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  1. Article ; Online: Trans-Atlantic twists and turns.

    Joyce, Johanna A

    Nature cancer

    2024  

    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-024-00747-8
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  2. Article ; Online: Jeffrey W. Pollard (1950-2023).

    Qian, Bin-Zhi / Joyce, Johanna A

    Immunity

    2023  Volume 56, Issue 6, Page(s) 1153–1154

    Language English
    Publishing date 2023-06-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2023.05.016
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    Zs.A 4227: Show issues Location:
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  3. Article ; Online: How I made my lab meetings more inclusive with a rapid-relay technique.

    Joyce, Johanna

    Nature

    2024  

    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-024-00580-0
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    Zs.A 26: Show issues Location:
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    Zs.MO 244: Show issues

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  4. Article ; Online: The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth.

    de Visser, Karin E / Joyce, Johanna A

    Cancer cell

    2023  Volume 41, Issue 3, Page(s) 374–403

    Abstract: Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment (TME) includes diverse immune cell types, cancer-associated fibroblasts, ... ...

    Abstract Cancers represent complex ecosystems comprising tumor cells and a multitude of non-cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment (TME) includes diverse immune cell types, cancer-associated fibroblasts, endothelial cells, pericytes, and various additional tissue-resident cell types. These host cells were once considered bystanders of tumorigenesis but are now known to play critical roles in the pathogenesis of cancer. The cellular composition and functional state of the TME can differ extensively depending on the organ in which the tumor arises, the intrinsic features of cancer cells, the tumor stage, and patient characteristics. Here, we review the importance of the TME in each stage of cancer progression, from tumor initiation, progression, invasion, and intravasation to metastatic dissemination and outgrowth. Understanding the complex interplay between tumor cell-intrinsic, cell-extrinsic, and systemic mediators of disease progression is critical for the rational development of effective anti-cancer treatments.
    MeSH term(s) Humans ; Endothelial Cells ; Ecosystem ; Neoplasms ; Carcinogenesis ; Cell Transformation, Neoplastic ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2023.02.016
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  5. Article ; Online: Closing the scissor-shaped curve: Strategies to promote gender equality in academia.

    Joyce, Johanna A / Masina, Slavica / Michalik, Liliane / Pot, Caroline / Sempoux, Christine / Amati, Francesca

    Cell

    2024  Volume 187, Issue 6, Page(s) 1335–1342

    Abstract: Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses ... ...

    Abstract Gender inequality in STEM fields remains pervasive and undermines the ability for talented individuals to excel. Despite advances, women still encounter obstacles in pursuing academic careers and reaching leadership positions. This commentary discusses the "scissor-shaped curve" and examines effective strategies to fix it, including data-driven initiatives that we have implemented at our university.
    MeSH term(s) Humans ; Female ; Gender Equity ; Academia ; Leadership ; Universities
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2024.01.050
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  6. Article ; Online: Cranial imaging window implantation technique for longitudinal multimodal imaging of the brain environment in live mice.

    Croci, Davide / Zomer, Anoek / Kowal, Joanna / Joyce, Johanna A

    STAR protocols

    2023  Volume 4, Issue 2, Page(s) 102197

    Abstract: Intravital two-photon microscopy of the mouse brain requires visual access without affecting normal cognitive functions, which is crucial for longitudinal imaging studies that may last several months. In this protocol, we describe the surgical ... ...

    Abstract Intravital two-photon microscopy of the mouse brain requires visual access without affecting normal cognitive functions, which is crucial for longitudinal imaging studies that may last several months. In this protocol, we describe the surgical implantation of a metal-free cranial imaging window, which can be used to perform two-photon microscopy and magnetic resonance imaging in the same animal. This multimodal imaging platform enables the investigation of dynamic processes in the central nervous system at a cellular and macroscopic level. For complete details on the use and execution of this protocol in the context of brain cancer, please refer to Zomer et al.
    Language English
    Publishing date 2023-03-24
    Publishing country United States
    Document type Journal Article
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2023.102197
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  7. Article ; Online: Cranial imaging window implantation technique for longitudinal multimodal imaging of the brain environment in live mice

    Davide Croci / Anoek Zomer / Joanna Kowal / Johanna A. Joyce

    STAR Protocols, Vol 4, Iss 2, Pp 102197- (2023)

    2023  

    Abstract: Summary: Intravital two-photon microscopy of the mouse brain requires visual access without affecting normal cognitive functions, which is crucial for longitudinal imaging studies that may last several months. In this protocol, we describe the surgical ... ...

    Abstract Summary: Intravital two-photon microscopy of the mouse brain requires visual access without affecting normal cognitive functions, which is crucial for longitudinal imaging studies that may last several months. In this protocol, we describe the surgical implantation of a metal-free cranial imaging window, which can be used to perform two-photon microscopy and magnetic resonance imaging in the same animal. This multimodal imaging platform enables the investigation of dynamic processes in the central nervous system at a cellular and macroscopic level.For complete details on the use and execution of this protocol in the context of brain cancer, please refer to Zomer et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
    Keywords Cancer ; Immunology ; Microscopy ; Model Organisms ; Neuroscience ; Science (General) ; Q1-390
    Subject code 616
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Diagnoses and Treatment of Behavioral and Psychological Symptoms of Dementia Among Racially and Ethnically Diverse Persons Living with Dementia.

    Thunell, Johanna A / Joyce, Geoffrey F / Ferido, Patricia M / Chen, Yi / Guadamuz, Jenny S / Qato, Dima M / Zissimopoulos, Julie M

    Journal of Alzheimer's disease : JAD

    2024  

    Abstract: Background: Behavioral and psychological symptoms of dementia (BPSD) and prescribed central nervous system (CNS) active drugs to treat them are prevalent among persons living with Alzheimer's disease and related dementias (PLWD) and lead to negative ... ...

    Abstract Background: Behavioral and psychological symptoms of dementia (BPSD) and prescribed central nervous system (CNS) active drugs to treat them are prevalent among persons living with Alzheimer's disease and related dementias (PLWD) and lead to negative outcomes for PLWD and their caregivers. Yet, little is known about racial/ethnic disparities in diagnosis and use of drugs to treat BPSD.
    Objective: Quantify racial/ethnic disparities in BPSD diagnoses and CNS-active drug use among community-dwelling PLWD.
    Methods: We used a retrospective cohort of community-dwelling Medicare Fee-for-Service beneficiaries with dementia, continuously enrolled in Parts A, B and D, 2017-2019. Multivariate logistic models estimated rates of BPSD diagnosis and, conditional on diagnosis, CNS-active drug use.
    Results: Among PLWD, 67.1% had diagnoses of an affective, psychosis or hyperactivity symptom. White (68.3%) and Hispanic (63.9%) PLWD were most likely, Blacks (56.6%) and Asians (52.7%) least likely, to have diagnoses. Among PLWD with BPSD diagnoses, 78.6% took a CNS-active drug. Use was highest among whites (79.3%) and Hispanics (76.2%) and lowest among Blacks (70.8%) and Asians (69.3%). Racial/ethnic differences in affective disorders were pronounced, 56.8% of white PLWD diagnosed; Asians had the lowest rates (37.8%). Similar differences were found in use of antidepressants.
    Conclusions: BPSD diagnoses and CNS-active drug use were common in our study. Lower rates of BPSD diagnoses in non-white compared to white populations may indicate underdiagnosis in clinical settings of treatable conditions. Clinicians' review of prescriptions in this population to reduce poor outcomes is important as is informing care partners on the risks/benefits of using CNS-active drugs.
    Language English
    Publishing date 2024-04-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231266
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    Zs.A 6084: Show issues Location:
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  9. Article ; Online: Therapeutic Targeting of the Tumor Microenvironment.

    Bejarano, Leire / Jordāo, Marta J C / Joyce, Johanna A

    Cancer discovery

    2021  Volume 11, Issue 4, Page(s) 933–959

    Abstract: Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of- ... ...

    Abstract Strategies to therapeutically target the tumor microenvironment (TME) have emerged as a promising approach for cancer treatment in recent years due to the critical roles of the TME in regulating tumor progression and modulating response to standard-of-care therapies. Here, we summarize the current knowledge regarding the most advanced TME-directed therapies, which have either been clinically approved or are currently being evaluated in trials, including immunotherapies, antiangiogenic drugs, and treatments directed against cancer-associated fibroblasts and the extracellular matrix. We also discuss some of the challenges associated with TME therapies, and future perspectives in this evolving field. SIGNIFICANCE: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Cancer-Associated Fibroblasts ; Extracellular Matrix ; Humans ; Immunotherapy/trends ; Neoplasms/drug therapy ; Tumor Microenvironment
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2021-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2625242-9
    ISSN 2159-8290 ; 2159-8274
    ISSN (online) 2159-8290
    ISSN 2159-8274
    DOI 10.1158/2159-8290.CD-20-1808
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  10. Article ; Online: What do you most hope spatial molecular profiling will help us understand? Part 1.

    Theis, Fabian J / Dar, Daniel / Vento-Tormo, Roser / Vicković, Sanja / Wang, Linghua / Kagohara, Luciane T / Rendeiro, André F / Joyce, Johanna A

    Cell systems

    2023  Volume 14, Issue 6, Page(s) 423–427

    Language English
    Publishing date 2023-06-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2854138-8
    ISSN 2405-4720 ; 2405-4712
    ISSN (online) 2405-4720
    ISSN 2405-4712
    DOI 10.1016/j.cels.2023.05.009
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