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Book: San wen juan

Huang, Wuzhong / Ruan, Meihui

(Hong xing fu quan ji : 洪醒夫全集 ; / Huang wu zhong, ruan mei hui zhu bian ; 7)

2001

Series title	Hong xing fu quan ji : 洪醒夫全集 / Huang wu zhong, ruan mei hui zhu bian ; 7
Language	Chinese
Size	294 p, ill
Publisher	Zhang hua xian wen hua ju
Publishing place	Zhanghua
Document type	Book
ISBN	9570284196 ; 9789570284195
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Clinical and ultrasound features of 46 children with suppurative osteoarthritis: experience from two centers.

Huang, Sai-Feng / Teng, Yue / Hui-Qing Shi / Chen, Wen-Juan / Zhang, Xue-Hua

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 220

Abstract: Objective: Diagnosing musculoskeletal infections in children is challenging. In recent years, with the advancement of ultrasound technology, high-resolution ultrasound has unique advantages for musculoskeletal children. The aim of this work is to ... ...

Abstract	Objective: Diagnosing musculoskeletal infections in children is challenging. In recent years, with the advancement of ultrasound technology, high-resolution ultrasound has unique advantages for musculoskeletal children. The aim of this work is to summarize the ultrasonographic and clinical characteristics of children with pyogenic arthritis and osteomyelitis. This study provides a simpler and more effective diagnostic basis for clinical treatment. Methods: Fifty children with osteomyelitis or arthritis were diagnosed via ultrasound, and the results of the ultrasound diagnosis were compared with those of magnetic resonance imaging and surgery. Clinical and ultrasound characteristics were also analyzed. Results: Out of 50 patients, 46 were confirmed to have suppurative infection by surgical and microbiological examination. Among these 46 patients, 26 were diagnosed with osteomyelitis and 20 had arthritis. The manifestations of osteomyelitis were subperiosteal abscess (15 patients), bone destruction (17 patients), bone marrow abscess (9 patients), and adjacent joint abscess (13 patients). Osteomyelitis mostly affects the long bones of the limbs, femur and humerus (10 and 9 patients, respectively), followed by the ulna, radius, tibia and fibula (one patient each). The manifestations of arthritis were joint pus (20 patients) and joint capsule thickening (20 patients), and hip dislocation (8 patients). All the patients had arthritis involving the hip joint. Conclusion: Subperiosteal abscess, bone destruction, and joint abscess with dislocation are ultrasonographic features of pyogenic osteoarthritis. The findings of this work can improve the early diagnosis and differentiation of pyogenic osteoarthritis and provide a reliable basis for treatment.
MeSH term(s)	Child ; Humans ; Abscess/diagnostic imaging ; Abscess/microbiology ; Arthritis, Infectious/diagnostic imaging ; Arthritis, Infectious/therapy ; Fibula ; Osteoarthritis ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/therapy
Language	English
Publishing date	2024-04-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-024-04563-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Remodeling the Electronic Structure of Metallic Nickel and Ruthenium via Alloying in a Molecular Template for Sustainable Hydrogen Evolution.

Li, Xuan / Long, Shui-Hong / Zhang, Xue-Feng / Huang, Wen-Juan / Du, Zi-Yi / Lu, Ying-Bing / Cao, Li-Ming / He, Chun-Ting

Inorganic chemistry

2024 Volume 63, Issue 12, Page(s) 5761–5768

Abstract: The reasonably constructed high-performance electrocatalyst is crucial to achieve sustainable electrocatalytic water splitting. Alloying is a prospective approach to effectively boost the activity of metal electrocatalysts. However, it is a difficult ... ...

Abstract	The reasonably constructed high-performance electrocatalyst is crucial to achieve sustainable electrocatalytic water splitting. Alloying is a prospective approach to effectively boost the activity of metal electrocatalysts. However, it is a difficult subject for the controllable synthesis of small alloying nanostructures with high dispersion and robustness, preventing further application of alloy catalysts. Herein, we propose a well-defined molecular template to fabricate a highly dispersed NiRu alloy with ultrasmall size. The catalyst presents superior alkaline hydrogen evolution reaction (HER) performance featuring an overpotential as low as 20.6 ± 0.9 mV at 10 mA·cm
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.4c00540
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Article ; Online: Complexation of Fluorofenidone by Cucurbit[7]uril and β-Cyclodextrin: Keto-Enol Tautomerization to Enhance the Solubility.

Ma, Wen-Juan / Chen, Hua-Yu / Huang, Yong-Liang / Chen, Jia-Mei / Lu, Tong-Bu

Molecular pharmaceutics

2023 Volume 20, Issue 9, Page(s) 4517–4527

Abstract: This study is designed to compare drug encapsulation by cucurbit[7]uril and β-cyclodextrin, using fluorofenidone as a model drug. Single-crystal X-ray diffraction analysis was employed to successfully determine the crystal structures of fluorofenidone· ... ...

Abstract	This study is designed to compare drug encapsulation by cucurbit[7]uril and β-cyclodextrin, using fluorofenidone as a model drug. Single-crystal X-ray diffraction analysis was employed to successfully determine the crystal structures of fluorofenidone·H
MeSH term(s)	Rats ; Animals ; Solubility ; beta-Cyclodextrins/chemistry ; Macrocyclic Compounds/chemistry ; Bridged-Ring Compounds/chemistry
Chemical Substances	cucurbit(7)uril ; 5-methyl-1-(3-fluorophenyl)-2-(1H)-pyridone ; beta-Cyclodextrins ; Macrocyclic Compounds ; Bridged-Ring Compounds
Language	English
Publishing date	2023-08-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00213
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Article ; Online: Interferon-regulatory factor-1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14-3-3γ axis.

Chen, Xuan-Ying / Xie, Meng-Qi / Huang, Wei-Lin / Li, Wen-Juan / Lv, Yan-Ni / Peng, Xiao-Ping

ESC heart failure

2024 Volume 11, Issue 2, Page(s) 986–1000

Abstract: Aim: Myocardial injury is a significant cause of death. This study investigated the role and underlying mechanism of interferon-regulatory factor-1 (IRF1) in bevacizumab (BVZ)-induced cardiomyocyte injury.: Methods and results: HL-1 cells and C57BL/6 ...

Abstract	Aim: Myocardial injury is a significant cause of death. This study investigated the role and underlying mechanism of interferon-regulatory factor-1 (IRF1) in bevacizumab (BVZ)-induced cardiomyocyte injury. Methods and results: HL-1 cells and C57BL/6 mice receiving BVZ treatment were used to establish in vitro and in vivo models of myocardial injury. The relationship between VEGFA and 14-3-3γ was verified through co-immunoprecipitation and Glutathione S Transferase (GST) pull-down assay. Cell viability and apoptosis were analysed by MTT, propidium iodide (PI) staining and flow cytometry. The release of lactate dehydrogenase (LDH), cardiac troponins T (cTnT), and creatine kinase MB (CK-MB) was measured using the enzyme linked immunosorbent assay. The effects of knocking down IRF1 on BVZ-induced mice were analysed in vivo. IRF1 levels were increased in BVZ-treated HL-1 cells. BVZ treatment induced apoptosis, inhibited cell viability, and promoted the release of LDH, cTnT, and CK-MB. IRF1 silencing suppressed BVZ-induced myocardial injury, whereas IRF1 overexpression had the opposite effect. IRF1 regulated VEGFA expression by binding to its promoter, with the depletion of VEGFA or 14-3-3γ reversing the effects of IRF1 knockdown on the cell viability and apoptosis of BVZ-treated HL-1 cells. 14-3-3γ overexpression promoted cell proliferation, inhibited apoptosis, and reduced the release of LDH, cTnT, and CK-MB, thereby alleviating BVZ-induced HL-1 cell damage. In vivo, IRF1 silencing alleviated BVZ-induced cardiomyocyte injury by regulating the VEGFA/14-3-3γ axis. Conclusion: The IRF1-mediated VEGFA/14-3-3γ signalling pathway promotes BVZ-induced myocardial injury. Our study provides evidence for potentially new target genes for the treatment of myocardial injury.
MeSH term(s)	Mice ; Animals ; Bevacizumab/pharmacology ; Vascular Endothelial Growth Factor A ; Cardiotoxicity ; Mice, Inbred C57BL ; Interferons
Chemical Substances	Bevacizumab (2S9ZZM9Q9V) ; Vascular Endothelial Growth Factor A ; Interferons (9008-11-1)
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.14640
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Insights into the metabolic pathways and biodegradation mechanisms of chloroacetamide herbicides.

Chen, Shao-Fang / Chen, Wen-Juan / Huang, Yaohua / Wei, Ming / Chang, Changqing

Environmental research

2023 Volume 229, Page(s) 115918

Abstract: Chloroacetamide herbicides are widely used around the world due to their high efficiency, resulting in increasing levels of their residues in the environment. Residual chloroacetamides and their metabolites have been frequently detected in soil, water ... ...

Abstract	Chloroacetamide herbicides are widely used around the world due to their high efficiency, resulting in increasing levels of their residues in the environment. Residual chloroacetamides and their metabolites have been frequently detected in soil, water and organisms and shown to have toxic effects on non-target organisms, posing a serious threat to the ecosystem. As such, rapid and efficient techniques that eliminate chloroacetamide residues from the ecosystem are urgently needed. Degradation of these herbicides in the environment mainly occurs through microbial metabolism. Microbial strains such as Acinetobacter baumannii DT, Bacillus altitudinis A16, Pseudomonas aeruginosa JD115, Sphingobium baderi DE-13, Catellibacterium caeni DCA-1, Stenotrophomonas acidaminiphila JS-1, Klebsiella variicola B2, and Paecilomyces marquandii can effectively degrade chloroacetamide herbicides. The degradation pathway of chloroacetamide herbicides in aerobic bacteria is mainly initiated by an N/C-dealkylation reaction, followed by aromatic ring hydroxylation and cleavage processes, whereas dechlorination is the initial reaction in anaerobic bacteria. The molecular mechanisms associated with bacterial degradation of chloroacetamide herbicides have been explored, with amidase, hydrolase, reductase, ferredoxin and cytochrome P450 oxygenase currently known to play a pivotal role in the catabolic pathways of chloroacetamides. The fungal pathway for the degradation of these herbicides is more complex with more diversified products, and the degradation enzymes and genes involved remain to be discovered. However, there are few reviews specifically summarizing the microbial degrading species and biochemical mechanisms of chloroacetamide herbicides. Here, we briefly summarize the latest progress resulting from research on microbial strain resources and enzymes involved in degradation of these herbicides and their corresponding genes. Furthermore, we explore the biochemical pathways and molecular mechanisms for biodegradation of chloroacetamide herbicides in depth, thereby providing a reference for further research on the bioremediation of such herbicides.
MeSH term(s)	Herbicides/analysis ; Biodegradation, Environmental ; Ecosystem ; Metabolic Networks and Pathways
Chemical Substances	Herbicides ; chloroacetamide (2R97846T1L)
Language	English
Publishing date	2023-04-14
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115918
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advances in Studies of Chiglitazar Sodium, a Novel PPAR Pan-Agonist, for the Treatment of Type 2 Diabetes Mellitus.

Zhang, Xin-Hui / Tian, Yun-Fei / Huang, Guang-Liang / Cui, Wen-Yan / Sun, Qian / He, Wen-Juan / Liu, Xiu-Ju

Current medical science

2023 Volume 43, Issue 5, Page(s) 890–896

Abstract: Chiglitazar sodium is a new peroxisome proliferator-activated receptor (PPAR) pan-agonist with independent intellectual property rights in China. It can treat type 2 diabetes mellitus and regulate metabolism by modestly activating PPARα, PPARγ, and PPARδ ...

Abstract	Chiglitazar sodium is a new peroxisome proliferator-activated receptor (PPAR) pan-agonist with independent intellectual property rights in China. It can treat type 2 diabetes mellitus and regulate metabolism by modestly activating PPARα, PPARγ, and PPARδ to improve insulin sensitivity, regulate blood glucose, and promote fatty acid oxidation and utilization. Chiglitazar sodium has a significant insulin-sensitizing effect and is advantageous in reducing fasting and postprandial blood glucose levels, particularly at the 48 mg dose in patients with concomitant high triglycerides in terms of blood glucose and triglyceride level control.
Language	English
Publishing date	2023-06-16
Publishing country	China
Document type	Journal Article
ZDB-ID	2931065-9
ISSN	2523-899X ; 2096-5230
ISSN (online)	2523-899X
ISSN	2096-5230
DOI	10.1007/s11596-023-2760-3
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Article ; Online: Insights into the metabolic pathways and biodegradation mechanisms of chloroacetamide herbicides

Chen, Shao-Fang / Chen, Wen-Juan / Huang, Yao-Hua / Wei, Ming / Chang, Changqing

Environmental Research. 2023, p.115918-

2023 , Page(s) 115918–

Abstract	Chloroacetamide herbicides are widely used around the world due to their high efficiency, resulting in increasing levels of their residues in the environment. Residual chloroacetamides and their metabolites have been frequently detected in soil, water and organisms and shown to have toxic effects on non-target organisms, posing a serious threat to the ecosystem. As such, rapid and efficient techniques that eliminate chloroacetamide residues from the ecosystem are urgently needed. Degradation of these herbicides in the environment mainly occurs through microbial metabolism. Microbial strains such as Acinetobacter baumannii DT, Bacillus altitudinis A16, Pseudomonas aeruginosa JD115, Sphingobium baderi DE-13, Catellibacterium caeni DCA-1, Stenotrophomonas acidaminiphila JS-1, Klebsiella variicola B2, and Paecilomyces marquandii can effectively degrade chloroacetamide herbicides. The degradation pathway of chloroacetamide herbicides in aerobic bacteria is mainly initiated by an N/C-dealkylation reaction, followed by aromatic ring hydroxylation and cleavage processes, whereas dechlorination is the initial reaction in anaerobic bacteria. The molecular mechanisms associated with bacterial degradation of chloroacetamide herbicides have been explored, with amidase, hydrolase, reductase, ferredoxin and cytochrome P450 oxygenase currently known to play a pivotal role in the catabolic pathways of chloroacetamides. The fungal pathway for the degradation of these herbicides is more complex with more diversified products, and the degradation enzymes and genes involved remain to be discovered. However, there are few reviews specifically summarizing the microbial degrading species and biochemical mechanisms of chloroacetamide herbicides. Here, we briefly summarize the latest progress resulting from research on microbial strain resources and enzymes involved in degradation of these herbicides and their corresponding genes. Furthermore, we explore the biochemical pathways and molecular mechanisms for biodegradation of chloroacetamide herbicides in depth, thereby providing a reference for further research on the bioremediation of such herbicides.
Keywords	Acinetobacter baumannii ; Bacillus altitudinis ; Klebsiella variicola ; Paecilomyces marquandii ; Pseudomonas aeruginosa ; Sphingomonas ; Stenotrophomonas ; amidase ; aromatic compounds ; biodegradation ; bioremediation ; cytochrome P-450 ; dechlorination ; ecosystems ; fungi ; hydroxylation ; metabolism ; metabolites ; oxidoreductases ; research ; soil ; toxicity ; Chloroacetamide herbicides ; Degradation pathways ; Molecular mechanisms
Language	English
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115918
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Lower subcutaneous fat index predicts bone metastasis in breast cancer.

Wang, Wen / Huang, Wen-Juan / Liu, Ping-Ping / Fu, Shuang / Zhang, Meng-Lin / Zhang, Xin / Wang, Rui-Tao / Huang, Yuan-Xi

Cancer biomarkers : section A of Disease markers

2023 Volume 38, Issue 1, Page(s) 121–130

Abstract: Background: Bone metastases affect 50% to 70% of breast cancer (BC) patients and have a high mortality rate. Adipose tissue loss plays a pivotal role in the progression of cancer.: Objective: This study aims to evaluate the prognostic value of ... ...

Abstract	Background: Bone metastases affect 50% to 70% of breast cancer (BC) patients and have a high mortality rate. Adipose tissue loss plays a pivotal role in the progression of cancer. Objective: This study aims to evaluate the prognostic value of adipose tissue for bone metastasis in BC patients. Methods: 517 BC patients were studied retrospectively. Patients' characteristics before the surgery were collected. Quantitative measurements of the subcutaneous fat index (SFI) were performed at the level of the eleventh thoracic vertebra. In order to adjust for the heterogeneity between the low SFI and high SFI groups, propensity score matching (PSM) was used. The Kaplan-Meier method was used to estimate the 5-year bone metastatic incidence. The prognostic analysis was performed with the Cox regression models. Results: Compared with the patients without bone metastasis, the patients with bone metastasis had reduced SFI levels. In addition, Kaplan-Meier analysis revealed that patients with low SFI were more likely to develop bone metastases. The independent predictive value of SFI for bone metastases was confirmed by Cox regression analysis. The survival analysis was repeated after PSM with a 1:1 ratio, yielding similar results (P< 0.05). Conclusions: SFI is an independent predictor of bone metastasis in BC patients.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/pathology ; Retrospective Studies ; Bone Neoplasms ; Breast/pathology ; Prognosis ; Subcutaneous Fat/pathology
Language	English
Publishing date	2023-08-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2203517-5
ISSN	1875-8592 ; 1574-0153 ; 1875-8592
ISSN (online)	1875-8592 ; 1574-0153
ISSN	1875-8592
DOI	10.3233/CBM-230011
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Article ; Online: CAR products from novel sources: a new avenue for the breakthrough in cancer immunotherapy.

Huang, Jiawen / Yang, Qian / Wang, Wen / Huang, Juan

Frontiers in immunology

2024 Volume 15, Page(s) 1378739

Abstract: Chimeric antigen receptor (CAR) T cell therapy has transformed cancer immunotherapy. However, significant challenges limit its application beyond B cell-driven malignancies, including limited clinical efficacy, high toxicity, and complex autologous cell ... ...

Abstract	Chimeric antigen receptor (CAR) T cell therapy has transformed cancer immunotherapy. However, significant challenges limit its application beyond B cell-driven malignancies, including limited clinical efficacy, high toxicity, and complex autologous cell product manufacturing. Despite efforts to improve CAR T cell therapy outcomes, there is a growing interest in utilizing alternative immune cells to develop CAR cells. These immune cells offer several advantages, such as major histocompatibility complex (MHC)-independent function, tumor microenvironment (TME) modulation, and increased tissue infiltration capabilities. Currently, CAR products from various T cell subtypes, innate immune cells, hematopoietic progenitor cells, and even exosomes are being explored. These CAR products often show enhanced antitumor efficacy, diminished toxicity, and superior tumor penetration. With these benefits in mind, numerous clinical trials are underway to access the potential of these innovative CAR cells. This review aims to thoroughly examine the advantages, challenges, and existing insights on these new CAR products in cancer treatment.
MeSH term(s)	Humans ; Neoplasms/therapy ; Neoplasms/immunology ; Receptors, Chimeric Antigen/immunology ; Receptors, Chimeric Antigen/genetics ; Immunotherapy, Adoptive/methods ; Animals ; Tumor Microenvironment/immunology ; T-Lymphocytes/immunology
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1378739
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