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  1. Article ; Online: Medicine-Engineering Interdisciplinary Research Based on Bibliometric Analysis: A Case Study on Medicine-Engineering Institutional Cooperation of Shanghai Jiao Tong University.

    Wang, Qingwen / Cui, Tingting / Deng, Peiwen

    Journal of Shanghai Jiaotong University (science)

    2022  , Page(s) 1–16

    Abstract: ... Targeted at the scientific literature and patent literature published by Shanghai Jiao Tong University ...

    Abstract This article aims to provide reference for medicine-engineering interdisciplinary research. Targeted at the scientific literature and patent literature published by Shanghai Jiao Tong University, this article attempts to set up co-occurrence matrix of medicine-engineering institutional information which was extracted from address fields of the papers, so as to construct the medicine-engineering intersection datasets. The dataset of scientific literature was analyzed using bibliometrics and visualization methods from multiple dimensions, and the most active factors, such as trends of output, journal and subject distribution, were identified from the indicators of category normalized citation impact (CNCI), times cited, keywords, citation topics and the degree of medicine-engineering interdisplinary. Research on hotspots and trends was discussed in detail. Analyses of the dataset of patent literature showed research themes and measured the degree for technology convergence of medicine-engineering.
    Language English
    Publishing date 2022-05-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 2630146-5
    ISSN 1995-8188 ; 1007-1172
    ISSN (online) 1995-8188
    ISSN 1007-1172
    DOI 10.1007/s12204-022-2418-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sanjin tablets for acute uncomplicated lower urinary tract infection (syndrome of dampness-heat in the lower jiao)

    Jian Lyu / Yan-ming Xie / Zhan Gao / Jian-wu Shen / Yue-yi Deng / Song-tao Xiang / Wen-xi Gao / Wen-tong Zeng / Chun-he Zhang / Dan-hui Yi / Lian-xin Wang / Zhi-fei Wang

    Trials, Vol 20, Iss 1, Pp 1-

    protocol for randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical trial

    2019  Volume 9

    Abstract: ... in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental ...

    Abstract Abstract Background Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency, and suprapubic pain or tenderness. Approximately 150 million people are diagnosed with UTI each year worldwide. The high recurrence rate of lower UTI is a common problem of clinical treatment. The misuse of antibiotics has led to the emergence of a number of resistant bacterial strains. Thus, traditional Chinese medicine is considered as an alternative option for treating acute uncomplicated lower UTI. Thus, this study aims to evaluate the efficacy and safety of Sanjin tablets (SJT) for the treatment of acute uncomplicated lower UTI, explore whether SJT can reduce or substitute the use of antibiotics, and reduce the recurrence rate in the treatment of acute uncomplicated lower UTI. Methods/design In this study, a randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical study will be established. A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group; control group 1; and control group 2. The experimental group receives Sanjin tablets plus levofloxacin tablets (LT) placebo; the control group 1 receives LT plus SJT placebo; and the control group 2 receives SJT plus LT on the first five days, SJT plus LT placebo on the last two days. Each group will be treated for seven days and followed-up 1–2 times. The primary outcome measures of effective rate and recurrence rate are symptoms. Secondary outcome measures of effective rate and recurrence rate are the urine leukocytes, bacteriology examination, and safety assessment. Outcomes will be assessed at baseline and after treatment. Discussion This study protocol will provide the research data of efficacy and safety of SJT for the treatment of acute uncomplicated lower UTI. The first aim is to determine whether Sanjin tablets can reduce the use of antibiotics; the second aim is to determine whether Sanjin tablets can substitute the use of antibiotics. The recurrence rate will be assessed after cured to determine whether SJT can reduce the recurrence rate. The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment. Trial registration ClinicalTrials.gov, NCT03658291. Registered on 4 September 2018.
    Keywords Acute uncomplicated UTI ; Syndrome of dampness-heat in the lower jiao ; Randomized controlled trial ; Clinical trials ; Sanjin tablets ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2019-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Sanjin tablets for acute uncomplicated lower urinary tract infection (syndrome of dampness-heat in the lower jiao): protocol for randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical trial.

    Lyu, Jian / Xie, Yan-Ming / Gao, Zhan / Shen, Jian-Wu / Deng, Yue-Yi / Xiang, Song-Tao / Gao, Wen-Xi / Zeng, Wen-Tong / Zhang, Chun-He / Yi, Dan-Hui / Wang, Lian-Xin / Wang, Zhi-Fei

    Trials

    2019  Volume 20, Issue 1, Page(s) 446

    Abstract: ... patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be ...

    Abstract Background: Acute uncomplicated lower urinary tract infection (UTI) is one of the most common bacterial infections. Patients usually present with dysuria, urinary urgency, urinary frequency, and suprapubic pain or tenderness. Approximately 150 million people are diagnosed with UTI each year worldwide. The high recurrence rate of lower UTI is a common problem of clinical treatment. The misuse of antibiotics has led to the emergence of a number of resistant bacterial strains. Thus, traditional Chinese medicine is considered as an alternative option for treating acute uncomplicated lower UTI. Thus, this study aims to evaluate the efficacy and safety of Sanjin tablets (SJT) for the treatment of acute uncomplicated lower UTI, explore whether SJT can reduce or substitute the use of antibiotics, and reduce the recurrence rate in the treatment of acute uncomplicated lower UTI.
    Methods/design: In this study, a randomized, double-blind, double-dummy, parallel control of positive drug, multicenter clinical study will be established. A total of 252 patients with acute uncomplicated lower UTI (syndrome of dampness-heat in the lower jiao) will be randomly allocated in the ratio of 1:1:1 to three groups: experimental group; control group 1; and control group 2. The experimental group receives Sanjin tablets plus levofloxacin tablets (LT) placebo; the control group 1 receives LT plus SJT placebo; and the control group 2 receives SJT plus LT on the first five days, SJT plus LT placebo on the last two days. Each group will be treated for seven days and followed-up 1-2 times. The primary outcome measures of effective rate and recurrence rate are symptoms. Secondary outcome measures of effective rate and recurrence rate are the urine leukocytes, bacteriology examination, and safety assessment. Outcomes will be assessed at baseline and after treatment.
    Discussion: This study protocol will provide the research data of efficacy and safety of SJT for the treatment of acute uncomplicated lower UTI. The first aim is to determine whether Sanjin tablets can reduce the use of antibiotics; the second aim is to determine whether Sanjin tablets can substitute the use of antibiotics. The recurrence rate will be assessed after cured to determine whether SJT can reduce the recurrence rate. The results of this study will improve the rational use of drugs, especially the rational application of antibiotics. It will also enable safety evaluation from laboratory indices and adverse events, which will provide reliable evidence for clinical treatment.
    Trial registration: ClinicalTrials.gov, NCT03658291 . Registered on 4 September 2018.
    MeSH term(s) Administration, Oral ; Adult ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; China ; Double-Blind Method ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Female ; Humans ; Levofloxacin/administration & dosage ; Levofloxacin/adverse effects ; Lower Urinary Tract Symptoms/diagnosis ; Lower Urinary Tract Symptoms/drug therapy ; Lower Urinary Tract Symptoms/microbiology ; Male ; Middle Aged ; Multicenter Studies as Topic ; Randomized Controlled Trials as Topic ; Tablets ; Time Factors ; Treatment Outcome ; Urinary Tract Infections/diagnosis ; Urinary Tract Infections/drug therapy ; Urinary Tract Infections/microbiology ; Young Adult
    Chemical Substances Anti-Bacterial Agents ; Drugs, Chinese Herbal ; Tablets ; Levofloxacin (6GNT3Y5LMF)
    Language English
    Publishing date 2019-07-19
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-019-3539-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: Chu ji Hanyu du xie jiao cheng

    Lin, Yu / Song, Leyong / Deng, Wanyong / Liu, Ming

    (Hanyu du xie jiao cheng : 汉语读写教程 ; / Song Leyong zhubian[...])

    2003  

    Author's details Song Leyong zhubian; Lin Yu; Liu Ming bianzhu; Deng Wanyong Ying yi
    Series title Hanyu du xie jiao cheng : 汉语读写教程
    / Song Leyong zhubian[...]
    Language Chinese ; English
    Size 258 p, Ill
    Edition Di 1 ban, di 3 ci yin shua
    Publisher Beijing yu yan wen hua da xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 7561907753 ; 9787561907757
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  5. Book: Zhong ji Hanyu du xie jiao cheng

    Hou, Lingwen / Song, Leyong / Cheng, Kai / Deng, Wanyong

    (Hanyu du xie jiao cheng : 汉语读写教程 ; / Song Leyong zhubian[...])

    2000  

    Author's details Song Leyong zhubian; Hou Lingwen; Cheng Kai bianzhu; Deng Wanyong Ying yi
    Series title Hanyu du xie jiao cheng : 汉语读写教程
    / Song Leyong zhubian[...]
    Language Chinese ; English
    Size 186 p, Ill
    Edition Di 1 ban, di 3 ci yin shua
    Publisher Beijing yu yan wen hua da xue chu ban she
    Publishing place Beijing
    Document type Book
    ISBN 7561907761 ; 9787561907764
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  6. Book: Dun bo ben chan ji lu jiao

    Deng, Wenkuan / Rong, Xinjiang

    Collected collations of the Chan texts preserved in the Museum of Dunhuang city

    (Dun huang wen xian fen lei lu jiao cong kan ; 敦煌文獻分類錄校叢刊)

    1999  

    Author's details Deng wen kuan, rong xin jiang lu jiao
    Series title Dun huang wen xian fen lei lu jiao cong kan
    敦煌文獻分類錄校叢刊
    Language Chinese
    Dates of publication 1999-1998
    Size 2, 2, 4, 26, 41, 2, 2, 1, 527 p, ill, 21 cm
    Publisher Jiang su gu ji chu ban she
    Publishing place Nan jing
    Document type Book
    ISBN 7805199019 ; 9787805199016
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: Dun huang tian wen li fa wen xian ji jiao

    Deng, Wenkuan

    Collected collations of the astronomical texts and calendars from Dunhuang

    (Dun huang wen xian fen lei lu jiao cong kan ; 敦煌文獻分類錄校叢刊)

    1996  

    Title variant Collected collations of the astronomical texts and calendars from Dunhuang
    Author's details Deng wen kuan lu jiao
    Series title Dun huang wen xian fen lei lu jiao cong kan
    敦煌文獻分類錄校叢刊
    Keywords Astronomy, Chinese/History ; Calendar, Chinese/History
    Language Chinese
    Size 2, 7, 2, 14, 3, 767 p, ill, 21 cm
    Publisher Jiang su gu ji chu ban she
    Publishing place Nan jing
    Document type Book
    Note Includes bibliographical references (p. 759-763)
    ISBN 7805197997 ; 9787805197999
    Database Former special subject collection: coastal and deep sea fishing

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  8. Article: Elderly's Homesickness: Development of Elderly Homesickness Questionnaire.

    Deng, Zeming / Qiu, Yuehong / Xiao, Xueer / Jiao, Can

    Psychology research and behavior management

    2024  Volume 17, Page(s) 1533–1549

    Abstract: Introduction: Homesickness is a result of migration, and is related to adjustment difficulties and health problems, as well as clinical disorders. The aim of this study was to measure and explore the homesickness of Chinese elderly.: Methods: A total ...

    Abstract Introduction: Homesickness is a result of migration, and is related to adjustment difficulties and health problems, as well as clinical disorders. The aim of this study was to measure and explore the homesickness of Chinese elderly.
    Methods: A total of 355 non-local Chinese elderly in Shenzhen were recruited to measure demographic information and homesickness. and tested for reliability and validity. Patterns and influences of homesickness among Chinese elderly were explored through latent profile analysis and One-way ANOVA on the basis of EHQ.
    Results: A three-factor structure was verified in the 19-item elderly homesickness questionnaire (EHQ), namely "positive contact", "refusal to separate" and "homesickness behavior". The EHQ reports high validity and reliability. Chinese elderly had a high degree of homesickness, and homesickness among Chinese elderly varied significantly across variables such as age, occupation, and education level. Four homesickness patterns were found in Chinese elderly, named low homesick group, moderate homesick group, middle-high homesick group, and high homesick group. Coming from rural/urban areas and living with grandchildren are factors that affect classification.
    Conclusion: The present study reveals the high validity and reliability of the EHQ among Chinese elderly. The Chinese elderly reported high levels of homesickness, which varied significantly across levels of demographic factors. Four patterns of homesickness were found among the Chinese elderly, coming from rural/urban areas and living with grandchildren are the factors that affect classification. There may be a masking of the male contribution to the main effect due to the larger female sample.
    Language English
    Publishing date 2024-04-08
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2495093-2
    ISSN 1179-1578
    ISSN 1179-1578
    DOI 10.2147/PRBM.S451960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Correction to "An Electrochemical Sensor for Quantitation of the Oral Health Care Agent Chlorogenic Acid Based on Bimetallic Nanowires with Functionalized Reduced Graphene Oxide Nanohybrids".

    Li, Wei / Deng, Xiuli / Wu, Ziyu / Zhang, Louqiang / Jiao, Jian

    ACS omega

    2023  Volume 8, Issue 5, Page(s) 5136

    Abstract: This corrects the article DOI: 10.1021/acsomega.1c06612.]. ...

    Abstract [This corrects the article DOI: 10.1021/acsomega.1c06612.].
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Published Erratum
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c07031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vicious Cycle-Breaking Lipid Nanoparticles Remodeling Multicellular Crosstalk to Reverse Liver Fibrosis.

    Zhang, Ling-Feng / Deng, Wen-Qi / Huang, Qing-Wen / Zhang, Jiao-Jiao / Wang, Yi / Zhou, Tian-Jiao / Xing, Lei / Jiang, Hu-Lin

    Advanced materials (Deerfield Beach, Fla.)

    2024  Volume 36, Issue 16, Page(s) e2311474

    Abstract: During liver fibrogenesis, the reciprocal crosstalk among capillarized liver sinusoidal endothelial cells (LSECs), activated hepatic stellate cells (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating the ...

    Abstract During liver fibrogenesis, the reciprocal crosstalk among capillarized liver sinusoidal endothelial cells (LSECs), activated hepatic stellate cells (HSCs), and dysfunctional hepatocytes constructs a self-amplifying vicious cycle, greatly exacerbating the disease condition and weakening therapeutic effect. Limited by the malignant cellular interactions, the previous single-cell centric treatment approaches show unsatisfactory efficacy and fail to meet clinical demand. Herein, a vicious cycle-breaking strategy is proposed to target and repair pathological cells separately to terminate the malignant progression of liver fibrosis. Chondroitin sulfate-modified and vismodegib-loaded nanoparticles (CS-NPs/VDG) are designed to efficiently normalize the fenestrae phenotype of LSECs and restore HSCs to quiescent state by inhibiting Hedgehog signaling pathway. In addition, glycyrrhetinic acid-modified and silybin-loaded nanoparticles (GA-NPs/SIB) are prepared to restore hepatocytes function by relieving oxidative stress. The results show successful interruption of vicious cycle as well as distinct fibrosis resolution in two animal models through multiregulation of the pathological cells. This work not only highlights the significance of modulating cellular crosstalk but also provides a promising avenue for developing antifibrotic regimens.
    MeSH term(s) Animals ; Endothelial Cells/metabolism ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/therapeutic use ; Liver Cirrhosis ; Liver/metabolism ; Nanoparticles ; Liposomes
    Chemical Substances Lipid Nanoparticles ; Hedgehog Proteins ; Liposomes
    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1474949-X
    ISSN 1521-4095 ; 0935-9648
    ISSN (online) 1521-4095
    ISSN 0935-9648
    DOI 10.1002/adma.202311474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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