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  1. Article: Anemia That Presented with Desaturation: A Focus on Core Concepts.

    Shobhavat, Lakshmi / D'Costa, Antonio / Shroff, Karthik

    Case reports in pediatrics

    2021  Volume 2021, Page(s) 5583840

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2021-05-17
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2659094-3
    ISSN 2090-6811 ; 2090-6803
    ISSN (online) 2090-6811
    ISSN 2090-6803
    DOI 10.1155/2021/5583840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Changing outcomes of stem cell transplantation in primary immunodeficiencies: Results from a tertiary-care charitable trust hospital in Mumbai.

    Pandrowala, Ambreen / Desai, Mukesh / Madkaikar, Manisha / Kulkarni, Shilpa / Shobhavat, Lakshmi / Mishra, Jayashree / Jain, Shreepal / Chandane, Parmarth / Sehgal, Kunal / Chavan, Saroj / Karkera, Parag / Bendre, Pradnya / Thanky, Ameet / Rao, Sudha / Prabhu, Shakuntala / Bodhanwala, Minnie / Agarwal, Bharat / Hiwarkar, Prashant

    The journal of allergy and clinical immunology. Global

    2023  Volume 2, Issue 3, Page(s) 100105

    Abstract: Background: Hematopoietic stem cell transplantation in primary immunodeficiency disorders has come a long way since the first transplant in 1968. In India, pediatric stem cell transplantation long-term survival outcomes range from 62.5% to 75%, compared ...

    Abstract Background: Hematopoietic stem cell transplantation in primary immunodeficiency disorders has come a long way since the first transplant in 1968. In India, pediatric stem cell transplantation long-term survival outcomes range from 62.5% to 75%, compared to 90% in high-income countries.
    Objective: We present single-center data of primary immunodeficiency transplants with immune-reconstitution evaluation after transplantation from a charitable trust hospital.
    Methods: Retrospective data of children transplanted for primary immunodeficiency disorders from March 2019 to March 2022 in a newly established transplant unit were collected. Data of pretransplant infections and comorbidities, surveillance for carbapenem-resistant Enterobacteriaceae, transplant characteristics, donor source, graft-versus-host disease, posttransplant infections, immune reconstitution, overall survival at 1 year, and immunodeficiency-free survival were collated.
    Results: Twenty-one patients underwent transplantation for primary immunodeficiency disorders. The median age at transplantation was 3 years and 5 months (range, 7 months to 17 years). Seventy-five percent of the cohort had organ involvement, with lung being the most common organ involved, followed by central nervous system. Fifty-two percent of children had peritransplant infections, with most of them recognized at the pretransplant assessment. Among 20 of 21 children with engraftment, 94% had complete chimerism initially, with 33% developing mixed chimerism over time. The median duration of immunosuppression was 3 months after transplantation, and only 1 child required systemic graft-versus-host disease treatment for more than a year. Immune-reconstitution showed good T-cell recovery at 3 months and naive T-cell production at 6 months. There was no regimen-related or sepsis-related mortality. Overall survival of the cohort was 95% at 1-year follow-up. Immunodeficiency-free survival was 86% after a median follow-up of 20 months.
    Conclusions: Immunodeficiency-free and graft-versus-host disease-free survival can be achieved in the majority of children with primary immunodeficiencies using enhanced supportive care and the latest transplantation algorithms.
    Language English
    Publishing date 2023-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2023.100105
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  3. Article: Multisystem Inflammatory Syndrome in Children: Clinical Features and Management-Intensive Care Experience from a Pediatric Public Hospital in Western India.

    Shobhavat, Lakshmi / Solomon, Rekha / Rao, Sudha / Bhagat, Isha / Prabhu, Sanjay / Prabhu, Shakuntala / Chandrakar, Manoj / Bodhanwala, Minnie

    Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

    2020  Volume 24, Issue 11, Page(s) 1089–1094

    Abstract: ... intravenous immunoglobulin were used.: How to cite this article: Shobhavat L, Solomon R, Rao S, Bhagat I, Prabhu S, Prabhu ...

    Abstract Background: Multisystem inflammatory syndrome (MIS) associated with severe acute respiratory syndrome coronavirus (SARS-CoV-2) (MIS-C) in children is being increasingly reported across the world.
    Materials and methods: Children fulfilling the World Health Organization criteria of MIS-C needing pediatric intensive care unit between April 15 and July 26, 2020 were studied.
    Results: There were 21 patients with median age of 7 years [interquartile range (IQR) 1.9-12.1], of which 11 were females. SARS-CoV-2 real-time polymerase chain reaction positive in 8/21 and/or antibody positive 16/21. Fever was present in all patients, and gastrointestinal symptoms being second most frequent (16/21). One child had aplastic anemia, while the rest had no comorbidities. Nearly all presented with shock (
    Conclusion: In our cohort, MIS-C was seen in previously healthy children with fever, gastrointestinal symptoms, and shock. Early and aggressive management of shock and immune modulation with methyl-prednisolone and intravenous immunoglobulin were used.
    How to cite this article: Shobhavat L, Solomon R, Rao S, Bhagat I, Prabhu S, Prabhu S,
    Language English
    Publishing date 2020-09-29
    Publishing country India
    Document type Journal Article
    ZDB-ID 2121263-6
    ISSN 1998-359X ; 0972-5229
    ISSN (online) 1998-359X
    ISSN 0972-5229
    DOI 10.5005/jp-journals-10071-23658
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Subacute combined degeneration of the spinal cord in an adolescent girl.

    Mohanty, Sweta / Shobhavat, Lakshmi / Joshi, Rajesh

    Journal of tropical pediatrics

    2010  Volume 56, Issue 4, Page(s) 272–274

    Abstract: Subacute combined degeneration of the spinal cord (SACD), a condition resulting from vitamin B12 deficiency, generally affects elderly people. We present a 12-year-old girl, who, despite a non-vegetarian diet and no obvious etiological factors, developed ...

    Abstract Subacute combined degeneration of the spinal cord (SACD), a condition resulting from vitamin B12 deficiency, generally affects elderly people. We present a 12-year-old girl, who, despite a non-vegetarian diet and no obvious etiological factors, developed SACD.
    MeSH term(s) Child ; Diet ; Female ; Humans ; Injections, Intramuscular ; Magnetic Resonance Imaging ; Spinal Cord/pathology ; Subacute Combined Degeneration/drug therapy ; Subacute Combined Degeneration/etiology ; Subacute Combined Degeneration/pathology ; Treatment Outcome ; Vitamin B 12/therapeutic use ; Vitamin B 12 Deficiency/complications ; Vitamin B 12 Deficiency/drug therapy
    Chemical Substances Vitamin B 12 (P6YC3EG204)
    Language English
    Publishing date 2010-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 800065-7
    ISSN 1465-3664 ; 0449-3281 ; 0142-6338
    ISSN (online) 1465-3664
    ISSN 0449-3281 ; 0142-6338
    DOI 10.1093/tropej/fmp111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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