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  1. Article: Vaccine Strategies to Elicit Mucosal Immunity.

    Song, Yufeng / Mehl, Frances / Zeichner, Steven L

    Vaccines

    2024  Volume 12, Issue 2

    Abstract: Vaccines are essential tools to prevent infection and control transmission of infectious diseases that threaten public health. Most infectious agents enter their hosts across mucosal surfaces, which make up key first lines of host defense against ... ...

    Abstract Vaccines are essential tools to prevent infection and control transmission of infectious diseases that threaten public health. Most infectious agents enter their hosts across mucosal surfaces, which make up key first lines of host defense against pathogens. Mucosal immune responses play critical roles in host immune defense to provide durable and better recall responses. Substantial attention has been focused on developing effective mucosal vaccines to elicit robust localized and systemic immune responses by administration via mucosal routes. Mucosal vaccines that elicit effective immune responses yield protection superior to parenterally delivered vaccines. Beyond their valuable immunogenicity, mucosal vaccines can be less expensive and easier to administer without a need for injection materials and more highly trained personnel. However, developing effective mucosal vaccines faces many challenges, and much effort has been directed at their development. In this article, we review the history of mucosal vaccine development and present an overview of mucosal compartment biology and the roles that mucosal immunity plays in defending against infection, knowledge that has helped inform mucosal vaccine development. We explore new progress in mucosal vaccine design and optimization and novel approaches created to improve the efficacy and safety of mucosal vaccines.
    Language English
    Publishing date 2024-02-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines12020191
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Handbook of pediatric HIV care

    Zeichner, Steven L.

    2006  

    Title variant Pediatric HIV care
    Author's details ed. Steven L. Zeichner
    Keywords HIV Infections / diagnosis ; HIV Infections / therapy ; Child ; Infant
    Language English
    Size XXX, 871 S. : Ill., graph. Darst.
    Edition 2. ed.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT015345318
    ISBN 978-0-521-52906-8 ; 0-521-52906-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2008 A 387 order for loan Magazin

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  3. Book: Textbook of pediatric HIV care

    Zeichner, Steven L.

    2005  

    Title variant Pediatric HIV care
    Author's details ed. by Steven L. Zeichner
    Keywords Child ; Adolescent ; HIV Infections / complications ; HIV Infections / therapy
    Language English
    Size XXVI, 757 S. : Ill., graph. Darst.
    Publisher Cambridge Univ. Press
    Publishing place Cambridge u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013921018
    ISBN 978-0-521-82153-7 ; 0-521-82153-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 1797 order for loan Magazin

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  4. Article ; Online: Duration of Effective Antibody Levels After COVID-19.

    Cruz, Andrea T / Zeichner, Steven L

    Pediatrics

    2021  Volume 148, Issue 3

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Immunoglobulin G ; SARS-CoV-2
    Chemical Substances Antibodies, Viral ; Immunoglobulin G
    Language English
    Publishing date 2021-06-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2021-052589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.131: Show issues Location:
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  5. Book: Handbook of pediatric HIV care

    Zeichner, Steven L.

    1999  

    Author's details ed. Steven L. Zeichner
    Keywords HIV Infections / diagnosis ; HIV Infections / therapy ; Child ; Infant
    Language English
    Size XVIII, 670 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT010723945
    ISBN 0-7817-1771-X ; 978-0-7817-1771-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    1999 A 3944 order for loan Magazin

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  6. Article ; Online: Multisystem Inflammatory Syndrome in Children and SARS-CoV-2 Serology.

    Zeichner, Steven L / Cruz, Andrea T

    Pediatrics

    2020  Volume 146, Issue 6

    MeSH term(s) COVID-19 ; Child ; Humans ; Pandemics ; SARS-CoV-2 ; Syndrome ; Systemic Inflammatory Response Syndrome
    Keywords covid19
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-032888
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: COVID-19 in Children: Initial Characterization of the Pediatric Disease.

    Cruz, Andrea T / Zeichner, Steven L

    Pediatrics

    2020  Volume 145, Issue 6

    MeSH term(s) Betacoronavirus ; COVID-19 ; Child ; China ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-16
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2020-0834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: ACE-2-like enzymatic activity is associated with immunoglobulin in COVID-19 patients.

    Song, Yufeng / Myers, Regan / Mehl, Frances / Murphy, Lila / Brooks, Bailey / Wilson, Jeffrey M / Kadl, Alexandra / Woodfolk, Judith / Zeichner, Steven L

    mBio

    2024  Volume 15, Issue 4, Page(s) e0054124

    Abstract: Many mechanisms responsible for COVID-19 pathogenesis are well-established, but COVID-19 includes features with unclear pathogenesis, such as autonomic dysregulation, coagulopathies, and high levels of inflammation. The receptor for the SARS-CoV-2 spike ... ...

    Abstract Many mechanisms responsible for COVID-19 pathogenesis are well-established, but COVID-19 includes features with unclear pathogenesis, such as autonomic dysregulation, coagulopathies, and high levels of inflammation. The receptor for the SARS-CoV-2 spike protein receptor-binding domain (RBD) is angiotensin-converting enzyme 2 (ACE2). We hypothesized that some COVID-19 patients may develop antibodies that have a negative molecular image of RBD sufficiently similar to ACE2 to yield ACE2-like catalytic activity-ACE2-like abzymes. To explore this hypothesis, we studied patients hospitalized with COVID-19 who had plasma samples available obtained about 7 days after admission. ACE2 is a metalloprotease that requires Zn
    Importance: We provide what we believe to be the first description of angiotensin-converting enzyme 2 (ACE2)-like enzymatic activity associated with immunoglobulin in COVID-19 patients. COVID-19 includes many puzzling clinical features that have unclear pathogenesis, including a hyperinflammatory state, abnormalities of the clotting cascade, and blood pressure instability. We hypothesized that some patients with COVID-19 patients may produce antibodies against SARS-CoV-2 with enzymatic activity, or abzymes, that target important proteolytic regulatory cascades. The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein binds ACE2 on the surface of the future host cell. This means that the RBD has a negative molecular image of ACE2. We hypothesized that some antibodies produced against the RBD would have, in turn, a negative molecular image of the RBD sufficiently similar to ACE2 to have ACE2-like catalytic activity. In other words, some anti-RBD antibodies would be ACE2-like abzymes. Abzymes elicited by SARS-CoV-2 infection have the potential to affect host physiology.
    MeSH term(s) Humans ; Angiotensin-Converting Enzyme 2 ; Antibodies ; COVID-19 ; Peptides ; Protein Binding ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Antibodies ; Peptides ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; ACE2 protein, human (EC 3.4.17.23)
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00541-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fever, Rash, and Cough in a 7-Year-Old Boy.

    Luu, Lydia A / Makin, Thomas A / Borish, Larry / Snavely, Emily A / Meyer, Jessica S / Zlotoff, Barrett J / Zeichner, Steven L

    Pediatrics

    2023  Volume 151, Issue 2

    Abstract: A 7-year-old boy presented to the emergency department with fever, cough, congestion, abdominal pain, myalgias, and morbilliform rash. Several aspects of the patient's history, including recent travel, living on a farm, exposure to sick contacts, and new ...

    Abstract A 7-year-old boy presented to the emergency department with fever, cough, congestion, abdominal pain, myalgias, and morbilliform rash. Several aspects of the patient's history, including recent travel, living on a farm, exposure to sick contacts, and new medications, resulted in a wide differential diagnosis. Initial laboratory testing revealed leukocytosis with neutrophilia and elevated atypical lymphocytes, but did not reveal any infectious causes of illness. He was discharged from the hospital, but then represented to the emergency department a day later with worsening rash, continued fever, abdominal pain, and poor intake. He was then admitted. A more comprehensive laboratory evaluation was initiated. During this hospital course, the patient's physical examination changed when he developed head and neck edema, and certain laboratory trends became clearer. With the assistance of several specialists, the team was able to reach a more definitive diagnosis and initiate treatment to appropriately manage his condition.
    MeSH term(s) Male ; Humans ; Child ; Cough/etiology ; Fever/etiology ; Abdominal Pain/etiology ; Leukocytosis ; Diagnosis, Differential ; Exanthema/etiology
    Language English
    Publishing date 2023-01-05
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-058194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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