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  1. Article: Preventing fraud in biomedical research.

    Cogan, Elie

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 932138

    Abstract: Scientific fraud represents, to varying degrees, an increasingly important part of medical literature and is estimated to make up nearly 20% of this literature. The increase in the number of articles accessible in preprint without peer review during the ... ...

    Abstract Scientific fraud represents, to varying degrees, an increasingly important part of medical literature and is estimated to make up nearly 20% of this literature. The increase in the number of articles accessible in preprint without peer review during the COVID-19 pandemic has led to an increase in the accessibility of fraudulent articles. In recent years, the viral increase in the number of predatory journals has contributed to polluting the scientific literature with articles whose content is unverifiable. Given the international nature of biomedical research, there is an urgent need to define unequivocally what is considered scientific fraud. In order to counter scientific misconduct, national and supranational procedures should be implemented to inform researchers at the beginning of their medical and biomedical training. Ethics commissions should implement local procedures for monitoring ongoing research. Finally, the fight against predatory journals requires information for researchers and the availability of tools to identify these journals.
    Language English
    Publishing date 2022-08-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.932138
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inflammation, infection, and cardiovascular risk.

    Goldman, Michel / Bondue, Antoine / Cogan, Elie

    Lancet (London, England)

    2024  Volume 403, Issue 10431, Page(s) 1023

    MeSH term(s) Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Factors ; Inflammation ; Heart Disease Risk Factors
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(23)02877-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Laser Doppler imaging evaluation of nitroglycerin patch application in systemic sclerosis patients.

    Pintea Bentea, Georgiana / Wauters, Aurélien / Wautrecht, Jean-Claude / Cogan, Elie

    Vascular medicine (London, England)

    2020  Volume 25, Issue 6, Page(s) 559–568

    Abstract: Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch ( ... ...

    Abstract Recent studies suggest the use of topical nitroglycerin (NTG) application in systemic sclerosis (SSc)-associated Raynaud phenomenon (RP). With the current study, we aimed to characterize for the first time the microvascular response to a NTG patch (Trinipatch
    MeSH term(s) Administration, Cutaneous ; Blood Flow Velocity ; Case-Control Studies ; Cold Temperature ; Female ; Hand/blood supply ; Humans ; Laser-Doppler Flowmetry ; Male ; Microcirculation/drug effects ; Middle Aged ; Nitroglycerin/administration & dosage ; Perfusion Imaging ; Predictive Value of Tests ; Regional Blood Flow ; Scleroderma, Systemic/diagnostic imaging ; Scleroderma, Systemic/drug therapy ; Scleroderma, Systemic/physiopathology ; Time Factors ; Transdermal Patch ; Treatment Outcome ; Vasodilation/drug effects ; Vasodilator Agents/administration & dosage
    Chemical Substances Vasodilator Agents ; Nitroglycerin (G59M7S0WS3)
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1311628-9
    ISSN 1477-0377 ; 1358-863X
    ISSN (online) 1477-0377
    ISSN 1358-863X
    DOI 10.1177/1358863X20953901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: CD3

    Carpentier, Caroline / Schandené, Liliane / Dewispelaere, Laurent / Heimann, Pierre / Cogan, Elie / Roufosse, Florence

    The journal of allergy and clinical immunology. In practice

    2021  Volume 9, Issue 6, Page(s) 2426–2439.e7

    Abstract: Background: Identification of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) is challenging, and has important prognostic and therapeutic implications.: Objective: This study was undertaken to assess diagnostic tools for L-HES ... ...

    Abstract Background: Identification of patients with lymphocytic variant hypereosinophilic syndrome (L-HES) is challenging, and has important prognostic and therapeutic implications.
    Objective: This study was undertaken to assess diagnostic tools for L-HES and to develop evidence-based diagnostic recommendations.
    Methods: Biomarkers of T-cell-driven disease were compared between patients with L-HES versus idiopathic HES (I-HES) variants. Those performed routinely (serum immunoglobulin levels, T-cell phenotyping, T-cell receptor [TCR] gene rearrangement patterns) were collected from medical files, whereas others were prospectively assessed on stored blood samples (serum CCL17/thymus and activation regulated chemokine [TARC] levels, in vitro cytokine production).
    Results: This study included 48 patients with I-HES and 20 with L-HES associated with a CD3
    Conclusion: Adapting the standard of procedure for T-cell phenotyping in patients with unexplained hypereosinophilia is currently the most reliable means of identifying those with CD3
    MeSH term(s) CD3 Complex ; CD4-Positive T-Lymphocytes ; Cytokines ; Humans ; Hypereosinophilic Syndrome/diagnosis ; Hypereosinophilic Syndrome/genetics ; T-Lymphocytes
    Chemical Substances CD3 Complex ; Cytokines
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.01.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Case Report: Comorbid Hyper-IgD Syndrome and Hidradenitis Suppurativa - A New Syndromic Form of HS? A Report of Two Cases.

    Guillem, Philippe / Mintoff, Dillon / Kabbani, Mariam / Cogan, Elie / Vlaeminck-Guillem, Virginie / Duquesne, Agnes / Benhadou, Farida

    Frontiers in immunology

    2022  Volume 13, Page(s) 883811

    Abstract: Hidradenitis Suppurativa (HS) is a chronic suppurative disease of the pilosebaceous unit. The current model of HS pathophysiology describes the condition as the product of hyperkeratinisation and inflammation at the hair follicular unit. Environmental ... ...

    Abstract Hidradenitis Suppurativa (HS) is a chronic suppurative disease of the pilosebaceous unit. The current model of HS pathophysiology describes the condition as the product of hyperkeratinisation and inflammation at the hair follicular unit. Environmental factors (such as smoking and obesity), gender, genetic predisposition, and skin dysbiosis are considered the main pathogenic drivers of the disease. Autoinflammatory syndromes associated with HS are rare but may help to highlight the potential roles of autoinflammation and dysregulated innate immune system in HS. Therefore, it is of major relevance to increase the awareness about these diseases in order to improve the understanding of the disease and to optimize the management of the patients. Herein, we report for the first time, to our knowledge, two clinical cases of Hyper-IgD syndrome-associated HS. Hyper-IgD is an autoinflammatory syndrome caused by a mevalonate kinase deficiency (MKD), a key kinase in the sterol and isoprenoid production pathway. We describe the potentially shared pathophysiological mechanisms underpinning comorbid MKD-HS and propose therapeutic options for the management of these patients.
    MeSH term(s) Comorbidity ; Hidradenitis Suppurativa/complications ; Humans ; Inflammation/complications ; Mevalonate Kinase Deficiency/complications ; Mevalonate Kinase Deficiency/diagnosis ; Skin ; Syndrome
    Language English
    Publishing date 2022-05-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.883811
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report.

    Goldman, Serge / Bron, Dominique / Tousseyn, Thomas / Vierasu, Irina / Dewispelaere, Laurent / Heimann, Pierre / Cogan, Elie / Goldman, Michel

    Frontiers in medicine

    2021  Volume 8, Page(s) 798095

    Abstract: Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid ...

    Abstract Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
    Language English
    Publishing date 2021-11-25
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.798095
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Multisystem Inflammatory Syndrome With Complete Kawasaki Disease Features Associated With SARS-CoV-2 Infection in a Young Adult. A Case Report.

    Cogan, Elie / Foulon, Pierre / Cappeliez, Olivier / Dolle, Nicole / Vanfraechem, Gaëlle / De Backer, Daniel

    Frontiers in medicine

    2020  Volume 7, Page(s) 428

    Abstract: A severe multisystem inflammatory syndrome associated with Kawasaki disease manifestations (MIS-C) has been recently reported in children with signs of recent infection with SARS-CoV-2. We here reported the case of a young adult woman who presented the ... ...

    Abstract A severe multisystem inflammatory syndrome associated with Kawasaki disease manifestations (MIS-C) has been recently reported in children with signs of recent infection with SARS-CoV-2. We here reported the case of a young adult woman who presented the complete manifestations of Kawasaki disease associated with a severe myocarditis, acute respiratory distress syndrome and hemodynamic instability a few weeks after a transient anosmia. The detection of specific antibodies to SARS-CoV-2 in the absence of detection of the virus suggested that the syndrome was the result of a delayed immune response to a recent COVID-19 infection. A combined treatment with colchicine, tocilizumab, high dose immunoglobulins, and methylprednisolone allowed to control the inflammatory process and to limit the development of coronary aneurysm. The patient recovered without sequelae. This case emphasized the importance of SARS-CoV-2 serology for the diagnosis of delayed immune complications of COVID-19. Clinicians caring for adult patients must be aware that not only children but also young adults can be affected by a multisystem inflammatory syndrome with KD features associated with COVID-19.
    Keywords covid19
    Language English
    Publishing date 2020-07-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2020.00428
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Formalisation de la supervision de l'apprentissage du raisonnement clinique.

    Cogan, Elie / Maisonneuve, Hubert / Leeman, Marc / Goffard, Jean-Christophe / Michelet, Estelle / Audétat, Marie-Claude

    La Revue de medecine interne

    2020  Volume 41, Issue 8, Page(s) 529–535

    Abstract: Since clinical reasoning is central to most decisions made in the clinic, it is essential to teach it with the greatest relevance. Knowing that around 10% of learners encounter major difficulties in clinical reasoning during their course, training ... ...

    Title translation How to formalise the supervision of learning of clinical reasoning.
    Abstract Since clinical reasoning is central to most decisions made in the clinic, it is essential to teach it with the greatest relevance. Knowing that around 10% of learners encounter major difficulties in clinical reasoning during their course, training supervisors in effective pedagogical interventions is crucial. Here we summarize the methods allowing supervisors to identify errors of clinical reasoning in medical students and interns and we explain remediation techniques adapted to the types of error identified. Access to short illustrative videos of a MOOC (Massive Open On line Course) devoted to the supervision of clinical reasoning constitutes practical help for supervisors who are not expert in the complexity of medical pedagogy at bedside.
    MeSH term(s) Clinical Competence ; Clinical Reasoning ; Curriculum/standards ; Education, Medical/methods ; Education, Medical/organization & administration ; Education, Medical/standards ; Faculty, Medical/education ; Faculty, Medical/organization & administration ; Faculty, Medical/standards ; Humans ; Learning ; Students, Medical/psychology ; Teacher Training/methods ; Teacher Training/organization & administration ; Teacher Training/standards
    Language French
    Publishing date 2020-07-13
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 604679-4
    ISSN 1768-3122 ; 0248-8663
    ISSN (online) 1768-3122
    ISSN 0248-8663
    DOI 10.1016/j.revmed.2020.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Eosinophilia Associated With CD3

    Carpentier, Caroline / Verbanck, Sylvain / Schandené, Liliane / Heimann, Pierre / Trépant, Anne-Laure / Cogan, Elie / Roufosse, Florence

    Frontiers in immunology

    2020  Volume 11, Page(s) 1765

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Adolescent ; Adult ; Aged ; CD3 Complex/immunology ; CD4-Positive T-Lymphocytes/immunology ; Female ; Humans ; Hypereosinophilic Syndrome/immunology ; Male ; Middle Aged ; Retrospective Studies ; T-Lymphocyte Subsets/immunology ; Young Adult
    Chemical Substances CD3 Complex
    Language English
    Publishing date 2020-08-11
    Publishing country Switzerland
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot

    Serge Goldman / Dominique Bron / Thomas Tousseyn / Irina Vierasu / Laurent Dewispelaere / Pierre Heimann / Elie Cogan / Michel Goldman

    Frontiers in Medicine, Vol

    A Case Report

    2021  Volume 8

    Abstract: Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid ...

    Abstract Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.
    Keywords mRNA vaccine ; T cell ; lymphoma ; COVID-19 ; angioimmunoblastic ; follicular ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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