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  1. Article ; Online: Depths of Dysfunctional Epithelial and Immune Crosstalk in Cystic Fibrosis Revealed.

    Yonker, Lael M / Kinane, T Bernard

    American journal of respiratory and critical care medicine

    2024  

    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202401-0181ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Response by Yonker et al to Letter Regarding Article, "Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis".

    Yonker, Lael M / Fasano, Alessio / Walt, David R

    Circulation

    2023  Volume 148, Issue 11, Page(s) 910–911

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Myocarditis/diagnosis ; Myocarditis/etiology ; Spike Glycoprotein, Coronavirus/genetics ; mRNA Vaccines
    Chemical Substances spike protein, SARS-CoV-2 ; COVID-19 Vaccines ; Spike Glycoprotein, Coronavirus
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.123.065629
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Carboxylated Nanoparticle Surfaces Enhance Association with Mucoid

    Deiss-Yehiely, Elad / Dzordzorme, Abigail E / Loiselle, Maggie Elizabeth / Yonker, Lael M / Hammond, Paula T

    ACS applied materials & interfaces

    2024  Volume 16, Issue 12, Page(s) 14573–14582

    Abstract: Pseudomonas ... ...

    Abstract Pseudomonas aeruginosa
    MeSH term(s) Humans ; Pseudomonas aeruginosa ; Polysaccharides, Bacterial ; Biofilms ; Carboxylic Acids ; Alginates ; Nanoparticles ; Sulfates
    Chemical Substances Polysaccharides, Bacterial ; Carboxylic Acids ; Alginates ; Sulfates
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c18656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Reply.

    Yonker, Lael M / Fasano, Alessio

    The Journal of pediatrics

    2020  Volume 228, Page(s) 314–315

    Keywords covid19
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.09.051
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  5. Article ; Online: Reply.

    Yonker, Lael M / Fasano, Alessio

    The Journal of pediatrics

    2020  Volume 229, Page(s) 314

    MeSH term(s) COVID-19 ; Child ; Humans ; Immunity ; SARS-CoV-2
    Language English
    Publishing date 2020-09-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.09.058
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  6. Article ; Online: The Spectrum of Postacute Sequelae of COVID-19 in Children: From MIS-C to Long COVID.

    Kane, Abigail S / Godfrey, Madeleine / Noval Rivas, Magali / Arditi, Moshe / Fasano, Alessio / Yonker, Lael M

    Annual review of virology

    2024  

    Abstract: The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from ... ...

    Abstract The effects of SARS-CoV-2 infection on children continue to evolve following the onset of the COVID-19 pandemic. Although life-threatening multisystem inflammatory syndrome in children (MIS-C) has become rare, long-standing symptoms stemming from persistent immune activation beyond the resolution of acute SARS-CoV-2 infection contribute to major health sequelae and continue to pose an economic burden. Shared pathophysiologic mechanisms place MIS-C and long COVID within a vast spectrum of postinfectious conditions characterized by intestinal dysbiosis, increased gut permeability, and varying degrees of immune dysregulation. Insights obtained from MIS-C will help shape our understanding of the more indolent and prevalent postacute sequelae of COVID and ultimately guide efforts to improve diagnosis and management of postinfectious complications of SARS-CoV-2 infection in children.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2764224-0
    ISSN 2327-0578 ; 2327-056X
    ISSN (online) 2327-0578
    ISSN 2327-056X
    DOI 10.1146/annurev-virology-093022-011839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Heart of the Problem in Multisystem Inflammatory Syndrome in Children.

    Boribong, Brittany P / Arya, Puneeta / Yonker, Lael M

    Med (New York, N.Y.)

    2021  Volume 2, Issue 9, Page(s) 993–995

    Abstract: Multisystem inflammatory syndrome in children (MIS-C) is a severe, life-threatening, post-COVID-19 hyperinflammatory illness that is not yet fully understood. In this issue ... ...

    Abstract Multisystem inflammatory syndrome in children (MIS-C) is a severe, life-threatening, post-COVID-19 hyperinflammatory illness that is not yet fully understood. In this issue of
    MeSH term(s) COVID-19/complications ; Child ; Connective Tissue Diseases ; Dendritic Cells ; Humans ; Monocytes ; Myocarditis/diagnosis ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Comment
    ISSN 2666-6340
    ISSN (online) 2666-6340
    DOI 10.1016/j.medj.2021.08.008
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  8. Article ; Online: Aerosol Production by Children Performing Spirometry and Implications During a Pandemic.

    Shah, Jhill / Moschovis, Peter P / Rooney, Jennifer / Singh, Dilpreet / Demokritou, Philip / Yonker, Lael M / Kinane, T Bernard

    Respiratory care

    2023  Volume 68, Issue 9, Page(s) 1254–1257

    MeSH term(s) Humans ; Child ; Pandemics ; Respiratory Aerosols and Droplets ; Spirometry ; Asthma
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.10200
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  9. Article ; Online: Neuropsychiatric adverse effects from CFTR modulators deserve a serious research effort.

    VanElzakker, Michael B / Tillman, Emma M / Yonker, Lael M / Ratai, Eva-Maria / Georgiopoulos, Anna M

    Current opinion in pulmonary medicine

    2023  Volume 29, Issue 6, Page(s) 603–609

    Abstract: Purpose of review: This review highlights the problem of neuropsychiatric adverse effects (AEs) associated with elexacaftor/tezacaftor/ivacaftor (ETI), current suboptimal mitigation approaches, a novel testable mechanistic hypothesis, and potential ... ...

    Abstract Purpose of review: This review highlights the problem of neuropsychiatric adverse effects (AEs) associated with elexacaftor/tezacaftor/ivacaftor (ETI), current suboptimal mitigation approaches, a novel testable mechanistic hypothesis, and potential solutions requiring further research.
    Recent findings: Studies show that a minority of persons with cystic fibrosis (PwCF) initiating cystic fibrosis transmembrane conductance regulator (CFTR) modulators experience neuropsychiatric AEs including worsening mood, cognition, anxiety, sleep, and suicidality. The GABA-A receptor is a ligand-gated chloride channel, and magnetic resonance spectroscopy neuroimaging studies have shown that reduced GABA expression in rostral anterior cingulate cortex is associated with anxiety and depression. Recent research details the impact of peripheral inflammation and the gut-brain axis on central neuroinflammation. Plasma ETI concentrations and sweat chloride have been evaluated in small studies of neuropsychiatric AEs but not validated to guide dose titration or correlated with pharmacogenomic variants or safety/efficacy.
    Summary: Although ETI is well tolerated by most PwCF, some experience debilitating neuropsychiatric AEs. In some cases, these AEs may be driven by modulation of CFTR and chloride transport within the brain. Understanding biological mechanisms is a critical next step in identifying which PwCF are likely to experience AEs, and in developing evidence-based strategies to mitigate them, while retaining modulator efficacy.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1285505-4
    ISSN 1531-6971 ; 1070-5287 ; 1078-1641
    ISSN (online) 1531-6971
    ISSN 1070-5287 ; 1078-1641
    DOI 10.1097/MCP.0000000000001014
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  10. Article ; Online: New insights into pulmonary hemorrhage.

    Yonker, Lael M / Hawley, Megan / Kinane, Thomas Bernard

    Pediatric investigation

    2019  Volume 3, Issue 4, Page(s) 207–208

    Language English
    Publishing date 2019-12-21
    Publishing country United States
    Document type Editorial
    ISSN 2574-2272
    ISSN (online) 2574-2272
    DOI 10.1002/ped4.12170
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