathways to therapeutic interventions. Distinguishing mechanistically how variants in FLT4 give rise to CHD may have potential to individualise genetic counselling in affected families.
    Language English
    Publishing date 2024-05-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvae104
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 565: Show issues Location:
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  9. Article ; Online: A neural network potential based on pairwise resolved atomic forces and energies.

    Kalayan, Jas / Ramzan, Ismaeel / Williams, Christopher D / Bryce, Richard A / Burton, Neil A

    Journal of computational chemistry

    2024  Volume 45, Issue 14, Page(s) 1143–1151

    Abstract: Molecular simulations have become a key tool in molecular and materials design. Machine learning (ML)-based potential energy functions offer the prospect of simulating complex molecular systems efficiently at quantum chemical accuracy. In previous work, ... ...

    Abstract Molecular simulations have become a key tool in molecular and materials design. Machine learning (ML)-based potential energy functions offer the prospect of simulating complex molecular systems efficiently at quantum chemical accuracy. In previous work, we have introduced the ML-based PairF-Net approach to neural network potentials, that adopts a pairwise interatomic scheme to predicting forces within a molecular system. Here, we further develop the PairF-Net model to intrinsically incorporate energy conservation and couple the model to a molecular mechanical (MM) environment within the OpenMM package. The updated PairF-Net model yields energy and force predictions and dynamical distributions in good agreement with the rMD17 dataset of ten small organic molecules in the gas-phase. We further show that these in vacuo ML models of small molecules can be applied to force predictions in aqueous solution via hybrid ML/MM simulations. We present a new benchmark dataset for these ten molecules in solution, obtained from QM/MM simulations, which we denote as rMD17-aq (https://zenodo.org/records/10048644); and assess the ability of PairF-Net to reproduce the molecular energy, atomic forces and dynamical distributions of these solution conformations via ML/MM simulations.
    Language English
    Publishing date 2024-01-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1479181-X
    ISSN 1096-987X ; 0192-8651
    ISSN (online) 1096-987X
    ISSN 0192-8651
    DOI 10.1002/jcc.27313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The nematode (

    Williams, Paul D E / Brewer, Matthew T / Aroian, Raffi / Robertson, Alan P / Martin, Richard J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: A novel group of biocidal compounds are the Crystal 3D (Cry) and Cytolytic (Cyt) proteins produced ... ...

    Abstract A novel group of biocidal compounds are the Crystal 3D (Cry) and Cytolytic (Cyt) proteins produced by
    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.20.567786
    Database MEDical Literature Analysis and Retrieval System OnLINE

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