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  1. Article: Biofilm Producing Methicillin-Resistant

    Kaushik, Ashlesha / Kest, Helen / Sood, Mangla / Steussy, Bryan W / Thieman, Corey / Gupta, Sandeep

    Pathogens (Basel, Switzerland)

    2024  Volume 13, Issue 1

    Abstract: Since its initial description in the 1960s, methicillin- ... ...

    Abstract Since its initial description in the 1960s, methicillin-resistant
    Language English
    Publishing date 2024-01-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens13010076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Role of Antifungals in Pediatric Critical Care Invasive Fungal Infections.

    Kaushik, Ashlesha / Kest, Helen

    Critical care research and practice

    2018  Volume 2018, Page(s) 8469585

    Abstract: Invasive fungal infections (IFIs) have seen considerable increase in pediatric intensive care units over the past several decades. IFIs are predominantly caused ... ...

    Abstract Invasive fungal infections (IFIs) have seen considerable increase in pediatric intensive care units over the past several decades. IFIs are predominantly caused by
    Language English
    Publishing date 2018-11-22
    Publishing country Egypt
    Document type Journal Article ; Review
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2018/8469585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Pediatric Methicillin-Resistant

    Kaushik, Ashlesha / Kest, Helen

    Microorganisms

    2018  Volume 6, Issue 2

    Abstract: Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges in diagnosis and management due to higher morbidity, effect on growth plate with ... ...

    Abstract Osteoarticular infections (OSI) are a significant cause of hospitalizations and morbidity in young children. The pediatric patient with OSI presents unique challenges in diagnosis and management due to higher morbidity, effect on growth plate with associated long-lasting sequelae, and challenges in early identification and management. Methicillin-resistant
    Language English
    Publishing date 2018-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms6020040
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: It Is Complicated: The Medico-Social Journey of an Undocumented Pregnant Adolescent.

    Kest, Helen / Kaushik, Ashlesha / Tehreem, Bushra / Goldberg, David

    Case reports in pediatrics

    2020  Volume 2020, Page(s) 6749630

    Abstract: Adolescent pregnancies are a global health problem with over 16 million children born to this age group globally. Adolescent females also represent almost half of all adolescent global migrants. Adolescent pregnancy by itself is associated with poor ... ...

    Abstract Adolescent pregnancies are a global health problem with over 16 million children born to this age group globally. Adolescent females also represent almost half of all adolescent global migrants. Adolescent pregnancy by itself is associated with poor health care access and morbidities; the additional risk of social insecurity in the case of undocumented adolescent migrants leads to higher risks for the mother and newborn. According to the CDC, adolescents comprise half of all new sexually transmitted diseases (STDs) including reported primary and secondary syphilis. Our case highlights the relationship between social insecurity for the undocumented adolescent migrant and excess risks for preventable mother-to-child transmission of communicable diseases. In formulating preventive measures and policies for the recent rise in sexually transmitted maternal diseases with resultant congenital infections, there is need for health care systems and providers to familiarize themselves with advocacy and other useful resources that will promote health care access for undocumented and other vulnerable adolescents. Additionally, local providers who work in areas with a large population of immigrant adolescents should utilize the untapped resources of these adolescents to develop youth community advocacy projects that link adolescents to health resources, including reproductive health.
    Language English
    Publishing date 2020-04-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659094-3
    ISSN 2090-6811 ; 2090-6803
    ISSN (online) 2090-6811
    ISSN 2090-6803
    DOI 10.1155/2020/6749630
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Epidemiologic Characteristics of Adolescents with COVID-19 Disease with Acute Hypoxemic Respiratory Failure.

    Kest, Helen / Kaushik, Ashlesha / Shaheen, Somia / Debruin, William / Zaveri, Sahil / Colletti, Mario / Gupta, Sandeep

    Critical care research and practice

    2022  Volume 2022, Page(s) 7601185

    Abstract: We report our experience of COVID-19 disease with hypoxemic respiratory failure among patients aged 12-21 years admitted to the intensive care unit at two tertiary care institutions in Northeastern and Midwestern United States. Our results showed that ... ...

    Abstract We report our experience of COVID-19 disease with hypoxemic respiratory failure among patients aged 12-21 years admitted to the intensive care unit at two tertiary care institutions in Northeastern and Midwestern United States. Our results showed that during the main study period that spanned the initial surge at both geographic locations, adolescents with SARS-COV-2 infection admitted to the ICU with respiratory failure were more likely to be male, black, and morbidly obese and with two or more comorbidities. The majority (79%) were admitted with COVID-19-related pneumonia and 15 developed respiratory failure; two-thirds of patients with respiratory failure (9/15, 60%) required mechanical ventilation (MV). More than two-thirds of patients (11/15, 75%) with respiratory failure were obese with BMI > 30 compared to those without respiratory failure (
    Language English
    Publishing date 2022-09-05
    Publishing country Egypt
    Document type Journal Article
    ZDB-ID 2573849-5
    ISSN 2090-1313 ; 2090-1305
    ISSN (online) 2090-1313
    ISSN 2090-1305
    DOI 10.1155/2022/7601185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: COVID-19 Vaccine Cardiac Complications: A Case Series on Implications of Marijuana in Adolescents With Myopericarditis.

    Zaveri, Sahil / Kest, Helen / Shah, Bhavin / DeBruin, William / Colletti, Mario

    Cureus

    2022  Volume 14, Issue 5, Page(s) e24665

    Abstract: We report on two critically ill pediatric patients, aged 16 and 18 years, presenting with acute myopericarditis at a tertiary-care center in New Jersey, United States. Both patients had their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ... ...

    Abstract We report on two critically ill pediatric patients, aged 16 and 18 years, presenting with acute myopericarditis at a tertiary-care center in New Jersey, United States. Both patients had their severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations, tested negative for SARS-CoV-2, and shared only significant history of asthma. Clinical presentations were similar to acute onset chest pain that worsened with deep inspiration. One patient reported a history of vaping and escalating marijuana use several hours preceding presentation. Both patients had elevated troponin on admission and had ST-segment elevation on electrocardiogram (EKG), thus prompting admission to the pediatric intensive care unit (PICU) for cardiac monitoring. Myopericarditis has multiple etiologies and is a newly described rare complication of the SARS-CoV-2 vaccine. It can also occur as a complication of vaping and frequent marijuana drug use. Our paper highlights the importance of a detailed social and drug history in adolescents presenting with chest pain. The clinical characterization is necessary to promote better case definitions and the design of targeted interventions for this vulnerable group.
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.24665
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Disseminated cryptococcosis with immunoglobulin G subclass deficiency.

    Kaushik, Ashlesha / Rao, Harini / Tengson, Roger / Rezk, Ahmed / Kest, Helen

    Pediatrics international : official journal of the Japan Pediatric Society

    2019  Volume 61, Issue 2, Page(s) 198–199

    MeSH term(s) Adolescent ; Antifungal Agents/therapeutic use ; Brain/diagnostic imaging ; Cerebrospinal Fluid/microbiology ; Cryptococcosis/complications ; Cryptococcosis/diagnosis ; Cryptococcosis/drug therapy ; Cryptococcus neoformans/isolation & purification ; Humans ; IgG Deficiency/complications ; Immunoglobulin G/blood ; Magnetic Resonance Imaging ; Male ; Skin/microbiology ; Skin/pathology
    Chemical Substances Antifungal Agents ; Immunoglobulin G
    Language English
    Publishing date 2019-02-11
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.13741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rooming-in for Well-term Infants Born to Asymptomatic Mothers with COVID-19: Correspondence.

    Kest, Helen / Kaushik, Ashlesha / Skroce, Linda / Bogusz, Jaimee / Datta-Bhutada, Subhashree

    Journal of the Pediatric Infectious Diseases Society

    2020  Volume 10, Issue 1, Page(s) 60–61

    MeSH term(s) Asymptomatic Infections ; Breast Feeding ; COVID-19/diagnosis ; Female ; Humans ; Infant, Newborn ; Object Attachment ; Pregnancy ; Pregnancy Complications, Infectious/diagnosis ; Retrospective Studies ; Rooming-in Care ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-11
    Publishing country England
    Document type Letter
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piaa120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with 2019 Novel Coronavirus (SARS-CoV-2) Infection.

    Kest, Helen / Kaushik, Ashlesha / DeBruin, William / Colletti, Mario / Goldberg, David

    Case reports in pediatrics

    2020  Volume 2020, Page(s) 8875987

    Abstract: We report three critically ill pediatric patients (aged 6-10 years), presenting with features of multisystem inflammatory syndrome in children (MIS-C) from April 4 to May 10, 2020, to a tertiary-care center in New Jersey, United States. All patients ... ...

    Abstract We report three critically ill pediatric patients (aged 6-10 years), presenting with features of multisystem inflammatory syndrome in children (MIS-C) from April 4 to May 10, 2020, to a tertiary-care center in New Jersey, United States. All patients tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and were previously healthy. Clinical presentations were similar with fever, abdominal pain, gastrointestinal complaints, and/or rash. One patient had altered mental status with cerebrospinal fluid (CSF) findings consistent with aseptic meningitis. Laboratory values were remarkable for high levels of C-reactive protein, D-dimers, B-type natriuretic peptide (BNP), and troponin in all patients. All had low albumin levels. Evaluation for other infectious etiologies was negative. All of the patients were critically ill, requiring admission to the intensive care unit. All had circulatory shock and needed inotropes. Two patients had respiratory failure requiring advanced respiratory support and one had cardiac dysfunction. All patients received steroids, and two received intravenous immunoglobulin (IVIG). One patient received tocilizumab. None of the children died. MIS-C is a recently recognized pediatric illness spectrum in association with SARS-CoV-2 infection, and clinical characterization is essential for understanding disease mechanisms to inform clinical practice.
    Keywords covid19
    Language English
    Publishing date 2020-07-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659094-3
    ISSN 2090-6811 ; 2090-6803
    ISSN (online) 2090-6811
    ISSN 2090-6803
    DOI 10.1155/2020/8875987
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Adolescents as partners in the fight against COVID-19.

    Kest, Helen / Kaushik, Ashlesha / Jagunla, Anne / Shaheen, Somia / Zaveri, Sahil / Fernandez, Ninia / Gupta, Sandeep / Goldberg, David

    International journal of pediatrics & adolescent medicine

    2021  Volume 9, Issue 2, Page(s) 113–116

    Abstract: We report our experience of COVID-19 disease burden among patients aged 0-21 years at two tertiary care institutions in the Northeast and Midwest from New Jersey and Iowa. Our results showed that during the initial surge (March to August 2020) at both ... ...

    Abstract We report our experience of COVID-19 disease burden among patients aged 0-21 years at two tertiary care institutions in the Northeast and Midwest from New Jersey and Iowa. Our results showed that during the initial surge (March to August 2020) at both geographic locations, majority of COVID-19 disease burden occurred in adolescents and that they were more likely to be hospitalized for COVID-related illnesses, as well as develop severe disease needing intensive care. The study results emphasize the need for providing more targeted interventions toward this group to help prevent disease acquisition and transmission.
    Language English
    Publishing date 2021-10-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2832064-5
    ISSN 2352-6467 ; 2352-6467
    ISSN (online) 2352-6467
    ISSN 2352-6467
    DOI 10.1016/j.ijpam.2021.10.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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