LIVIVO - Search results -

Search results

Result 1 - 10 of total 84615

Article ; Online: K

Suzuki, Yoshiaki / Yamamura, Hisao / Imaizumi, Yuji / Clark, Robert B / Giles, Wayne R

2020 Volume 9, Issue 7

Abstract: An improved understanding of fundamental physiological principles and progressive pathophysiological processes in human articular joints (e.g., shoulders, knees, elbows) requires detailed investigations of two principal cell types: synovial fibroblasts ... ...

Abstract	An improved understanding of fundamental physiological principles and progressive pathophysiological processes in human articular joints (e.g., shoulders, knees, elbows) requires detailed investigations of two principal cell types: synovial fibroblasts and chondrocytes. Our studies, done in the past 8-10 years, have used electrophysiological, Ca
MeSH term(s)	Animals ; Calcium/metabolism ; Chondrocytes/metabolism ; Chondrocytes/physiology ; Humans ; Membrane Potentials/physiology ; Potassium/metabolism ; Synovial Fluid/metabolism ; Synovial Fluid/physiology
Chemical Substances	Potassium (RWP5GA015D) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2020-06-29
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells9071577
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Up-regulated expression of two-pore domain K

Shima, Natsumi / Yamamura, Aya / Fujiwara, Moe / Amano, Taiki / Matsumoto, Kazuyuki / Sekine, Taiga / Okano, Haruka / Kondo, Rubii / Suzuki, Yoshiaki / Yamamura, Hisao

Frontiers in cardiovascular medicine

2024 Volume 11, Page(s) 1343804

Abstract: Background: Pulmonary arterial hypertension (PAH) is a severe and rare disease in the cardiopulmonary system. Its pathogenesis involves vascular remodeling of the pulmonary artery, which results in progressive increases in pulmonary arterial pressure. ... ...

Abstract	Background: Pulmonary arterial hypertension (PAH) is a severe and rare disease in the cardiopulmonary system. Its pathogenesis involves vascular remodeling of the pulmonary artery, which results in progressive increases in pulmonary arterial pressure. Chronically increased pulmonary arterial pressure causes right ventricular hypertrophy and subsequent right heart failure. Pulmonary vascular remodeling is attributed to the excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs), which are induced by enhanced Ca Objectives: In the present study, the functional expression of two-pore domain potassium KCNK channels was investigated in PASMCs from idiopathic PAH (IPAH) patients and experimental pulmonary hypertensive (PH) animals. Results: In IPAH-PASMCs, the expression of KCNK1/TWIK1 and KCNK2/TREK1 channels was up-regulated, whereas that of KCNK3/TASK1 and KCNK6/TWIK2 channels was down-regulated. The similar up-regulated expression of KCNK1 and KCNK2 channels was observed in the pulmonary arterial smooth muscles of monocrotaline-induced PH rats, Sugen 5416/hypoxia-induced PH rats, and hypoxia-induced PH mice. The facilitated proliferation of IPAH-PASMCs was suppressed by the KCNK channel blockers, quinine and tetrapentylammonium. The migration of IPAH-PASMCs was also suppressed by these channel blockers. Furthermore, increases in the proliferation and migration were inhibited by the siRNA knockdown of KCNK1 or KCNK2 channels. The siRNA knockdown also caused membrane depolarization and subsequent decrease in cytosolic [Ca Conclusion: Collectively, these findings indicate that the up-regulated expression of KCNK1 and KCNK2 channels facilitates the proliferation and migration of PASMCs via enhanced Ca
Language	English
Publishing date	2024-02-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2024.1343804
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Vitamin K

Xu, Wencheng / Meng, Kehan / Wu, Hongguang / Miura, Taro / Suzuki, Shunsuke / Chiyotanda, Masako / Tanaka, Sachiko / Sugiyama, Kentaro / Kawashima, Hisashi / Hirano, Toshihiko

Pediatrics international : official journal of the Japan Pediatric Society

2019 Volume 61, Issue 12, Page(s) 1188–1195

Abstract: ... The purpose of this study was to explore whether vitamin K: Methods: The immunosuppressive efficacy ... of vitamin K: Results: The mean (SD) IC: Conclusion: Vitamin K ...

Abstract	Background: Over 20 kinds of steroids, tacrolimus ointments, and cyclosporine capsules are usually recommended for the treatment of atopic dermatitis (AD), depending on the symptoms of patients. However, several side effects sometimes occur with the extensive use of these agents for the treatment of pediatric AD patients. The purpose of this study was to explore whether vitamin K Methods: The immunosuppressive efficacy of vitamin K Results: The mean (SD) IC Conclusion: Vitamin K
MeSH term(s)	Adult ; Cell Proliferation/drug effects ; Cells, Cultured ; Child ; Child, Preschool ; Cyclosporine/pharmacology ; Dermatitis, Atopic/drug therapy ; Female ; Healthy Volunteers ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/pharmacology ; Leukocytes, Mononuclear/drug effects ; Male ; Methylprednisolone/pharmacology ; Tacrolimus/pharmacology ; Vitamin K 2/administration & dosage ; Vitamin K 2/pharmacology ; Vitamin K 2/therapeutic use
Chemical Substances	Immunosuppressive Agents ; Vitamin K 2 (11032-49-8) ; Cyclosporine (83HN0GTJ6D) ; Tacrolimus (WM0HAQ4WNM) ; Methylprednisolone (X4W7ZR7023)
Language	English
Publishing date	2019-12-13
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.14014
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 848: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Cryo-EM Structure of K

Asai, Tatsuki / Adachi, Naruhiko / Moriya, Toshio / Oki, Hideyuki / Maru, Takamitsu / Kawasaki, Masato / Suzuki, Kano / Chen, Sisi / Ishii, Ryohei / Yonemori, Kazuko / Igaki, Shigeru / Yasuda, Satoshi / Ogasawara, Satoshi / Senda, Toshiya / Murata, Takeshi

Structure (London, England : 1993)

2021 Volume 29, Issue 3, Page(s) 203–212.e4

Abstract: The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization. Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical industry. The three-dimensional structure of the hERG channel was recently ... ...

Abstract	The hERG channel is a voltage-gated potassium channel involved in cardiac repolarization. Off-target hERG inhibition by drugs has become a critical issue in the pharmaceutical industry. The three-dimensional structure of the hERG channel was recently reported at 3.8-Å resolution using cryogenic electron microscopy (cryo-EM). However, the drug inhibition mechanism remains unclear because of the scarce structural information regarding the drug- and potassium-bound hERG channels. In this study, we obtained the cryo-EM density map of potassium-bound hERG channel complexed with astemizole, a well-known hERG inhibitor that increases risk of potentially fatal arrhythmia, at 3.5-Å resolution. The structure suggested that astemizole inhibits potassium conduction by binding directly below the selectivity filter. Furthermore, we propose a possible binding model of astemizole to the hERG channel and provide insights into the unusual sensitivity of hERG to several drugs.
MeSH term(s)	Astemizole/chemistry ; Astemizole/pharmacology ; Binding Sites ; Cryoelectron Microscopy ; ERG1 Potassium Channel/antagonists & inhibitors ; ERG1 Potassium Channel/chemistry ; ERG1 Potassium Channel/metabolism ; HEK293 Cells ; Humans ; Molecular Docking Simulation ; Potassium Channel Blockers/chemistry ; Potassium Channel Blockers/pharmacology ; Protein Binding
Chemical Substances	ERG1 Potassium Channel ; KCNH2 protein, human ; Potassium Channel Blockers ; Astemizole (7HU6337315)
Language	English
Publishing date	2021-01-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2020.12.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4141: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A bottom-up approach to the ion recognition mechanism of K

Suzuki, Yukina / Hirata, Keisuke / Lisy, James M / Ishiuchi, Shun-Ichi / Fujii, Masaaki

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 35, Page(s) 20803–20812

Abstract: K ...

Abstract	K
MeSH term(s)	Alkalies ; Coordination Complexes ; Ions/chemistry ; Lasers ; Metals, Alkali/chemistry ; Peptides ; Spectrum Analysis ; Water/chemistry
Chemical Substances	Alkalies ; Coordination Complexes ; Ions ; Metals, Alkali ; Peptides ; Water (059QF0KO0R)
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp01667b
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Reversible and monitorable nephrotoxicity in rats by the novel potent transcriptional enhanced associate domain (TEAD) inhibitor, K-975.

Otsuki, Hironori / Uemori, Takeshi / Inai, Yohei / Suzuki, Yui / Araki, Tetsuro / Nan-Ya, Ken-Ichiro / Yoshinari, Kouichi

The Journal of toxicological sciences

2024 Volume 49, Issue 4, Page(s) 175–191

Abstract: ... we evaluated the systemic toxicity of K-975, a novel TEAD inhibitor, in rats. When K-975 was administered ... revealed that K-975 at 300 mg/kg induced glomerular podocyte foot process effacement. After a 2-week ... the most sensitive marker for detecting K-975-induced nephrotoxicity. After 3 cycles of 1-week ...

Abstract	The Hippo pathway plays an important role in the growth, development, and regeneration of cells and organs. Transcriptional enhanced associate domain (TEAD), a transcription activator of the Hippo pathway, forms the complex with a transcriptional coactivator yes-associated protein (YAP) or a transcriptional coactivator PDZ-binding motif (TAZ). Their excessive activations are involved in carcinogenesis such as malignant pleural mesothelioma (MPM), and thus inhibition of the TEAD complex is expected to have potent anticancer activity against MPM. On the other hand, YAP or TAZ conditional knockout mice have been reported to show abnormal findings in various tissues, including the kidney, liver, and lung. In the present study, we evaluated the systemic toxicity of K-975, a novel TEAD inhibitor, in rats. When K-975 was administered orally to rats for 1 week, proteinuria suggestive of nephrotoxicity was observed. Electron microscopy revealed that K-975 at 300 mg/kg induced glomerular podocyte foot process effacement. After a 2-week recovery period, proteinuria with foot process effacement was recovered completely. Urinalysis and urinary biomarker evaluation suggested that the urinary albumin index (urinary albumin/urinary creatinine) was the most sensitive marker for detecting K-975-induced nephrotoxicity. After 3 cycles of 1-week administration followed by 2-week recovery periods, nephrotoxicity was reversible; however, incomplete reversibility was observed in rats with severe proteinuria. In conclusion, this study revealed that in rats, oral K-975 treatment induced severe proteinuria by podocyte foot process effacement, which was reversible and monitorable by the urinary albumin index, suggesting important information for developing K-975 as an anticancer drug.
MeSH term(s)	Mice ; Rats ; Animals ; Transcription Factors/metabolism ; Antineoplastic Agents/toxicity ; Proteinuria ; Albumins
Chemical Substances	Transcription Factors ; Antineoplastic Agents ; Albumins
Language	English
Publishing date	2024-04-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	770623-6
ISSN	1880-3989 ; 0388-1350
ISSN (online)	1880-3989
ISSN	0388-1350
DOI	10.2131/jts.49.175
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1682: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Localization of ATP-sensitive K

Zhou, Ming / Yoshikawa, Kiwamu / Akashi, Hideo / Miura, Mitsutaka / Suzuki, Ryoji / Li, Tao-Sheng / Abe, Hiroshi / Bando, Yoshio

World journal of experimental medicine

2019 Volume 9, Issue 2, Page(s) 14–31

Abstract: Background: ATP-sensitive K: Aim: To investigate the expression of K: Methods: Rabbit anti ... culture and immunocytochemistry.: Results: Immunoblot analysis showed that the five kinds of K ... Conclusion: Observations from the present study indicated that K ...

Abstract	Background: ATP-sensitive K Aim: To investigate the expression of K Methods: Rabbit anti-rat SUR1 peptide antibody was raised and purified by antigen immunoaffinity column chromatography. Four of Sprague-Dawley rats were used for liver protein extraction for immunoblot analysis, seven of them were used for immunohistochemistry both for the ABC method and immunofluorescence staining. Four of Wistar rats were used for the isolation of hepatic stellate cells (HSCs) and Kupffer cells for both primary culture and immunocytochemistry. Results: Immunoblot analysis showed that the five kinds of K Conclusion: Observations from the present study indicated that K
Language	English
Publishing date	2019-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2764849-7
ISSN	2220-315X
ISSN	2220-315X
DOI	10.5493/wjem.v9.i2.14
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Apoptotic Effects of a Thioether Analog of Vitamin K

Asami, Satoru / Suzuki, Mikana / Nakayama, Toshimitsu / Shimoda, Yasuyo / Miura, Motofumi / Kato, Koichi / Tokuda, Eiichi / Ono, Shinichi / Kawakubo, Takashi / Nishizawa, Kenji / Yamanaka, Kenzo / Suzuki, Takashi

International journal of toxicology

2021 Volume 40, Issue 6, Page(s) 517–529

Abstract: Research suggests that thioether analogs of vitamin K ...

Abstract	Research suggests that thioether analogs of vitamin K
MeSH term(s)	Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/toxicity ; Apoptosis/drug effects ; Humans ; Jurkat Cells/drug effects ; Leukemia/drug therapy ; Phosphorylation/drug effects ; Vitamin K 3/analogs & derivatives ; Vitamin K 3/therapeutic use ; Vitamin K 3/toxicity
Chemical Substances	Antineoplastic Agents ; Vitamin K 3 (723JX6CXY5)
Language	English
Publishing date	2021-10-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1379845-5
ISSN	1092-874X ; 1091-5818
ISSN (online)	1092-874X
ISSN	1091-5818
DOI	10.1177/10915818211047992
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1870: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Hypoxic stress upregulates K

Yamamura, Hideto / Suzuki, Yoshiaki / Yamamura, Hisao / Asai, Kiyofumi / Giles, Wayne / Imaizumi, Yuji

American journal of physiology. Cell physiology

2018 Volume 315, Issue 2, Page(s) C202–C213

Abstract: ... understood. Hypoxic stress can upregulate functional expression of specific K ...

Abstract	Brain capillary endothelial cells (BCECs) play a central role in maintenance of blood-brain barrier (BBB) function and, therefore, are essential for central nervous system homeostasis and integrity. Although brain ischemia damages BCECs and causes disruption of BBB, the related influence of hypoxia on BCECs is not well understood. Hypoxic stress can upregulate functional expression of specific K
MeSH term(s)	Animals ; Brain/metabolism ; Calcium/metabolism ; Cattle ; Cell Hypoxia/physiology ; Cell Line ; Cell Movement/physiology ; Cell Proliferation/physiology ; Central Nervous System/metabolism ; Down-Regulation/physiology ; Dynamins/metabolism ; Endothelial Cells/metabolism ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Potassium Channels, Inwardly Rectifying/metabolism ; Up-Regulation/physiology
Chemical Substances	Hypoxia-Inducible Factor 1, alpha Subunit ; Kir2.1 channel ; Potassium Channels, Inwardly Rectifying ; Dynamins (EC 3.6.5.5) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-05-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00154.2017
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.89: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: High-throughput screening of small-molecules libraries identified antibacterials against clinically relevant multidrug-resistant A. baumannii and K. pneumoniae.

Blasco, Benjamin / Jang, Soojin / Terauchi, Hiroki / Kobayashi, Naoki / Suzuki, Shuichi / Akao, Yuichiro / Ochida, Atsuko / Morishita, Nao / Takagi, Terufumi / Nagamiya, Hiroyuki / Suzuki, Yamato / Watanabe, Toshiaki / Lee, Hyunjung / Lee, Sol / Shum, David / Cho, Ahreum / Koh, Dahae / Park, Soonju / Lee, Honggun /

Kim, Kideok / Ropponen, Henni-Karoliina / Augusto da Costa, Renata Maria / Dunn, Steven / Ghosh, Sunil / Sjö, Peter / Piddock, Laura J V

EBioMedicine

2024 Volume 102, Page(s) 105073

Abstract: ... for generation of hit compounds active against multidrug-resistant (MDR) strains of K. pneumoniae and ... compounds with confirmed activity against K. pneumoniae and/or drug-resistant A. baumannii. Two new chemical ... with antibacterial activity against multidrug-resistant critical priority pathogens such as K. pneumoniae and ...

Abstract	Background: The current pipeline for new antibiotics fails to fully address the significant threat posed by drug-resistant Gram-negative bacteria that have been identified by the World Health Organization (WHO) as a global health priority. New antibacterials acting through novel mechanisms of action are urgently needed. We aimed to identify new chemical entities (NCEs) with activity against Klebsiella pneumoniae and Acinetobacter baumannii that could be developed into a new treatment for drug-resistant infections. Methods: We developed a high-throughput phenotypic screen and selection cascade for generation of hit compounds active against multidrug-resistant (MDR) strains of K. pneumoniae and A. baumannii. We screened compound libraries selected from the proprietary collections of three pharmaceutical companies that had exited antibacterial drug discovery but continued to accumulate new compounds to their collection. Compounds from two out of three libraries were selected using "eNTRy rules" criteria associated with increased likelihood of intracellular accumulation in Escherichia coli. Findings: We identified 72 compounds with confirmed activity against K. pneumoniae and/or drug-resistant A. baumannii. Two new chemical series with activity against XDR A. baumannii were identified meeting our criteria of potency (EC Interpretation: This work provides proof of principle for the screening strategy developed to identify NCEs with antibacterial activity against multidrug-resistant critical priority pathogens such as K. pneumoniae and A. baumannii. The screening and hit selection cascade established here provide an excellent foundation for further screening of new compound libraries to identify high quality starting points for new antibacterial lead generation projects. Funding: BMBF and GARDP.
MeSH term(s)	Humans ; High-Throughput Screening Assays ; Small Molecule Libraries/pharmacology ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Anti-Bacterial Agents/pharmacology ; Escherichia coli ; Drug Resistance, Multiple, Bacterial
Chemical Substances	Small Molecule Libraries ; Anti-Bacterial Agents
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2024.105073
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 7090: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito