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Article ; Online: Total Joint Arthroplasty in Patients Who Are Obese or Morbidly Obese: An Ethical Analysis.

Lachance, Andrew D / Steika, Roman / Lutton, Jeffrey / Chessa, Frank

The Journal of bone and joint surgery. American volume

2024 Volume 106, Issue 7, Page(s) 659–664

MeSH term(s)	Humans ; Obesity, Morbid/complications ; Obesity, Morbid/surgery ; Arthroplasty, Replacement, Knee ; Ethical Analysis ; Postoperative Complications/surgery ; Retrospective Studies ; Body Mass Index
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.23.00617
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Article: Conversion of Patellofemoral Arthroplasty to Robotic-Assisted Total Knee Arthroplasty.

Lachance, Andrew D / Steika, Roman / Lutton, Jeffrey / Austin, David

Arthroplasty today

2023 Volume 23, Page(s) 101215

Abstract: Conversion of patellofemoral arthroplasty to total knee arthroplasty (TKA) has been described as similar to primary TKA, although it may come with more challenges and worse outcomes. With the increased rate of revision following conversion TKA vs primary ...

Abstract	Conversion of patellofemoral arthroplasty to total knee arthroplasty (TKA) has been described as similar to primary TKA, although it may come with more challenges and worse outcomes. With the increased rate of revision following conversion TKA vs primary TKA, robotically assisted TKA provides an alternative technique to manual conversion. We present 3 cases of robot-assisted conversion of prior patellofemoral arthroplasty to TKA with good mechanical and clinical outcomes and no intraoperative complications.
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Case Reports
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2023.101215
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Article: No Difference in Range of Motion, Components, or Complications Following Conversion of Robotic-Assisted Total Knee Arthroplasty Compared to Manual TKA After Undergoing Manual or Robotic-Assisted Unicompartmental Knee Arthroplasty.

Lachance, Andrew D / Edelstein, Alexander / Stilwell, Mason / Lutton, Jeffrey

Arthroplasty today

2023 Volume 24, Page(s) 101269

Abstract: Background: Conversion surgery from unicondylar knee arthroplasty (UKA) to total knee arthroplasty (TKA) remains a challenge due to scarring, implant/cement removal, and loss of bony landmarks. Robotic-assisted (RA) TKA may assist in challenges seen in ... ...

Abstract	Background: Conversion surgery from unicondylar knee arthroplasty (UKA) to total knee arthroplasty (TKA) remains a challenge due to scarring, implant/cement removal, and loss of bony landmarks. Robotic-assisted (RA) TKA may assist in challenges seen in manual conversion TKA. The aim of this study is to identify if there are differences in components and functional outcomes dependent on manual/RA primary UKA and conversion TKA. Methods: A retrospective chart review was performed on patients undergoing conversion from UKA to TKA over a 10-year period at a single institution. Data extracted included surgical technique, reason for UKA failure, range of motion at 1 year, need for augments, and utilization of revision components. Results: Forty-nine patients (50 knees) with a UKA converted to a TKA were divided into 4 groups based on primary and conversion surgery: manual-to-manual (n = 11), manual-to-robot (n = 11), robot-to-manual (n = 11), and robot-to-robot (n = 17). There was no difference in need for augments ( Conclusions: Our study did not show any statistically significant differences of primary RA or manual UKA to RA or manual TKA in terms of range of motion at 1 year, complications, or differences in components. RA conversion from UKA to TKA is a new but equivalent technique to manual conversion. Primary surgery may impact the requirement for augments during conversion surgery.
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ISSN	2352-3441
ISSN	2352-3441
DOI	10.1016/j.artd.2023.101269
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Article: Disorder and Sorption Preferences in a Highly Stable Fluoride-Containing Rare-Earth

Lutton-Gething, A R Bonity J / Spencer, Ben F / Whitehead, George F S / Vitorica-Yrezabal, Iñigo J / Lee, Daniel / Attfield, Martin P

Chemistry of materials : a publication of the American Chemical Society

2024 Volume 36, Issue 4, Page(s) 1957–1965

Abstract: Rare-earth (RE) metal-organic frameworks (MOFs) synthesized in the presence of fluorine-donating modulators or linkers are an important new subset of functional MOFs. However, the exact nature of the ... ...

Abstract	Rare-earth (RE) metal-organic frameworks (MOFs) synthesized in the presence of fluorine-donating modulators or linkers are an important new subset of functional MOFs. However, the exact nature of the RE
Language	English
Publishing date	2024-02-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1500399-1
ISSN	1520-5002 ; 0897-4756
ISSN (online)	1520-5002
ISSN	0897-4756
DOI	10.1021/acs.chemmater.3c02849
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Article ; Online: Influence of backside seating parameters and augmented baseplate components in virtual planning for reverse shoulder arthroplasty.

Werner, Brian C / Lin, Albert / Lenters, Timothy R / Lutton, David / Creighton, R Alexander / Port, Joshua / Doody, Scott / Metcalfe, Nick / Knopf, David

Journal of shoulder and elbow surgery

2023

Abstract: Background: The primary goal of this investigation was to examine the influence of a backside seating percentage variable on volume of reamed bone and contact area in virtual planning for glenoid baseplate placement for reverse total shoulder ... ...

Abstract	Background: The primary goal of this investigation was to examine the influence of a backside seating percentage variable on volume of reamed bone and contact area in virtual planning for glenoid baseplate placement for reverse total shoulder arthroplasty (RTSA). The secondary goal was to assess how the option of augmented glenoid baseplate components affected reamed volume and cortical contact area of virtually positioned baseplates. Methods: Nine surgeons virtually planned 30 RTSA cases using a commercially available software system. The 30 cases were chosen to span a spectrum of glenoid deformity. The study consisted of 3 phases. In phase 1, cases were planned with the backside seating percentage blinded and without the option of augmented baseplate components. In phase 2, the backside seating parameter was unblinded. In phase 3, augmented baseplate components were added as an option. Implant version and inclination were recorded. By use of computer-assisted design models, total volume of bone reamed, as well as reamed cortical volume and cancellous volume, was calculated. Total, cortical, and cancellous baseplate contact areas were also calculated. Finally, total glenoid lateralization was calculated for each phase and compared. Results: Mean implant version was clinically similar across phases but was statistically significantly lower in phase 3 (P = .006 compared with phase 1 and P = .001 compared with phase 2). Mean implant inclination was clinically similar across phases but was statistically significantly lower in phase 3 (P < .001). Phase 3 had statistically significantly lower cancellous and total reamed bone volumes compared with phase 1 and phase 2 (P < .001 for all comparisons). Phase 3 had statistically significantly larger cortical contact area, lower cancellous contact area, and larger total contact area compared with phase 1 and phase 2 (P < .001 for all comparisons). Phase 3 had significantly greater glenoid lateralization (mean, 10.5 mm) compared with phase 1 (mean, 7.8 mm; P < .001) and phase 2 (mean, 7.9 mm; P < .001). Conclusions: Across a wide range of glenoid pathology during virtual surgical planning, experienced shoulder arthroplasty surgeons chose augmented baseplates frequently, and the option of a full-wedge augmented baseplate resulted in statistically significantly greater correction of glenoid deformity, improved total and cortical baseplate contact area, less cancellous reamed bone, and greater glenoid lateralization. Backside seating information does not have a significant impact on how glenoid baseplates are virtually positioned for RTSA, nor does it impact the baseplate contact area or volume of reamed bone.
Language	English
Publishing date	2023-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1170782-3
ISSN	1532-6500 ; 1058-2746
ISSN (online)	1532-6500
ISSN	1058-2746
DOI	10.1016/j.jse.2023.10.024
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Article ; Online: A method for measuring intra-tissue swelling pressure using a needle micro-osmometer.

Krull, C M / Lutton, A D / Olesik, J W / Walter, B A

European cells & materials

2020 Volume 40, Page(s) 146–159

Abstract: The intervertebral disc's ability to resist load and facilitate motion arises largely from osmotic swelling pressures that develop within the tissue. Changes in the disc's osmotic environment, diurnally and with disease, have been suggested to regulate ... ...

Abstract	The intervertebral disc's ability to resist load and facilitate motion arises largely from osmotic swelling pressures that develop within the tissue. Changes in the disc's osmotic environment, diurnally and with disease, have been suggested to regulate cellular activity, yet knowledge of in vivo osmotic environments is limited. Therefore, the first objective of this study was to demonstrate proof-of-concept for a method to measure intra-tissue swelling pressure and osmolality, modeling micro-osmometer fluid flux using Darcy's law. The second objective was to compare flux-based measurements of the swelling pressure within nucleus pulposus (NP) tissue against ionic swelling pressures predicted by Gibbs-Donnan theory. Pressures (0.03- 0.57 MPa) were applied to NP tissue (n = 25) using equilibrium dialysis, and intra-tissue swelling pressures were measured using flux. Ionic swelling pressures were determined from inductively coupled plasma optical emission spectrometry measurements of intra-tissue sodium using Gibbs-Donnan calculations of fixed charge density and intra-tissue chloride. Concordance of 0.93 was observed between applied pressures and flux- based measurements of swelling pressure. Equilibrium bounds for effective tissue osmolalities engendered by a simulated diurnal loading cycle (0.2-0.6 MPa) were 376 and 522 mOsm/kg H2O. Significant differences between flux and Gibbs-Donnan measures of swelling pressure indicated that total tissue water normalization and non-ionic contributions to swelling pressure were significant, which suggested that standard constitutive models may underestimate intra-tissue swelling pressure. Overall, this micro-osmometer technique may facilitate future validations for constitutive models and measurements of variation in the diurnal osmotic cycle, which may inform studies to identify diurnal- and disease-associated changes in mechanotransduction.
MeSH term(s)	Animals ; Cattle ; Intervertebral Disc/physiology ; Needles ; Nucleus Pulposus/physiology ; Osmolar Concentration ; Osmosis ; Permeability ; Physiology/methods ; Pressure
Language	English
Publishing date	2020-09-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2046669-9
ISSN	1473-2262 ; 1473-2262
ISSN (online)	1473-2262
ISSN	1473-2262
DOI	10.22203/eCM.v040a09
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Article: Exploring the breakdown of dairy protein gels during in vitro gastric digestion using time-lapse synchrotron deep-UV fluorescence microscopy.

Floury, Juliane / Bianchi, Tiago / Thévenot, Jonathan / Dupont, Didier / Jamme, Frédéric / Lutton, Evelyne / Panouillé, Maud / Boué, François / Le Feunteun, Steven

Food chemistry

2018 Volume 239, Page(s) 898–910

Abstract: A novel time-lapse synchrotron deep-UV microscopy methodology was developed that made use of the natural tryptophan fluorescence of proteins. It enabled the monitoring in situ of the microstructural changes of protein gels during simulated gastric ... ...

Abstract	A novel time-lapse synchrotron deep-UV microscopy methodology was developed that made use of the natural tryptophan fluorescence of proteins. It enabled the monitoring in situ of the microstructural changes of protein gels during simulated gastric digestion. Two dairy gels with an identical composition, but differing by the coagulation mode, were submitted to static in vitro gastric digestion. The kinetics of gel particle breakdown were quantified by image analysis and physico-chemical analyses of digesta. The results confirm the tendency of rennet gels, but not acid gels, to form compact protein aggregates under acidic conditions of the stomach. Consequently, the kinetics of proteolysis were much slower for the rennet gel, confirming the hypothesis of a reduced pepsin accessibility to its substrate. The particle shapes remained unchanged and the disintegration kinetics followed an exponential trend, suggesting that erosion was the predominant mechanism of the enzymatic breakdown of dairy gels in these experimental conditions.
Language	English
Publishing date	2018-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	243123-3
ISSN	1873-7072 ; 0308-8146
ISSN (online)	1873-7072
ISSN	0308-8146
DOI	10.1016/j.foodchem.2017.07.023
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Article: Comparative effect of heme analogues on hematopoiesis in lymphoproliferative disorders.

Lutton, J D / Chertkov, J L / Levere, R D / Abraham, N G

Leukemia & lymphoma

2011 Volume 5, Issue 2-3, Page(s) 179–185

Abstract: Anemia is a common characteristic of lymphoproliferative disorders (LPD) and the impairment of blood formation in these disorders is not fully understood. Heme synthesis and the heme degradative enzyme heme oxygenase are critical to hematopoietic ... ...

Abstract	Anemia is a common characteristic of lymphoproliferative disorders (LPD) and the impairment of blood formation in these disorders is not fully understood. Heme synthesis and the heme degradative enzyme heme oxygenase are critical to hematopoietic differentiation and disturbances may contribute to anemic states. Tin protoporphyrin (SnPP) is a potent inhibitor of heme oxygenase, and has proven to be a useful clinical agent. Bone marrow cells from seven patients with LPD were studied for their in vitro hemopoietic response to growth factors and SnPP. Heme oxygenase mRNA levels were determined by Northern blot analysis of bone marrow samples. Quantitation of hematopoiesis in cultures with erythropoietin or GM-CSF revealed adequate CFU-E, BFU-E and CFU-GM growth by LPD bone marrow. Inclusion of 10 μM SnPP in cultures was found to significantly enhance CFU-E/BFU-E growth by LPD marrows, whereas Zinc protoporphyrin had a marked inhibitory effect. Little or no effect by SnPP was seen on CFU-GM. In contrast, normal bone marrow cultures failed to show an enhanced response to 10 μM SnPP. Analysis of heme oxygenase mRNA levels revealed that LPD marrows had elevated expression of heme oxygenase mRNA as contrasted with normals. Furthermore, measurements revealed that heme oxygenase activity was markedly suppressed by SnPP in the LPD bone marrow cultures. Results lend further support to the importance of heme oxygenase in the differentiation process. Although LPD bone marrow cells may respond to erythropoietin in vitro, in stressed conditions where heme oxygenase is elevated, suppression of heme oxygenase may potentiate the erythropoietic response in this disease.
Language	English
Publishing date	2011-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.3109/10428199109068123
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Article ; Online: Complete Genome Sequences of Microbacterium paraoxydans Phages Cassita and Fransoyer.

Bauer, Brynn R / Brookins, Madelyn G / Fobbe, Spencer / Fredrickson, Jade R / Fretland, Aidan D / Grant, Nicole D / Katzenberger, Abigail S / Khan, Ali I / Kieffer, Brea L / Loken, Andrew M / Lopez, Ignacio / Lutton, Lindsay J / Marquette, Samantha A / Mears, MaKayla J / Moe, Cadence M / Parent, Alexandra K / Payne, Rodrick P / Peterson, Ida K / Pucillo, Hailey L /

Rickman, Brina E L / Stubson, Maddie A / Zimmerman, Elizabeth M / Spring, Ashlyn M / Klyczek, Karen K

Microbiology resource announcements

2022 Volume 11, Issue 11, Page(s) e0088522

Abstract: Phages Cassita and Fransoyer were isolated from soil in northwestern Wisconsin using Microbacterium paraoxydans as the host. The genomes of Cassita and Fransoyer are 61,868 bp and 62,277 bp, respectively, with direct terminal repeats. Both phages exhibit ...

Abstract	Phages Cassita and Fransoyer were isolated from soil in northwestern Wisconsin using Microbacterium paraoxydans as the host. The genomes of Cassita and Fransoyer are 61,868 bp and 62,277 bp, respectively, with direct terminal repeats. Both phages exhibit siphoviral morphology and are predicted to have lytic life cycles.
Language	English
Publishing date	2022-10-26
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/mra.00885-22
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Article ; Online: Sperm DNA damage measured by the alkaline Comet assay as an independent predictor of male infertility and in vitro fertilization success.

Simon, Luke / Lutton, Deborah / McManus, Joanne / Lewis, Sheena E M

Fertility and sterility

2011 Volume 95, Issue 2, Page(s) 652–657

Abstract: Objective: To evaluate sperm DNA fragmentation and semen parameters to diagnose male factor infertility and predict pregnancy after IVF.: Design: Prospective study.: Setting: Academic research laboratory.: Patient(s): Seventy-five couples ... ...

Abstract	Objective: To evaluate sperm DNA fragmentation and semen parameters to diagnose male factor infertility and predict pregnancy after IVF. Design: Prospective study. Setting: Academic research laboratory. Patient(s): Seventy-five couples undergoing IVF and 28 fertile donors. Intervention(s): Sperm DNA fragmentation was measured by the alkaline Comet assay in semen and sperm after density gradient centrifugation (DGC). Binary logistic regression was used to analyze odds ratios (OR) and relative risks (RR) for IVF outcomes. Main outcome measure(s): Semen parameters and sperm DNA fragmentation in semen and DGC sperm compared with fertilization rates, embryo quality, and pregnancy. Result(s): Men with sperm DNA fragmentation at more than a diagnostic threshold of 25% had a high risk of infertility (OR: 117.33, 95% confidence interval [CI]: 12.72-2,731.84, RR: 8.75). Fertilization rates and embryo quality decreased as sperm DNA fragmentation increased in semen and DGC sperm. The risk of failure to achieve a pregnancy increased when sperm DNA fragmentation exceeded a prognostic threshold value of 52% for semen (OR: 76.00, CI: 8.69-1,714.44, RR: 4.75) and 42% for DGC sperm (OR: 24.18, CI: 2.89-522.34, RR: 2.16). Conclusion(s): Sperm DNA testing by the alkaline Comet assay is useful for both diagnosis of male factor infertility and prediction of IVF outcome.
MeSH term(s)	Adult ; Comet Assay/methods ; DNA Damage/physiology ; Female ; Fertilization in Vitro/methods ; Humans ; Infertility, Male/diagnosis ; Infertility, Male/genetics ; Infertility, Male/pathology ; Infertility, Male/therapy ; Male ; Middle Aged ; Pregnancy ; Prognosis ; Semen Analysis/methods ; Spermatozoa/metabolism ; Spermatozoa/pathology ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2011-02
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	80133-1
ISSN	1556-5653 ; 0015-0282
ISSN (online)	1556-5653
ISSN	0015-0282
DOI	10.1016/j.fertnstert.2010.08.019
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