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Article ; Online: Cefepime-induced neurotoxicity in a patient with renal dysfunction

Daniela V. SILVA / Cleni VERONEZE / Priscila L. GUIMARÃES

Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde, Vol 14, Iss 1, Pp 917-

a case report

2023 Volume 917

Abstract: Cefepime is an antimicrobial widely used in the hospital environment. During the development phases, the drug proved to be safe and, therefore, was approved and marketed. After the commercialization of cefepime, case reports involving a serious adverse ... ...

Abstract	Cefepime is an antimicrobial widely used in the hospital environment. During the development phases, the drug proved to be safe and, therefore, was approved and marketed. After the commercialization of cefepime, case reports involving a serious adverse reaction were emerging. Cefepime-Induced Neurotoxicity (CIN) is a reaction that occurs most often in patients with renal dysfunction, damage to the blood-brain barrier or advanced age. Dose adjustment should be made according to creatinine clearance in order to prevent adverse reaction. Among the symptoms are drowsiness, tremors, myoclonus, agitation, lowered level of consciousness, convulsions and coma. The electroencephalogram can be used to aid in the diagnosis, but it is not specific for this condition. In this article, we present a case report of a 52-year-old woman with acute renal failure who presented CIN after using cefepime, despite dose adjustments according to renal function. The patient presented the symptoms even after discontinuing the medication and hemodialysis did not reverse the condition. The patient’s physiological characteristics may have contributed to the outcome of the case. The description of CIN cases in the literature is important for a better understanding of the pathophysiology that involves the adverse reaction and prevention of new cases.
Keywords	Public aspects of medicine ; RA1-1270 ; Pharmacy and materia medica ; RS1-441 ; Therapeutics. Pharmacology ; RM1-950
Subject code	616
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Sociedade Brasileira de Farmácia Hospitalar e Serviços de Saúde
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of Storage Time on the Physical, Chemical, and Rheological Properties of Blueberry Jam: Experimental Measurements and Artificial Neural Network Simulation.

Guimarães, Daniela Helena Pelegrine / Ferreira, Ana Lúcia Gabas / Arce, Pedro Felipe

Foods (Basel, Switzerland)

2023 Volume 12, Issue 15

Abstract: Reversible data hiding (RDH) is crucial in modern data security, ensuring confidentiality and tamper-proofness in various industries like copyright protection, medical imaging, and digital forensics. As technology advances, RDH techniques become ... ...

Abstract	Reversible data hiding (RDH) is crucial in modern data security, ensuring confidentiality and tamper-proofness in various industries like copyright protection, medical imaging, and digital forensics. As technology advances, RDH techniques become essential, but the trade-off between embedding capacity and visual quality must be heeded. In this paper, the relative correlation between the pixel's local complexity and its directional prediction error is employed to enhance an efficient RDH without using a location map. An embedding process based on multiple cumulative peak region localization (MCPRL) is proposed to hide information in the 3D-directional prediction error histogram with a lower local complexity value and avoid the underflow/overflow problems. The carrier image is divided into three color channels, and then each channel is split into two non-overlapping sets: blank and shadow. Two half-directional prediction errors (the blank set and the shadow set) are constructed to generate a full-directional prediction error for each color channel belonging to the host image. The local complexity value and directional prediction error are critical metrics in the proposed embedding process to improve security and robustness. By utilizing these metrics to construct a 3D stego-Blank Set, the 3D stego-shadow Set will be subsequently constructed using the 3D blank set. The proposed technique outperforms other state-of-the-art techniques in terms of embedding capacity, image quality, and robustness against attacks without an extra location map. The experimental results illustrate the effectiveness of the proposed method for various 3D RDH techniques.
Language	English
Publishing date	2023-07-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12152853
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Article ; Online: Multisystem inflammatory syndrome in children (MISC): A systematic review.

Guimarães, Daniela / Pissarra, Rita / Reis-Melo, Ana / Guimarães, Hercília

International journal of clinical practice

2021 Volume 75, Issue 11, Page(s) e14450

Abstract: Objective: The aim of this systematic review was to analyse current literature and reported cases of multisystem inflammatory syndrome in children (MISC), concerning its clinical spectrum, complications associated, therapeutic strategies and ... ...

Abstract	Objective: The aim of this systematic review was to analyse current literature and reported cases of multisystem inflammatory syndrome in children (MISC), concerning its clinical spectrum, complications associated, therapeutic strategies and distinguishing features of other clinical syndromes. Methods: Extensive literature research was performed in MEDLINE (through PubMed), Scopus and Web of Science from December 2019 to December 2020. First analysis included all article titles and abstracts screening to identify relevant studies, and second analysis included a full-text screening of previously selected studies. Eligibility was assessed independently by two authors, and disagreements were resolved by discussion and consensus. Data were extracted on MISC definition, demographic data, clinical features, diagnostic tests, laboratory analysis and imaging, therapeutical approach and outcomes. Results: Common symptoms included gastrointestinal (70%), rash (57%) and cardiovascular (52% with shock). Notable differences with Kawasaki disease were identified including age, clinical presentation and cardiac involvement. Thirty per cent presented positive severe acute respiratory syndrome coronavirus-2 reverse transcription polymerase chain reaction and 51% positive serologies. Sixty-two per cent received intravenous immunoglobulin and 42% glucocorticoids. Sixty-two per cent required intensive care and 21 children died (<2%). Severe presentations were associated with neurological symptoms, hepatitis and acute kidney injury. Conclusions: MISC raises concern on its severe cardiac involvement at presentation, with frequent intensive care and immunomodulatory therapy need. Short-term outcomes seem to be favourable, with cardiac dysfunction recovery and low mortality rates.
MeSH term(s)	COVID-19/complications ; Child ; Humans ; Immunoglobulins, Intravenous ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
Chemical Substances	Immunoglobulins, Intravenous
Language	English
Publishing date	2021-06-23
Publishing country	England
Document type	Journal Article ; Systematic Review
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14450
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Article ; Online: Effect of Storage Time on the Physical, Chemical, and Rheological Properties of Blueberry Jam: Experimental Measurements and Artificial Neural Network Simulation

Guimarães, Daniela Helena Pelegrine / Ferreira, Ana Lúcia Gabas / Arce, Pedro Felipe

Foods. 2023 July 27, v. 12, no. 15

2023

Abstract	Reversible data hiding (RDH) is crucial in modern data security, ensuring confidentiality and tamper-proofness in various industries like copyright protection, medical imaging, and digital forensics. As technology advances, RDH techniques become essential, but the trade-off between embedding capacity and visual quality must be heeded. In this paper, the relative correlation between the pixel’s local complexity and its directional prediction error is employed to enhance an efficient RDH without using a location map. An embedding process based on multiple cumulative peak region localization (MCPRL) is proposed to hide information in the 3D-directional prediction error histogram with a lower local complexity value and avoid the underflow/overflow problems. The carrier image is divided into three color channels, and then each channel is split into two non-overlapping sets: blank and shadow. Two half-directional prediction errors (the blank set and the shadow set) are constructed to generate a full-directional prediction error for each color channel belonging to the host image. The local complexity value and directional prediction error are critical metrics in the proposed embedding process to improve security and robustness. By utilizing these metrics to construct a 3D stego-Blank Set, the 3D stego-shadow Set will be subsequently constructed using the 3D blank set. The proposed technique outperforms other state-of-the-art techniques in terms of embedding capacity, image quality, and robustness against attacks without an extra location map. The experimental results illustrate the effectiveness of the proposed method for various 3D RDH techniques.
Keywords	blueberries ; neural networks ; storage time
Language	English
Dates of publication	2023-0727
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2704223-6
ISSN	2304-8158
ISSN	2304-8158
DOI	10.3390/foods12152853
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Article ; Online: A Retrospective Cohort Study to Investigate the Impact of Cardiovascular Comorbidities on Knee Osteoarthritis Progression.

Parente, Hugo / Guimarães, Francisca / Soares, Catarina Dantas / Ferreira, Maria Pontes / Azevedo, Soraia / Santos-Faria, Daniela / Peixoto, Daniela / Afonso, Carmo / Tavares-Costa, José / Teixeira, Filipa

Mediterranean journal of rheumatology

2023 Volume 34, Issue 2, Page(s) 279–281

Language	English
Publishing date	2023-03-30
Publishing country	Greece
Document type	Journal Article
ZDB-ID	3019943-8
ISSN	2529-198X ; 2459-3516
ISSN (online)	2529-198X
ISSN	2459-3516
DOI	10.31138/mjr.34.2.279
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Article ; Online: Facing the Unknown: An Inductive Analysis of the Lived Experience of Medical Residents during the COVID-19 Pandemic.

Guimarães-Fernandes, Flávio / Benoit, Laelia / de Oliveira, Luiza Magalhães / Neto, Paulo Chenaud / Feniman, Débora Chou / Correia, Aline Villalobo / de Oliveira Bosoni, Nathaly / Macaya, Daniela Medina / Miguel, Euripedes Constantino / Ceron-Litvoc, Daniela / Castellana, Gustavo Bonini

Psychopathology

2024 , Page(s) 1–13

Abstract: Introduction: The COVID-19 pandemic had significant repercussions for the everyday life and public health of society. Healthcare professionals were particularly vulnerable. Here, we interviewed medical residents about their lived experiences during the ... ...

Abstract	Introduction: The COVID-19 pandemic had significant repercussions for the everyday life and public health of society. Healthcare professionals were particularly vulnerable. Here, we interviewed medical residents about their lived experiences during the pandemic to offer a phenomenological analysis. To this end, we discuss their pandemic experiences considering Jaspers' "limit situation" concept - that is, a radical shift from their everyday experiences, to one causing them to question the basis of their very existence. Methods: We interviewed 33 medical residents from psychiatry and other specialties from the Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP) who either (a) worked directly with COVID-19 patients or (b) provided psychiatric care to other healthcare professionals. Semi-structured interviews were developed using the Inductive Process to Analyze the Structure of lived Experience (IPSE). Results: The descriptions of the lived experiences of medical residents during the pandemic were organized into four content themes: (a) existential defense, (b) limit situations during the COVID-19 pandemic, (c) changes in lived experience, and (d) new world meanings through lived experience. Conclusion: During the COVID-19 pandemic, medical residents experienced what can be thought of as a "limit situation," as they encountered the healthcare delivery challenges coupled with the social isolation imposed by the COVID-19 pandemic. These challenges included fear of infection and potential death, uncertainty about the future, and the emotional overload caused by the sharp increase in patient deaths. That said, after facing such a limit situation, residents reported feeling strengthened by this experience. This is consistent with the notion that when confronted with limit situations, we draw on our resources to overcome adversity and, in turn, reap existential gains. Health care providers might use these experiences to energize their own professional approach.
Language	English
Publishing date	2024-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	605604-0
ISSN	1423-033X ; 0254-4962
ISSN (online)	1423-033X
ISSN	0254-4962
DOI	10.1159/000536135
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Article ; Online: Barcode-style lateral flow immunochromatographic strip for the semi-quantitative detection of ochratoxin A in coffee samples.

Contreras Alvarez, Luis Alberto / Lazo Jara, Marcia Daniela / Campos, Fabiana Vasconcelos / de Oliveira, Jairo Pinto / Guimarães, Marco César Cunegundes

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2024 Volume 41, Issue 4, Page(s) 424–437

Abstract: Ochratoxin A (OTA) is a mycotoxin contaminating agricultural products produced by fungi, associated with important toxic effects. Thus, the development of fast, sensitive, and economical approaches for OTA detection is crucial. In this study, a barcode- ... ...

Abstract	Ochratoxin A (OTA) is a mycotoxin contaminating agricultural products produced by fungi, associated with important toxic effects. Thus, the development of fast, sensitive, and economical approaches for OTA detection is crucial. In this study, a barcode-style lateral flow assay for the semi-quantitative detection of OTA in coffee samples was developed. To achieve this goal, a BSA-OTA complex was immobilized in three test zones to compete with OTA molecules in the sample for binding with anti-OTA antibodies labeled with gold nanoparticles. Different concentrations of OTA in the sample produced distinct colour patterns, allowing semi-quantification of the analyte. The assay exhibited high sensitivity, with a limit of detection of 2.5 µg.L
MeSH term(s)	Coffee/chemistry ; Gold/chemistry ; Reproducibility of Results ; Food Contamination/analysis ; Metal Nanoparticles/chemistry ; Ochratoxins/analysis
Chemical Substances	ochratoxin A (1779SX6LUY) ; Coffee ; Gold (7440-57-5) ; Ochratoxins
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2024.2313115
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Article ; Online: Open the eyes to see the lesion: the hidden stroke.

Ferro, Daniela / Lopes, Carolina / Filipe, João Pedro / Guimarães, Joana

Acta neurologica Belgica

2021 Volume 122, Issue 5, Page(s) 1343–1344

MeSH term(s)	Cerebral Infarction ; Humans ; Stroke/diagnostic imaging ; Thalamus
Language	English
Publishing date	2021-01-12
Publishing country	Italy
Document type	Journal Article
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-020-01546-5
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Article ; Online: National Vitamin A Supplementation Program in primary care: what is the reality in Minas Gerais, Brazil?

Miranda, Wanessa Debôrtoli de / Guimarães, Eliete Albano de Azevedo / Campos, Daniela Souzalima / Luz, Zélia Maria Profeta da

Ciencia & saude coletiva

2023 Volume 28, Issue 8, Page(s) 2323–2333

Abstract: The present study aimed to evaluate the National Vitamin A Supplementation Program in Minas Gerais, adopting the mixed sequential explanatory method. The quantitative approach adopted the multidimensional instrument per the components of vitamin A ... ...

Title translation	Programa Nacional de Suplementação de Vitamina A na atenção primária: qual a realidade em Minas Gerais, Brasil?
Abstract	The present study aimed to evaluate the National Vitamin A Supplementation Program in Minas Gerais, adopting the mixed sequential explanatory method. The quantitative approach adopted the multidimensional instrument per the components of vitamin A supplementation and food and nutrition education. We employed an analysis matrix with parameters to define the implementation as adequate, partially adequate, inadequate, and critical. We used semi-structured interviews in the qualitative approach. The "process" dimension was better evaluated than the "structure", with an implementation level (IL) of 84.6% and 78.5%, respectively. The Program's strengths include supplementation planning, achieving goals, recording information, supporting breastfeeding, and the performance of Community Health Workers. Weaknesses are fragmented work, analysis of information limits, access to the Program's actions, implementation of educational actions, and lack of or insufficient availability of nutritionists and training. The Program's reality only partially considered health promotion actions and focused on vitamin A supplementation. Implementing food and nutritional education actions is imperative to face vitamin A deficiency.
MeSH term(s)	Humans ; Vitamin A ; Brazil ; Health Education ; Dietary Supplements ; Primary Health Care
Chemical Substances	Vitamin A (11103-57-4)
Language	English
Publishing date	2023-04-28
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2078799-6
ISSN	1678-4561 ; 1678-4561
ISSN (online)	1678-4561
ISSN	1678-4561
DOI	10.1590/1413-81232023288.05922023
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Article ; Online: Could ultrasound and muscle elastography be associated with clinical assessment, laboratory and nailfold capillaroscopy in juvenile dermatomyositis patients?

de Andrade, Renata Lopes Francisco / Mendonça, José Alexandre / Piotto, Daniela Petry / Guimarães, Julio Brandão / Terreri, Maria Teresa

Advances in rheumatology (London, England)

2023 Volume 63, Issue 1, Page(s) 48

Abstract: Background: Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting disease activity and tissue damage. ...

Abstract	Background: Juvenile Dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy in children. Imaging exams are useful for muscle assessment, with ultrasonography (US) being a promising tool in detecting disease activity and tissue damage. There are few studies about muscle elastography. Objectives: Our aim was to associate clinical, laboratory, and nailfold capillaroscopy (NC) assessments with US in JDM patients; and to compare the findings of US and Strain Elastography (SE) from patients and healthy controls. Methods: An analytic cross-sectional study was performed with JDM patients and healthy controls. Patients underwent clinical exam to access muscle strength and completed questionnaires about global assessment of the disease and functional capacity. Patients were submitted to NC and measurement of muscle enzymes. All subjects underwent US assessment, using gray scale, Power Doppler (PD), and SE. Results: Twenty-two JDM patients and fourteen controls, aged between 5 and 21 years, matched for age and sex were assessed. In qualitative and semi-quantitative gray scale, we observed a higher frequency of alterations in patients (p < 0.001), while in PD, there was a higher frequency of positivity in patients' deltoids and anterior tibialis (p < 0.001). Active disease was associated with an important change in the semi-quantitative gray scale in deltoids (p = 0.007), biceps brachii (p = 0.001) and quadriceps femoris (p = 0.005). The SE demonstrated a high negative predictive value of 87.2. Conclusion: US was able, through gray scale, to differentiate JDM patients from controls, while PD achieved such differentiation only for deltoids and anterior tibialis. The semi-quantitative gray scale showed disease activity in proximal muscles. SE was not able to differentiate patients from controls.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Adolescent ; Young Adult ; Adult ; Dermatomyositis/diagnosis ; Elasticity Imaging Techniques ; Microscopic Angioscopy ; Cross-Sectional Studies ; Muscle, Skeletal/diagnostic imaging
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article
ISSN	2523-3106
ISSN (online)	2523-3106
DOI	10.1186/s42358-023-00330-2
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