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  1. Book ; Online: Brain and Human Body Modeling 2020

    Makarov, Sergey N. / Noetscher, Gregory M. / Nummenmaa, Aapo

    2021  

    Abstract: This open access book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields. Readers working on any ... ...

    Abstract ​This open access book describes modern applications of computational human modeling in an effort to advance neurology, cancer treatment, and radio-frequency studies including regulatory, safety, and wireless communication fields. Readers working on any application that may expose human subjects to electromagnetic radiation will benefit from this book's coverage of the latest models and techniques available to assess a given technology's safety and efficacy in a timely and efficient manner. Describes computational human body phantom construction and application; Explains new practices in computational human body modeling for electromagnetic safety and exposure evaluations; Includes a survey of modern applications for which computational human phantoms are critical
    Keywords Medicine (General) ; Agriculture (General)
    Size 1 electronic resource (407 pages)
    Publisher Springer Nature
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020676428
    ISBN 9783030456238 ; 3030456234
    DOI 10.1007/978-3-030-45623-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Brain and Human Body Modeling 2020

    Makarov, Sergey N. / Noetscher, Gregory M. / Nummenmaa, Aapo

    Computational Human Models Presented at EMBC 2019 and the BRAIN Initiative® 2019 Meeting

    2021  

    Author's details edited by Sergey N. Makarov, Gregory M. Noetscher, Aapo Nummenmaa
    Keywords Biomedical engineering ; Electronic circuits
    Subject code 610.28
    Language English
    Size 1 Online-Ressource (XI, 407 p. 223 illus., 199 illus. in color)
    Edition 1st ed. 2021
    Publisher Springer International Publishing ; Imprint: Springer
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT020568157
    ISBN 978-3-030-45623-8 ; 9783030456221 ; 9783030456245 ; 9783030456252 ; 3-030-45623-4 ; 3030456226 ; 3030456242 ; 3030456250
    DOI 10.1007/978-3-030-45623-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article: Editorial: Neuroelectronics: towards symbiosis of neuronal systems and emerging electronics.

    Mikhaylov, Alexey N / Shchanikov, Sergey A / Demin, Vyacheslav A / Makarov, Valeri A / Kazantsev, Victor B

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1227798

    Language English
    Publishing date 2023-06-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1227798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Electric Field Comparison for TMS Using Different Neuroimaging Segmentation Methods.

    Zaidi, Tayeb A / Makarov, Sergey N / Fujimoto, Kyoko

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

    2021  Volume 2021, Page(s) 6565–6568

    Abstract: Computational electromagnetic modeling is a powerful technique to evaluate the effects of electrical stimulation of the human brain. The results of these simulations can vary depending on the specific segmentation of the head and brain generated from the ...

    Abstract Computational electromagnetic modeling is a powerful technique to evaluate the effects of electrical stimulation of the human brain. The results of these simulations can vary depending on the specific segmentation of the head and brain generated from the patient images. Using an existing boundary element fast multipole method (BEM-FMM) electromagnetic solver, this work evaluates the electric field differences modeled using two neuroimaging segmentation methods. A transcranial magnetic stimulation (TMS) coil targeting both the primary motor cortex and the dorsolateral prefrontal cortex (DLPFC) was simulated. Average field differences along a 100 mm line from the coil were small (2% for motor cortex, 3% for DLPFC) and the average field differences in the regions directly surrounding the target stimulation point were 5% for the motor cortex and 2% for DLPFC. More studies evaluating different coils and other segmentation options may further improve the computational modeling for robust TMS treatment.Clinical relevance- Patient-specific computational modeling will provide more information to clinicians for improved localization and targeting of neuromodulation therapies.
    MeSH term(s) Brain/diagnostic imaging ; Dorsolateral Prefrontal Cortex ; Humans ; Motor Cortex/diagnostic imaging ; Neuroimaging ; Transcranial Magnetic Stimulation
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 2694-0604
    ISSN (online) 2694-0604
    DOI 10.1109/EMBC46164.2021.9630719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Synthesis of the Indole-Based Inhibitors of Bacterial Cystathionine γ-Lyase NL1-NL3.

    Potapov, Konstantin V / Novikov, Roman A / Novikov, Maxim A / Solyev, Pavel N / Tomilov, Yury V / Kochetkov, Sergey N / Makarov, Alexander A / Mitkevich, Vladimir A

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 8

    Abstract: Bacterial cystathionine γ-lyase (bCSE) is the main producer of ... ...

    Abstract Bacterial cystathionine γ-lyase (bCSE) is the main producer of H
    MeSH term(s) Cystathionine gamma-Lyase ; Anti-Bacterial Agents/chemistry ; Indoles/chemistry ; Bacteria
    Chemical Substances Cystathionine gamma-Lyase (EC 4.4.1.1) ; Anti-Bacterial Agents ; Indoles
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28083568
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 81: Show issues

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  6. Article: Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors.

    Alexandrova, Liudmila A / Khandazhinskaya, Anastasia L / Matyugina, Elena S / Makarov, Dmitriy A / Kochetkov, Sergey N

    Microorganisms

    2022  Volume 10, Issue 7

    Abstract: Tuberculosis (TB) is the oldest human infection disease. Mortality from TB significantly decreased in the 20th century, because of vaccination and the widespread use of antibiotics. However, about a third of the world's population is currently infected ... ...

    Abstract Tuberculosis (TB) is the oldest human infection disease. Mortality from TB significantly decreased in the 20th century, because of vaccination and the widespread use of antibiotics. However, about a third of the world's population is currently infected with
    Language English
    Publishing date 2022-06-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms10071299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perovskite Nanowire Laser for Hydrogen Chloride Gas Sensing.

    Markina, Daria I / Anoshkin, Sergey S / Masharin, Mikhail A / Khubezhov, Soslan A / Tzibizov, Ivan / Dolgintsev, Dmitriy / Terterov, Ivan N / Makarov, Sergey V / Pushkarev, Anatoly P

    ACS nano

    2023  

    Abstract: Detection of hazardous volatile organic and inorganic species is a crucial task for addressing human safety in the chemical industry. Among these species, there are hydrogen halides (HX, X = Cl, Br, I) vastly exploited in numerous technological processes. ...

    Abstract Detection of hazardous volatile organic and inorganic species is a crucial task for addressing human safety in the chemical industry. Among these species, there are hydrogen halides (HX, X = Cl, Br, I) vastly exploited in numerous technological processes. Therefore, the development of a cost-effective, highly sensitive detector selective to any HX gas is of particular interest. Herein, we demonstrate the optical detection of hydrogen chloride gas with solution-processed halide perovskite nanowire lasers grown on a nanostructured alumina substrate. An anion exchange reaction between a CsPbBr
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.2c11013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effect of meninges on the electric fields in TES and TMS. Numerical modeling with adaptive mesh refinement.

    Weise, Konstantin / Wartman, William A / Knösche, Thomas R / Nummenmaa, Aapo R / Makarov, Sergey N

    Brain stimulation

    2022  Volume 15, Issue 3, Page(s) 654–663

    Abstract: Background: When modeling transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS) in the brain, the meninges - dura, arachnoid, and pia mater - are often neglected due to high computational costs.: Objective: We ... ...

    Abstract Background: When modeling transcranial electrical stimulation (TES) and transcranial magnetic stimulation (TMS) in the brain, the meninges - dura, arachnoid, and pia mater - are often neglected due to high computational costs.
    Objective: We investigate the impact of the meningeal layers on the cortical electric field in TES and TMS while considering the headreco segmentation as the base model.
    Method: We use T1/T2 MRI data from 16 subjects and apply the boundary element fast multipole method with adaptive mesh refinement, which enables us to accurately solve this problem and establish method convergence at reasonable computational cost. We compare electric fields in the presence and absence of various meninges for two brain areas (M1
    Results: Maximum electric fields in the cortex for focal TES consistently increase by approximately 30% on average when the meninges are present in the CSF volume. Their effect on the maximum field can be emulated by reducing the CSF conductivity from 1.65 S/m to approximately 0.85 S/m. In stark contrast to that, the TMS electric fields in the cortex are only weakly affected by the meningeal layers and slightly (∼6%) decrease on average when the meninges are included.
    Conclusion: Our results quantify the influence of the meninges on the cortical TES and TMS electric fields. Both focal TES and TMS results are very consistent. The focal TES results are also in a good agreement with a prior relevant study. The solver and the mesh generator for the meningeal layers (compatible with SimNIBS) are available online.
    MeSH term(s) Brain/physiology ; Humans ; Meninges ; Surgical Mesh ; Transcranial Direct Current Stimulation/methods ; Transcranial Magnetic Stimulation/methods
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2022.04.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6740: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Synthetic Optimizations for Gram-Scale Preparation of 1-

    Potapov, Konstantin V / Novikov, Roman A / Solyev, Pavel N / Kochetkov, Sergey N / Makarov, Alexander A / Mitkevich, Vladimir A

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 21

    Abstract: Heptose phosphates-unique linkers between endotoxic lipid A ... ...

    Abstract Heptose phosphates-unique linkers between endotoxic lipid A and
    MeSH term(s) Phosphates ; Glucose ; Heptoses ; Pathogen-Associated Molecular Pattern Molecules ; Lipopolysaccharides
    Chemical Substances Phosphates ; Glucose (IY9XDZ35W2) ; Heptoses ; Pathogen-Associated Molecular Pattern Molecules ; Lipopolysaccharides
    Language English
    Publishing date 2022-11-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27217534
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: 5-Substituted Uridines with Activity against Gram-Positive Bacteria.

    Makarov, Dmitry A / Negrya, Sergey D / Jasko, Maxim V / Karpenko, Inna L / Solyev, Pavel N / Chekhov, Vladimir O / Kaluzhny, Dmitry N / Efremenkova, Olga V / Vasilyeva, Byazilya F / Chizhov, Alexander O / Avdanina, Darya A / Zhgun, Alexander A / Kochetkov, Sergey N / Alexandrova, Liudmila A

    ChemMedChem

    2023  Volume 18, Issue 21, Page(s) e202300366

    Abstract: The emergence of drug-resistant strains of pathogenic microorganisms necessitates the creation of new drugs. A series of uridine derivatives containing an extended substituent at the C-5 position as well as C-5 alkyloxymethyl, alkylthiomethyl, ... ...

    Abstract The emergence of drug-resistant strains of pathogenic microorganisms necessitates the creation of new drugs. A series of uridine derivatives containing an extended substituent at the C-5 position as well as C-5 alkyloxymethyl, alkylthiomethyl, alkyltriazolylmethyl, alkylsulfinylmethyl and alkylsulfonylmethyl uridines were obtained in order to explore their antimicrobial properties and solubility. It has been shown that new ribonucleoside derivatives have an order of magnitude better solubility in water compared to their 2'-deoxy analogues and effectively inhibit the growth of a number of Gram-positive bacteria, including resistant strains of Mycobacterium smegmatis (MIC=15-200 μg/mL) and Staphylococcus aureus (MIC=25-100 μg/mL). Their activity is comparable to that of some antibiotics used in medicine.
    MeSH term(s) Uridine/pharmacology ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Gram-Positive Bacteria ; Gram-Negative Bacteria
    Chemical Substances Uridine (WHI7HQ7H85) ; Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-10-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2218496-X
    ISSN 1860-7187 ; 1860-7179
    ISSN (online) 1860-7187
    ISSN 1860-7179
    DOI 10.1002/cmdc.202300366
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6280: Show issues Location:
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