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Article ; Online: Apoptosis, autophagic cell death, and necroptosis: different types of programmed cell death in bovine corpus luteum regression.

Hojo, Takuo / Skarzynski, Dariusz J / Okuda, Kiyoshi

The Journal of reproduction and development

2022

Abstract: In mammals, the corpus luteum (CL) is a transient organ that secretes progesterone (P4). In the absence of pregnancy, the CL undergoes regression (luteolysis), which is a crucial preparation step for the next estrous cycle. Luteolysis, initiated by ... ...

Abstract	In mammals, the corpus luteum (CL) is a transient organ that secretes progesterone (P4). In the absence of pregnancy, the CL undergoes regression (luteolysis), which is a crucial preparation step for the next estrous cycle. Luteolysis, initiated by uterine prostaglandin F
Language	English
Publishing date	2022-11-17
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2039060-9
ISSN	1348-4400 ; 0916-8818
ISSN (online)	1348-4400
ISSN	0916-8818
DOI	10.1262/jrd.2022-097
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Multiple roles of hypoxia in bovine corpus luteum.

Nishimura, Ryo / Okuda, Kiyoshi

The Journal of reproduction and development

2020 Volume 66, Issue 4, Page(s) 307–310

Abstract: There has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic ... ...

Abstract	There has been increasing interest in the role of hypoxia in the microenvironment of organs, because of the discovery of hypoxia-inducible factor-1 (HIF1), which acts as a transcription factor for many genes activated specifically under hypoxic conditions. The ovary changes day by day during the estrous cycle as it goes through phases of follicular growth, ovulation, and formation and regression of the corpus luteum (CL). These phenomena are regulated by hypothalamic and pituitary hormones, sex steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis via transcription of a potent angiogenic factor, vascular endothelial growth factor (VEGF), that is regulated by HIF1. A CL forms with a rapid increase of angiogenesis that is mainly induced by HIF1-VEGF signaling. Hypoxia also contributes to luteolysis by down-regulating progesterone synthesis and by up-regulating apoptosis of luteal cells. This review focuses on recent studies on the roles of hypoxia- and HIF1-regulated genes in the regulation of bovine CL function.
MeSH term(s)	Animals ; Cattle ; Corpus Luteum/metabolism ; Female ; Glucose Transporter Type 1/metabolism ; Hypoxia/metabolism ; Hypoxia-Inducible Factor 1/metabolism ; Luteolysis/physiology ; Membrane Proteins/metabolism ; Ovary/metabolism ; Proto-Oncogene Proteins/metabolism ; Vascular Endothelial Growth Factor A/metabolism
Chemical Substances	Glucose Transporter Type 1 ; Hypoxia-Inducible Factor 1 ; Membrane Proteins ; Proto-Oncogene Proteins ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2020-04-04
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2039060-9
ISSN	1348-4400 ; 0916-8818
ISSN (online)	1348-4400
ISSN	0916-8818
DOI	10.1262/jrd.2020-018
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Article ; Online: Apoptosis, autophagic cell death, and necroptosis

Takuo HOJO / Dariusz J. SKARZYNSKI / Kiyoshi OKUDA

The Journal of Reproduction and Development, Vol 68, Iss 6, Pp 355-

different types of programmed cell death in bovine corpus luteum regression

2022 Volume 360

Abstract	In mammals, the corpus luteum (CL) is a transient organ that secretes progesterone (P4). In the absence of pregnancy, the CL undergoes regression (luteolysis), which is a crucial preparation step for the next estrous cycle. Luteolysis, initiated by uterine prostaglandin F2α (PGF) in cattle, is usually divided into two phases, namely functional luteolysis characterized by a decline in P4 concentration and structural luteolysis characterized by the elimination of luteal tissues from the ovary. Programmed cell death (PCD) of luteal cells, including luteal steroidogenic cells (LSCs) and luteal endothelial cells (LECs), plays a crucial role in structural luteolysis. The main types of PCD are caspase-dependent apoptosis (type 1), autophagic cell death (ACD) via the autophagy-related gene (ATG) family (type 2), and receptor-interacting protein kinase (RIPK)-dependent programmed necrosis (necroptosis, type 3). However, these PCD signaling pathways are not completely independent and interact with each other. Over the past several decades, most studies on luteolysis have focused on apoptosis as the principal mode of bovine luteal cell death. Recently, ATG family members were reported to be expressed in bovine CL, and their levels increased during luteolysis. Furthermore, the expression of RIPKs, which are crucial mediators of necroptosis, is reported to increase in bovine CL during luteolysis and is upregulated by pro-inflammatory cytokines in bovine LSCs and LECs. Therefore, apoptosis, ACD, and necroptosis may contribute to bovine CL regression. In this article, we present the recent findings regarding the mechanisms of the three main types of PCD and the contribution of these mechanisms to luteolysis.
Keywords	apoptosis ; autophagic cell death ; corpus luteum ; necroptosis ; programmed cell death ; Reproduction ; QH471-489 ; Internal medicine ; RC31-1245
Subject code	610
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	The Society for Reproduction and Development
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Conference proceedings: Progress in clinical enzymology

Okuda, Kiyoshi

a selection of papers derived from presentations at the 7th International Congress on Clinical Enzymology, Osaka, Japan, Sept. 11 - 14, 1988

(Clinica chimica acta ; 185,3)

1989

Event/congress	International Congress on Clinical Enzymology (7, 1988, Osaka)
Author's details	guest ed.: Kiyoshi Okuda
Series title	Clinica chimica acta ; 185,3
Keywords	Blood Cells / enzymology / congresses ; Enzymes / congresses ; Immunoenzyme Techniques / congresses
Language	English
Size	S. 221 - 367 : Ill., graph. Darst.
Publisher	Elsevier
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book ; Conference proceedings
HBZ-ID	HT003451761
Database	Catalogue ZB MED Medicine, Health

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Ud II Zs 173 -185-	verfügbar in Königswinter	Königswinter

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Book ; Conference proceedings: Automation and new technology in the clinical laboratory

Okuda, Kiyoshi

proceedings of the IUPAC 3rd International Congress on Automation and New Technology in the Clinical Laboratory held in Kobe, Japan, 5 - 8 September 1988

1990

Title variant	ANT
Institution	International Union of Pure and Applied Chemistry
Event/congress	International Congress on Automation and New Technology in the Clinical Laboratory (3, 1988, Kōbe)
Author's details	ed. by Kiyoshi Okuda
Keywords	Laboratory Techniques and Procedures / methods / congresses ; Laboratory Techniques and Procedures / instrumentation / congresses
Size	VIII, 318 S. : Ill., graph. Darst.
Publisher	Blackwell
Publishing place	Oxford u.a.
Publishing country	Great Britain
Document type	Book ; Conference proceedings
HBZ-ID	HT003604321
ISBN	0-632-02819-X ; 978-0-632-02819-1
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
1992 A 3977	order for loan	Magazin

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Article ; Online: Identification of

Otsuki, Yuji / Okuda, Yuki / Naruse, Kiyoshi / Saya, Hideyuki

G3 (Bethesda, Md.)

2020 Volume 10, Issue 1, Page(s) 311–319

Abstract: The body coloration of animals is due to pigment cells derived from neural crest cells, which are multipotent and differentiate into diverse cell types. Medaka ( ...

Abstract	The body coloration of animals is due to pigment cells derived from neural crest cells, which are multipotent and differentiate into diverse cell types. Medaka (
MeSH term(s)	Animals ; Fish Proteins/genetics ; Fish Proteins/metabolism ; Melanophores/metabolism ; Microphthalmia-Associated Transcription Factor/genetics ; Microphthalmia-Associated Transcription Factor/metabolism ; Mutation ; Oryzias/genetics ; PAX7 Transcription Factor/genetics ; PAX7 Transcription Factor/metabolism ; SOXD Transcription Factors/genetics ; SOXD Transcription Factors/metabolism ; Skin Pigmentation/genetics ; Stem Cell Factor/genetics ; Stem Cell Factor/metabolism
Chemical Substances	Fish Proteins ; Microphthalmia-Associated Transcription Factor ; PAX7 Transcription Factor ; SOXD Transcription Factors ; Stem Cell Factor
Language	English
Publishing date	2020-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2629978-1
ISSN	2160-1836 ; 2160-1836
ISSN (online)	2160-1836
ISSN	2160-1836
DOI	10.1534/g3.119.400561
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Article ; Online: Involvement of activin signal pathway in cyclic apoptosis of the oviductal isthmic epithelium in cows.

Yamamoto, Yuki / Ito, Sayaka / Okuda, Kiyoshi / Kimura, Koji

Theriogenology

2020 Volume 153, Page(s) 143–150

Abstract: Activin (ACV) A induces various cellular functions via activin receptor type 2 (ACVR2A/2B)-activin receptor-like kinase (ALK) 4 -Smad 2/3 pathway. Although the production of ACVA is indicated in bovine oviducts, its role on the oviduct is unclear. ... ...

Abstract	Activin (ACV) A induces various cellular functions via activin receptor type 2 (ACVR2A/2B)-activin receptor-like kinase (ALK) 4 -Smad 2/3 pathway. Although the production of ACVA is indicated in bovine oviducts, its role on the oviduct is unclear. Oviductal isthmus needs to change its function rapidly at peri-fertilization, however, the mechanism is unknown. This study was aimed to clarify the role of ACVA in the morphological changes of oviductal isthmus in cows. First, mRNA expressions of INHBA (ACVA component) and its receptors (ALK4, ACVR2A and ACVR2B) in the isthmic tissues were examined throughout the estrous cycle. INHBA was the highest, however, ACVR2A was the lowest on the day of ovulation, suggesting reduced ACV signal transduction in the isthmus just after ovulation. Proteins of ACVRs and Smad2/3 were clearly detected in the cultured epithelial cells. It is known that ACVA regulates cellular apoptosis. Our data showed that the number of cleaved caspase-3-positive epithelial cells was largest at 2-3 days after ovulation in the isthmus. Interestingly, our study demonstrated that follistatin (ACV/TGFB/BMP inhibitor) significantly decreased the BCL2/BAX ratio in the cultured isthmic epithelial cells. To clarify which ALK pathway is involved in the regulation of BCL2/BAX ratio, the effects of SB431542 (ACV signaling (ALK4) and TGFB signaling (ALK5) inhibitor), SB525334 (ALK5 inhibitor) and LDN193189 (BMP signaling (ALK2/3) inhibitor) were investigated in the next study. The results showed that only SB431542 significantly decreased BCL2/BAX and the others had no effects. These results suggest that decreased ACVA-ACVR2A-ALK4 signal at the post-ovulation induces cyclic apoptosis of isthmic epithelial cells in bovine oviducts.
MeSH term(s)	Activin Receptors/genetics ; Activin Receptors/metabolism ; Activins/genetics ; Activins/metabolism ; Animals ; Apoptosis ; Benzamides/pharmacology ; Cattle ; Dioxoles/pharmacology ; Epithelial Cells/metabolism ; Epithelium/physiology ; Fallopian Tubes/physiology ; Female ; Gene Expression Regulation/drug effects ; Imidazoles/pharmacology ; Proto-Oncogene Proteins c-bcl-2/genetics ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Quinoxalines/pharmacology ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Chemical Substances	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide ; 6-(2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline ; Benzamides ; Dioxoles ; Imidazoles ; Proto-Oncogene Proteins c-bcl-2 ; Quinoxalines ; RNA, Messenger ; activin A ; bcl-2-Associated X Protein ; Activins (104625-48-1) ; Activin Receptors (EC 2.7.11.30)
Language	English
Publishing date	2020-05-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2020.05.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Involvement of activin signal pathway in cyclic apoptosis of the oviductal isthmic epithelium in cows

Yamamoto, Yuki / Ito, Sayaka / Okuda, Kiyoshi / Kimura, Koji

Theriogenology. 2020 Sept. 01, v. 153

2020

Abstract	Activin (ACV) A induces various cellular functions via activin receptor type 2 (ACVR2A/2B)-activin receptor-like kinase (ALK) 4 -Smad 2/3 pathway. Although the production of ACVA is indicated in bovine oviducts, its role on the oviduct is unclear. Oviductal isthmus needs to change its function rapidly at peri-fertilization, however, the mechanism is unknown. This study was aimed to clarify the role of ACVA in the morphological changes of oviductal isthmus in cows. First, mRNA expressions of INHBA (ACVA component) and its receptors (ALK4, ACVR2A and ACVR2B) in the isthmic tissues were examined throughout the estrous cycle. INHBA was the highest, however, ACVR2A was the lowest on the day of ovulation, suggesting reduced ACV signal transduction in the isthmus just after ovulation. Proteins of ACVRs and Smad2/3 were clearly detected in the cultured epithelial cells. It is known that ACVA regulates cellular apoptosis. Our data showed that the number of cleaved caspase-3-positive epithelial cells was largest at 2–3 days after ovulation in the isthmus. Interestingly, our study demonstrated that follistatin (ACV/TGFB/BMP inhibitor) significantly decreased the BCL2/BAX ratio in the cultured isthmic epithelial cells. To clarify which ALK pathway is involved in the regulation of BCL2/BAX ratio, the effects of SB431542 (ACV signaling (ALK4) and TGFB signaling (ALK5) inhibitor), SB525334 (ALK5 inhibitor) and LDN193189 (BMP signaling (ALK2/3) inhibitor) were investigated in the next study. The results showed that only SB431542 significantly decreased BCL2/BAX and the others had no effects. These results suggest that decreased ACVA-ACVR2A-ALK4 signal at the post-ovulation induces cyclic apoptosis of isthmic epithelial cells in bovine oviducts.
Keywords	apoptosis ; epithelium ; estrous cycle ; follistatin ; oviductal isthmus ; ovulation ; signal transduction
Language	English
Dates of publication	2020-0901
Size	p. 143-150.
Publishing place	Elsevier Inc.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2020.05.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Ghost introgression in ricefishes of the genus Adrianichthys in an ancient Wallacean lake.

Yamahira, Kazunori / Kobayashi, Hirozumi / Kakioka, Ryo / Montenegro, Javier / Masengi, Kawilarang W A / Okuda, Noboru / Nagano, Atsushi J / Tanaka, Rieko / Naruse, Kiyoshi / Tatsumoto, Shoji / Go, Yasuhiro / Ansai, Satoshi / Kusumi, Junko

Journal of evolutionary biology

2023 Volume 36, Issue 10, Page(s) 1484–1493

Abstract: Because speciation might have been promoted by ancient introgression from an extinct lineage, it is important to detect the existence of 'ghost introgression' in focal taxa and examine its contribution to their diversification. In this study, we examined ...

Abstract	Because speciation might have been promoted by ancient introgression from an extinct lineage, it is important to detect the existence of 'ghost introgression' in focal taxa and examine its contribution to their diversification. In this study, we examined possible ghost introgression and its contributions to the diversification of ricefishes of the genus Adrianichthys in Lake Poso, an ancient lake on Sulawesi Island, in which some extinctions are known to have occurred. Population-genomic analysis revealed that two extant Adrianichthys species, A. oophorus and A. poptae are reproductively isolated from each other. Comparisons of demographic models demonstrated that introgression from a ghost population, which diverged from the common ancestor of A. oophorus and A. poptae, is essential for reconstructing the demographic history of Adrianichthys. The best model estimated that the divergence of the ghost population greatly predated the divergence between A. oophorus and A. poptae, and that the ghost population secondarily contacted the two extant species within Lake Poso more recently. Genome scans and simulations detected a greatly divergent locus, which cannot be explained without ghost introgression. This locus was also completely segregated between A. oophorus and A. poptae. These findings suggest that variants that came from a ghost population have contributed to the divergence between A. oophorus and A. poptae, but the large time-lag between their divergence and ghost introgression indicates that the contribution of introgression may be restricted.
MeSH term(s)	Lakes ; Phylogeny
Language	English
Publishing date	2023-09-22
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1465318-7
ISSN	1420-9101 ; 1010-061X
ISSN (online)	1420-9101
ISSN	1010-061X
DOI	10.1111/jeb.14223
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Article ; Online: Multiple roles of hypoxia in ovarian function: roles of hypoxia-inducible factor-related and -unrelated signals during the luteal phase.

Nishimura, Ryo / Okuda, Kiyoshi

Reproduction, fertility, and development

2015

Abstract: There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1. Ovarian function has several phases that change ... ...

Abstract	There is increasing interest in the role of oxygen conditions in the microenvironment of organs because of the discovery of a hypoxia-specific transcription factor, namely hypoxia-inducible factor (HIF) 1. Ovarian function has several phases that change day by day, including ovulation, follicular growth and corpus luteum formation and regression. These phases are regulated by many factors, including pituitary hormones and local hormones, such as steroids, peptides and cytokines, as well as oxygen conditions. Hypoxia strongly induces angiogenesis because transcription of the potent angiogenic factor vascular endothelial growth factor (VEGF) is regulated by HIF1. Follicular development and luteal formation are accompanied by a marked increase in angiogenesis assisted by HIF1-VEGF signalling. Hypoxia is also one of the factors that induces luteolysis by suppressing progesterone synthesis and by promoting apoptosis of luteal cells. The present review focuses on recent studies of hypoxic conditions, as well as HIF1-regulated genes and proteins, in the regulation of ovarian function.
Language	English
Publishing date	2015-05-05
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RD15010
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