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  1. Article ; Online: Biosorption of arsenic (III) from aqueous solution using calcium alginate immobilized dead biomass of Acinetobacter sp. strain Sp2b.

    Khandelwal, Renu / Keelka, Sneha / Jain, Neha / Jain, Prachi / Kumar Sharma, Mukesh / Kaushik, Pallavi

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9972

    Abstract: This study presents a novel biosorbent developed by immobilizing dead Sp2b bacterial biomass into calcium alginate (CASp2b) to efficiently remove arsenic ( ... ...

    Abstract This study presents a novel biosorbent developed by immobilizing dead Sp2b bacterial biomass into calcium alginate (CASp2b) to efficiently remove arsenic (As
    MeSH term(s) Alginates/chemistry ; Alginates/metabolism ; Acinetobacter/metabolism ; Acinetobacter/genetics ; Arsenic/metabolism ; Biomass ; Water Pollutants, Chemical/metabolism ; Biodegradation, Environmental ; Adsorption ; Kinetics ; Hydrogen-Ion Concentration ; Water Purification/methods ; Temperature ; Thermodynamics
    Chemical Substances Alginates ; Arsenic (N712M78A8G) ; Water Pollutants, Chemical
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-60329-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Guillain Barre syndrome mimicking brain death.

    Sarna, Mukesh Kumar / Shah, Sarthak / Rijhwani, Puneet / Goyal, Gourav / Jain, Anand Kumar / Goel, Pallaavi

    The journal of the Royal College of Physicians of Edinburgh

    2024  , Page(s) 14782715241244839

    Abstract: A 49-year-old female patient presented at the hospital with a history of herpetic blisters, frequent episodes of vomiting and loose stools, bilateral upper and lower limb weakness, and diminishing sensorium. She was diagnosed with hyponatraemia and ... ...

    Abstract A 49-year-old female patient presented at the hospital with a history of herpetic blisters, frequent episodes of vomiting and loose stools, bilateral upper and lower limb weakness, and diminishing sensorium. She was diagnosed with hyponatraemia and respiratory failure and later became unconscious with absent brainstem reflexes. The patient was initially treated for herpetic encephalitis, a chronic obstructive pulmonary disease with acute exacerbation, hyponatraemia and neuroparalytic snake bite. Further evaluation, however, identified the uncommon Guillain Barre syndrome presentation with overlap of Bickerstaff brainstem encephalitis. This is an uncommon disorder characterised by the involvement of higher mental functions, fixed dilated pupils, absent brainstem reflexes and quadriplegia that resembles a neuroparalytic snake bite and brain death. After receiving intravenous immunoglobulins for treatment, the patient completely recovered.
    Language English
    Publishing date 2024-04-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2866363-9
    ISSN 2042-8189 ; 0953-0932
    ISSN (online) 2042-8189
    ISSN 0953-0932
    DOI 10.1177/14782715241244839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3088 -Suppl.-: Show issues Location:
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  3. Article ; Online: Report of a collaborative study to establish the first Indian Pharmacopoeia reference standard for teriparatide.

    Jadaun, Gaurav Pratap Singh / Kalaivani, M / Kumar, Mukesh / Singh, Gyanendra Nath / Raghuvanshi, Rajeev Singh / Jain, Parveen

    Biologicals : journal of the International Association of Biological Standardization

    2024  Volume 86, Page(s) 101755

    Abstract: A collaborative study was conducted to establish the first Indian Pharmacopoeia Reference Standard (IPRS) for teriparatide to be used in quality control testing of marketed products in compliance with the Indian Pharmacopoeia (IP) monograph. The study ... ...

    Abstract A collaborative study was conducted to establish the first Indian Pharmacopoeia Reference Standard (IPRS) for teriparatide to be used in quality control testing of marketed products in compliance with the Indian Pharmacopoeia (IP) monograph. The study objective was to evaluate the candidate standard in terms of the WHO International Standard (IS) to assign its content in mg per vial terms. This study involved four laboratories from India and the candidate standard was calibrated against the WHO IS by each participant laboratory using high-performance liquid chromatography (HPLC) assay method per IP monograph. Direct calibration of the candidate standard resulted in an assigned content of 1.02 mg per vial. Based on the study results the candidate standard was judged suitable to serve as the first IPRS for teriparatide for identification and assay by HPLC.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1017370-5
    ISSN 1095-8320 ; 1045-1056
    ISSN (online) 1095-8320
    ISSN 1045-1056
    DOI 10.1016/j.biologicals.2024.101755
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    Zs.A 879: Show issues Location:
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  4. Article: Orthodontic management after unilateral extraction of a compound odontoma and an impacted canine.

    Kumar, Mukesh / Goyal, Manish / Kaur, Amandeep / Jain, Atam Dev / Maheshwari, Amit

    Journal of clinical orthodontics : JCO

    2023  Volume 57, Issue 2, Page(s) 101–109

    MeSH term(s) Humans ; Odontoma/surgery ; Tooth, Impacted/diagnostic imaging ; Tooth, Impacted/surgery ; Incisor ; Cuspid
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 410668-4
    ISSN 0022-3875
    ISSN 0022-3875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies.

    Pathak, Anchal / Pal, Ajay Kumar / Roy, Subhadeep / Nandave, Mukesh / Jain, Keerti

    Stem cells international

    2024  Volume 2024, Page(s) 9077926

    Abstract: Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. "Angiogenic switch" indicates a time-restricted event where the imbalance between pro- and antiangiogenic factors results in the transition from prevascular ...

    Abstract Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. "Angiogenic switch" indicates a time-restricted event where the imbalance between pro- and antiangiogenic factors results in the transition from prevascular hyperplasia to outgrowing vascularized tumor, which eventually leads to the malignant cancer progression. In the last decade, molecular players, i.e., angiogenic biomarkers and underlying molecular pathways involved in tumorigenesis, have been intensely investigated. Disrupting the initiation and halting the progression of angiogenesis by targeting these biomarkers and molecular pathways has been considered as a potential treatment approach for tumor angiogenesis. This review discusses the currently known biomarkers and available antiangiogenic therapies in cancer, i.e., monoclonal antibodies, aptamers, small molecular inhibitors, miRNAs, siRNAs, angiostatin, endostatin, and melatonin analogues, either approved by the U.S. Food and Drug Administration or currently under clinical and preclinical investigations.
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2573856-2
    ISSN 1687-9678 ; 1687-966X
    ISSN (online) 1687-9678
    ISSN 1687-966X
    DOI 10.1155/2024/9077926
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Conference proceedings: An Unusual Case of EHBO

    Pandey, Vivek / Singh, Shashank / Nijhawan, Sandeep / Gupta, Gaurav / Jain, Mukesh Kumar / Bharadwaj, Hemendra

    Journal of Digestive Endoscopy

    2024  Volume 15, Issue 01

    Event/congress ENDOCON 2024, New Delhi, 2024-04-19
    Language English
    Publishing date 2024-03-01
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2733732-7
    ISSN 0976-5050 ; 0976-5042 ; 0976-5050
    ISSN (online) 0976-5050
    ISSN 0976-5042 ; 0976-5050
    DOI 10.1055/s-0044-1786258
    Database Thieme publisher's database

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  7. Article ; Online: Role of Angiogenesis and Its Biomarkers in Development of Targeted Tumor Therapies

    Anchal Pathak / Ajay Kumar Pal / Subhadeep Roy / Mukesh Nandave / Keerti Jain

    Stem Cells International, Vol

    2024  Volume 2024

    Abstract: Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. “Angiogenic switch” indicates a time-restricted event where the imbalance between pro- and antiangiogenic factors results in the transition from prevascular ...

    Abstract Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. “Angiogenic switch” indicates a time-restricted event where the imbalance between pro- and antiangiogenic factors results in the transition from prevascular hyperplasia to outgrowing vascularized tumor, which eventually leads to the malignant cancer progression. In the last decade, molecular players, i.e., angiogenic biomarkers and underlying molecular pathways involved in tumorigenesis, have been intensely investigated. Disrupting the initiation and halting the progression of angiogenesis by targeting these biomarkers and molecular pathways has been considered as a potential treatment approach for tumor angiogenesis. This review discusses the currently known biomarkers and available antiangiogenic therapies in cancer, i.e., monoclonal antibodies, aptamers, small molecular inhibitors, miRNAs, siRNAs, angiostatin, endostatin, and melatonin analogues, either approved by the U.S. Food and Drug Administration or currently under clinical and preclinical investigations.
    Keywords Internal medicine ; RC31-1245
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Genome-wide discovery of genetic variations between rice cultivars with contrasting drought stress response and their potential functional relevance.

    Shankar, Rama / Dwivedi, Anuj Kumar / Singh, Vikram / Jain, Mukesh

    Physiologia plantarum

    2023  Volume 175, Issue 2, Page(s) e13879

    Abstract: Drought stress is a serious threat to rice productivity. Investigating genetic variations between drought-tolerant (DT) and drought-sensitive (DS) rice cultivars may decipher the candidate genes/regulatory regions involved in drought stress tolerance/ ... ...

    Abstract Drought stress is a serious threat to rice productivity. Investigating genetic variations between drought-tolerant (DT) and drought-sensitive (DS) rice cultivars may decipher the candidate genes/regulatory regions involved in drought stress tolerance/response. In this study, whole-genome resequencing data of four DS and five DT rice cultivars were analyzed. We identified a total of approximately 4.8 million single nucleotide polymorphisms (SNPs) and 0.54 million insertions/deletions (InDels). The genetic variations (162,638 SNPs and 17,217 InDels) differentiating DS and DT rice cultivars were found to be unevenly distributed throughout the rice genome; however, they were more frequent near the transcription start and stop sites than in the genic regions. The cis-regulatory motifs representing the binding sites of stress-related transcription factors (MYB, HB, bZIP, ERF, ARR, and AREB) harboring the SNPs/InDels in the promoter regions of a few differentially expressed genes (DEGs) were identified. Importantly, many of these DEGs were located within the drought-associated quantitative trait loci. Overall, this study provides a valuable large-scale genotyping resource and facilitates the discovery of candidate genes associated with drought stress tolerance in rice.
    MeSH term(s) Oryza/genetics ; Droughts ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Sequence Analysis, DNA ; Stress, Physiological/genetics
    Language English
    Publishing date 2023-02-18
    Publishing country Denmark
    Document type Journal Article
    ZDB-ID 2020837-6
    ISSN 1399-3054 ; 0031-9317
    ISSN (online) 1399-3054
    ISSN 0031-9317
    DOI 10.1111/ppl.13879
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  9. Article ; Online: Nanoparticles as potential hallmarks of drought stress tolerance in plants.

    Kandhol, Nidhi / Jain, Mukesh / Tripathi, Durgesh Kumar

    Physiologia plantarum

    2022  Volume 174, Issue 2, Page(s) e13665

    Abstract: Plants are inevitably exposed to drought stress limiting their growth and causing yield loss, thus inciting food crises across the world. Nanoparticles (NPs) are regarded as effective and promising tools for modulation of crop yield to overcome current ... ...

    Abstract Plants are inevitably exposed to drought stress limiting their growth and causing yield loss, thus inciting food crises across the world. Nanoparticles (NPs) are regarded as effective and promising tools for modulation of crop yield to overcome current and future constraints in sustainable agricultural production by upgrading the plant tolerance mechanism under abiotic stress conditions, including drought. NPs exhibit alleviating effects against drought stress via induction of physiological and biochemical readjustments accompanied by modulation of gene expression involved in drought response/tolerance. NPs ameliorate drought-induced reduction in carbon assimilation via increasing the photosynthetic activity. The improved root growth, upregulation of aquaporins, modification of intracellular water metabolism, accumulation of compatible solutes and ion homeostasis are the major mechanisms used by NPs to mitigate the osmotic stress caused by water deficit. NPs reduce water loss from leaves through stomatal closure due to fostered abscisic acid (ABA) accumulation and ameliorate oxidative stress damage by reducing reactive oxygen species and activating the antioxidant defense system. This review provides an evolutionary foundation regarding drought stress in plant life and summarizes the interactions between NPs and plants under drought. The subsequent impact of NPs on plant development and productivity and recent nanobiotechnological approaches to improve drought stress resilience are presented. On the whole, this review highlights the significance of NPs in dealing with the global problem of water scarcity faced by farmers.
    MeSH term(s) Droughts ; Gene Expression Regulation, Plant ; Nanoparticles ; Plant Stomata/physiology ; Plants/genetics ; Plants/metabolism ; Stress, Physiological/genetics ; Water/metabolism
    Chemical Substances Water (059QF0KO0R)
    Language English
    Publishing date 2022-03-26
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 2020837-6
    ISSN 1399-3054 ; 0031-9317
    ISSN (online) 1399-3054
    ISSN 0031-9317
    DOI 10.1111/ppl.13665
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  10. Article: Comparison between peripheral nerve stimulator-guided serratus anterior plane block versus transversus abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy under general anaesthesia: A double-blind randomised controlled trial.

    Prasad, Mukesh Kumar / Jain, Payal / Neha / Varshney, Rohit Kumar / Gogia, Pratiksha / Jheetay, Gurdeep S

    Indian journal of anaesthesia

    2023  Volume 67, Issue 8, Page(s) 685–689

    Abstract: Background and aims: Laparoscopic cholecystectomy (LC) is a widely accepted surgical procedure associated with postoperative pain. This study was done to compare peripheral nerve stimulator (PNS)-guided serratus anterior plane block (SAP) and ... ...

    Abstract Background and aims: Laparoscopic cholecystectomy (LC) is a widely accepted surgical procedure associated with postoperative pain. This study was done to compare peripheral nerve stimulator (PNS)-guided serratus anterior plane block (SAP) and transversus abdominis plane (TAP) block for postoperative analgesia for patients undergoing LC.
    Methods: Following approval from the ethical committee, 70 patients for LC were randomly assigned to Group S: SAP block and Group T: TAP block. The blocks were performed under PNS guidance, and 20 ml of 0.375% ropivacaine was administered. The severity of pain was measured using a visual analogue scale (VAS). The study's primary objective was the evaluation of the postoperative VAS score. The time of the first dose of rescue analgesia and total tramadol consumption for 24 h postoperatively were secondary objectives. All the statistical calculation was done using statistical analyses for Social Sciences for Windows version 23.0 (IBM Corp, NY, USA).
    Results: Lower VAS score was seen in patients of TAP block at rest as well as movement at 6 h (
    Conclusion: TAP block guided by the PNS improves postoperative pain with less tramadol consumption and during the postoperative period without significant complications.
    Language English
    Publishing date 2023-08-15
    Publishing country India
    Document type Journal Article
    ZDB-ID 412570-8
    ISSN 0019-5049
    ISSN 0019-5049
    DOI 10.4103/ija.ija_205_23
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1841: Show issues Location:
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