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Article: Intravenous versus Partial Oral Antibiotic Therapy in the Treatment of Uncomplicated Bloodstream Infection Due to

Broermann, Lynn E / Al-Hasan, Majdi N / Withers, Sarah / Benbow, Kristina L / Ramsey, Taylor / McTavish, Meghan / Winders, Hana R

Microorganisms

2023 Volume 11, Issue 9

Abstract: This retrospective cohort study examines effectiveness of partial oral antibiotic regimens in uncomplicated bloodstream infections (BSIs) due ... ...

Abstract	This retrospective cohort study examines effectiveness of partial oral antibiotic regimens in uncomplicated bloodstream infections (BSIs) due to
Language	English
Publishing date	2023-09-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720891-6
ISSN	2076-2607
ISSN	2076-2607
DOI	10.3390/microorganisms11092313
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Article ; Online: Effectiveness of the Program to Encourage Active, Rewarding Lives (PEARLS) to reduce depression: a multi-state evaluation.

Smith, Matthew Lee / Steinman, Lesley E / Montoya, Carol N / Thompson, Meghan / Zhong, Lixian / Merianos, Ashley L

Frontiers in public health

2023 Volume 11, Page(s) 1169257

Abstract: Introduction: An estimated 15% of community-dwelling older adults have depressive symptoms in the U.S. The Program to Encourage Active, Rewarding Lives (PEARLS) is an evidence-based program for managing late-life depression. PEARLS is a home/community- ... ...

Abstract	Introduction: An estimated 15% of community-dwelling older adults have depressive symptoms in the U.S. The Program to Encourage Active, Rewarding Lives (PEARLS) is an evidence-based program for managing late-life depression. PEARLS is a home/community-based collaborative care model delivered by community-based organizations to improve access to quality depression care. Trained staff actively screen for depression to improve recognition, teach problem-solving and activity planning skills for self-management, and connect participants to other supports and services as needed. Methods: This study examined 2015-2021 data from 1,155 PEARLS participants across four states to assess PEARLS effectiveness to reduce depressive symptoms. The clinical outcomes were measured by the self-reported PHQ-9 instrument to assess changes in depressive symptoms scored as depression-related severity, clinical remission, and clinical response. A generalized estimating equation (GEE) model was fitted to examine changes in composite PHQ-9 scores from baseline to the final session. The model adjusted for participants' age, gender, race/ethnicity, education level, income level, marital status, number of chronic conditions, and number of PEARLS sessions attended. Cox proportional hazards regression models were conducted to estimate the hazard ratio for improvement of depressive symptoms (i.e., remission or response), while adjusting for the covariates. Results: PHQ-9 scale scores significantly improved from baseline to their final sessions (mean difference = -5.67, SEM = 0.16, Discussion: Findings confirm that PEARLS is an effective program to improve depressive symptoms among older adults in diverse real-world community settings and can be a more accessible option for depressive older adults who are traditionally underserved by clinical care.
MeSH term(s)	Humans ; Aged ; Depression/therapy ; Depression/diagnosis ; Depressive Disorder ; Home Care Services
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1169257
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Article ; Online: Overlapping Crises: Climate Disaster Susceptibility and Incarceration.

Cowan, Kristen N / Peterson, Meghan / LeMasters, Katherine / Brinkley-Rubinstein, Lauren

International journal of environmental research and public health

2022 Volume 19, Issue 12

Abstract: Climate-related disasters are becoming more frequent all over the world; however, there is significant variability in the impact of disasters, including which specific communities are the most vulnerable. The objective of this descriptive study was to ... ...

Abstract	Climate-related disasters are becoming more frequent all over the world; however, there is significant variability in the impact of disasters, including which specific communities are the most vulnerable. The objective of this descriptive study was to examine how climate disaster susceptibility is related to the density of incarceration at the county level in the United States. Percent of the population incarcerated in the 2010 census and the Expected Annual Loss (EAL) from natural hazards were broken into tertiles and mapped bivariately to examine the overlap of areas with high incarceration and susceptibility to climate disasters. Over 13% of counties were in the highest tertile for both incarceration and EAL, with four states containing over 30% of these counties. The density of incarceration and climate disaster susceptibility are overlapping threats that must be addressed concurrently through (1) decarceration, (2) developing standardized guidance on evacuated incarcerated individuals during disasters, and (3) more deeply understanding how the health of everyone in these counties is jeopardized when prisons suffer from climate disasters.
MeSH term(s)	Climate ; Climate Change ; Disaster Planning ; Disasters ; Floods ; Humans ; United States
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19127431
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Article ; Online: Overlapping Crises

Kristen N. Cowan / Meghan Peterson / Katherine LeMasters / Lauren Brinkley-Rubinstein

International Journal of Environmental Research and Public Health, Vol 19, Iss 7431, p

Climate Disaster Susceptibility and Incarceration

2022 Volume 7431

Abstract	Climate-related disasters are becoming more frequent all over the world; however, there is significant variability in the impact of disasters, including which specific communities are the most vulnerable. The objective of this descriptive study was to examine how climate disaster susceptibility is related to the density of incarceration at the county level in the United States. Percent of the population incarcerated in the 2010 census and the Expected Annual Loss (EAL) from natural hazards were broken into tertiles and mapped bivariately to examine the overlap of areas with high incarceration and susceptibility to climate disasters. Over 13% of counties were in the highest tertile for both incarceration and EAL, with four states containing over 30% of these counties. The density of incarceration and climate disaster susceptibility are overlapping threats that must be addressed concurrently through (1) decarceration, (2) developing standardized guidance on evacuated incarcerated individuals during disasters, and (3) more deeply understanding how the health of everyone in these counties is jeopardized when prisons suffer from climate disasters.
Keywords	incarceration ; climate ; vulnerability ; geography ; disasters ; preparedness ; Medicine ; R
Subject code	333
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Purposeful Stakeholder Engagement for Improved Environmental Flow Outcomes

Meghan L. Mussehl / Avril C. Horne / J. Angus Webb / N. LeRoy Poff

Frontiers in Environmental Science, Vol

2022 Volume 9

Abstract: Rivers are dynamic social-ecological systems that support societies and ecosystems in a multitude of ways, giving rise to a variety of user groups and competing interests. Environmental flows (e-flows) programs developed to protect riverine environments ... ...

Abstract	Rivers are dynamic social-ecological systems that support societies and ecosystems in a multitude of ways, giving rise to a variety of user groups and competing interests. Environmental flows (e-flows) programs developed to protect riverine environments are often conceived by water managers and researchers. This is despite continued calls for increased public participation to include local communities and Indigenous peoples in the development process. Failure to do so undermines social legitimacy and program effectiveness. In this paper, we describe how adaptive management of e-flows allows an opportunity to incorporate a diversity of stakeholder views through an iterative process. However, to achieve this, stakeholder engagement must be intentionally integrated into the adaptive management cycle. Stakeholder engagement in e-flows allows for the creation of a shared understanding of a river and opens collaborative and innovative management strategies that address multiple axes of uncertainty. Here, we describe a holistic framework that unifies current participatory engagement attempts and existing technical methods into a complete strategy. The framework identifies the primary steps in an e-flows adaptive management cycle, describes potential roles of various stakeholders, and proposes potential engagement tools. Restructuring e-flows methods to adequately include stakeholders requires a shift from being driven by deliverables, such as reports and flow recommendations, to focusing on people-oriented outcomes, such as continuous learning and fostering relationships. While our work has been placed in the context of e-flows, the intentional integration of stakeholder engagement in adaptive management is pertinent to natural resources management generally.
Keywords	adaptive management ; rivers ; participatory methods ; stakeholder engagement ; social-ecological system (SES) ; environmental water ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Trial of thromboxane receptor inhibition with ifetroban: TP receptors regulate eicosanoid homeostasis in aspirin-exacerbated respiratory disease.

Laidlaw, Tanya M / Buchheit, Kathleen M / Cahill, Katherine N / Hacker, Jonathan / Cho, Laura / Cui, Jing / Feng, Chunli / Chen, Chongjia C / Le, Meghan / Israel, Elliot / Boyce, Joshua A

The Journal of allergy and clinical immunology

2023 Volume 152, Issue 3, Page(s) 700–710.e3

Abstract: Background: Aspirin-exacerbated respiratory disease (AERD) is the triad of asthma, nasal polyposis, and respiratory reactions to COX-1 inhibitors. Overproduction of cysteinyl leukotrienes and underproduction of prostaglandin E: Objective: Our aim was ...

Abstract	Background: Aspirin-exacerbated respiratory disease (AERD) is the triad of asthma, nasal polyposis, and respiratory reactions to COX-1 inhibitors. Overproduction of cysteinyl leukotrienes and underproduction of prostaglandin E Objective: Our aim was to determine whether ifetroban, a TP receptor antagonist, attenuates aspirin-induced respiratory symptoms in patients with AERD. Methods: A total of 35 patients with AERD completed a 4-week double-blinded, placebo-controlled trial of ifetroban and underwent an oral aspirin challenge. The primary outcome was change in the provocative dose of aspirin that caused a 2-point increase in Total Nasal Symptom Score. Changes in lung function, eicosanoid levels, and platelet and mast cell activation were assessed. Cultured human nasal fibroblasts were stimulated with or without the TP agonist U46619 and assayed for prostanoid production. Results: Ifetroban was well tolerated in AERD and did not change the mean 2-point increase in Total Nasal Symptom Score (P = .763). Participants taking ifetroban had greater aspirin-induced nasal symptoms and a greater decline in FEV Conclusion: Contrary to our hypothesis, TP receptor blockade worsened aspirin-induced reactions in AERD, possibly by exacerbating dysregulation of the eicosanoid system. TP signaling on stromal cells may be critical to maintaining PGE
MeSH term(s)	Animals ; Mice ; Humans ; Prostaglandins ; Thromboxanes/therapeutic use ; Leukotriene E4 ; Receptors, Thromboxane/therapeutic use ; Asthma, Aspirin-Induced/drug therapy ; Asthma, Aspirin-Induced/diagnosis ; Aspirin/adverse effects ; Eicosanoids ; Dinoprostone ; Homeostasis ; Sinusitis/chemically induced
Chemical Substances	Prostaglandins ; ifetroban (E833KT807K) ; Thromboxanes ; Leukotriene E4 (75715-89-8) ; Receptors, Thromboxane ; Aspirin (R16CO5Y76E) ; Eicosanoids ; Dinoprostone (K7Q1JQR04M)
Language	English
Publishing date	2023-04-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2023.03.030
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Article ; Online: Diversity, Equity, and Inclusion within Pediatric Adherence Science.

Williford, Desireé N / Sweenie, Rachel / Ramsey, Rachelle R / McGrady, Meghan E / Crosby, Lori E / Modi, Avani C

Journal of clinical psychology in medical settings

2022 Volume 30, Issue 2, Page(s) 330–341

Abstract: Given the long-standing history of systemic racism in psychological science, diversity, equity, and inclusion (DEI) efforts are increasingly vital to the advancement and improvement of the field. This commentary extends the seminal work of the article ... ...

Abstract	Given the long-standing history of systemic racism in psychological science, diversity, equity, and inclusion (DEI) efforts are increasingly vital to the advancement and improvement of the field. This commentary extends the seminal work of the article Upending Racism in Psychological Science: Strategies to Change How Our Science is Conducted, Reported, Reviewed, and Disseminated (Buchanan et al., Am Psychol, https://doi.org/10.31234/osf.io/6nk4x , 2020) by providing tangible applications and recommendations to improve DEI integration into pediatric adherence science. Real-world adherence examples are discussed regarding the challenges faced in systematically integrating DEI principles, potential solutions to overcoming barriers, and the implications of these efforts on scientific advancement in an effort to address and dismantle research practices that perpetuate inequity and White supremacy. Specifically, we provide discourse and practical guidance related to the conduct, reporting, reviewing, and dissemination of pediatric adherence science to promote dialog and produce actionable change toward the promotion of health equity and social justice.
MeSH term(s)	Humans ; Child ; Diversity, Equity, Inclusion ; Chlorhexidine ; Health Equity
Chemical Substances	Chlorhexidine (R4KO0DY52L)
Language	English
Publishing date	2022-12-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1235893-9
ISSN	1573-3572 ; 1068-9583
ISSN (online)	1573-3572
ISSN	1068-9583
DOI	10.1007/s10880-022-09922-4
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Article ; Online: Public Response to a Social Media Tobacco Prevention Campaign: Content Analysis.

Majmundar, Anuja / Le, NamQuyen / Moran, Meghan Bridgid / Unger, Jennifer B / Reuter, Katja

JMIR public health and surveillance

2020 Volume 6, Issue 4, Page(s) e20649

Abstract: ... Twitter: n=1004; Facebook: n=176; Instagram: n=62), many comments used a negative tone (42.75%) and ...

Abstract	Background: Prior research suggests that social media-based public health campaigns are often targeted by countercampaigns. Objective: Using reactance theory as the theoretical framework, this research characterizes the nature of public response to tobacco prevention messages disseminated via a social media-based campaign. We also examine whether agreement with the prevention messages is associated with comment tone and nature of the contribution to the overall discussion. Methods: User comments to tobacco prevention messages, posted between April 19, 2017 and July 12, 2017, were extracted from Twitter, Facebook, and Instagram. Two coders categorized comments in terms of tone, agreement with message, nature of contribution, mentions of government agency and regulation, promotional or spam comments, and format of comment. Chi-square analyses tested associations between agreement with the message and tone of the public response and the nature of contributions to the discussions. Results: Of the 1242 comments received (Twitter: n=1004; Facebook: n=176; Instagram: n=62), many comments used a negative tone (42.75%) and disagreed with the health messages (39.77%), while the majority made healthy contributions to the discussions (84.38%). Only 0.56% of messages mentioned government agencies, and only 0.48% of the comments were antiregulation. Comments employing a positive tone (84.13%) or making healthy contributions (69.11%) were more likely to agree with the campaign messages (P=0.01). Comments employing a negative tone (71.25%) or making toxic contributions (36.26%) generally disagreed with the messages (P=0.01). Conclusions: The majority of user comments in response to a tobacco prevention campaign made healthy contributions. Our findings encourage the use of social media to promote dialogue about controversial health topics such as smoking. However, toxicity was characteristic of comments that disagreed with the health messages. Managing negative and toxic comments on social media is a crucial issue for social media-based tobacco prevention campaigns to consider.
Language	English
Publishing date	2020-12-07
Publishing country	Canada
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/20649
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Article ; Online: Allowable room temperature excursions for refrigerated medications: A 20-year review.

Orth, Lucas E / Ellingson, Amanda S / Azimi, Sara F / Martinez, Joseph T / Alhadad, Amal A / Tran, Brenda C / Allen, Chase W / Nguyen, Cecilia T / Duong, Tony / Burkdoll, Jordan S / Yoo, Jenny / Blackmer, Allison B / Jeffres, Meghan N

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

2022 Volume 79, Issue 15, Page(s) 1296–1300

Abstract: Purpose: The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency.: Methods: During a 12-month ... ...

Abstract	Purpose: The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency. Methods: During a 12-month period ending in June 2021, the prescribing information and published monographs from multiple pharmacy compendia were reviewed for all medications and biologic products approved by the US Food and Drug Administration (FDA) for human use since January 2000. Products that were subsequently withdrawn from the US market were excluded. When temperature excursion data was unavailable in published form, product manufacturers were surveyed via telephone and/or email. Acceptable storage information for all products for which storage is recommended at temperatures below room temperature (20-25 °C [68-77 °F]) was compiled and arranged in tabular format. Results: Of the 705 products or formulations approved by FDA during the predefined time period, 246 were identified as requiring storage at temperatures below room temperature. After review of available prescribing information and manufacturer communications, if applicable, acceptable periods of excursion to temperatures at room temperature or higher were identified for 214 products (87%). Conclusion: Information related to acceptable periods of room temperature excursion was compiled for a total of 214 products approved for US distribution since 2000. The included tables may increase patient safety and decrease medication loss or related expenditures.
MeSH term(s)	Drug Stability ; Drug Storage ; Humans ; Pharmaceutical Preparations ; Pharmaceutical Services ; Temperature ; United States ; United States Food and Drug Administration
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2022-03-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1224627-x
ISSN	1535-2900 ; 1079-2082
ISSN (online)	1535-2900
ISSN	1079-2082
DOI	10.1093/ajhp/zxac118
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Article ; Online: Public Response to a Social Media Tobacco Prevention Campaign

Majmundar, Anuja / Le, NamQuyen / Moran, Meghan Bridgid / Unger, Jennifer B / Reuter, Katja

JMIR Public Health and Surveillance, Vol 6, Iss 4, p e

Content Analysis

2020 Volume 20649

Abstract: ... and the nature of contributions to the discussions. ResultsOf the 1242 comments received (Twitter: n ... 1004; Facebook: n=176; Instagram: n=62), many comments used a negative tone (42.75%) and disagreed ...

Abstract	BackgroundPrior research suggests that social media–based public health campaigns are often targeted by countercampaigns. ObjectiveUsing reactance theory as the theoretical framework, this research characterizes the nature of public response to tobacco prevention messages disseminated via a social media–based campaign. We also examine whether agreement with the prevention messages is associated with comment tone and nature of the contribution to the overall discussion. MethodsUser comments to tobacco prevention messages, posted between April 19, 2017 and July 12, 2017, were extracted from Twitter, Facebook, and Instagram. Two coders categorized comments in terms of tone, agreement with message, nature of contribution, mentions of government agency and regulation, promotional or spam comments, and format of comment. Chi-square analyses tested associations between agreement with the message and tone of the public response and the nature of contributions to the discussions. ResultsOf the 1242 comments received (Twitter: n=1004; Facebook: n=176; Instagram: n=62), many comments used a negative tone (42.75%) and disagreed with the health messages (39.77%), while the majority made healthy contributions to the discussions (84.38%). Only 0.56% of messages mentioned government agencies, and only 0.48% of the comments were antiregulation. Comments employing a positive tone (84.13%) or making healthy contributions (69.11%) were more likely to agree with the campaign messages (P=0.01). Comments employing a negative tone (71.25%) or making toxic contributions (36.26%) generally disagreed with the messages (P=0.01). ConclusionsThe majority of user comments in response to a tobacco prevention campaign made healthy contributions. Our findings encourage the use of social media to promote dialogue about controversial health topics such as smoking. However, toxicity was characteristic of comments that disagreed with the health messages. Managing negative and toxic comments on social media is a crucial issue for social media–based ...
Keywords	Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2020-12-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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