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Article ; Online: Lockdown cardiomyopathy: from a COVID-19 pandemic to a loneliness pandemic.

Sekar, Baskar / Kurdi, Hibba / Smith, David

2021 Volume 28, Issue 1, Page(s) 2

Abstract: Social distancing/isolation is vital for infection control but can adversely impact on mental health. As the spread of COVID-19 is contained, mental health issues will surface with particular concerns for elderly, isolated populations. We present a case ... ...

Abstract	Social distancing/isolation is vital for infection control but can adversely impact on mental health. As the spread of COVID-19 is contained, mental health issues will surface with particular concerns for elderly, isolated populations. We present a case of Takotsubo cardiomyopathy related to lockdown anxiety.
Language	English
Publishing date	2021-11-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1354589-9
ISSN	1753-4313 ; 0969-6113
ISSN (online)	1753-4313
ISSN	0969-6113
DOI	10.5837/bjc.2021.002
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Zs.A 4578: Show issues

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Article ; Online: Women not in cardiology: where are we going wrong? A survey of the perceptions and barriers to training.

Kurdi, Hibba / Morgan, Holly / Williams, Claire

The British journal of cardiology

2020 Volume 27, Issue 4, Page(s) 30

Abstract: In the UK, there is a difference between the medical specialties and cardiology in recruitment of women. Research, thus far, has concentrated on women already in cardiology. Although invaluable in understanding barriers to training, these studies fail to ...

Abstract	In the UK, there is a difference between the medical specialties and cardiology in recruitment of women. Research, thus far, has concentrated on women already in cardiology. Although invaluable in understanding barriers to training, these studies fail to provide insight into why other trainees chose an alternative. Therefore, we designed a survey aimed at medical personnel, evaluating why higher trainees in other specialties overlooked cardiology. An online survey was distributed via email to non-cardiology higher trainees in Wales. Questions covered previous clinical experiences of cardiology, interactions with cardiologists, and tried to identify deterrent factors. There were 227 responses received over six weeks: 61.7% (n=137) female respondents, 23.5% (n=52) less than full-time. Of these, 49% completed a cardiology placement previously. Bullying was witnessed and experienced equally among genders, females witnessed and experienced sexism, 24% (n=24) and 13% (n=13), respectively. In contrast, male trainees witnessed and experienced sexism 14% (n=7) and 0%. There were 62% (n=133) who felt cardiologists and registrars were unapproachable. Work-life balance ranked first (40%), as the most important factor influencing career choice. The negative attitudes of cardiologists and registrars was ranked top 3 for not pursuing cardiology. In conclusion, many barriers exist to cardiology training including poor worklife balance, sexism and lack of less than full-time opportunities. However, this survey highlights that the behaviour of cardiologists and registrars has the potential to impact negatively on trainees. It is, therefore, our responsibility to be aware of this and encourage change.
Language	English
Publishing date	2020-10-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1354589-9
ISSN	1753-4313 ; 0969-6113
ISSN (online)	1753-4313
ISSN	0969-6113
DOI	10.5837/bjc.2020.030
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4578: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Multimodality Imaging for Cardiotoxicity: State of the Art and Future Perspectives.

Artico, Jessica / Abiodun, Aderonke / Shiwani, Hunain / Kurdi, Hibba / Chen, Daniel / Tyebally, Sara / Moon, James C / Westwood, Mark / Manisty, Charlotte H

Journal of cardiovascular pharmacology

2022 Volume 80, Issue 4, Page(s) 547–561

Abstract: Abstract: Modern cancer therapies have significantly improved survival leading to a growing population of cancer survivors. Similarly, both conventional and newer treatments are associated with a spectrum of cardiovascular disorders with potential long- ... ...

Abstract	Abstract: Modern cancer therapies have significantly improved survival leading to a growing population of cancer survivors. Similarly, both conventional and newer treatments are associated with a spectrum of cardiovascular disorders with potential long-term sequelae. Prompt detection and treatment of these complications is, therefore, pivotal to enable healthy survivorship and reduce cardiovascular morbidity. Advanced multimodality imaging is a valuable tool for stratifying patient risk, identifying cardiovascular toxicity during and after therapy, and predicting recovery. This review summarizes the potential cardiotoxic complications of anticancer therapies and the multimodality approaches available in each case with special focus on newer techniques and the added value of biomarkers ultimately leading to earlier diagnosis and better prognostication.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Biomarkers ; Cardiotoxicity/etiology ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/diagnostic imaging ; Cardiovascular System ; Humans ; Neoplasms/complications ; Neoplasms/drug therapy
Chemical Substances	Antineoplastic Agents ; Biomarkers
Language	English
Publishing date	2022-10-01
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001281
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Zs.A 1471: Show issues

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Article ; Online: Correlations Between Cardiac Magnetic Resonance and Myocardial Histologic Findings in Fabry Disease.

JACC. Cardiovascular imaging

2023 Volume 16, Issue 12, Page(s) 1629–1632

MeSH term(s)	Humans ; Fabry Disease/diagnostic imaging ; Fabry Disease/pathology ; Predictive Value of Tests ; Heart ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Hypertrophy, Left Ventricular
Language	English
Publishing date	2023-08-02
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	2491503-8
ISSN	1876-7591 ; 1936-878X
ISSN (online)	1876-7591
ISSN	1936-878X
DOI	10.1016/j.jcmg.2023.06.011
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Zs.A 6846: Show issues

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Article ; Online: Eligibility for dapagliflozin in unselected patients hospitalised with decompensated heart failure.

Kurdi, Hibba / Shah, Parin / Barker, Simon / Harris, Daniel / Dicken, Benjamin / Edwards, Carey / Jenkins, Geraint

The British journal of cardiology

2021 Volume 28, Issue 2, Page(s) 18

Abstract: Patients with heart failure with reduced ejection fraction (HFrEF) who received the sodium-glucose co-transport 2 inhibitor, dapagliflozin, in the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) study have a significant ... ...

Abstract	Patients with heart failure with reduced ejection fraction (HFrEF) who received the sodium-glucose co-transport 2 inhibitor, dapagliflozin, in the DAPA-HF (Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure) study have a significant reduction in worsening heart failure (HF) and cardiovascular death. It is uncertain what proportion of patients admitted to a large regional cardiac centre with decompensated heart failure would be eligible for dapagliflozin post-discharge based on their characteristics at discharge. The DAPA-HF study criteria were retrospectively applied to a cohort of 521 consecutive patients referred to the inpatient HF service in a tertiary cardiac centre in South West Wales between April 2017 and April 2018. Inclusion criteria: left ventricular ejection fraction (LVEF) < 40%, New York Heart Association (NYHA) class II-IV symptoms and an elevated N-terminal pro-B-type naturietic peptide (NT-proBNP). Exclusion criteria: systolic blood pressure (SBP) < 95 mmHg, estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m2 or type 1 diabetes mellitus. We did not have complete NTproBNP data for the cohort, as it was not routinely measured at the time in our institute. There were 478 patients, mean age 78 ± 13 years, 57% male and 91% NYHA class II-IV symptoms, were included in the analysis. Of these, 247 patients had HFrEF, 219 (46%) patients met the inclusion criteria, 231 (48%) were excluded as LVEF was > 40%, and 48 (10%) were excluded with NYHA class I symptoms. Of the 219 patients who met the inclusion criteria, 13 (5.9%) had a SBP < 95 mmHg, 48 (22%) had eGFR < 30 ml/min/1.73 m2, leaving 136 (28.5% of total and 55% of those with HFrEF) who met DAPA-HF study criteria. In our study, 28.5% of all heart failure admissions and 55% of patients with HFrEF would be eligible for dapagliflozin post-discharge according to the DAPA-HF study entry criteria.
Language	English
Publishing date	2021-04-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1354589-9
ISSN	1753-4313 ; 0969-6113
ISSN (online)	1753-4313
ISSN	0969-6113
DOI	10.5837/bjc.2021.018
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4578: Show issues

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Article: Multiple spontaneous coronary thrombosis causing ST-elevation myocardial infarction in a patient with COVID-19.

Kurdi, Hibba / Obaid, Daniel R / UlHaq, Zia / Ionescu, Adrian / Sekar, Baskar

British journal of hospital medicine (London, England : 2005)

2020 Volume 81, Issue 7, Page(s) 1–6

MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronary Angiography ; Coronary Thrombosis/complications ; Coronary Thrombosis/diagnostic imaging ; Coronary Thrombosis/therapy ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Percutaneous Coronary Intervention ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/etiology ; ST Elevation Myocardial Infarction/therapy ; Tomography, X-Ray Computed
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Case Reports ; Journal Article
ISSN	1750-8460
ISSN	1750-8460
DOI	10.12968/hmed.2020.0337
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical utilisation of implantable loop recorders in adults with Fabry disease-a multi-centre snapshot study.

Roy, Ashwin / Vijapurapu, Ravi / Kurdi, Hibba / Orsborne, Christopher / Woolfson, Peter / Kalla, Manish / Jovanovic, Ana / Miller, Christopher A / Moon, James C / Hughes, Derralynn A / Geberhiwot, Tarekegn / Steeds, Richard P

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1323214

Abstract: Fabry disease (FD) is an X-linked deficiency of alpha-galactosidase-A, leading to lysosomal storage of sphingolipids in multiple organs. Myocardial accumulation contributes to arrhythmia and sudden death, the most common cause of FD mortality. Therefore, ...

Abstract	Fabry disease (FD) is an X-linked deficiency of alpha-galactosidase-A, leading to lysosomal storage of sphingolipids in multiple organs. Myocardial accumulation contributes to arrhythmia and sudden death, the most common cause of FD mortality. Therefore, there is a need for risk stratification and prediction to target device therapy. Implantable loop recorders (ILRs) allow for continual rhythm monitoring for up to 3 years. Here, we performed a retrospective study to evaluate current ILR utilisation in FD and quantify the burden of arrhythmia that was detected, which resulted in a modification of therapy. This was a snapshot assessment of 915 patients with FD across three specialist centres in England during the period between 1 January 2000 and 1 September 2022. In total, 22 (2.4%) patients underwent clinically indicated ILR implantation. The mean implantation age was 50 years and 13 (59%) patients were female. Following implantation, nine (41%) patients underwent arrhythmia detection, requiring intervention (six on ILR and three post-ILR battery depletion). Three patients experienced sustained atrial high-rate episodes and were started on anticoagulation. Three had non-sustained tachyarrhythmia and were started on beta blockers. Post-ILR battery depletion, one suffered complete heart block and two had sustained ventricular tachycardia, all requiring device therapy. Those with arrhythmia had a shorter PR interval on electrocardiography. This study demonstrates that ILR implantation in FD uncovers a high burden of arrhythmia. ILRs are likely to be underutilised in this pro-arrhythmic cohort, perhaps restricted to those with advanced FD cardiomyopathy. Following battery depletion in three patients as mentioned above, greater vigilance and arrhythmia surveillance are advised for those experiencing major arrhythmic events post-ILR monitoring. Further work is required to establish who would benefit most from implantation.
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1323214
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Massive pulmonary embolism in patients with extreme bleeding risk: a case series on the successful use of ultrasound-assisted, catheter directed thrombolysis in a district general hospital.

He, Jingzhou / Clayton, Benjamin / Kurdi, Hibba / Gibbons, Michael / Watkinson, Anthony / Sharp, Andrew S P

Journal of thrombosis and thrombolysis

2020 Volume 51, Issue 4, Page(s) 1120–1126

Abstract: Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or cardiovascular collapse in these ... ...

Abstract	Massive pulmonary embolism (PE), characterised by profound arterial hypotension, is a life-threatening emergency with a 90-day mortality of over 50%. Systemic thrombolysis can significantly reduce the risk of death or cardiovascular collapse in these patients, by around 50%, but these benefits are offset by a fivefold increased risk of intracranial haemorrhage and major bleeding, which may limit its use in patients at high risk of catastrophic haemorrhage. We describe a case series of 3 patients presenting with massive PE, each with extreme risk of bleeding and contra-indication to systemic thrombolysis, treated successfully with ultrasound-assisted, catheter directed thrombolysis (U-ACDT). Our experience of this novel technique using the EkoSonic Endovascular System (Ekos, BTG, London, UK) on carefully selected patients has demonstrated the potential to improve clinical status in shocked patients, with minimal bleed risk. There have been several clinical studies evaluating the Ekos system. Both the ULTIMA and SEATTLE II studies have shown significant reductions in RV/LV ratio by CT scanning when compared to standard anticoagulation in patients with intermediate-risk PE, with minimal bleeding complications. However, there is a pressing need for a randomised trial demonstrating improvement in robust clinical outcomes when comparing U-ACDT to simple anticoagulation. We believe that this case series adds new insight and highlights the potential of catheter directed thrombolysis in this high-risk patient cohort and consideration should be made to its use in cases where systemic thrombolysis is felt to be too high risk.
MeSH term(s)	Anticoagulants/therapeutic use ; Catheters ; Fibrinolytic Agents/therapeutic use ; Hemorrhage ; Hospitals, General ; Humans ; Pulmonary Embolism/drug therapy ; Thrombolytic Therapy ; Treatment Outcome
Chemical Substances	Anticoagulants ; Fibrinolytic Agents
Language	English
Publishing date	2020-08-31
Publishing country	Netherlands
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1230645-9
ISSN	1573-742X ; 0929-5305
ISSN (online)	1573-742X
ISSN	0929-5305
DOI	10.1007/s11239-020-02258-6
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Article: Multiple spontaneous coronary thrombosis causing ST-elevation myocardial infarction in a patient with COVID-19

Kurdi, Hibba / Obaid, Daniel R / UlHaq, Zia / Ionescu, Adrian / Sekar, Baskar

Br J Hosp Med (Lond)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #690701
Database	COVID19

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Article ; Online: Impact of COVID-19 on primary percutaneous coronary intervention centres in the UK: a survey.

Adlan, Ahmed M / Lim, Ven G / Dhillon, Gurpreet / Kurdi, Hibba / Doolub, Gemina / Elamin, Nadir / Aziz, Amir / Sastry, Sanjay / Davis, Gershan

The British journal of cardiology

2020 Volume 27, Issue 2, Page(s) 17

Abstract: During the coronavirus disease (COVID-19) pandemic, the British Cardiovascular Society/British Cardiovascular Intervention Society and the British Heart Rhythm Society recommended to postpone non-urgent elective work and that primary percutaneous ... ...

Abstract	During the coronavirus disease (COVID-19) pandemic, the British Cardiovascular Society/British Cardiovascular Intervention Society and the British Heart Rhythm Society recommended to postpone non-urgent elective work and that primary percutaneous coronary intervention (PCI) should remain the treatment of choice for patients with ST-segment elevation myocardial infarction (STEMI). We sought to determine the impact of COVID-19 on the primary PCI service within the United Kingdom (UK). A survey of 43 UK primary PCI centres was performed and a significant reduction in the number of cath labs open was found (pre-COVID 3.6±1.8
Language	English
Publishing date	2020-06-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1354589-9
ISSN	1753-4313 ; 0969-6113
ISSN (online)	1753-4313
ISSN	0969-6113
DOI	10.5837/bjc.2020.017
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