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  1. Article ; Online: m

    Bushkin, G Guy / Pincus, David / Morgan, Jeffrey T / Richardson, Kris / Lewis, Caroline / Chan, Sze Ham / Bartel, David P / Fink, Gerald R

    Nature communications

    2019  Volume 10, Issue 1, Page(s) 3414

    Abstract: ... methyladenosine (m ...

    Abstract Despite the vast number of modification sites mapped within mRNAs, known examples of consequential mRNA modifications remain rare. Here, we provide multiple lines of evidence to show that Ime4p, an N6-methyladenosine (m
    MeSH term(s) 3' Untranslated Regions ; Adenosine/analogs & derivatives ; Adenosine/metabolism ; Gene Expression Regulation, Fungal ; Meiosis ; Methylation ; RNA, Messenger/chemistry ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Saccharomyces cerevisiae/chemistry ; Saccharomyces cerevisiae/cytology ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
    Chemical Substances 3' Untranslated Regions ; RME1 protein, S cerevisiae ; RNA, Messenger ; Repressor Proteins ; Saccharomyces cerevisiae Proteins ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2019-07-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-11232-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Standing on the shoulders of a giant: The legacy of Robert M. Sellers.

    Williams, Amber D / Aronson, Krista Maywalt / Chavous, Tabbye M / Cooke, Deanna Y / Glover, Ciara Smalls / Hoggard, Lori S / Kohn-Wood, Laura / Lesane-Brown, Chase L / Lewis-McCoy, R L'Heureux / Martin, Pamela P / Rowley, Stephanie J / Seaton, Eleanor K / Smith-Bynum, Mia A / Wout, Daryl A / Yip, Tiffany / Neblett, Enrique W

    The American psychologist

    2023  Volume 78, Issue 4, Page(s) 441–456

    Abstract: Robert M. Sellers, PhD, most known for his influential and highly cited Multidimensional Model ...

    Abstract Robert M. Sellers, PhD, most known for his influential and highly cited Multidimensional Model of Racial Identity (MMRI), is one of the most prolific and foundational Black scholars in psychology. From racial identity theory development and measurement to conceptual and methodological innovations in studying the lived experiences of Black people, Sellers' scholarship centers on the lives of Black communities. Sellers' mentorship and contributions to the professional development of scholars and professionals of color have supported and catalyzed new intergenerational knowledge building by these scholars, ensuring a perpetuating and far-reaching legacy in psychology. In this article, we: (a) celebrate Sellers' enduring contribution to the racial identity literature and its profound impact on psychology as a discipline as well as numerous subfields of psychology, (b) outline his contributions to the racial socialization literature, (c) describe methodological innovations in racial identity and racial socialization research advanced through his scholarship, and (d) summarize his contributions in professional development and mentorship and his leadership roles. Sellers' scholarly contributions and mentorship have transformed the discipline of psychology and the social sciences broadly speaking, making him one of the most influential psychologists in the modern era. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    MeSH term(s) Humans ; Black People/psychology ; Knowledge ; Leadership ; Mentors ; Models, Psychological ; Psychology/history ; Racial Groups/psychology ; Social Identification ; Social Sciences/history ; Socialization ; Psychological Theory
    Language English
    Publishing date 2023-06-28
    Publishing country United States
    Document type Biography ; Journal Article
    ZDB-ID 209464-2
    ISSN 1935-990X ; 0003-066X
    ISSN (online) 1935-990X
    ISSN 0003-066X
    DOI 10.1037/amp0001129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 997: Show issues Location:
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  3. Article ; Online: Targeting the RNA m

    Paris, Jasmin / Morgan, Marcos / Campos, Joana / Spencer, Gary J / Shmakova, Alena / Ivanova, Ivayla / Mapperley, Christopher / Lawson, Hannah / Wotherspoon, David A / Sepulveda, Catarina / Vukovic, Milica / Allen, Lewis / Sarapuu, Annika / Tavosanis, Andrea / Guitart, Amelie V / Villacreces, Arnaud / Much, Christian / Choe, Junho / Azar, Ali /
    van de Lagemaat, Louie N / Vernimmen, Douglas / Nehme, Ali / Mazurier, Frederic / Somervaille, Tim C P / Gregory, Richard I / O'Carroll, Dónal / Kranc, Kamil R

    Cell stem cell

    2019  Volume 25, Issue 1, Page(s) 137–148.e6

    Abstract: ... stem cells (LSCs). Here, we show that the mRNA m ...

    Abstract Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation, generating self-renewing leukemic stem cells (LSCs). Here, we show that the mRNA m
    MeSH term(s) Animals ; Cell Self Renewal ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Neoplastic Stem Cells/physiology ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; THP-1 Cells
    Chemical Substances RNA, Small Interfering ; RNA-Binding Proteins ; YTHDF2 protein, human ; YTHDF2 protein, mouse
    Language English
    Publishing date 2019-04-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2019.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6589: Show issues Location:
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    Zs.MG 75: Show issues

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  4. Article: M/M/Infinity Birth-Death Processes - A Quantitative Representational Framework to Summarize and Explain Phase Singularity and Wavelet Dynamics in Atrial Fibrillation.

    Dharmaprani, Dhani / Jenkins, Evan / Aguilar, Martin / Quah, Jing X / Lahiri, Anandaroop / Tiver, Kathryn / Mitchell, Lewis / Kuklik, Pawel / Meyer, Christian / Willems, Stephan / Clayton, Richard / Nash, Martyn / Nattel, Stanley / McGavigan, Andrew D / Ganesan, Anand N

    Frontiers in physiology

    2021  Volume 11, Page(s) 616866

    Abstract: ... model computer simulations. We demonstrated: (i) that λ : Conclusion: M/M/∞ birth-death processes provide ...

    Abstract Rationale: A quantitative framework to summarize and explain the quasi-stationary population dynamics of unstable phase singularities (PS) and wavelets in human atrial fibrillation (AF) is at present lacking. Building on recent evidence showing that the formation and destruction of PS and wavelets in AF can be represented as renewal processes, we sought to establish such a quantitative framework, which could also potentially provide insight into the mechanisms of spontaneous AF termination.
    Objectives: Here, we hypothesized that the observed number of PS or wavelets in AF could be governed by a common set of renewal rate constants λ
    Methods and results: AF was studied in in a multimodality, multispecies study in humans, animal experimental models (rats and sheep) and Ramirez-Nattel-Courtemanche model computer simulations. We demonstrated: (i) that λ
    Conclusion: M/M/∞ birth-death processes provide an accurate quantitative representational architecture to characterize PS and wavelet population dynamics in AF, by providing governing equations to understand the regeneration of PS and wavelets during sustained AF, as well as providing insight into the mechanism of spontaneous AF termination.
    Language English
    Publishing date 2021-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.616866
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  5. Article: Disease, Its Conditions and Treatment: An Inaugural Essay Submitted to the Medical Faculty of the University of Louisville, March 5, 1852, for the Degree of M. D.

    Lewis, Waldo

    Western journal of medicine and surgery

    2024  Volume 9, Issue 4, Page(s) 292–302

    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Oxo-M and 4-PPBP Delivery

    Park, Ga Young / Tarafder, Solaiman / Eyen, Samantha Lewis / Park, Soomin / Kim, Ryunhyung / Siddiqui, Zain / Kumar, Vivek / Lee, Chang H

    Frontiers in bioengineering and biotechnology

    2022  Volume 10, Page(s) 773004

    Abstract: We have recently identified novel small molecules, Oxo-M and 4-PPBP, which specifically stimulate ... of Oxo-M and 4-PPBP from MDP hydrogels and the effect of MDP-released small molecules on tenogenic ...

    Abstract We have recently identified novel small molecules, Oxo-M and 4-PPBP, which specifically stimulate endogenous tendon stem/progenitor cells (TSCs), leading to potential regenerative healing of fully transected tendons. Here, we investigated an injectable, multidomain peptide (MDP) hydrogel providing controlled delivery of the small molecules for regenerative tendon healing. We investigated the release kinetics of Oxo-M and 4-PPBP from MDP hydrogels and the effect of MDP-released small molecules on tenogenic differentiation of TSCs and
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.773004
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  7. Article ; Online: Towards understanding antimicrobial activity, cytotoxicity and the mode of action of dichapetalins A and M using in silico and in vitro studies.

    Chama, Mary Anti / Modos, Dezso / Mervin, Lewis Howard / Owusu, Kofi Baffour-Awuah / Ayine-Tora, Daniel Moscoh / Egyir, Beverly / Paemka, Lily / Yankson, George / Ohashi, Mitsuko / Afzal, Avid Muammar / Bender, Andreas

    Toxicon : official journal of the International Society on Toxinology

    2021  Volume 193, Page(s) 28–37

    Abstract: ... antiparasitic potentials, we isolated and identified the known dichapetalins A and M from the roots ... Leishmania donovani using the Alamar Blue assay system. Dichapetalins A and M were more potent against B. cereus ...

    Abstract Dichapetalum madagascariense Poir (Dichapetalaceae) is traditionally used to treat bacterial infections, jaundice, urethritis and viral hepatitis in Africa. Its root contains a broad spectrum of biologically active dichapetalins. To evaluate the plant's effect on human MCF-7 cells and its' antibacterial and antiparasitic potentials, we isolated and identified the known dichapetalins A and M from the roots. Both dichapetalins were tested on six bacterial strains (Shigella flexneri, Bacillus cereus, Salmonella paratyphi B, Listeria monocytogenes, Escherichia coli, Staphylococcus aureus) and two parasite strains; Trypanosoma brucei brucei, and Leishmania donovani using the Alamar Blue assay system. Dichapetalins A and M were more potent against B. cereus with IC
    MeSH term(s) Africa ; Anti-Bacterial Agents/pharmacology ; Computer Simulation ; Humans ; Microbial Sensitivity Tests ; Plant Extracts/pharmacology ; Staphylococcus aureus
    Chemical Substances Anti-Bacterial Agents ; Plant Extracts
    Language English
    Publishing date 2021-01-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2021.01.002
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 501: Show issues Location:
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  8. Article ; Online: A tribute to George Polgar, M.D.

    Allen, Julian Lewis

    Pediatric investigation

    2019  Volume 3, Issue 4, Page(s) 197–198

    Language English
    Publishing date 2019-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12158
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  9. Article: Totally Excited about Moving Mobility and Exercise (TEAM M

    Shaw, Angela M / Robert, Rhonda / Kresta, Kimberly / Andersen, Clark R / Lewis, Betsy / Maetzold, Brittni / Valderrama, Raymund / Cion, Ian / Tewari, Priti

    Children (Basel, Switzerland)

    2022  Volume 9, Issue 2

    Abstract: ... Exercise (TEAM M: Results: Compared to baseline, patient refusals to participate in physical therapy ...

    Abstract Background: Pediatric, adolescent and young adult (PAYA) patients are less active than their healthy counterparts, particularly during inpatient stays.
    Methods: We conducted a quality improvement initiative to increase activity levels in patients admitted to our pediatric oncology and cellular therapy unit using a Plan-Do-Study-Act (PDSA) model. An interdisciplinary team was assembled to develop an incentive-based inpatient exercise and activity program titled Totally Excited About Moving Mobility and Exercise (TEAM M
    Results: Compared to baseline, patient refusals to participate in physical therapy decreased significantly (24% vs. 2%) (
    Conclusions: An incentive-based exercise program for young oncology inpatients greatly improved patient activity levels, participation in physical therapy and influenced professional caregivers' beliefs.
    Language English
    Publishing date 2022-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children9020186
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  10. Article ; Online: D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception.

    Gaston, Benjamin / Baby, Santhosh M / May, Walter J / Young, Alex P / Grossfield, Alan / Bates, James N / Seckler, James M / Wilson, Christopher G / Lewis, Stephen J

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 10038

    Abstract: We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of D-cystine diethyl ester (D-cystine diEE) or D-cystine dimethyl ester (D-cystine diME) on morphine- ...

    Abstract We have identified thiolesters that reverse the negative effects of opioids on breathing without compromising antinociception. Here we report the effects of D-cystine diethyl ester (D-cystine diEE) or D-cystine dimethyl ester (D-cystine diME) on morphine-induced changes in ventilation, arterial-blood gas chemistry, A-a gradient (index of gas-exchange in the lungs) and antinociception in freely moving rats. Injection of morphine (10 mg/kg, IV) elicited negative effects on breathing (e.g., depression of tidal volume, minute ventilation, peak inspiratory flow, and inspiratory drive). Subsequent injection of D-cystine diEE (500 μmol/kg, IV) elicited an immediate and sustained reversal of these effects of morphine. Injection of morphine (10 mg/kg, IV) also elicited pronounced decreases in arterial blood pH, pO
    MeSH term(s) Analgesics, Opioid/adverse effects ; Animals ; Blood Gas Analysis ; Carbon Dioxide/blood ; Cystine/analogs & derivatives ; Cystine/pharmacology ; Cystine/therapeutic use ; Drug Evaluation, Preclinical ; Hydrogen-Ion Concentration ; Male ; Morphine/adverse effects ; Oxygen/blood ; Pulmonary Ventilation/drug effects ; Rats, Sprague-Dawley ; Rats
    Chemical Substances Analgesics, Opioid ; Carbon Dioxide (142M471B3J) ; Cystine (48TCX9A1VT) ; Morphine (76I7G6D29C) ; Oxygen (S88TT14065) ; cystine dimethyl ester (VEO23D129R)
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-89455-2
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