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  1. Article: Multidimensional Impact of Dupilumab on Chronic Rhinosinusitis with Nasal Polyps: A Complete Health Technology Assessment of Clinical, Economic, and Non-Clinical Domains.

    La Mantia, Ignazio / Ottaviano, Giancarlo / Ragusa, Martina / Trimarchi, Matteo / Foglia, Emanuela / Schettini, Fabrizio / Bellavia, Daniele / Cantone, Elena

    Journal of personalized medicine

    2024  Volume 14, Issue 4

    Abstract: Chronic RhinoSinusitis with Nasal Polyps (CRSwNP) represents a condition mainly caused by the type 2 inflammation presence and marked by the existence of polyps within the nasal and paranasal sinuses. The standard of care includes intranasal steroids, ... ...

    Abstract Chronic RhinoSinusitis with Nasal Polyps (CRSwNP) represents a condition mainly caused by the type 2 inflammation presence and marked by the existence of polyps within the nasal and paranasal sinuses. The standard of care includes intranasal steroids, additional burst of systemic steroids, if needed, and surgery. However, recurrence is common, especially among patients with comorbid type 2 inflammatory diseases. Recently, biological drugs, addressing the underlying cause of the disease, have been approved in Italy (dupilumab, omalizumab, and mepolizumab). A Health Technology Assessment was conducted to define multidimensional impact, assuming Italian NHS perspective and a 12-month time horizon. The EUnetHTA Core Model was deployed, using the following methods to analyze the domains: (i) literature evidence; (ii) administration of semi-structured questionnaires to 17 healthcare professionals; (iii) health economics tools to define the economic sustainability for the system. Evidence from NMA and ITC showed a more favorable safety profile and better efficacy for dupilumab compared with alternative biologics. All the analyses, synthesizing cost and efficacy measures, showed that dupilumab is the preferable alternative. Specifically, the cost per responder analysis for dupilumab, exhibiting a 67.0% response rate at Week 52, is notably economical at 14,209EUR per responder. This presents a more economical profile compared with the cost per responder for omalizumab (36.2% response rate) at 24,999EUR and mepolizumab (28.5% response rate) at 31,863EUR. These results underscore dupilumab's potential, not merely in terms of clinical outcomes, but also in terms of economic rationality, thereby solidifying its status as a valid and preferrable alternative in the management of CRSwNP, in the context of the Italian NHS.
    Language English
    Publishing date 2024-03-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14040347
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Obstructive Sleep Apnoea in Children with Down Syndrome: A Multidisciplinary Approach.

    Borrelli, Melissa / Corcione, Adele / Rongo, Roberto / Cantone, Elena / Scala, Iris / Bruzzese, Dario / Martina, Stefano / Strisciuglio, Pietro / Michelotti, Ambrosina / Santamaria, Francesca

    Journal of personalized medicine

    2022  Volume 13, Issue 1

    Abstract: A comprehensive evaluation of obstructive sleep apnoea (OSA) may allow for the development of more efficient management of Down syndrome (DS). We aimed to evaluate the effect of a multidisciplinary approach to DS with OSA. A total of 48 DS children aged ... ...

    Abstract A comprehensive evaluation of obstructive sleep apnoea (OSA) may allow for the development of more efficient management of Down syndrome (DS). We aimed to evaluate the effect of a multidisciplinary approach to DS with OSA. A total of 48 DS children aged 4−12 years were prospectively investigated with nasal endoscopy, orthodontic examination, and overnight polygraphy (PG); the Italian Child Sleep Habits Questionnaire (CSHQ-IT) was filled out by the mothers. The total CSHQ-IT score was 63 (96% of children reporting sleep problems). The major ear, nose, and throat characteristics were enlarged palatine tonsils (62%), adenoid tonsils (85%), and chronic rhinosinusitis (85%). DS children showed orthognathic profile in 68% of cases, class I relationship in 63%, and cross-bite in 51%. PG revealed OSA in 67% of cases (37% mild, 63% moderate−severe). The oxygen desaturation index (ODI) was higher in the group with OSA (5.2) than with non-OSA (1.3; p < 0.001). The ODI was higher (p = 0.001) and SpO2 lower (p = 0.03) in children with moderate−severe OSA than with mild OSA. The apnoea−hypopnea index (AHI) and percentage time with SpO2 < 90% were higher in DS children with grade III than with grade I or II adenoids (5 vs. 1, p = 0.04, and 1.2 vs. 0.1, p = 0.01, respectively). No significant correlations were found between PG and the total CSHQ-IT score or orthodontic data. However, children showing associated cross-bite, grade III adenoids and size 3 or 4 palatine tonsils showed higher AHI and ODI than those without (p = 0.01 and p = 0.04, respectively). A coordinated multidisciplinary approach with overnight PG is a valuable tool when developing diagnostic protocols for OSA in DS.
    Language English
    Publishing date 2022-12-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm13010071
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Adaptation to Varying Salinity in

    Hobmeier, Karina / Cantone, Martina / Nguyen, Quynh Anh / Pflüger-Grau, Katharina / Kremling, Andreas / Kunte, Hans Jörg / Pfeiffer, Friedhelm / Marin-Sanguino, Alberto

    Frontiers in microbiology

    2022  Volume 13, Page(s) 846677

    Abstract: The halophilic γ- ... ...

    Abstract The halophilic γ-proteobacterium
    Language English
    Publishing date 2022-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.846677
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction to: Linguistic adaptation and psychometric evaluation of Italian version of children's sleep habits questionnaire.

    Borrelli, Melissa / Scala, Iris / Festa, Paola / Bruzzese, Dario / Michelotti, Ambrosina / Cantone, Elena / Corcione, Adele / Fragnito, Martina / Miranda, Vincenzo / Santamaria, Francesca

    Italian journal of pediatrics

    2021  Volume 47, Issue 1, Page(s) 216

    Language English
    Publishing date 2021-11-03
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-021-01159-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Book ; Online ; Thesis: Computational Methods for Analysis and Simulations of High Throughput Scale Regulatory Networks in Neurobiology

    Cantone, Martina [Verfasser] / Vera González, Julio [Akademischer Betreuer] / Vera González, Julio [Gutachter]

    2020  

    Author's details Martina Cantone ; Gutachter: Julio Vera González ; Betreuer: Julio Vera González
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU)
    Publishing place Erlangen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Linguistic adaptation and psychometric evaluation of Italian version of children's sleep habits questionnaire.

    Borrelli, Melissa / Scala, Iris / Festa, Paola / Bruzzese, Dario / Michelotti, Ambrosina / Cantone, Elena / Corcione, Adele / Fragnito, Martina / Miranda, Vincenzo / Santamaria, Francesca

    Italian journal of pediatrics

    2021  Volume 47, Issue 1, Page(s) 170

    Abstract: Background: The Children's Sleep Habits Questionnaire (CSHQ) is a parent-report questionnaire used to examine sleep behavior in children. Linguistic adaptation of CSHQ into several languages and/or psychometric analysis of reliability have been ... ...

    Abstract Background: The Children's Sleep Habits Questionnaire (CSHQ) is a parent-report questionnaire used to examine sleep behavior in children. Linguistic adaptation of CSHQ into several languages and/or psychometric analysis of reliability have been published.
    Main text: Our aim was to translate the original 33-items CSHQ from English to Italian and to examine its reliability for use in 4-10 years-old children of Italy. After translation and back-translation procedure of the original CSHQ, the Italian CSHQ (CSHQ-IT) was administered to 69 mothers of healthy children. Reliability of CSHQ-IT was examined by the internal consistency of the scale (using the Cronbach's alpha coefficient), and by the test-retest analysis obtained by asking mothers who had completed the CSHQ-IT at baseline to re-complete it after a two-week interval (measured with the Lin's Concordance Correlation Coefficient, CCC). The CSHQ-IT showed adequate internal consistency (Cronbach's alpha = 0.81 for the total scale). The total CSHQ-IT score showed a strong correlation in retests (CCC 0.87; 95% Confidence Interval, 0.80; 0.92).
    Conclusion: CSHQ-IT is a valuable tool for evaluating sleep behavior in children 4-10 years-old in Italy. Future research should be implemented to provide definitive validity of CSHQ-IT in children with sleep-disordered breathing.
    MeSH term(s) Child ; Child, Preschool ; Humans ; Italy ; Language ; Psychometrics ; Reproducibility of Results ; Sleep ; Surveys and Questionnaires ; Translations
    Language English
    Publishing date 2021-08-09
    Publishing country England
    Document type Letter
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/s13052-021-01119-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1961: Show issues Location:
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  7. Article: Corrigendum: Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection.

    Cantone, Martina / Santos, Guido / Wentker, Pia / Lai, Xin / Vera, Julio

    Frontiers in physiology

    2017  Volume 8, Page(s) 817

    Abstract: This corrects the article on p. 645 in vol. 8, PMID: 28912729.]. ...

    Abstract [This corrects the article on p. 645 in vol. 8, PMID: 28912729.].
    Language English
    Publishing date 2017-10-30
    Publishing country Switzerland
    Document type Journal Article ; Published Erratum
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2017.00817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identification of 2,4-Dinitro-Biphenyl-Based Compounds as MAPEG Inhibitors.

    Di Micco, Simone / Terracciano, Stefania / Pierri, Martina / Cantone, Vincenza / Liening, Stefanie / König, Stefanie / Garscha, Ulrike / Hofstetter, Robert Klaus / Koeberle, Andreas / Werz, Oliver / Bruno, Ines / Bifulco, Giuseppe

    ChemMedChem

    2022  Volume 17, Issue 22, Page(s) e202200327

    Abstract: We identified 2,4-dinitro-biphenyl-based compounds as new inhibitors of leukotriene ... ...

    Abstract We identified 2,4-dinitro-biphenyl-based compounds as new inhibitors of leukotriene C
    MeSH term(s) Molecular Docking Simulation ; Glutathione Transferase ; 5-Lipoxygenase-Activating Proteins ; Biphenyl Compounds/pharmacology ; Prostaglandin-E Synthases/metabolism
    Chemical Substances diphenyl (2L9GJK6MGN) ; Glutathione Transferase (EC 2.5.1.18) ; 5-Lipoxygenase-Activating Proteins ; Biphenyl Compounds ; Prostaglandin-E Synthases (EC 5.3.99.3)
    Language English
    Publishing date 2022-10-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202200327
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6280: Show issues Location:
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  9. Article: Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection.

    Cantone, Martina / Santos, Guido / Wentker, Pia / Lai, Xin / Vera, Julio

    Frontiers in physiology

    2017  Volume 8, Page(s) 645

    Abstract: Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among the 10 most frequent causes of death worldwide. These infections still lack effective treatments in many developing countries and in immunocompromised populations like ...

    Abstract Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among the 10 most frequent causes of death worldwide. These infections still lack effective treatments in many developing countries and in immunocompromised populations like infants, elderly people and transplanted patients. The interaction between bacteria and the host is a complex system of interlinked intercellular and the intracellular processes, enriched in regulatory structures like positive and negative feedback loops. Severe pathological condition can emerge when the immune system of the host fails to neutralize the infection. This failure can result in systemic spreading of pathogens or overwhelming immune response followed by a systemic inflammatory response. Mathematical modeling is a promising tool to dissect the complexity underlying pathogenesis of bacterial lung infection at the molecular, cellular and tissue levels, and also at the interfaces among levels. In this article, we introduce mathematical and computational modeling frameworks that can be used for investigating molecular and cellular mechanisms underlying bacterial lung infection. Then, we compile and discuss published results on the modeling of regulatory pathways and cell populations relevant for lung infection and inflammation. Finally, we discuss how to make use of this multiplicity of modeling approaches to open new avenues in the search of the molecular and cellular mechanisms underlying bacterial infection in the lung.
    Language English
    Publishing date 2017-08-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2017.00645
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Transcriptional Profiling of Ligand Expression in Cell Specific Populations of the Adult Mouse Forebrain That Regulates Neurogenesis.

    Azim, Kasum / Akkermann, Rainer / Cantone, Martina / Vera, Julio / Jadasz, Janusz J / Küry, Patrick

    Frontiers in neuroscience

    2018  Volume 12, Page(s) 220

    Abstract: In the adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates mainly neurons and few glial cells lifelong. A large body of evidence has shed ... ...

    Abstract In the adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the largest and most active source of neural stem cells (NSCs) that generates mainly neurons and few glial cells lifelong. A large body of evidence has shed light on the distinct families of signaling ligands (i.e., morphogens, growth factors, secreted molecules that alter signaling pathways) in regulating NSC biology. However, most of the research has focused on the mRNA expression of individual or few signaling ligands and their pathway components in specific cell types of the CNS in the context of neurogenesis. A single unifying study that underlines the expression of such molecules comprehensively in different cell types in spatial contexts has not yet been reported. By using whole genome transcriptome datasets of individual purified cell specific populations of the adult CNS, the SVZ niche, NSCs, glial cells, choroid plexus, and performing a bioinformatic meta-analysis of signaling ligands, their expression in the forebrain was uncovered. Therein, we report that a large plethora of ligands are abundantly expressed in the SVZ niche, largely from the vasculature than from other sources that may regulate neurogenesis. Intriguingly, this sort of analysis revealed a number of ligands with unknown functions in neurogenesis contexts that warrants further investigations. This study therefore serves as a framework for investigators in the field for understanding the expression patterns of signaling ligands and pathways regulating neurogenesis.
    Language English
    Publishing date 2018-04-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2018.00220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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